Click here to see Part 2 - Inversions involving the TRB locus
| Locus | Chromosomal localization | Translocation | Other involved genes (1) | Clinical entities (2) | ||
| TRB | 7q34 | t(1;7)(p32;q34) | TAL1 | T cell acute lymphoblastic leukemia (T-ALL) | ||
| t(1;7)(p34;q34) | LCK | T cell acute lymphoblastic leukemia (T-ALL) | ||||
| t(7;9)(q34;q32) | TAL2 | T cell acute lymphoblastic leukemia (T-ALL) | ||||
| t(7;9)(q34;q34) | NOTCH1 | T cell acute lymphoblastic leukemia (T-ALL) | ||||
| t(7;10)(q34;q24) | TLX1 | T cell acute lymphoblastic leukemia (T-ALL) non-Hodgkin lymphomia (NHL) |
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| t(7;11)(q34;p13) | LMO2 | T cell acute lymphoblastic leukemia (T-ALL) | ||||
| t(7;19)(q34;p13) | LYL1 | T cell acute lymphoblastic leukemia (T-ALL) | ||||
IMGT notes:
| (1) | For the list of genes (other than IG or TR) involved in the translocations, click here. |
| (2) | Information on clinical entities are from the literature and from the Atlas of Genetics and Cytogenetics in Oncology and Haematology. For a list of the clinical entities quoted in the translocation tables, click here. |
| Locus | Chromosomal localization | Inversion | Other involved genes | Clinical entities |
| TRB | 7q34 | inv(7)(p14;q34) | TRG | Ataxia telangiectasis Leukemia |
Created: 23/11/2000
Last updated: Wednesday, 29-Jun-2011 17:06:06 CEST
Author: Marie-Paule Lefranc
Editors: Sandrine Béranger and Céline Protat
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
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