Gene exon/intron splicing sites: Human immunoglobulin constant genes IGHC

Gene exon/intron organization: Human immunoglobulin constant genes IGHC

For more information, see Gene tables and Alignments of alleles (IMGT Repertoire).

IGHC
gene
and
allele name
(1)
5' exon 3' exon codon_start
Exons Last
complete
codon (2)
Codon
resulting
from
splicing
First
complete
codon (2)
Exons
IGHA1*01 (3)   (A) 1.3
S
TCC
CH1 3
G CA
CH1 124
P
CCA
(V) 2
P
CCC
H+CH2 3
G TT
H+CH2 124
S
TCC
(G) 1.3
N
AAC
CH3 3
G GA
CH3 (4) 125
A
GCG
(G) 2
S
TCT
M 3
G GC
IGHA2*01 (3)   (A) 1.3
S
TCC
CH1 3
G CA
CH1 124
P
CCA
(V) 2
P
CCC
H+CH2 3
G TT
H+CH2 124
S
TCC
(G) 1.3
N
AAC
CH3 3
G GA
CH3 (4) 125
A
GCG
(G) 2
S
TCT
M 3
G GC
IGHD*01 (3)   (A) 1.3
P
CCC
CH1 3
G CA
CH1 124
P
CCA
(E) 2
S
TCT
H1 3
G AG
H1 34
T
ACA
(G) 2
R
AGA
H2 3
G GA
H2 24
P
CCA
(E) 1.6
G
TGT
CH2 3
G AG
CH2 124
P
CCC
(A) 1.2
A
GCG
CH3 3
G CT
CH3 124
S
AGC
T (Y)
AT
2
V
GTA
CHS 3
(Y)
AC
2
L
CTG
M1
M1 53
K
AAG
  1
V
GTG
M2 1
IGHE*01 (3)   (A) 1.3
S
TCC
CH1 3
G CC
CH1 122
S
AGC
(E) 1.6
C
TGC
CH2 3
G TC
CH2 125
A
GCA
(D) 1.4
S
TCC
CH3 3
G AT
CH3 125
S
AGC
(G) 1.3
P
CCG
CH4 3
G GC
CH4 (4) 125
P
CCC
(E) 2
L
CTG
M1 3
G AG
M1 41
M
ATG
  1
V
GTG
M2 1
IGHG1*01 (3)   (A) 1.3
S
TCC
CH1 3
G CC
CH1 121
V
GTT
(E) 2
P
CCC
H 3
G AG
H 15
P
CCA
(A) 1.5
P
CCT
CH2 3
G CA
CH2 125
K
AAA
(G) 1.3
Q
CAG
CH3 3
G GG
CH3 (4) 125
P
CCG
(E) 2
L
CTG
M1 3
G AG
M1 44
K
AAG
  1
V
GTG
M2 1
IGHG2*01 (3)   (A) 1.3
S
TCC
CH1 3
G CC
CH1 121
V
GTT
(E) 2
R
CGC
H 3
G AG
H 12
P
CCA
(A) 1.5
P
CCA
CH2 3
G CA
CH2 125
K
AAA
(G) 1.3
Q
CAG
CH3 3
G GG
CH3 (4) 125
P
CCG
(E) 2
L
CTG
M1 3
G AG
M1 44
K
AAG
  1
V
GTG
M2 1
IGHG3*01 (3)   (A) 1.3
S
TCC
CH1 3
G CT
CH1 121
V
GTT
(E) 2
L
CTC
H1 3
G AG
H1 17
P
CCA
(E) 2
P
CCC
H2 3
G AG
H2 15
P
CCA
(E) 2
P
CCC
H3 3
G AG
H3 15
P
CCA
(E) 2
P
CCC
H4 3
G AG
H4 15
P
CCA
(A) 1.5
P
CCT
CH2 3
G CA
CH2 125
K
AAA
(G) 1.3
Q
CAG
CH3 3
G GA
CH3 (4) 125
P
CCG
(E) 2
L
CTG
M1 3
G AG
M1 44
K
AAG
  1
V
GTG
M2 1
IGHG4*01 (3)   (A) 1.3
S
TCC
CH1 3
G CT
CH1 121
V
GTT
(E) 2
S
TCC
H 3
G AG
H 12
P
CCA
(A) 1.5
P
CCT
CH2 3
G CA
CH2 125
K
AAA
(G) 1.3
Q
CAG
CH3 3
G GG
CH3 (4) 125
L
CTG
(E) 2
L
CTG (5)
M1 3
G AG (5)
M1 44
K
AAG (5)
  1
V
GTG (5)
M2 1
IGHGP*01 (3)   (A) 1.3
S
TCC
CH1 3
G CC
CH1 121
V
CTT
(E) 2
P
CCC
H 3
G AG
H 17
A
GCA
(A) 1.5
T
ACT
CH2 3
A CA
CH2 125
K
AAA
(G) 1.3
Q
CAG
CH3 3
G GG
CH3 (4) 125
P
CCG
(E) 2
L
CTG
M1 3
G AG
M1 44
K
AAG
  1
V
GTG
M2 1
IGHM*01 (3)   (G) 1.3
S
AGT
CH1 3
G GG
CH1 124
P
CCA
(V) 1.4
I
ATT
CH2 3
G TG
CH2 127
P
CCC
(D) 1.3
Q
CAA
CH3 3
G AT
CH3 125
K
AAG
(G) 1.4
V
GTG
CH4 3
G GG
CH4 (4) 125
T
ACC
(E) 2
G
GGG
M1 3
G AG
M1 39
K
AAG
  1
V
GTG
M2 1

IMGT notes:
(1)Only allele *01 is shown. The IGHEP1 pseudogene is not included in this table.
(2)Position of the last complete codon of the 5' exon and that of the first complete codon of the 3' exon are according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.
(3)The last nucleotide G of the IGH J-REGION, part of the codon resulting from the splicing with CH1, is indicated for each IGHC gene.
(4)The donor splice of the 5' exon is an internal donor splice (INT-DONOR-SPLICE) involved in the splicing of the IGH membrane chain transcript. IMGT Education>Tutorials>Immunoglobulins and B cells>Molecular genetics of immunoglobulins>Figure 7
(5)Defined by homology with the other IGHG genes. Needs to be confirmed by sequencing.


Created: 11/08/2003
Author: Marie-Paule Lefranc
Editor: Laurent Douchy
Contact: Marie-Paule Lefranc

Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.


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