The hinge exon(s) are shown at the end of the protein display.The IGHC protein display numbering is according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.
Only the *01 allele of each functional, ORF and in-frame pseudogenes C-REGION is shown.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CH-S and in pages edited before 14/10/2009).
The hinge exon(s) are shown at the end of the protein display.
_____________________________________________________________________________________________________________________________________________________________________________________________
IGHC
genes
_____________________________________________________________________________________________________________________________________________________________________________________________
A AB B BC C CD D DE E EF F FG G CH-S
--------------> ----------> ------> -------> -----------> -------> ---------->
1 10 15 16 20 23 30 36 39 41 45 77 84 85 89 96 97 104 110 118 121 130 140 150
7654321|........|....|123|...|...... ...|.....| |.....|1234567|......|12345677654321|..........|12|....... .....|....... ..|.........|.........|.........|
CH1
L36871 ,IGHA (E)SKTSPSVFPLSLCHQES....EGYVVIGCLVQ GFFPP.EPVN VTWNAGKDST....SVKNFPPMKAATG.....SLYTMSSQLTLPAAQC..PDDSSVKC QVQHA...SSPSK AVSVPCK
L36872 ,IGHE (A)TSQDLSVFPLASCCKDNIA..STSVTLGCLVT GYLP..MSTT VTWDTGSLNK....NVTTFPTTFHETY.....GLHSIVSQVTASGKW....AKQRFTC SVAHA...ESTAI NKTFS
AF354264,IGHG1 c (A)STTAPSVFPLAPSCGSTS...GSTVALACLVS GYFP..EPVT VSWNSGSLTS....GVHTFPSVLQSS......GLHSLSSMVTVPSSRW...PSETFTC NVVHPA..SNTKV DKPV
AF354265,IGHG2 c (A)STTAPSVFPLAPSCGSTS...GSTVALACLVS GYFP..EPVT VSWNSGSLTS....GVHTFPSVLQSS......GLYSLSSMVTVPSSRW...PSETFTC NVAHPA..SKTKV DKPV
AF354266,IGHG3 c (A)STTAPSVFPLAPSCGSQS...GSTVALACLVS GYIP..EPVT VSWNSVSLTS....GVHTFPSVLQSS......GLYSLSSMVTVPSSRW...PSETFTC NVAHPA..TNTKV DKPV
AF354267,IGHG4 c (A)STTAPSVFPLAPSCGSTS...GSTVALACLVS GYFP..EPVT VSWNSGSLTS....GVHTFPSVLQSS......GLYSLSSTVTVPSSRW...PSETFTC NVVHPA..SNTKV DKPV
CH2
L36871 ,IGHA (1) CNEPRLSLQKPALEDLLL..GSNASLTCTLS GLKDP.KGAT FTWNPSKGKE....PIQKNPERDSCG.......CYSVSSVLPGCADPW..NHGDTFSC TATHPE..SKSPI TVSITKTT
L36872 ,IGHE (A)CALNFIPPTVKLFHSSCNPVGDT.HTTIQLLCLIS GYVP..GDME VIWLVDGQKATN..IFPYTAPGTKEG......NVTSTHSELNITQGEW..VSQKTYTC QVTYQ....GFTF KDEARKCS
AF354264,IGHG1 c (V)PEPLGGPSVLIFPPKPKDILRI.TRTPEVTCVVL DLGREDPEVQ ISWFVDGKEVH...TAKTQSREQQFN......GTYRVVSVLPIEHQDW..LTGKEFKC RVNHID..LPSPI ERTISKAR
AF354265,IGHG2 c (A)PEMLGGPSVFIFPPKPKDTLLI.ARTPEVTCVVV DLDPEDPEVQ ISWFVDGKQMQ...TAKTQPREEQFN......GTYRVVSVLPIGHQDW..LKGKQFTC KVNNKA..LPSPI ERTISKAR
AF354266,IGHG3 c (G)CGLLGGPSVFIFPPKPKDILVT.ARTPTVTCVVV DLDPENPEVQ ISWFVDSKQVQ...TANTQPREEQSN......GTYRVVSVLPIGHQDW..LSGKQFKC KVNNKA..LPSPI EEIISKTP
AF354267,IGHG4 c (V)PESLGGPSVFIFPPKPKDILRI.TRTPEITCVVL DLGREDPEVQ ISWFVDGKEVH...TAKTQPREQQFN......STYRVVSVLPIEHQDW..LTGKEFKC RVNHIG..LPSPI ERTISKAR
CH3
L36871 ,IGHA (E)HIPPQVHLLPPPSEELAL..NELVTLTCLVR GFKP..KDVL VRWLQGTQELPQE.KYLTWEPLKEPDQ....TNMFAVTSMLRVTAEDW..KQGEKFSC MVGHEA.LPMSFT QKTIDRLA...GKPTHVNVSVVMAEVDGICY
L36872 ,IGHE (E)SDPRGVTSYLSPPSPLDLYV..HKAPKITCLVV DLATM.EGMN LTWYRESKEPV...NPGPLNKKDHFN......GTITVTSTLPVNTNDW..IEGETYYC RVTHPH..LPKDI VRSIAKAP
AF354264,IGHG1 c (G)RAHKPSVYVLPPSPKELSS..SDTVSITCLIK DFYP..PDID VEWQSNGQQEPER.KHRMTPPQLDED......GSYFLYSKLSVDKSRW..QQGDPFTC AVMHET.LQNHYT DLSLSHSP...GK
AF354265,IGHG2 c (G)QAHQPSVYVLPPSREELS...KNTVSLTCLIK DFFP..PDID VEWQSNGQQEPES.KYRTTPPQLDED......GSYFLYSKLSVDKSRW..QRGDTFIC AVMHEA.LHNHYT QESLSHSP...GK
AF354266,IGHG3 c (G)QAHQPNVYVLPPSRDEMS...KNTVTLTCLVK DFFP..PEID VEWQSNGQQEPES.KYRMTPPQLDED......GSYFLYSKLSVDKSRW..QRGDTFIC AVMHEA.LHNHYT QISLSHSP...GK
AF354267,IGHG4 c (G)QAHQPSVYVLPPSPKELSS..SDTVTLTCLIK DFFP..PEID VEWQSNGQPEPES.KYHTTAPQLDED......GSYFLYSKLSVDKSRW..QQGDTFTC AVMHEA.LQNHYT DLSLSHSP...GK
CH4
L36872 ,IGHE (G)KRAPPDVYLFLPPEEEQGT..KDRVTLTCLIQ NFFP..ADIS VQWLRNDSPIQTD.QYTTTGPHKVSGS....RPAFFIFSRLEVSRVDW..EQKNKFTC QVVHEALSGSRIL QKWVSKTP...GK
Hinge
L36871 ,IGHA (1) (D)NSHPCHPCPS
AF354264,IGHG1 c (F)NECRCTDTPPCP
AF354265,IGHG2 c (P)KRENGRVPRPPDCPKCP
AF354266,IGHG3 c (A)KECECKCNCNNCPCP
AF354267,IGHG4 c (P)KESTCKCISPCP
c: cDNA sequence
IMGT note:(1) In the IGHA gene, the hinge (H) and CH2 are joined in a single exon.
Created: 22/10/2002
Author: Nathalie Bosc
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.
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