Click here to see Part 2 - Inversions involving the TRA locus
| Locus | Chromosomal localization | Translocation | Other involved genes (1) | Clinical entities (2) | |
| TRA | 14q11.2 | t(1;14)(p32;q11) | TAL1 | T cell acute lymphoblastic leukemia (T-ALL) | |
| t(8;14)(q24;q11) | MYC | T cell acute lymphoblastic leukemia (T-ALL) | |||
| t(10;14)(q24;q11) | TLX1 | T cell acute lymphoblastic leukemia (T-ALL) non-Hodgkin lymphoma (NHL) |
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| t(11;14)(p13;q11) | LMO2 | T cell acute lymphoblastic leukemia (T-ALL) |
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| t(14;14)(q11;q32) | TCL1A | T cell chronic lymphocytic leukemia (T-CLL) T cell prolymphocytic leukemia (T-PLL) |
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| t(14;21)(q11;q22) | unknown (21q22) | T cell acute lymphoblastic leukemia (T-ALL) |
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| t(X;14)(q28;q11) | MTCP1 | T prolymphocytic leukemia |
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IMGT notes:
| (1) | For the list of genes (other than IG or TR) involved in the translocations, click here. |
| (2) | Information on clinical entities are from the literature and from the Atlas of Genetics and Cytogenetics in Oncology and Haematology. For a list of the clinical entities quoted in the translocation tables, click here. |
| Locus | Chromosomal localization | Inversion | Other involved genes | Clinical entities | ||
| TRA | 14q11.2 | inv(14)(q11;q32) | IGH | T cell lymphoma | ||
| TCL1A | T cell prolymphocytic leukemia (T-PLL) T cell acute lymphoblastic leukemia (T-ALL) |
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Created: 29/03/2001
Last updated: Monday, 11-Jul-2011 12:57:02 CEST
Author: Marie-Paule Lefranc
Editors: Sandrine Béranger and Céline Protat
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
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