Here you are: IMGT Web resources > IMGT Repertoire (IG and TR) > 1. Locus and genes > Gene table
Citing this page: Pallarès, N. et al., Exp. Clin. Immunogenet., 16, 36-60 (1999). PMID:10087405 pdf

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T), and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

Click on the gene name to get the corresponding IMGT/Gene-DB entry.
Click on the accession number to get the corresponding IMGT/LIGM-DB entry.

Orphon genes are designated by a number for the subgroup (if known) followed by a slash, OR (for Orphon), the chromosome number, a dash and a specific gene number

The 7 human (Homo sapiens) IGHV subgroups form three clans (Figure IGHV clans). One additional clan only contains one pseudogene. Clans comprise, respectively:

IMGT subgroup IMGT gene name IMGT allele name Fct Chromosomal localisation R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Accession numbers Positions in the sequence (V-REGION) Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence (V-REGION)
IGHV1 IGHV1/OR15-1 IGHV1/OR15-1*01 ORF 15q11.2 HC15-1 MAP Z29631 [14] 1-294 DP-1 Z12303 [13]
IGHV1/OR15-1*02 ORF 15q11.2 RF.BM, YF.PB2 AJ004954 [18] (7) c 25-320
P 15q11.2 (7)
IGHV1/OR15-2 IGHV1/OR15-2*01 P 15q11.2 V54 MAP L25543 [10] (1) 229-524 HC15-2 MAP Z29632 [14]
DP-22 Z12324 [13]
IGHV1/OR15-3 IGHV1/OR15-3*01 P 15q11.2 HC15-3 MAP Z29595 [14] (12) 1-294 DP-19 Z12321 [13]
IGHV1/OR15-3*02 ORF 15q11.2 COS-4 MAP Z17390 [14] 1-260
IGHV1/OR15-3*03 P 15q11.2 HA2 J00238 [11] (12) 375-668
IGHV1/OR15-4 IGHV1/OR15-4*01 P 15q11.2 HC15-4 MAP Z29596 [14] (1) 1-294 DP-23 Z12325 [13]
IGHV1/OR15-5 IGHV1/OR15-5*01 ORF 15q11.2 HC15-5 MAP Z29633 [14] 1-260 COS-14 MAP Z18899 [14]
IGHV1/OR15-5*02 ORF 15q11.2 DP-12 Z12314 [13] 1-294
IGHV1/OR15-6 IGHV1/OR15-6*01 P 15q11.2 HC15-6 MAP Z29634 [14] (3) 1-249 COS-18 MAP Z18903 [14]
IGHV1/OR15-6*02 P 15q11.2 DP-24 Z12326 [13] (9) 1-293
IGHV1/OR15-9 IGHV1/OR15-9*01 ORF 15q11.2 V13C MAP L25542 [10] (4) 188-483
IGHV1/OR16-1 (13) IGHV1/OR16-1*01 P 16p11.2 HC16-1 MAP Z29599 [14] (9) 1-257 DP-17 Z12319 [13]
IGHV1/OR16-2 (13) IGHV1/OR16-2*01 P 16p11.2 HC16-2 MAP Z29600 [14] (9) 1-257 DP-20 Z12322 [13]
65-1 X55585 [9]
IGHV1/OR16-3 (14) IGHV1/OR16-3*01 P 16p11.2 HC16-3 MAP Z29639 [14] (8) 1-203 15-1 X92211 [3]
IGHV1/OR16-4 (14) IGHV1/OR16-4*01 P 16p11.2 COS-11 MAP Z17397 [14] (8) 1-203 65-3 X55586 [9]
IGHV1/OR16-4*02 P 16p11.2 HC16-4 MAP Z29601 [14] (8) 1-203
IGHV1/OR21-1 IGHV1/OR21-1*01 ORF 21p11.2 CTD-2503J9 MAP AF254982 [19] 164866-165161 VH20 X92282 [6] (2)
IGHV2 IGHV2/OR16-5 (15) IGHV2/OR16-5*01 ORF 16p11.2 VF2-26 MAP L25544 [10] (4) 170-470 YAC1 MAP Z18919 [14]
HC16-5 MAP Z29602 [14]
IGHV3 IGHV3/OR15-7 IGHV3/OR15-7*01 ORF 15q11.2 HC15-7 MAP Z29597 [14] 1-300
IGHV3/OR15-7*02 ORF 15q11.2 VHD26 MAP M36530 [2] 247-546
IGHV3/OR15-7*03 ORF 15q11.2 DP-30 Z12332 [13] 1-300
IGHV3/OR15-7*04 P 15q11.2 V3 X07449 [8] (5) 189-488
IGHV3/OR16-6 (16) IGHV3/OR16-6*01 P 16p11.2 VF3-15P MAP L25545 [10] (10) 326-628 HC16-6 MAP Z29603 [14]
DP-36 Z12602 [13]
psiRC M99410 [1]
IGHV3/OR16-7 (16) IGHV3/OR16-7*01 P 16p11.2 HC16-7 MAP Z29604 [14] (10) 1-301 DP-37 Z12603 [13]
IGHV3/OR16-7*02 P 16p11.2 COS-20 MAP Z18905 [14] 1-301
IGHV3/OR16-7*03 P 16p11.2 COS-30 MAP Z29594 [14] 1-210
IGHV3/OR16-8 (17) IGHV3/OR16-8*01 ORF 16p11.2 HC16-8 MAP Z29605 [14] 1-294 DP-39 Z12339 [13]
65-4 X56164 [9] (4)
IGHV3/OR16-9 (17) IGHV3/OR16-9*01 ORF 16p11.2 HC16-9 MAP Z29606 [14] 1-294 DP-40 Z12340 [13]
15-2B X92219 [3] (4)
IGHV3/OR16-10 (18) IGHV3/OR16-10*01 ORF 16p11.2 HC16-10 MAP Z29607 [14] 1-291 DP-44 Z12344 [13]
65-2 X56163 [9]
IGHV3/OR16-10*02 ORF 16p11.2 DP-45 Z12345 [13] 1-291
IGHV3/OR16-11 (18) IGHV3/OR16-11*01 P 16p11.2 HC16-11 MAP Z29608 [14] (9) 1-290 DP-85 Z27454 [13]
IGHV3/OR16-12 (17) IGHV3/OR16-12*01 ORF 16p11.2 HC16-12 MAP Z29609 [14] 1-294 DP-84 Z27511 [13]
IGHV3/OR16-13 (19) IGHV3/OR16-13*01 ORF 16p11.2 HC16-13 MAP Z29610 [14] 1-294 DP-87 Z27456 [13]
IGHV3/OR16-14 (19) IGHV3/OR16-14*01 P 16p11.2 HC16-14 MAP Z29611 [14] (1) 1-294 COS-13 MAP Z18918 [14]
IGHV3/OR16-15 (20) IGHV3/OR16-15*01 P 16p11.2 VF3-16P MAP L25546 [10] (1) 204-499 YAC2 MAP Z27497 [14]
IGHV3/OR16-15*02 P 16p11.2 HC16-15 MAP Z29612 [14] (1) 1-294 VHGL3.4 Z14217 [5]
IGHV3/OR16-16 (20) IGHV3/OR16-16*01 P 16p11.2 HC16-16 MAP Z29613 [14] (1) 1-294 DP-82 Z15100
VHGL3.5 Z14218 [5] (11)
VHGL3.7 Z14220 [5] (11)
IGHV4 IGHV4/OR15-8 IGHV4/OR15-8*01 ORF 15q11.2 HC15-8 MAP Z29598 [14] 1-116 DP-69 Z12369 [13]
4d255 L10093 [15]
VH4.17 X56361 [12]
VH4.23 X56366 [12]
VH4MC1 X92247 [4]
H5 M95115 [16]
4.40 X92231 [17]
IGHV4/OR15-8*02 ORF 15q11.2 V11 X05712 [7] (6) 262-557

MAP: Mapped sequences.
c: cDNA sequence

IMGT notes:
  1. (1) STOP-CODON in FR2-IMGT.
  2. (2) INSERTION of one nucleotide (a), leading to a frameshift, is probably a sequencing error. The sequence X92282, previously assigned to IGHV1/OR15-5*02, has been shown to correspond to IGHV1/OR21-1*01 (message sent by Ruth Seal (HGNC) to Marie-Paule Lefranc on the 24/03/2010).
  3. (3) DELETION of ten nucleotides leading to a frameshift.
  4. (4) Unusual V-HEPTAMER and V-NONAMER sequences.
  5. (5) Frameshifts due to INSERTIONs and DELETIONs. The sequence described in the manuscript is different from the one submitted to the EMBL data library.
  6. (6) Unusual V-HEPTAMER sequence: cacatga instead of cacagtg.
  7. (7) HSeq:c15_43769, Hs T41390 sent by Ruth Lovering (HGNC) on the 15/12/2004 is a pseudogene owing to a deletion of 3' end L-PART1, L-INTRON-L and 5' L-PART-2, leading to a frameshift. It is not excluded that the other sequences of IGHV1/OR15-1 are pseudogenes instead of ORF, for the same reason.
  8. (8) Truncated V-GENE with completely divergent 3' region.
  9. (9) DELETION of one nucleotide in FR1-IMGT leading to a frameshift.
  10. (10) INSERTION of one nucleotide in FR1 leading to a frameshift.
  11. (11) Germline transcript.
  12. (12) STOP-CODON in FR1-IMGT.
  13. (13) Related counterpart at 14q32.33: IGHV1-14.
  14. (14) Related counterpart at 14q32.33: IGHV1-12.
  15. (15) Related counterpart at 14q32.33: IGHV2-26.
  16. (16) Related counterpart at 14q32.33: IGHV3-15.
  17. (17) Related counterpart at 14q32.33: IGHV3-11.
  18. (18) Related counterpart at 14q32.33: IGHV3-13.
  19. (19) Related counterpart at 14q32.33: IGHV3-74.
  20. (20) Related counterpart at 14q32.33: IGHV3-16.
IMGT references:
  1. [1] Adderson, E,E. et al., J. Immunol., 151, 800-809 (1993). PMID: 8335909
  2. [2] Buluwela, L. et al., EMBO. J., 7, 2003-2010 (1988) . PMID: 3138112
  3. [3] Berman, J.E. et al., EMBO J., 7, 727-738 (1988). PMID: 3396540
  4. [4] Campbell, M.J. et al., Mol. Immunol., 29, 193-203 (1992). PMID: 1542297
  5. [5] Cuisinier, A.M. et al., Eur. J. Immunol., 23, 110-118 (1993). PMID: 8419161
  6. [6] Humphries, C.G. et al., Nature, 331, 446-449 (1988) . PMID: 3123998
  7. [7] Lee, K.H. et al., J. Mol. Biol., 195, 761-768 (1987). PMID: 3116265
  8. [8] Matsuda, F. et al., EMBO J., 7, 1047-1051 (1988) . PMID: 2841108
  9. [9] Matsuda, F. et al., EMBO J., 9, 2501-2506 (1990). PMID: 2114977
  10. [10] Nagaoka, H. et al., Genomics, 22, 189-197 (1994). PMID: 7959766
  11. [11] Rechavi, G. et al., Proc. Natl. Acad. Sci. U.S.A., 80, 855-859 (1983) . PMID: 6298778
  12. [12] Sanz, I. et al., EMBO J., 8, 3741-3748 (1989) . PMID: 2511001
  13. [13] Tomlinson, I.M. et al., J. Mol. Biol., 227, 776-798 (1992) . PMID: 1404388
  14. [14] Tomlinson, I.M. et al., Hum. Molec. Genet., 3, 853-860 (1994). PMID: 7951227
  15. [15] van der Maarel, S. et al., J. Immunol., 150, 2858-2868 (1993). PMID: 8454861
  16. [16] van Es, J.H. et al., J. Immunol., 149, 492-497 (1992) . PMID: 1624796
  17. [17] Weng, N.P. et al., Eur. J. Immunol., 22, 1075-1082 (1992). PMID: 1348029
  18. [18] Thompson, A. et al., Immunogenetics, 48, 305-311 (1998). PMID: 9745007
  19. [19] Hattori, M. et al., Unpublished.
See also (IMGT Scientific chart):