IMGT Repertoire (IG and TR)
Alignment of alleles: Rabbit (Oryctolagus cuniculus) IGKC2
When several alleles are shown, the nucleotide mutations and amino acid
changes for a given codon are indicated in red letters. These polymorphic mutations are reported in
Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the
IMGT unique numbering.
Blanks indicate partial sequences (blanks at the 5' and/or 3' end).
Exon names are shown between parentheses on the first line.
Cysteine involved in the disulfide bridge are shown in purple.
STOP-CODON is indicated by an asterisk.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CH-S and in pages edited before 14/10/2009).
1.8 1.7 1.6 1.5 1.4 1.3 1.2 1.1 1 2 3 4 5 6 7 8 9 10 11 12
R D P V A P S V L L F P P S K E
X00232 IGKC2*01 F ... ... ... ... cgt gat cca gtt gcg cct tct gtc ctc ctc ttc cca cca tct aag gag
V00885 IGKC2*01 F ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
X05801 IGKC2*01 F ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
X05800 IGKC2*02 F ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
X56061 IGKC2*03 F (1) ... ... ... ... --- --- --- --- --a --- --- --- --- --- --- --- --- --- --- ---
M22543 IGKC2*03 F ... ... ... ... --- --- --- --- --a --- --- --- --- --- --- --- --- --- --- ---
K01280 IGKC2*04 (F) (2) ... ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---
_____AB_____ ____________
15.1 15.3
13 14 15 15.2 16 17 18 19 20 21 22 23 24 25 26 27 28 29
E L T T G T A T I V C V A N K F Y
X00232 IGKC2*01 F gag ctg aca ... ... ... act gga aca gcc acc atc gtg tgc gtg gcg aat aaa ttc tat
V00885 IGKC2*01 F --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
X05801 IGKC2*01 F --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
X05800 IGKC2*02 F --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
X56061 IGKC2*03 F (1) --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
M22543 IGKC2*03 F --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
K01280 IGKC2*04 (F) (2) --- --- --- ... ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- ---
___________BC_______________ _____________CD_________
45.1 45.3 45.5
30 31 34 35 36 37 38 39 40 41 42 43 44 45 45.2 45.4 45.6
P S D I T V T W K V D G T T Q Q S
X00232 IGKC2*01 F ccc ... ... agt gac atc acc gtc acc tgg aag gtg gat ggc acc acc caa cag agc ...
V00885 IGKC2*01 F --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...
X05801 IGKC2*01 F --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...
X05800 IGKC2*02 F --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...
X56061 IGKC2*03 F (1) --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...
M22543 IGKC2*03 F --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...
K01280 IGKC2*04 (F) (2) --- ... ... --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ...
____ ___________________________DE_______________
45.7 84.1 84.3 84.5 84.7 85.6 85.4
77 78 79 80 81 82 83 84 84.2 84.4 84.6 85.7 85.5
G I E N S K T P Q S P E D N
X00232 IGKC2*01 F ... ggc atc gag aac agt aaa aca ccg cag agc ccc gaa gac ... ... ... ... ... aat
V00885 IGKC2*01 F ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---
X05801 IGKC2*01 F ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---
X05800 IGKC2*02 F ... --- --- --- --- --- --- --- --- --- --- --t --- --- ... ... ... ... ... ---
X56061 IGKC2*03 F (1) ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---
M22543 IGKC2*03 F ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---
K01280 IGKC2*04 (F) (2) ... --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... ---
____________ ___EF___
85.2 96.1
85.3 85.1 85 86 87 88 89 90 91 92 93 94 95 96 96.2 97 98 99
T Y S L S S T L S L T S A Q Y N S H
X00232 IGKC2*01 F acc tac agc ctg agc agc act ctg tca ctg acc agc gca cag tac ... ... aac agc cac
V00885 IGKC2*01 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
X05801 IGKC2*01 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
X05800 IGKC2*02 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
X56061 IGKC2*03 F (1) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
M22543 IGKC2*03 F --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
K01280 IGKC2*04 (F) (2) --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... --- --- ---
_________________________FG________________________
100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119
S V Y T C E V V Q G S A S P I V Q
X00232 IGKC2*01 F agc gtg tac acc tgc gag gtg gtc caa ggc tca ... ... ... gcc tca ccg atc gtc cag
V00885 IGKC2*01 F --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- --- --- --- ---
X05801 IGKC2*01 F --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- --- --- --- ---
X05800 IGKC2*02 F --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- --- --- --- ---
X56061 IGKC2*03 F (1) --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- --- --- --- ---
M22543 IGKC2*03 F --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- --- --- --- ---
L
K01280 IGKC2*04 (F) (2) --- --- --- --- --- --- --- --- --- --- --- ... ... ... --- --- -t- --- --- ---
120 121 122 123 124 125 126
S F N R G D C
X00232 IGKC2*01 F agc ttc aac agg ggt gac tgc
V00885 IGKC2*01 F --- --- --- --- --- --- ---
X05801 IGKC2*01 F --- --- --- --- --- --- ---
X05800 IGKC2*02 F --- --- --- --- --- --- ---
X56061 IGKC2*03 F (1) --- --- --- --- --- --- ---
M22543 IGKC2*03 F --- --- --- --- --- --- ---
K01280 IGKC2*04 (F) (2) --- --- --- --- --- --- ---
| (1) | This allele was identified in the subspecies sp.algirus. |
| (2) | This allele was identified in the strain : Basilea. |
Authors: Fatena Bellahcene
Editor: Chantal Ginestoux
Contact: Marie-Paule Lefranc
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References to cite:
Lefranc, M.-P. et al.,
Nucleic Acids Research, 27, 209-212 (1999)
Cover of NAR;
Ruiz, M. et al.,
Nucleic Acids Research, 28, 219-221 (2000);
Lefranc, M.-P.,
Nucleic Acids Research, 29, 207-209 (2001);
Lefranc, M.-P.,
Nucleic Acids Res., 31, 307-310 (2003);
Lefranc, M.-P. et al.,
In Silico Biol., 5, 0006 (2004) [Epub],
5, 45-60 (2005);
Lefranc, M.-P. et al.,
Nucleic Acids Res., 33, D593-D597 (2005)
Full text;
Lefranc, M.-P. et al.,
Nucleic Acids Research 2009 37:
D1006-D1012; doi:10.1093/nar/gkn838
Full text.
For any other use please contact Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr.
IMGT founder and director: Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr
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