Only the *01 allele of each functional, ORF and in-frame pseudogene V-REGION is shown.
Dots indicate gaps according to the IMGT unique numbering. Blanks at the 5' and/or 3' end indicate partial sequences.
Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.
___________________________________________________________________________________________________________________________________________________
IGHV FR1-IMGT CDR1-IMGT FR2-IMGT CDR2-IMGT FR3-IMGT CDR3-IMGT
gene (1-26) (27-38) (39-55) (56-65) (66-104) (105-115)
___________________________ __________________________ ____________ _________________ ___________ _______________________________________ ___________
1 10 20 30 40 50 60A 70 80 90 100 110
.........|.........|...... ...|........ .|.........|..... ....|...... ....|.........|.........|.........|.... .....|.....
#c AF437728,IGHV1S1 QVVLTETGG.DAMKPGETLRLTCKTS GFDFSSSW.... MGWVRQQPERGLDWIGE INSGG.GTI.. HYHPSFK.GRFTISRDNSKNLLYLDLGSLKSEDTAVYFC AR
#c AF437724,IGHV2S1 AVEIKETGG.GIWKPGDSITLTCRCS GFTFTDYY.... MHWARQQPGSGLEWVGM VRNPA.NGGTT EYSPTLR.DRVTISRDNSRSEVYLQIKTLKAEDSALYYC AR
#c AF437725,IGHV3S1 DIVLTQSGS.EVKQPGQSVNLRCTGS GFDMNSYY.... IEWVRQFPGGGFEWLVQ YLKPG.AGSN. YVNPTVQ.GRFSGSV..DSSSFYLQMNNLQVADTAMYYC AR
#c AF437729,IGHV4S1 SIVLTQKEL.EQGSPGSTIVLQCPFS GFSPSDHH.... VSWVRQTPGKTELEWLG GSRTG.QTT.. YISPAVK.GKMTPST..IGSTAQLQINQLRPEDTAVYYC AR
#c AF437726,IGHV5S1 QVKLEESGG.RAVTPGASLQLNCKAT GFDFGPGGYA.. MNWVRQQPGKGLEWVAY HYTGSGGTNYI YYSPSVQ.GRFTISRDVPQRLLHLDMKNVKTEDTGTYYC AR
#c AF437731,IGHV6S1 AITLKETGG.GVKKPGDTTRLTCQVS GFSLSNND.... VSWVRQSPGQGLQWLGT MWDDG.ST... DLSPSIK.DRTSISRDVPKGEVYLDISKMKTEDTGTYYC AR
#c AF437727,IGHV7S1 DIVLSQSAA.EVKPPGQSLKLKCAVT GFDVSSYY.... MSWVKQAPGKGFEWIVS YYDSN.PSNH. NYNPTFQ.SRFSASK..DSSNFYLQMNNLQVADTSVYYC AR
#c AF437734,IGHV8S1 QVSLTETGG.GVKKPGESLRLSCKGS GYNFGSYG.... LSWVRQQPGKGLEWVAY ISSGS.TNI.. YYSPSLK.DRTTISRDNSQSLLYLDMTNLRLEDTGTYYS AR
#c: rearranged cDNA The proteolytic cleavage site between the leader peptide and the V-REGION is putative and the assignment of amino acid 1 to one or the other region is uncertain.
Created: 23/07/2003
Software material and data coming from IMGT server may be used for academic research only,
provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics
information system® http://www.imgt.org
(founder and director: Marie-Paule Lefranc, Montpellier, France)."
References to cite:
Lefranc, M.-P. et al.,
Nucleic Acids Research, 27, 209-212 (1999)
Cover of NAR;
Ruiz, M. et al.,
Nucleic Acids Research, 28, 219-221 (2000);
Lefranc, M.-P.,
Nucleic Acids Research, 29, 207-209 (2001);
Lefranc, M.-P.,
Nucleic Acids Res., 31, 307-310 (2003);
Lefranc, M.-P. et al.,
In Silico Biol., 5, 0006 (2004) [Epub],
5, 45-60 (2005);
Lefranc, M.-P. et al.,
Nucleic Acids Res., 33, D593-D597 (2005)
Full text;
Lefranc, M.-P. et al.,
Nucleic Acids Research 2009 37:
D1006-D1012; doi:10.1093/nar/gkn838
Full text.
Author: Nathalie Bosc
Contact: Marie-Paule Lefranc
|
IMGT founder and director: Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr
Bioinformatics manager: Véronique Giudicelli Veronique.Giudicelli@igh.cnrs.fr Computer manager: Patrice Duroux Patrice.Duroux@igh.cnrs.fr Webmaster: Chantal Ginestoux Chantal.Ginestoux@igh.cnrs.fr |
|
|
|
|
Citing IMGT © Copyright 1995-2012 IMGT®, the international ImMunoGeneTics information system® |
|||
