When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated
in red letters.
Dashes indicate identical nucleotides. Dots indicate gaps by comparison to the longest
sequence. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).
The nucleotide between parentheses at the beginning of exons comes from a DONOR-SPLICE (n from ngt). The first nucleotide from an INT-DONOR-SPLICE is underlined (n from ngt).
Exon names are shown between parentheses on the first line.
The Cysteines involved in the IG CH1, CH2 and CH3 intrachain disulfide bridge are shown with a larger letter C in purple.
The Cysteines involved in the H-L or H-H interchain disulfide bridge are shown with a larger letter C in black.
STOP-CODON is indicated by an asterisk.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CH-S and in pages edited before 14/10/2009).
1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
A T S Q D L S V F P L A S C C
L36872 ,IGHE*01 (CH1) (G)CC ACC AGC CAG GAC CTG TCT GTG TTC CCC TTG GCC TCC TGC TGT
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
K D N I A S T S V T L G C L V T G Y
L36872 ,IGHE*01 (CH1) AAA GAC AAC ATC GCC ... ... AGT ACC TCT GTT ACA CTG GGC TGT CTG GTC ACC GGC TAT
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
L P M S T T V T W D T G S L N K
L36872 ,IGHE*01 (CH1) CTC CCC ... ... ATG TCG ACA ACT GTG ACC TGG GAC ACG GGG TCT CTA AAT AAG ... ...
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
N V T T F P T T F H E T Y
L36872 ,IGHE*01 (CH1) ... ... AAT GTC ACG ACC TTC CCC ACC ACC TTC CAC GAG ACC TAC ... ... ... ... ...
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
G L H S I V S Q V T A S G K W A
L36872 ,IGHE*01 (CH1) GGC CTC CAC AGC ATC GTC AGC CAG GTG ACC GCC TCG GGC AAG TGG ... ... ... ... GCC
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
K Q R F T C S V A H A E S T A I N
L36872 ,IGHE*01 (CH1) AAA CAG AGG TTC ACC TGC AGC GTG GCT CAC GCT ... ... ... GAG TCC ACC GCC ATC AAC
119 120 121 122
K T F S
L36872 ,IGHE*01 (CH1) AAG ACC TTC AGT G
1.7 1.6 1.5 1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
A C A L N F I P P T V K L F H S S C
L36872 ,IGHE*01 (CH2) CA TGT GCC TTA AAC TTC ATT CCG CCT ACC GTG AAG CTC TTC CAC TCC TCC TGC
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
N P V G D T H T T I Q L L C L I S G Y
L36872 ,IGHE*01 (CH2) AAC CCC GTC GGT GAT ACC ... CAC ACC ACC ATC CAG CTC CTG TGC CTC ATC TCT GGC TAC
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
V P G D M E V I W L V D G Q K A T N
L36872 ,IGHE*01 (CH2) GTC CCA ... ... GGT GAC ATG GAG GTC ATC TGG CTG GTG GAT GGG CAA AAG GCT ACA AAC
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
I F P Y T A P G T K E G
L36872 ,IGHE*01 (CH2) ... ... ATA TTC CCA TAC ACT GCA CCC GGC ACA AAG GAG GGC ... ... ... ... ... ...
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
N V T S T H S E L N I T Q G E W V S
L36872 ,IGHE*01 (CH2) AAC GTG ACC TCT ACC CAC AGC GAG CTC AAC ATC ACC CAG GGC GAG TGG ... ... GTA TCC
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
Q K T Y T C Q V T Y Q G F T F K
L36872 ,IGHE*01 (CH2) CAA AAA ACC TAC ACC TGC CAG GTC ACC TAT CAA ... ... ... ... GGC TTT ACC TTT AAA
119 120 121 122 123 124 125
D E A R K C S
L36872 ,IGHE*01 (CH2) GAT GAG GCT CGC AAG TGC TCA G
1.5 1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
E S D P R G V T S Y L S P P S P
L36872 ,IGHE*01 (CH3) AG TCC GAC CCC CGA GGC GTG ACG AGC TAC CTG AGC CCA CCC AGC CCC
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
L D L Y V H K A P K I T C L V V D L
L36872 ,IGHE*01 (CH3) CTT GAC CTG TAT GTC ... ... CAC AAG GCG CCC AAG ATC ACC TGC CTG GTA GTG GAC CTG
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
A T M E G M N L T W Y R E S K E P V
L36872 ,IGHE*01 (CH3) GCC ACC ATG ... GAA GGC ATG AAC CTG ACC TGG TAC CGG GAG AGC AAA GAA CCC GTG ...
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
N P G P L N K K D H F N
L36872 ,IGHE*01 (CH3) ... ... AAC CCG GGC CCT TTG AAC AAG AAG GAT CAC TTC AAT ... ... ... ... ... ...
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
G T I T V T S T L P V N T N D W I E
L36872 ,IGHE*01 (CH3) GGG ACG ATC ACA GTC ACG TCT ACC CTG CCA GTG AAC ACC AAT GAC TGG ... ... ATC GAG
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
G E T Y Y C R V T H P H L P K D I V
L36872 ,IGHE*01 (CH3) GGC GAG ACC TAC TAT TGC AGG GTG ACC CAC CCG CAC ... ... CTG CCC AAG GAC ATC GTG
119 120 121 122 123 124 125
R S I A K A P
L36872 ,IGHE*01 (CH3) CGC TCC ATT GCC AAG GCC CCT G
1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11
G K R A P P D V Y L F L P P E
L36872 ,IGHE*01 (CH4) GC AAG CGT GCC CCC CCG GAT GTG TAC TTG TTC CTG CCA CCG GAG
___AB_______ ________
15.1 15.3
12 13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28
E E Q G T K D R V T L T C L I Q N F
L36872 ,IGHE*01 (CH4) GAG GAG CAG GGG ACC ... ... AAG GAC AGA GTC ACC CTC ACG TGC CTG ATC CAG AAC TTC
_________BC_____________________ ___________CD_______
45.1 45.3 45.5
29 30 31 32 33 34 35 36 39 40 41 42 43 44 45 45.2 45.4
F P A D I S V Q W L R N D S P I Q T
L36872 ,IGHE*01 (CH4) TTC CCC ... ... GCG GAC ATT TCA GTG CAA TGG CTG CGA AAC GAC AGC CCC ATC CAG ACA
________ _________________________DE_____________
45.7 84.1 84.3 84.5 84.7 85.6
45.6 77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
D Q Y T T T G P H K V S G S R
L36872 ,IGHE*01 (CH4) GAC ... CAG TAC ACC ACC ACG GGG CCC CAC AAG GTC TCG GGC TCC ... ... ... ... AGG
________________ _EF_____
85.4 85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98
P A F F I F S R L E V S R V D W E Q
L36872 ,IGHE*01 (CH4) CCT GCC TTC TTC ATC TTC AGC CGC CTG GAG GTT AGC CGG GTG GAC TGG ... ... GAG CAG
_______________________FG___________________________
99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118
K N K F T C Q V V H E A L S G S R I L Q
L36872 ,IGHE*01 (CH4) AAA AAC AAA TTC ACC TGC CAA GTG GTG CAT GAG GCG CTG TCC GGC TCT AGG ATC CTC CAG
CH-S____
119 120 121 122 123 124 125 126 127 128 129 130
K W V S K T P G K *
L36872 ,IGHE*01 (CH4) AAA TGG GTG TCC AAA ACC CCC ... ... ... GGT AAA
Created: 22/10/2002
Author: Nathalie Bosc
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
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IMGT founder and director: Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr
Bioinformatics manager: Véronique Giudicelli Veronique.Giudicelli@igh.cnrs.fr Computer manager: Patrice Duroux Patrice.Duroux@igh.cnrs.fr Webmaster: Chantal Ginestoux Chantal.Ginestoux@igh.cnrs.fr |
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