IMGT Repertoire (IG and TR)
Alignment of alleles: Rabbit (Oryctolagus cuniculus) IGHA1
When several alleles are shown, the nucleotide mutations and amino acid
changes for a given codon are indicated in red letters. These polymorphic mutations are reported in
Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the
IMGT unique numbering.
Blanks indicate partial sequences (blanks at the 5' and/or 3' end).
Exon names are shown between parentheses on the first line.
Cysteine involved in the disulfide bridge are shown in purple.
STOP-CODON is indicated by an asterisk.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CH-S and in pages edited before 14/10/2009).
1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11 12
D P A T T P I L F P L S L P C P
X51647 IGHA1*01 F (CH1) ... ... ... ... gat ccc gca acc acc ccc atc ctc ttc ccg ctg agc ctc ccc tgt cct
AY386696 IGHA1*02 F ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
_____AB_____ ____________
15.1 15.3
13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28 29
L S G Q P V V V G C L I Q G F F
X51647 IGHA1*01 F (CH1) ctc tct ... ... ... ... gga cag ccc gtg gtc gtc ggc tgc ctg atc cag ggc ttc ttc
V
AY386696 IGHA1*02 F g-g --- ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
_______BC___________________ _____________CD_________
45.1 45.3 45.5
30 31 34 35 36 37 38 39 40 41 42 43 44 45 45.2 45.4 45.6
P L G P L N V K W T I S G
X51647 IGHA1*01 F (CH1) ccc ctg ... ggc cct ctg aat gtg aag tgg acc atc agc ggg ... ... ... ... ... ...
AY386696 IGHA1*02 F --- --- ... --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ...
____ ___________________________DE_______________
45.7 84.1 84.3 84.5 84.7 85.6 85.4
77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
E N V T F P P V Q L D T S G
X51647 IGHA1*01 F (CH1) ... gag aac gtg acc ttc cct cct gtc cag ttg gac acc tca ... ... ... ... ... ggc
AY386696 IGHA1*02 F ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---
____________ ___EF___
85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98 99
L Y T T S S L L N L T D E E C P
X51647 IGHA1*01 F (CH1) ctg tac acc acg agt agc cta ctg aac ctg aca gat gaa gag tgt ... ... ... ... cct
AY386696 IGHA1*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ---
_________________________FG_________________________
100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119
T C V A C H V E H N E V D R Y L
X51647 IGHA1*01 F (CH1) aca tgt gtg gcc tgc cac gtg gaa cac aat ... ... ... ... gaa gtg gac aga tat ctg
AY386696 IGHA1*02 F --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---
120 121 122 123 124
I L P C P
X51647 IGHA1*01 F (CH1) atc ctg ccc tgc cca
AY386696 IGHA1*02 F --- --- --- --- ---
1 2 3 4 5 6 7 8 9 10
D T H S S C P P T S
X51647 IGHA1*01 F (H) gat acc cac agc tcc tgc ccc ccc acc tcc
AY386696 IGHA1*02 F --- --- --- --- --- --- --- --- --- ---
1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11 12
C G E P S L S L Q R P D L R
X51647 IGHA1*01 F (CH2) ... ... ... ... ... ... tgc ggg gag ccc agc ctg tcc ctg cag cgg cca gac ctc aga
AY386696 IGHA1*02 F ... ... ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
_____AB_____ ____________
15.1 15.3
13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28 29
D L L L G S D A S L T C T L R G L K
X51647 IGHA1*01 F (CH2) gac ctg ctc ctg ... ... ggc tca gac gcc agc ctc acc tgc acc ctg aga ggc ctg aag
AY386696 IGHA1*02 F --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
_______BC___________________ _____________CD_________
45.1 45.3 45.5
30 31 34 35 36 37 38 39 40 41 42 43 44 45 45.2 45.4 45.6
D P K D A V F T W E P T N G N E
X51647 IGHA1*01 F (CH2) gac ccc ... aag gat gcc gtc ttc acc tgg gag ccc aca aac ggg aac gaa ... ... ...
AY386696 IGHA1*02 F --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...
____ ___________________________DE_______________
45.7 84.1 84.3 84.5 84.7 85.6 85.4
77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
P V Q Q S P Q R D P C G
X51647 IGHA1*01 F (CH2) ... ccg gtc cag cag agc ccc cag cgt gac ccc tgc ggc ... ... ... ... ... ... ...
AY386696 IGHA1*02 F ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ...
____________ ___EF___
85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98 99
C Y S V S S V L P G C A E T W T A G
X51647 IGHA1*01 F (CH2) tgc tac agt gtg tcc agt gtg ctg ccc ggc tgt gcg gag acc tgg ... ... act gcg ggg
P N
AY386696 IGHA1*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- c-- --- ... ... -a- --- ---
_________________________FG_________________________
100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119
T E F T C T V T H P E I E G S S L T A
X51647 IGHA1*01 F (CH2) aca gag ttc acc tgc aca gtc acc cac cct gag ... ata gag ggc agc tcc ctg aca gcc
AY386696 IGHA1*02 F --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
120 121 122 123 124 125
T I R K D T
X51647 IGHA1*01 F (CH2) acc atc aga aaa gac aca
S
AY386696 IGHA1*02 F --- --- --c --- --- ---
1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11 12
G S L T P P Q V H L L P P P S E
X51647 IGHA1*01 F (CH3) ... ... ... ... ggc agc ctc acc ccg ccc cag gtc cac ctg ctg ccg ccg cca tca gaa
AY386696 IGHA1*02 F ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
_____AB_____ ____________
15.1 15.3
13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28 29
E L A L N A L V T L T C L V R G F S
X51647 IGHA1*01 F (CH3) gag ctg gcc ctc ... ... aac gcg ctg gtg acg ctg acc tgc ctg gtg agg ggc ttc agc
AY386696 IGHA1*02 F --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
_______BC___________________ _____________CD_________
45.1 45.3 45.5
30 31 34 35 36 37 38 39 40 41 42 43 44 45 45.2 45.4 45.6
P K D V L V Y W T N K G V V V P K D
X51647 IGHA1*01 F (CH3) ccc ... ... aag gac gtg ctg gtg tac tgg aca aac aaa ggc gtg gtg gtc cca aaa gac
AY386696 IGHA1*02 F --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --c --- ---
____ ___________________________DE_______________
45.7 84.1 84.3 84.5 84.7 85.6 85.4
77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
S F L V W K P L P E P G Q E P T
X51647 IGHA1*01 F (CH3) ... agc ttc ctg gtg tgg aag ccc ctg cca gag ccc ggc cag gaa ... ... ... ccc acc
AY386696 IGHA1*02 F ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---
____________ ___EF___
85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98 99
T Y A V T S L L R V S A E D W N Q G
X51647 IGHA1*01 F (CH3) acc tac gcc gtc acc agc ctg ctg cgc gtg tcg gcc gag gac tgg ... ... aac cag ggg
AY386696 IGHA1*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
_________________________FG_________________________
100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119
D S Y S C V V G H E G L A E H F T Q K
X51647 IGHA1*01 F (CH3) gac agc tac tcc tgc gtg gtg ggc cat gag ggc ... ctg gcc gag cac ttc acc cag aag
AY386696 IGHA1*02 F --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
______________________________________CH-S__
120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139
T I D R Q A G K P T H V N V S V V
X51647 IGHA1*01 F (CH3) acc atc gac cgc caa gcg ... ... ... ggt aaa ccc acc cac gtc aac gtg tct gtg gtc
AY386696 IGHA1*02 F --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- ---
____________________________________
140 141 142 143 144 145 146 147 148
V A D V E G V C Y
X51647 IGHA1*01 F (CH3) gtg gca gac gtg gaa ggc gtg tgc tac
AY386696 IGHA1*02 F --- --- --- --- --- --- --- --- ---
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
G C Q E P L P C V V L D L P Q D S L E E
AY386696 IGHA1*02 F (M) ggt tgt cag gag ccc ctg ccc tgt gtg gtg ctg gat ctg cca cag gac agc ctg gag gag
21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40
E A P S D S L W P T T V T L L T L F L L
AY386696 IGHA1*02 F (M) gag gcc cct agc gac agc ctg tgg ccc acc acc gtc acc ctc ctc act ctc ttc ctg ctg
41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60
S L F Y S T A L T M T S I R G P P G S K
AY386696 IGHA1*02 F (M) agc ctg ttc tac agc aca gct ctg acc atg acc agc atc cgg ggc cca cct ggc agc aaa
61 62 63 64 65
E G P Q Y
AY386696 IGHA1*02 F (M) gag gga ccc cag tac
Last updated: Tuesday, 22-May-2012 22:02:31 CEST
Authors: Fatena Bellahcene, Claire Poiron and Christèle Martinez-Jean
Editor: Chantal Ginestoux
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only,
provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics
information system® http://www.imgt.org
(founder and director: Marie-Paule Lefranc, Montpellier, France)."
References to cite:
Lefranc, M.-P. et al.,
Nucleic Acids Research, 27, 209-212 (1999)
Cover of NAR;
Ruiz, M. et al.,
Nucleic Acids Research, 28, 219-221 (2000);
Lefranc, M.-P.,
Nucleic Acids Research, 29, 207-209 (2001);
Lefranc, M.-P.,
Nucleic Acids Res., 31, 307-310 (2003);
Lefranc, M.-P. et al.,
In Silico Biol., 5, 0006 (2004) [Epub],
5, 45-60 (2005);
Lefranc, M.-P. et al.,
Nucleic Acids Res., 33, D593-D597 (2005)
Full text;
Lefranc, M.-P. et al.,
Nucleic Acids Research 2009 37:
D1006-D1012; doi:10.1093/nar/gkn838
Full text.
For any other use please contact Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr.
IMGT founder and director: Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr
Bioinformatics manager: Véronique Giudicelli
Veronique.Giudicelli@igh.cnrs.fr
Computer manager: Patrice Duroux
Patrice.Duroux@igh.cnrs.fr
Webmaster: Chantal Ginestoux
Chantal.Ginestoux@igh.cnrs.fr
Citing IMGT | Warranty disclaimer and copyright notice | Privacy policy and advertisement policy
© Copyright 1995-2012 IMGT®, the international ImMunoGeneTics information system®