Protein display: Nurse shark (Ginglymostoma cirratum) IGH V-REGIONs

Only the *01 allele of each functional, ORF and in-frame pseudogene V-REGION is shown.

Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.

Dots indicate gaps according to the IMGT unique numbering. Blanks at the 5' and/or 3' end indicate partial sequences.

_______________________________________________________________________________________________________________________________________________

      IGHV                        FR1-IMGT              CDR1-IMGT     FR2-IMGT         CDR2-IMGT               FR3-IMGT                  CDR3-IMGT
      gene                         (1-26)                (27-38)       (39-55)          (56-65)                 (66-104)                 (105-115)
  ________________________ __________________________ ____________ _________________ __________ _______________________________________ ___________  
                           1       10        20         30         40        50         60         70        80        90        100       110

                           .........|.........|...... ...|........ .|.........|..... ....|..... ....|.........|.........|.........|.... .....|.....    

#c M92851  ,IGHV1S1        EITLIQPEA.ETGHPGGSLSLTCKTR GFNLGSSS.... MYWIRQVPGQGLEWIVY YYSSSMN... NYAPAIK.DRFTAAKDTSNNIFALEMRSVKIDDTAIYYC TR
#c AF327520,IGHV1S2        DIMLTQPEA.ETSIPGGSLKLTCKIS GFDLEYHG.... MNWVRQIQGQGLEWLIY YYIVSDT... HYNPGIG.NRFTASKDISNNMIALDIVNLKTEDSAIYYC ARG
#c U51450  ,IGHV1S3        EIVLNQTES.VVKKLGESHKLTCTES EFGLSGYG.... IHWVRQATGKGLEWLTA ILTSGAK... YYAPAIQ.DRFEISK..DSDTVYLKVTNLTVDDTAIYYC AR
   L38965  ,IGHV2S1        ARVDQTPKT.ITKETGESLTINCVLR DTSYALGS.... TYWYRKKLGST.NEE.. .......... ..SISKG.GRYVETVNSGSKSFSLRINGLKVEDSWTYRC KA
   L38966  ,IGHV2S2        ARVDQTPKT.ITKETGESLTINCVLS DTSCAWDS.... TYWYRKKLDST.NEE.. .......... ..STSKG.GRYVETVNSESTSFSLRINDLTVEDSGTYRC RA
   L38967  ,IGHV2S3        ARVDQTPKT.ITKETGESLTINCVLR DTSYALGS.... TYWYRKKLGST.NEE.. .......... ..SISKG.GRYVETVNSGSKSLSLRINGLKVEDSWTYRC KA
   L38968  ,IGHV2S4        ARVDQTPRS.VTKETGESLTINCVLR DASYALGS.... TCWYRKKSGST.NEE.. .......... ..SISKG.GRYVETVNSGSKSFSLRINDLTVEDGGTYRC GV
#c U18680  ,IGHV2S5        ARVDQTPQE.ITKETGESLSINCVLR DSNCALPS.... TYWNRKKSGST.NEE.. .......... ..TISKG.GRYVETVNSGSKSFSLRINDLTVEDSGTYRC KV
#c U18681  ,IGHV2S6        ARVDQTPRS.VTKETGESLTINCVLR DSSYALGS.... TCWDRKKSGST.KYV.. .......... ..GIVMG.GRYVETVNSGSKSFSLRINDLTVEDGGTYRC AT
#c U18682  ,IGHV2S7        GRVDQTPRS.VTKEAGESLTINCVLH DARYGLGR.... TCWGRPVPDRT.YME.. .......... ..LISLG.GRYSQTVNSGSKSFSLTINDLTVEDSGTYRC GV
#c U18683  ,IGHV2S8        ARVDQTPKS.VTKETGESLTINCVLR DASFGPGR.... TCWYRKPSGSL.NDE.. .......... ..SSISV.GRYFETTNSGSKSFSLRINDLTVEDGGTYRC GV
#c U18684  ,IGHV2S9                                    HEYALGS.... TCWYRKKSGST.NEE.. .......... ..SISLG.GRYVETVNSGSKSFSLRINDLTVEDGGTYRC GV
#c U18685  ,IGHV2S10       ARVDQTPTS.VTKLTGESLTINCVIR DATNALVR.... TCWYRKLSGRT.NEE.. .......... ..SIEKG.GRYVETVNSGSKSFSLRINDLTTEDGGTYRC GV
#c U18686  ,IGHV2S11       ERVDQTPHS.ITKETGESLTINCVLR DSACGLSN.... AQWYRERSGST.KEE.. .......... ..NISQG.ARYVETVNRESKSFSLRINDLTVEDSGSYRC MA
#c U18687  ,IGHV2S12       ARVDQTPRS.VTKETGESLTINCVLR DASYALGH.... TCWFRKKSGST.KEE.. .......... ..NISPG.GRYVETVNSVQKSFSLRINDLTVEDGGTYRC GG
#c U18688  ,IGHV2S13       VRVDQTPQT.ITKETGESLTINCVLR DSNCALSS.... TYWYRKKSGST.NEE.. .......... ..KVSKG.GRYVETVNSGSKSFSLRINDLTVEDSGTYRC KT
#c U18689  ,IGHV2S14       ARVDQTPRS.VTKETGESVTINCVLR DATYDVAN.... TFWYRKKSGST.IEE.. .......... ..SISKG.GRYVERINRGSKSFSLTIKALIVEDGGNYRC GL
#c U18690  ,IGHV2S15       VRVDQTPRS.VTKETGESLTINCVVR ELSYALGS.... TCWYRKKSGST.NEE.. .......... ..SISKG.GRYVETVNSGSKSFSLRINDLTVEDGGTYRC GV
#c U18691  ,IGHV2S16              QT.ITKETGESLTINCVPR DMNCALSS.... TYWYRKKSGSS.NEE.. .......... ..SISKG.GRYVETVNSGSKSFSLRINDLTVEDSGTYRC RL
#c U18692  ,IGHV2S17       ARLDQTPRS.VTKEAGESLTINCVLR DASYSLGS.... TCWLRKKSGST.NEE.. .......... ..RISKG.GRYVETVNSGSKSFSLRINDLTVEDGGTYRC GR
#c U18693  ,IGHV2S18       NRVDQTPRS.VTKETGESLTINCVLR EAPYALGK.... TCWYRKKSGST.NEQ.. .......... ..SISKG.GRYVETVNSELKSFSLRINDLTVEDGGTYRC GA
#c U18694  ,IGHV2S19       ARVDQTPRS.VTKETGESLTINCVLR DVSLVKGG.... TCWYRKKSGST.KEE.. .......... ..SISIG.GRYVETVNSGSKSFSLRINDLTVADGGNYRC GV
#c U18695  ,IGHV2S20       ARVDQTPRT.VTRETGESLTINCVLR DANYALGG.... TCWYRKKSGST.NEE.. .......... ..IISGS.GRYVETVNSGTKSFSLRINELVVEDGGTYRC GV
#c U18696  ,IGHV2S21       ARVDQTPRS.VTKETGESLTINCVLR DANYGLGR.... TCWYRKSPGST.KEE.. .......... ..SISKG.GRYVETVNSASDSFALRINDLAVEDGGTYRC GA
#c U18697  ,IGHV2S22       ARVDQTPRS.VTKETGESLTINCGLR DANYSLAS.... TCWYRKKSGST.NEE.. .......... ..SISKG.GRYVETVNSGSKSFSLRINDLTVEDGGTYRC GV
#c U18698  ,IGHV2S23       ARLDQTPRS.VTKETGESLTINCVLR DATDAEIR.... PCWYRTKSGSD.NEE.. .......... ..SVRKG.DRYVETVNSASQSFSLRINDLTVEDAGTYRC GV
#c U18699  ,IGHV2S24       FRVDQTPRS.VTKETGESLTINCVLR DADYALGT.... TCWYRKKSGSP.NEE.. .......... ..RISPG.GRYVETRNSERKSFSLRINDLAVEDGGTYRC AV
#c U18700  ,IGHV2S25       ARVDQTPRS.VTKETGESLTINCVLR DATYSLGS.... TCWYRKKSGST.NEE.. .......... ..SISKG.GRYVETVNSGSKSFSLRINDLTVEDGGTYRC GV
#c U18701  ,IGHV2S26       ERVDQTPRS.VAKAEGQVLTINCVLR GANYELAKGS.. TCWYRKKSGSK.VEE.. .......... ..SITKG.GRYVETVNSGSKSFSLRINDLTIEDAGDYRC AA
#c U18702  ,IGHV2S27          DQTPRS.VTKETGESLTINCVLR DATSALGN.... TCWSRKKSLST.REE.. .......... ..IIAKG.GRYVETVNSGSKSFSLRINDLTVEDGGTYRC GV
#c U18703  ,IGHV2S28       ARVDQTPRS.VTKTEGESLTINCVLR DATDALGR.... TCWYRQKADST.NEE.. .......... ..SISKG.GRFVETVNSGSKSFSLRINDLVVEDGGTYRC GV
#c U18705  ,IGHV2S30       VRLDQTPTS.VTKETGESLTINCVLR DASYTLGS.... TCWYRKKAGST.NEE.. .......... ..NISKG.GRYVETVRSGSRSFSLRINDLTVEDGGTYRC GV
#c U18706  ,IGHV2S31       RRVDQTPRS.VTKETGESLTINCVLR DARSVLGS.... TCWYRKKSGST.NEE.. .......... ..SISKG.GRYVETINSGS.AFSLTINDLTIEDAGTYRC GV
#c U18707  ,IGHV2S32       ARVDQTPRS.VTKETGESLTINCVLR DASYELGS.... TCWYRKKLGST.NEE.. .......... ..RISKG.GRYVETVNSGSKSCSLRINDLTVEDGGTYRC GV
#c U18708  ,IGHV2S33       ARVDQTPRS.VTKETGESLTINCVLR DANYPLGS.... TCWFRKKSGST.NEE.. .......... ..SISLG.GRYVETVNSGSKSSSLRINDLTVEDGGTFRC GL
#c U18709  ,IGHV2S34          DQTPRS.VTKETGESVTLNCVLR DAYHALNY.... NCWYRKKPGGT.SEE.. .......... ..RLPRG.GRYVETFNSASDSFSLRITDLTPEDGGTYRC GA
#c U18710  ,IGHV2S35       ARVDQTPRS.VTKETGESLTINCVLR DATYALTN.... TCWYRKKSGST.NLE.. .......... ..SISKG.GRYVETVNSGSKSFSLRINDLEVEDGGTYHC GV
#c U18711  ,IGHV2S36       ARVDQTPRS.VTKETGESLTINCVLR DAKYALGN.... TCWYRTLQGST.DDE.. .......... ..SIEKG.GRFVETVNSGSKSFSLRINDVTVEDGGTYRC GV
#c U18712  ,IGHV2S37       ARVDQTPRS.VTKETGESLTINCVLR DASYALGS.... TCWYRKKPGST.NEE.. .......... ..SISKG.GRYVETVNSGSKSFSLRINDLTLEDGGTYRC GV
#c U18713  ,IGHV2S38       VRVDQTPQT.ITKETGESLTINCVLR DSNCPLSD.... TSWYRKKSGST.NEE.. .......... ..SMSKG.GRYVETVNSGSKSFSLRINDLTVEDSGTYRC KL
#c U18714  ,IGHV2S39       ARLDQTPQT.ITKETGESLTINCVLR DSDCASFG.... TSWYRKKSGSS.IEK.. .......... ..SIGKG.GQYVETVDSNAKSFSLRINDLTVEDSGTYRC KV
#c U18715  ,IGHV2S40       ARVDQTPQT.ITKETGESLTINCVLR DANYALGR.... TCWYRKKSGST.HEE.. .......... ..VIEKG.GRYVETVNSGSKSFSMRINDLTVEDSGTFRC GV
#c U18716  ,IGHV2S41       NRLDQTPHS.ITKETGESLTINCVLR DSNCASLI.... TRWYRKKSGST.NEE.. .......... ..SISKG.GRYVETVNRGSKSFSLRINDLTVEDSGTYRC GG
#c U18717  ,IGHV2S42       ARVDQTPTS.VTKETGESLTINCALR DPSLALES.... TCWYRLKSGST.NEE.. .......... ..LISTG.GRYVETVNSGSKSFSLRIKDLTVEDGGTYRC TV
#c U18718  ,IGHV2S43       ARVDQTPRS.VTKETGESLTINCVLR DAIYTVGS.... TCWYRKKSGST.AVE.. .......... ..SISKG.GRYVETVNSGSKSFSLRINDLTVEDGGTYRC GA
#c U18719  ,IGHV2S44            TPRS.ERKETGESLTINCVRR DANNALGR.... TCWYRIRSGST.NEE.. .......... ..SISIG.GRYVETVNKGSNSFSLRINDLTAEDGGTYRC AV
#c U18720  ,IGHV2S45       ARVDQTPRS.VTKETGESLTINCVLR DASYALGS.... TCWYRKKSGST.NEE.. .......... ..SISKG.GRYVETVNSGSKSFSLRINDLTVEDGGTYRC GV
#c U18721  ,IGHV2S46       ARVDQTPRS.VTKETGESLTINCVLR DASYALGS.... TCWYRKKSGST.NEE.. .......... ..SISKG.GRYVETVNSGSKSFSLRINDLTVEDGGTYRC ..
#c U18722  ,IGHV2S47       ARVDQTPAS.VTKETGDSLTINCVLR DASYDLGE.... TCWYRTKSGSS.DEK.. .......... ..RIKKG.RRYVETVSSGSKSFSLTIKDLVSEDSGTYRC GH
#c U18723  ,IGHV2S48       ARVDQTPRS.VTKETGESLTINCVLR DANYALGS.... TCWYRKKSGST.NEE.. .......... ..TISKG.GRYVETVNSGSQSFSLRINDLTVEDGGTYRC GT
#c U18724  ,IGHV2S49       ARVAQTPRS.VTKETGESLTINCALV DARFDGGE.... TCWFRKKSGSI.IEE.. .......... ..TISKG.GRYVETVNSGQESFSLRIKDLTVEDSGTYRC GV
#c U18725  ,IGHV2S50       WRVLQTPSA.VTKETGESLTINCVLR DSPQSLAG.... TCWYFTRSGSR.SEE.. .......... ..RIRAG.GRYVETVNSGSKSFSLKINDLTVEDGGTYRC GV
#c U18726  ,IGHV2S51       ARVDQTPQT.ITKETGESLTINCVLR NSACALST.... TYWYRKKSAST.NEE.. .......... ..SISKG.GRYVETVNSGSKSFSLRINDLTVEDSGTYRC MV  




#c: rearranged cDNA
IMGT note:
(1) In IGHV2S12, there is a discrepancy between the publication (Greenberg, A.S. et al., Nature, 374, 168-173 (1995).) and the EMBL flat file for positions 85-90 (according to IMGT numbering). In the publication, the amino acid sequence is K S F S L R and is similar to other sequences found in the same species and described in the same paper. The nucleotide sequence aat ctt tta (translation N L L) found in the EMBL flat file is an editing error. We propose in alignment a potential nucleotide sequence (in italics) deduced from the amino acid sequence, by comparison to the other Ginglymostoma cirratum sequences.(Dominique Scaviner, IMGT annotator).

Last updated: Monday, 11-Jul-2011 12:57:02 CEST
Created: 28/01/2002
Author: Dominique Scaviner
Contact: Marie-Paule Lefranc

IMGT Home page | IMGT Repertoire (IG and TR) | IMGT Repertoire (MH) | IMGT Repertoire (RPI) | IMGT Index | IMGT Scientific chart | IMGT Education

Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.

IMGT founder and director: Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr
Bioinformatics manager: Véronique Giudicelli Veronique.Giudicelli@igh.cnrs.fr
Computer manager: Patrice Duroux Patrice.Duroux@igh.cnrs.fr
Webmaster: Chantal Ginestoux Chantal.Ginestoux@igh.cnrs.fr 		     

Citing IMGT
Warranty disclaimer and copyright notice
Privacy policy and advertisement policy

© Copyright 1995-2012 IMGT®, the international ImMunoGeneTics information system®