IMGT Repertoire (IG and TR)
Alignment of alleles: Rabbit (Oryctolagus cuniculus) IGHM
When several alleles are shown, the nucleotide mutations and amino acid
changes for a given codon are indicated in red letters. These polymorphic mutations are reported in
Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the
IMGT unique numbering.
Blanks indicate partial sequences (blanks at the 5' and/or 3' end).
Exon names are shown between parentheses on the first line.
Cysteine involved in the disulfide bridge are shown in purple.
STOP-CODON is indicated by an asterisk.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CH-S and in pages edited before 14/10/2009).
1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11 12
V S L S S P T L Y P L V S C E G
J00666 IGHM*01 F (CH1) ... ... ... ... gtg agc ctg tca tct cca act ctg tac ccg ctc gtc tcc tgc gag ggt
AY386695 IGHM*02 F ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
AY386696 IGHM*02 F ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
_____AB_____ ____________
15.1 15.3
13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28 29
A L T D G N L V A M G C L A R D F L
J00666 IGHM*01 F (CH1) gcc ctg acc gat ... ... ggg aac ctg gtg gcc atg ggc tgc ctg gcg cgg gac ttt ctg
AY386695 IGHM*02 F --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
AY386696 IGHM*02 F --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
_______BC___________________ _____________CD_________
45.1 45.3 45.5
30 31 34 35 36 37 38 39 40 41 42 43 44 45 45.2 45.4 45.6
P S S V T F S W S F K N N S E I S S
J00666 IGHM*01 F (CH1) ccc ... ... agc tcc gtc acc ttc tcc tgg agc ttc aag aac aac tct gag atc agc agc
AY386695 IGHM*02 F --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
AY386696 IGHM*02 F --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
____ ___________________________DE_______________
45.7 84.1 84.3 84.5 84.7 85.6 85.4
77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
R T V R T F P V V K R G D
J00666 IGHM*01 F (CH1) cgg acc gtc agg acc ttc ccg gtg gtg aag aga ggg gac ... ... ... ... ... ... ...
AY386695 IGHM*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ...
AY386696 IGHM*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ...
____________ ___EF___
85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98 99
K Y M A T S Q V L V P S K D V L Q G T E
J00666 IGHM*01 F (CH1) aag tat atg gcc acc tcg cag gtg ctg gtg ccc tcc aag gat gtc ctc cag ggc aca gag
AY386695 IGHM*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
AY386696 IGHM*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
_________________________FG_________________________
100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119
E Y L V C K V Q H S N S N R D L
J00666 IGHM*01 F (CH1) gag tac ctg gtg tgc aaa gtc cag cac agc ... ... ... ... aac agc aac aga gac ctg
AY386695 IGHM*02 F --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---
AY386696 IGHM*02 F --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---
120 121 122 123 124
R V S F P
J00666 IGHM*01 F (CH1) cga gtg tcc ttt ccc
AY386695 IGHM*02 F --- --- --- --- ---
AY386696 IGHM*02 F --- --- --- --- ---
1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11 12
V D S E L P P N V S V F I P P R D
J00666 IGHM*01 F (CH2) ... ... ... gtg gac tca gag ctg ccc ccc aac gtg agc gtg ttc atc cca cct cga gac
AY386695 IGHM*02 F ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
AY386696 IGHM*02 F ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
_____AB_____ ____________
15.1 15.3
13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28 29
S F S G S G T R K S R L I C Q A T G F S
J00666 IGHM*01 F (CH2) tcc ttc agc ggc tct ggc aca cgc aag tcc agg ctc atc tgc cag gcc aca ggt ttc agc
AY386695 IGHM*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
AY386696 IGHM*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
_______BC___________________ _____________CD_________
45.1 45.3 45.5
30 31 34 35 36 37 38 39 40 41 42 43 44 45 45.2 45.4 45.6
P K Q I S V S W L R D G Q K V E S
J00666 IGHM*01 F (CH2) ccc ... ... aaa cag atc agc gtg tcc tgg ctg cgc gat ggg cag aag gtg gag tct ...
AY386695 IGHM*02 F --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...
AY386696 IGHM*02 F --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...
____ ___________________________DE_______________
45.7 84.1 84.3 84.5 84.7 85.6 85.4
77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
G V L T K P V E A E T K G A G P A
J00666 IGHM*01 F (CH2) ... ggc gtc ctc acc aag ccg gtg gag gct gaa acc aaa ggg gct ... ... ggg cct gcg
AY386695 IGHM*02 F ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
AY386696 IGHM*02 F ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
____________ ___EF___
85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98 99
T F S I S S M L T I T E S D W L S Q
J00666 IGHM*01 F (CH2) acc ttt agc atc agc agc atg ctg acc atc acc gag agc gac tgg ... ... ctg agc cag
AY386695 IGHM*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
AY386696 IGHM*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
_________________________FG_________________________
100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119
S L Y T C R V D H R G I F F D K
J00666 IGHM*01 F (CH2) agc ctg tac acc tgc cgc gtg gac cac agg ... ... ... ... ggc atc ttc ttc gat aag
AY386695 IGHM*02 F --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---
AY386696 IGHM*02 F --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- --- --- --- --- ---
120 121 122 123 124 125 126 127 128
N V S M S S E C S
J00666 IGHM*01 F (CH2) aac gtg tcc atg tcc tcc gag tgc agc
AY386695 IGHM*02 F --- --- --- --- --- --- --- --- ---
AY386696 IGHM*02 F --- --- --- --- --- --- --- --- ---
1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11 12
T P S P G I Q V F P I A P S F A
J00666 IGHM*01 F (CH3) ... ... ... ... acc cca tcc cca ggc atc cag gtc ttc ccc atc gcc cct tcg ttc gcc
AY386695 IGHM*02 F ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
AY386696 IGHM*02 F ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
_____AB_____ ____________
15.1 15.3
13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28 29
D T F L S K S A R L I C L V T D L T
J00666 IGHM*01 F (CH3) gac acc ttc ctc ... ... agc aag tca gcc agg ctg atc tgc ctg gtc aca gac ctg acc
AY386695 IGHM*02 F --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
AY386696 IGHM*02 F --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
_______BC___________________ _____________CD_________
45.1 45.3 45.5
30 31 34 35 36 37 38 39 40 41 42 43 44 45 45.2 45.4 45.6
T Y G S L N I S W A S H N G K A L
J00666 IGHM*01 F (CH3) acc tat ... ggc agc ctc aac atc tcc tgg gca agc cat aac ggc aaa gcc ctg ... ...
AY386695 IGHM*02 F --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
AY386696 IGHM*02 F --- --- ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ...
____ ___________________________DE_______________
45.7 84.1 84.3 84.5 84.7 85.6 85.4
77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
D T H M N I T E S H P N A
J00666 IGHM*01 F (CH3) ... gac acc cac atg aac atc acc gag agc cac ccc aac ... ... ... ... ... ... gcc
AY386695 IGHM*02 F ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
AY386696 IGHM*02 F ... --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ... ---
____________ ___EF___
85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98 99
T F S A M G E A S V C A E D W E S G
J00666 IGHM*01 F (CH3) acc ttc agc gcc atg ggc gag gcc agc gtg tgc gcg gag gat tgg ... ... gag tct ggg
AY386695 IGHM*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
AY386696 IGHM*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
_________________________FG_________________________
100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119
E Q F T C T V T H A D L P F P L K H
J00666 IGHM*01 F (CH3) gag cag ttc acg tgc acc gtg acc cac gcc gac ... ... ctg ccc ttc ccg ctg aag cac
AY386695 IGHM*02 F --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
AY386696 IGHM*02 F --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- --- --- --- --- ---
120 121 122 123 124 125
T I S K S R
J00666 IGHM*01 F (CH3) acc atc tcc aag tcc agg
AY386695 IGHM*02 F --- --- --- --- --- ---
AY386696 IGHM*02 F --- --- --- --- --- ---
1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11 12
E V A K H P P A V Y V L P P A R E
J00666 IGHM*01 F (CH4) ... ... ... gag gtg gcc aag cac ccc ccg gcg gtg tac gtg ctg ccg cca gcc cgg gag
K01357 IGHM*01 F ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
AY386695 IGHM*02 F ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
AY386696 IGHM*02 F ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
_____AB_____ ____________
15.1 15.3
13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28 29
Q L V L R E S A T V T C L V K G F S
J00666 IGHM*01 F (CH4) cag ctg gtc ctg ... ... cga gag tcg gcc acc gtg acc tgc ctg gtc aag ggc ttc tcg
K01357 IGHM*01 F --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
AY386695 IGHM*02 F --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
AY386696 IGHM*02 F --- --- --- --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
_______BC___________________ _____________CD_________
45.1 45.3 45.5
30 31 34 35 36 37 38 39 40 41 42 43 44 45 45.2 45.4 45.6
P A D V F V Q W Q Q R G Q P L S S D
J00666 IGHM*01 F (CH4) ccg ... ... gca gat gtg ttc gtg cag tgg cag cag agg ggg cag ccc ttg tcc tca gac
K01357 IGHM*01 F --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
AY386695 IGHM*02 F --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
AY386696 IGHM*02 F --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
____ ___________________________DE_______________
45.7 84.1 84.3 84.5 84.7 85.6 85.4
77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
K Y V T S A P A P E P Q A P G
J00666 IGHM*01 F (CH4) ... aag tac gtg acc agc gcc cca gcg ccc gag ccc cag gcc ... ... ... ... cca ggc
K01357 IGHM*01 F ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- ---
AY386695 IGHM*02 F ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- ---
AY386696 IGHM*02 F ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... --- ---
____________ ___EF___
85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98 99
L Y F T H S T L T V T E E D W N S G
J00666 IGHM*01 F (CH4) ctg tac ttc acc cac agc acc ctg acc gtg acc gag gag gac tgg ... ... aac tcc ggg
K01357 IGHM*01 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
AY386695 IGHM*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
AY386696 IGHM*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
_________________________FG_________________________
100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119
E T F T C V V G H E A L P H M V T E R
J00666 IGHM*01 F (CH4) gag acg ttc acc tgc gtc gtg ggc cac gag gcc ... ctg ccg cac atg gtg acc gag agg
K01357 IGHM*01 F --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
AY386695 IGHM*02 F --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
AY386696 IGHM*02 F --- --- --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- ---
______________________________________CH-S__
120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139
T V D K S T G K P T L Y N V S L I
J00666 IGHM*01 F (CH4) acc gtg gac aag tcc act ... ... ... ggt aaa ccc acc ttg tac aat gtg tcc ctg atc
K01357 IGHM*01 F --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- ---
AY386695 IGHM*02 F --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- ---
AY386696 IGHM*02 F --- --- --- --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- ---
____________________________________
140 141 142 143 144 145 146 147 148
M S D T A S T C Y
J00666 IGHM*01 F (CH4) atg tct gac acg gcc agc acc tgc tac
K01357 IGHM*01 F --- --- --- --- --- --- --- --- ---
AY386695 IGHM*02 F --- --- --- --- --- --- --- --- --
AY386696 IGHM*02 F --- --- --- --- --- --- --- --- --
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
E G E V G A E E E G F E N L W T T A S T
K01357 IGHM*01 F (M1) gaa ggg gag gta ggc gcc gag gag gag ggc ttt gag aac ctg tgg acc acc gcc tcc acc
AY386695 IGHM*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
AY386696 IGHM*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39
F I V L F L L S L F Y S T T V T L F K
K01357 IGHM*01 F (M1) ttc atc gtc ctg ttc ctg ctg agc ctc ttc tac agc acc acg gtc act ctg ttc aag
AY386695 IGHM*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
AY386696 IGHM*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
1 2
V K
K01357 IGHM*01 F (M2) gtg aag
AY386695 IGHM*02 F --- ---
AY386696 IGHM*02 F --- ---
Created: 17/09/2010
Last updated: Tuesday, 22-May-2012 22:02:31 CEST
Authors: Fatena Bellahcene, Claire Poiron and Christèle Martinez-Jean
Editor: Chantal Ginestoux
Contact: Marie-Paule Lefranc
Last updated: Tuesday, 22-May-2012 22:02:31 CEST
Authors: Fatena Bellahcene, Claire Poiron and Christèle Martinez-Jean
Editor: Chantal Ginestoux
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only,
provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics
information system® http://www.imgt.org
(founder and director: Marie-Paule Lefranc, Montpellier, France)."
References to cite:
Lefranc, M.-P. et al.,
Nucleic Acids Research, 27, 209-212 (1999)
Cover of NAR;
Ruiz, M. et al.,
Nucleic Acids Research, 28, 219-221 (2000);
Lefranc, M.-P.,
Nucleic Acids Research, 29, 207-209 (2001);
Lefranc, M.-P.,
Nucleic Acids Res., 31, 307-310 (2003);
Lefranc, M.-P. et al.,
In Silico Biol., 5, 0006 (2004) [Epub],
5, 45-60 (2005);
Lefranc, M.-P. et al.,
Nucleic Acids Res., 33, D593-D597 (2005)
Full text;
Lefranc, M.-P. et al.,
Nucleic Acids Research 2009 37:
D1006-D1012; doi:10.1093/nar/gkn838
Full text.
For any other use please contact Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr.
IMGT founder and director: Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr
Bioinformatics manager: Véronique Giudicelli
Veronique.Giudicelli@igh.cnrs.fr
Computer manager: Patrice Duroux
Patrice.Duroux@igh.cnrs.fr
Webmaster: Chantal Ginestoux
Chantal.Ginestoux@igh.cnrs.fr
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