The IGHC protein display numbering is according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.
Only the *01 allele of each functional, ORF and in-frame pseudogenes C-REGION is shown.
Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CH-S and in pages edited before 14/10/2009).
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IGHC
genes
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A AB B BC C CD D DE E EF F FG G
--------------> ----------> ------> -------> -----------> -------> ---------->
1 10 15 16 20 23 30 36 39 41 45 77 84 85 89 96 97 104 110 118 121 130 140 150
7654321|........|....|123|...|...... ...|.....| |.....|1234567|......|12345677654321|..........|12|....... .....|....... ..|.........|.........|.........|
CH1
c AF437724,IGHM AQKAAPTVFPVASCSEPSP...DGFISLGLLAT EFLP..NDVS FTWRSQLSIDAS..LFLPKTYPSVISA....KGTYIGSSQLLLPFTEC..QKPNNIFC EVKHS....LGEK VYSVICP
c AF437727,IGHW ATPSGPSVYPVSPCCDVQKS..QDPLKIGCFVT ADSP...SDN IQWFLGSSQISS..GVTQYPEVYSNG.......RYSLSSVLNLKSADW...NDKSYEC RFGTQ...KKPVQ KRGCKED
CH2
c AF437724,IGHM DFTVILPKVSIFLPATQE.....STFINLVCLVE GFRP..KNAK VTWSKNRQPVNT..GVLTFATVLDEN......KNFTTTSSLRITREDW..NKEAEFMC QASHPR..WNETV TKNISKPLV
c AF437727,IGHW CPNKIPKIELYMASCEPDD...PKNMYLFCDLS DFAP..EDIE VAWFRGTSTVT...DFITIGNVTEVNK.....CSFHTSSKLKLVPEDW..SNGMEYKC LATHS....TKSV EKKISSCTA
CH3
c AF437724,IGHM PGSTLEDVKVIGIAPSIEDILL..AKSAHVSCLVY GLLSP.ENCN ISWARSSEPKKS..FKFPFEEIPNEN......GTFSIISKMPICPAEW..NSEEEFTC IVEHES..LPTPE RVTIKKHNG
c AF437727,IGHW CPKPSPTIELMKSSYRDFFT..KKKGTLTCNVT SFLK..NTIV ILKQDNRDLV....KKQLSSSEATGN......GTWNVHISFDISEADW....RKTFIC EAQHT....CKTD KKTLN
CH4
c AF437724,IGHM GILKKPKIVLLPPTSEDLSN..SETVTLTCLVK GFSP..ADLF LKWHHNGAPVPD..AEYSDTNKLQDAG....NESFSMYSKLEIRVEDW..NNGHSFTC IVGHE....SLDL NVSSKTIDKSSGKPSSVNVTVIMSDTAGAY
c AF437727,IGHW PEETKEQKKPSVKIHKAVS..SIFNTLICIIS GYYP..DEIF VKWEQNGHPGNT..EASTHPAVYDKAS.....KSYTMQSILLIPIEDV..KEASIWSC MVGHSALSEMMSD STEVKPF
CH5
c AF437727,IGHW AQPKVPPTVAISEPSADENN...EQRLNIDCIAY GFFP..KNIA IQWLSQEPKKL...LVKTFDVELGES......GTYSIKSILNLSKEEW...HEGQFTC DVKHEA..TKTRI LRNTTNTHACS
CH6
c AF437727,IGHW EYMAAPDVYTIKPSYEDIVI..NRKATLTCLVV GYEL..DSVN ITWTENDSLIT...DGISSNTEIHSN......GTETVKGLLGIPADDW..LNGRKYSC KVAHSA..LPTPK LMDMWFEEGST
CH7
c AF437727,IGHW ETKSKTRAPEVNLRLPTPEEVKK..DENLTLICLIE NYFP..DYVF VQWRENNTRIHSS.NYRNSDSYFNQKT.....NAYTMDSKLVVQTKDW..DEGKTYTC MVNH.....ISST WTIFKEGNKHTGKPTTVNLSVYLTEGKRECHV
M1 M2
c AF437735,IGHM EHVYIVENVADDDSDSLWSTASTFIILFLISLLYSAGVTVFK VK
CONNECTING_REGION | TRANSMEMBRANE-REGION | CYTOPLASMIC-REGION
c: cDNA sequence
IMGT note:
5' and 3' end of exons need to be confirmed with genomic sequence.
Created: 23/07/2003
Author: Nathalie Bosc
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
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IMGT founder and director: Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr
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