IMGT Repertoire (IG and TR)
Alignment of alleles: Rabbit (Oryctolagus cuniculus) IGHA13
When several alleles are shown, the nucleotide mutations and amino acid
changes for a given codon are indicated in red letters. These polymorphic mutations are reported in
Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the
IMGT unique numbering.
Blanks indicate partial sequences (blanks at the 5' and/or 3' end).
Exon names are shown between parentheses on the first line.
Cysteine involved in the disulfide bridge are shown in purple.
STOP-CODON is indicated by an asterisk.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CH-S and in pages edited before 14/10/2009).
1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11 12
X82119 IGHA13*01 F (CH1) ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ...
X00353 IGHA13*02 F ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ...
_____AB_____ ____________
15.1 15.3
13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28 29
N S Q Y V V V G C L I R G F
X82119 IGHA13*01 F (CH1) ... ... ... ... ..g aat ... tca cag tat gtg gtc gtc ggc tgc ctg atc cgg ggc ttc
X00353 IGHA13*02 F ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ...
_______BC___________________ _____________CD_________
45.1 45.3 45.5
30 31 34 35 36 37 38 39 40 41 42 43 44 45 45.2 45.4 45.6
F P P G P L S V S W T V N G E N V
X82119 IGHA13*01 F (CH1) ttc ccc ccg ... ggc cct ctg agt ... gtg agc tgg acc gtc aac ggg gag aat gtg ...
X00353 IGHA13*02 F ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ... ...
____ ___________________________DE_______________
45.7 84.1 84.3 84.5 84.7 85.6 85.4
77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
S A Y N F P P A Q S G T S
X82119 IGHA13*01 F (CH1) ... ... ... agc gcc tat aac ttc ccg cct gcc cag tct ggc act tca ... ... ... ...
X00353 IGHA13*02 F ... ... ... ... ... ... ... ... ... ... ... --- --- --- --- --- ... ... ... ...
____________ ___EF___
85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98 99
G P Y T A C S E L I L P V T Q C L
X82119 IGHA13*01 F (CH1) ... ggc ccg tac acc gca tgc agc gag ctg atc cta cca gtt acg cag tgt ... ... ctt
X00353 IGHA13*02 F ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ---
_________________________FG_________________________
100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119
G Q K S A A C H V E Y N S V I N E
X82119 IGHA13*01 F (CH1) ggc caa aaa agc gca gcc tgc cac gtg gag tac aac ... ... ... tca gta ata aac gag
X00353 IGHA13*02 F --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- --- --- ---
120 121 122 123 124 125 126
S L P V P F P
X82119 IGHA13*01 F (CH1) agt ctg ccc gtg ccc ttc cca
X00353 IGHA13*02 F --- --- --- --- --- --- ---
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
D C C P A N S C C T C P S S S S R N L I
X82119 IGHA13*01 F (H) gac tgc tgc cca gcc aac agc tgc tgc acc tgc ccc agc tcc agc tct aga aac ctc atc
X00353 IGHA13*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
21 22
S G
X82119 IGHA13*01 F (H) tca ggc
X00353 IGHA13*02 F --- ---
1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11 12
C Q P S L S L Q R P D L G
X82119 IGHA13*01 F (CH2) ... ... ... ... ... ... ... tgc cag ccc agc ctg tcc ctg cag cgg cca gac ctc ggg
X00353 IGHA13*02 F ... ... ... ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- ---
_____AB_____ ____________
15.1 15.3
13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28 29
D L L L G R D A S L T C T L S G L K
X82119 IGHA13*01 F (CH2) gac ctg ctc ctg ... ... ggc cgg gac gcc agc ctc acc tgc acc ctg agc ggc ctg aag
X00353 IGHA13*02 F --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
_______BC___________________ _____________CD_________
45.1 45.3 45.5
30 31 34 35 36 37 38 39 40 41 42 43 44 45 45.2 45.4 45.6
N P E D A V F T W E P T N G N E
X82119 IGHA13*01 F (CH2) aac ccc ... gag gat gcc gtc ttc act tgg gag ccc aca aac ggc aac gaa ... ... ...
X00353 IGHA13*02 F --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ...
____ ___________________________DE_______________
45.7 84.1 84.3 84.5 84.7 85.6 85.4
77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
P V Q Q R A Q R D L S G
X82119 IGHA13*01 F (CH2) ... ccc gtc cag cag aga gcc cag cgt gac ctc agt ggc ... ... ... ... ... ... ...
X00353 IGHA13*02 F ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ...
____________ ___EF___
85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98 99
C Y S V S S V L P S S A E T W K A R
X82119 IGHA13*01 F (CH2) tgc tac agt gtg tcc agt gtc cta ccc agc agt gcg gag acc tgg ... ... aaa gcg agg
X00353 IGHA13*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
_________________________FG_________________________
100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119
T E F T C T V T H P E I D S G S L T A
X82119 IGHA13*01 F (CH2) aca gag ttc acc tgc aca gtc acc cac cct gag ... ata gac agt ggc tcc cta aca gcc
X00353 IGHA13*02 F --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
120 121 122 123
T I S R
X82119 IGHA13*01 F (CH2) acc atc agc aga
X00353 IGHA13*02 F --- --- --- ---
1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11 12
G V V T P P Q V H L L P P P S E
X82119 IGHA13*01 F (CH3) ... ... ... ... ggt gtc gtc acc ccg ccc cag gtc cac ctg ctg ccg ccg ccg tcg gag
X00353 IGHA13*02 F ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
_____AB_____ ____________
15.1 15.3
13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28 29
E L A L N E Q V T L T C L V R G F S
X82119 IGHA13*01 F (CH3) gag ctg gcc ctg ... ... aat gag cag gtg acg ctg acc tgc ctg gtg cgg ggc ttc agc
X00353 IGHA13*02 F --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
_______BC___________________ _____________CD_________
45.1 45.3 45.5
30 31 34 35 36 37 38 39 40 41 42 43 44 45 45.2 45.4 45.6
P K D V L V S W R H Q G Q E V P E D
X82119 IGHA13*01 F (CH3) ccg ... ... aag gat gtg ctg gtg tcc tgg agg cac cag ggc cag gag gtc cct gaa gac
X00353 IGHA13*02 F --c ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
____ ___________________________DE_______________
45.7 84.1 84.3 84.5 84.7 85.6 85.4
77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
S F L V W K S M P E S S Q D K A
X82119 IGHA13*01 F (CH3) ... agc ttc ctg gtg tgg aag tcc atg ccc gag tcc agc cag gac ... ... ... aaa gcc
X00353 IGHA13*02 F ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- ---
____________ ___EF___
85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98 99
T Y A I T S L L R V P A E D W N Q G
X82119 IGHA13*01 F (CH3) acc tac gcc att acc agc ctg ctg cgc gtg ccg gcc gag gac tgg ... ... aac cag ggg
X00353 IGHA13*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
_________________________FG_________________________
100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119
D T Y S C M V G H E G L A E H F T Q K
X82119 IGHA13*01 F (CH3) gac acc tat tcc tgc atg gtg ggc cat gag ggc ... ctg gcc gag cac ttc acc cag aag
X00353 IGHA13*02 F --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
______________________________________CH-S__
120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139
T I D R L A G K P T H V N V S V V
X82119 IGHA13*01 F (CH3) acc atc gac cgc ctg gcg ... ... ... ggt aaa ccc acc cac gtc aac gtg tct gtg gtc
X00353 IGHA13*02 F --- --- --- --- --t --- ... ... ... --- --- --- --- --- --- --- --- --- --- ---
____________________________________
140 141 142 143 144 145 146 147 148
V A D V E A V C Y
X82119 IGHA13*01 F (CH3) gtg gca gac gta gaa gcc gtg tgc tac
X00353 IGHA13*02 F --- --- --- --- --- --- --- --- ---
Last updated: Tuesday, 22-May-2012 22:02:31 CEST
Authors: Fatena Bellahcene, Claire Poiron and Christèle Martinez-Jean
Editor: Chantal Ginestoux
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only,
provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics
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(founder and director: Marie-Paule Lefranc, Montpellier, France)."
References to cite:
Lefranc, M.-P. et al.,
Nucleic Acids Research, 27, 209-212 (1999)
Cover of NAR;
Ruiz, M. et al.,
Nucleic Acids Research, 28, 219-221 (2000);
Lefranc, M.-P.,
Nucleic Acids Research, 29, 207-209 (2001);
Lefranc, M.-P.,
Nucleic Acids Res., 31, 307-310 (2003);
Lefranc, M.-P. et al.,
In Silico Biol., 5, 0006 (2004) [Epub],
5, 45-60 (2005);
Lefranc, M.-P. et al.,
Nucleic Acids Res., 33, D593-D597 (2005)
Full text;
Lefranc, M.-P. et al.,
Nucleic Acids Research 2009 37:
D1006-D1012; doi:10.1093/nar/gkn838
Full text.
For any other use please contact Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr.
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