The IGHC protein display numbering is according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.
Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CH-S and in pages edited before 14/10/2009).
The hinge exon(s) are shown at the end of the protein display._____________________________________________________________________________________________________________________________________________________________________________________________
IGHC
genes
_____________________________________________________________________________________________________________________________________________________________________________________________
A AB B BC C CD D DE E EF F FG G CH-S
--------------> ----------> ------> -------> -----------> -------> ---------->
1 10 15 16 20 23 30 36 39 41 45 77 84 85 89 96 97 104 110 118 121 130 140 150
7654321|........|....|123|...|...... ...|.....| |.....|1234567|......|12345677654321|..........|12|....... .....|....... ..|.........|.........|.........|
CH1
AF109167,IGHA (E)SETSPSIFPLSLGNNDP....AGQVVIGCLVQ GFFPS.APLS VTWNQNGDSV....SVRNFPAVLAGS.......LYTMSSQLTLPASLC..PKGQSVTC QVQHL...SKASK TVAVPCIIQ
U63640 ,IGHE (A)SIQAPSIYPLRLCCTE.....EARVRLGCLVK DYLP..GSVT VTWDTVPLDG....STLTFPSIQMASS.....SLYITTSQLTISGE.....QSKEFTC RVLHP...ETIQL NKTST
X16701 ,IGHG1 (1) (A)STTAPKVYPLSSCCGDKS...SSTVTLGCLVS SYMP..EPVT VTWNSGALKS....GVHTFPAVLQSS......GLYSLSSMVTVPGST....SGQTFTC NVAHPA..SSTKV DKAV
M36946 ,IGHG2 (2) (A)STTAPKVYPLSSCCGDKS...SSTVTLGCLVS SYMP..EPVT VTWNSGALKS....GVHTFPAVLQSS......GLYSLSSMVTVPGST....SGQTFTC NVAHPA..SSTKV DKAV
U63638 ,IGHG3 (3) (A)STTAPKVYPLASSCGDTS...SSTVTLGCLVS SYMP..EPVT VTWNSGALKS....GVHTFPAVRQSS......GLYSLSSMVTVPASSS...ETQTFTC NVAHPA..SSTKV DKAVTARRPVPTTPKTTIPPGKPTTP
U63637 ,IGHM (E)GESHPKVFPLVSCVSSPSD..ESTVALGCLAR DFVP..NSVS FSWKFNNSTVSSE.RFWTFPEVLRDG.......LWSASSQVVLPSSSAFQGPDDYLVC EVQHPK.GGKTVG TVRVIAT
CH2
AF109167,IGHA NCEPSLSVQPPALEDLLL..GSNASLTCTLS GLKSA.EGAS FTWNPTGGKT....AVQGSPKRDSCG.......CYSVSSVLPGCADPW..NSGQTFSC SVTHPE..SKSSL TATIKKDL
U63640 ,IGHE (E)CVKNFSDPSVKLFFSSCNPNGDT.QTTIHLLCRIS AYTP..GKIK VTWLVDGLQSEE..LYARSGPEIQEG......NLTSTYSEVNITQGQW..VSEKTYTC RVNYY....GYNF ESHAHRCT
X16701 ,IGHG1 (P)PELPGGPSVFIFPPKPKDTLTI.SGTPEVTCVVV DVGHDDPEVK FSWFVDDVEVN...TATTKPREEQFN......STYRVVSALRIQHQDW..TGGKEFKC KVHNEG..LPAPI VRTISRTK
M36946 ,IGHG2 (C)CVREPSVFIFPPKPKDTLMI.TGTPEVTCVVV NVGHDNPEVQ FSWFVDDVEVH...TARTKPREEQFN......STYRVVSALPIQHQDW..TGGKEFKC KVNIKG..LSASI VRIISRSK
U63638 ,IGHG3 (E)PLGGLSVFIFPPKPKDTLTI.SGTPEVTCVVV DVGQDDPEVQ FSWFVDDVEVH...TARTKPREEQFN......STYRVVSALRIQHQDW..LQGKEFKC KVNNKG..LPAPI VRTISRTK
U63637 ,IGHM (K)AEVLSPVVSVFVPPRNSLSGDGNSKSSLICQAT DFSP..KQIS LSWFRDGKRIVS..GISEGQVETVQSS....PITFRAYSMLTITERDW..LSQNAYTC QVEHN....KETF QKNVSSSCDV
CH3
AF109167,IGHA (G)NTFRPQVHLLPPPSEELAL..NELVTLTCLVR GFSP..KEVL VRWLQGNQELPRE.KYLTWGPLPEAGQS...VTTFAVTSVLRVDAEVW..KQGDTFSC MVGHEA.LPLAFT QKTIDRLA...GKPTHVNVSVVMSEVDGVCY
U63640 ,IGHE (A)ESEPRVSAYLSPPTPLELYV..NKSPKITCLVV DLANE.KNLS LTWSRANGKPV...HAGPPEIKRQFN......GTVTVTSTLPVDVTDW..VEGETYYC KVSHRD..LPTDI QRSISKDV
X16701 ,IGHG1 (G)PAREPQVYVLAPPQEELS...KSTVSLTCMVT SFYP..DYIA VEWQRNGQPESED.KYGTTPPQLDAD......SSYFLYSKLRVDRNSW..QEGDTYTC VVMHEA.LHNHYT QKSTSKSA...GK
M36946 ,IGHG2 (G)PAREPQVYVLDPPKEELS...KSTVSVTCMVI GFYP..EDVD VEWQRDRQTESED.KYRTTPPQLDAD......RSYFLYSKLRVDRNSW..QRGDTYTC VVMHEA.LHNHYM QKSTSKSA...GK
U63638 ,IGHG3 (G)QAREPQVYVLAPPREELS...KSTLSLTCLIT GFYP..EEID VEWQRNGQPESED.KYHTTAPQLDAD......GSYFLYSKLRVNKSSW..QEGDHYTC AVMHEA.LRNHYK EKSISRSP...GK
U63637 ,IGHM (A)PPSPIGVFTIPPSFADIFL..TKSAKLSCLVT NLASY.DGLN ISWSRQNAKAL...ETHTYFERHLND.......TFSARGEASVCSEDW..ESGEEFTC TVAHSD..LPFPE KNAVSKPK
CH4
U63640 ,IGHE (G)KRLAPKDYVFLADGKELEN..EEELTLTCMIQ NFFP..RDIF VRWLHNKELMGAD.QHTTTQPHRDDNN....TPAFFAYSRLAVPRANW..KRGDEFTS QVIHEALPRTRTL EKSVFINS...GK
U63637 ,IGHM (D)VAMKPPSVYLLPPTREQLSL..RESASVTCLVK AFAP..ADVF VQWLQRGEPVTKS.KYVTSARAPEPQDP...SVVYFVHSILTVAEEDW..SKGETYTC VV.HEA.LPHMVT ERTVDKST...GKPTLYNVSLVLSDTASTCY
Hinge
AF109167,IGHA (D)SSSCCVP
X16701 ,IGHG1 (D)PTCKPSPCDCCP
M36946 ,IGHG2 (G)VSSDCSKPNNQH
U63638 ,IGHG3 (K)SEVEKTPCQCSKCP
M1 M2
U63637 ,IGHM (E)GEVSAEEEGFENLNTMASTFIVLFLLSLFYSTTVTLFK VK
CONNECTING-REGION| TRANSMEMBRANE-REGION | CYTOPLASMIC-REGION
IMGT notes:| (1) | IGHG1*03 (cDNA) has a polymorphic amino acid INSERTION between codon 99 and 100 in the IMGT unique numbering for C-DOMAIN |
| (2) | IGHG2*02 (cDNA) has a polymorphic amino acid INSERTION between codon 99 and 100 in the IMGT unique numbering for C-DOMAIN |
| (3) | Twenty-two additional amino acids are encoded by the 3' end of CH1. As this region is rich in proline (7 aa out of 22), it is likely to be part of the structural hinge [1]. |
Reference:
| [1] | Rabbani , H. et al., Immunogenetics, 46, 326-331 (1997). |
Created: 01/07/2002
Last updated: Monday, 11-Jul-2011 12:56:58 CEST
Author: Christèle Martinez-Jean
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
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