Only the *01 allele of each functional or ORF V-REGION is shown.
Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.
Dots indicate gaps according to the IMGT unique numbering. Blanks at the 5' and/or 3' end indicate partial sequences.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CH-S and in pages edited before 14/10/2009).
_________________________________________________________________________________________________________________________________________________
IGHV FR1-IMGT CDR1-IMGT FR2-IMGT CDR2-IMGT FR3-IMGT CDR3-IMGT
gene (1-26) (27-38) (39-55) (56-65) (66-104) (105-115)
_____________________________ __________________________ ____________ _________________ __________ _______________________________________ ___________
1 10 20 30 40 50 60 70 80 90 100 110
.........|.........|...... ...|........ .|.........|..... ....|..... ....|.........|.........|.........|.... .....|.....
Y00380 ,IGHV1S1 DVQLAQSES.VVIKPGGSHKLSCTAS GFTFSSYW.... MSWVRQAPGKGLQWESR ISDGGGST.. YYADSVK.GRFTISRDNNNNKLYLQMNNLKTEDTAMYYC ARH........
#c M24673 ,IGHV1S2 EVQLAQSES.VMIKPGGSHKLSCTAS GFTFSSTW.... MYWVRQTPGKGLQWLCH IHPDGSSA.. YYADSVK.GRFTISRDNNNNKFYLQMNNLQTEDTAVYYC AR
#c M94850 ,IGHV1S3 EVQLAQSES.VVIKPGGSHKLSCTAS GFTFSDHW.... MSWVRQAPGKGLQWVSN IKYDGAET.. NYADSVK.GRFTISRDNNNNKLYLQMNNLQTEDTAVYYC AR
#c M30024 ,IGHV1S4 DVQLDQSES..VIKPGGSHKLSSTAS GFTFSSYW.... MSWVRQAPGKGLQWVSL ISSDGGST.. YYADSVK.GRFTISRDNNNNKLYLQMNNLQTEDTAVYYC TR
#c M94841 ,IGHV1S5 DIQLDQSEP.VVIKPGGSHKLSCTAS GFTFSGYY.... MHWIRQAPGKGLQWVSR ISSDGGST.. VYADSVK.GRFTISRDNNNNKLYLQMNNLQTEDAAVYYC AR
#c M94854 ,IGHV1S6 DVQLAQSES.VVIKPGGSHKLSCTAS GFTFSDHW.... MNWVRQAPGKGLQWLSR IYDASHI... YYADSVK.GRFTISRDNNNNKLYLQMNNLQTEDTAVYYC RD
#c M94840 ,IGHV1S7 DVQLDQSEP.VVIKPGGSHKLSCTAS GFTFSSYG.... MGWVRQAPGKGLQWVSA ISSDGGST.. YYADSVK.GRFTISRDNNNNKLYLQMNNLQTEDTAVYYC TR
#c M94845 ,IGHV1S8 DVQLDQSES.VVIKPGGSHKLSCTAS GFTFSSYG.... MSWVRQAPGKGLQWVSY ISSGGGTI.. YYADSVK.GRFTISRDNNNNKLFLQMNNLQTEDTAVYYC AR
#c M94853 ,IGHV1S9 DVQLDQSEP.VVIKPGGSHKLSCTAS GFTFSTTW.... MSWVRQSPGNGLQWVSR IYDASNI... NYADSVK.GRFTVSKDNNNNKLYLQMNNLQTEDTAVYYC TT
#c M94843 ,IGHV1S10 DVQLVQSEP.VVIKPGGSHKLSCTAS GFTFSSTW.... MNWVRQAPGKGLQWVSR ISSGSGSNT. YYADSVK.GRFTISRDNNNNKLYLQMNNLQTEDTAVYYC ATK
#c M94851 ,IGHV1S11 DVQLDQSES.VVIKPGGSHKLSCTAS GFTFSSYS.... MHWIRQAPGRGLQWVSA ISNGGTT... YYADSVK.GRFTISRDNNNNKLYLQMNNLQTEDTGVYYC AR
#c M94839 ,IGHV1S12 DVQLAQSES.VVIKPGGSHKLSCTAS GFTFSSTW.... MYWVRQAPGKGLQWLCH IHPDGSSA.. YYADSVK.GRFTISRDNKNNKLYLQMNNLQTEDTAMYYC AR
#c M94844 ,IGHV1S13 DVQLDQSES.VVIKPGGSHKLSCTAS GFTFSSYG.... MGWVRQAPGKGLQWVSA ISSNGGST.. VYADSVK.GRFTISRDNNNNKLYLQMNNLQTEETAVYYC AR
#c M94847 ,IGHV1S14 DVQLAQSEP.VVIKLGGSHKLSCTAS GFTFSDYW.... MHWVRQAPGKGLQWLGE IHPNGGTT.. NYADSVK.GRFTISRDNNNNKLYLEMTNLQTEDTAVYYC AT
#c M94849 ,IGHV1S15 DMQLDQSES.VVIKPGGSHKLSCTAS GFTFSDYW.... MSWVRQAPGKGLQWLSD INYDGSTT.. RYADSVK.GRFTISRDNNNNKLYLQMNNLQTEDMAVYYC VRY
#c M94842 ,IGHV1S16 DVQLAQSES.VVIKPGGSHKLSCTAS GFTFIGHW.... MHWVRQAPGKRLQWLSD INYDGSTT.. RYADSVK.GRFTISRDNNNNKLYLQINNLQTEDTAVYYC TRY
#c M94848 ,IGHV1S17 DVQLAQSEP.VVIKPGGSHKLSCTAS GFTFSSYW.... MDWVRQAPGKGLQWVSD INYDGAET.. YYADSVK.GRFTISRDNNNNKLYLQMNNLQTEDTAVYYC AR
#c M94846 ,IGHV1S18 DVQLAQSES.VVIKPGGSHKLSCTAS GFTFSSNW.... MNWVRQAPGKGLQWVSY ISNDGSGT.. YYPSSFK.GRFTISRDNNNNKLYLQMNNLQTEDTAVYYC SSVTQ
#c M94852 ,IGHV1S19 DVQLAQSEP.VVIKPGGSHKLSCTAS GFTFSDYW.... MNWIRQAPGKGLQWVSA ISNGGST... YYADSVK.GEF
#c M30026 ,IGHV1S20 FIS FPSGTKT... YY?DSVK.GRFTISRDNNNNKLYLQMNNLQTEDTAVYYC TR
#c M24674 ,IGHV2S1 TLQESGP.GTVKPSESLRLTCTVS GFEITNYG.... LSWIRQPPGKGLEWIGT IVTGGNT... YIADILK.NRVTITKDNGKKQVYLQMTAMEVKDTAMYYC GR
#c M30025 ,IGHV2S2 QTLQESGP.GTVKPSESLRLTCTVS GFDLTSYG.... VCWIRQPPGKGLEWIGV VWNTGGT... AITDSIK.NRVTFTKDNGKKQVYLQMTGMEVKDTAMYYC AR
#c M30027 ,IGHV2S3 QTLQESGP.GTVKPSESLRLTCTVS GFDLTSYA.... VSWIRQPPGKGLEWIGH TT........ GIADSLK.NRVTITKDNGKKQVYLQMTGMEVKDTAMYYC AR
#c M30028 ,IGHV2S4 QTLQESGP.RTVKPSESLRLTCTVS GFELTRYA.... VNWMRQPPGKGPEWIGE VYGSGGT... AFADSLK.NRVTITKDNGKKQVYLQMTGMEVKDTAMYYC AD
#c M30029 ,IGHV2S5 VQESGP.GTVKPSESLRLTCTVS GFELTSYH.... MHWTRQPTGKGLEWIGA VWYHGGT... ALADSLK.SRVTITRDTGKKQVYLQMTGMEVKDTAMYYC AR
#c M30030 ,IGHV2S6 ALQESGP.GTVKPSESLRLTCTVS GFELTSFH.... ISWIRQPPGKGLEWIGA AWADGST... AIADSLK.NRVTITKDNGKKQVYLQMTGMEVKDTAMYYC AR
#c M24675 ,IGHV3S1 QISLTQPGT.VTVKPSEVLQLTCKVT GASLTDSSKIAC VQWVRQPVGKGLEWLGG IWYEASL... HYSQSLK.GRVTVSRDTNKGEVYLKLTGMKPEETAVYYC AT
#c M30031 ,IGHV3S2 QISLIQPGA.VTVKPSEVLQLTCKVT GASLTDRSKVYA VHWVRQPAGKGLEWLGE IRYNAGT... SYAQSLQ.GRITVSRDTNKGEVYLKLTGMKPEETAVYYC AR
#c M30032 ,IGHV3S3 SLQ.GRVTVSRDTNKGEVYLKLTGMKPEETAVYYC TR
#c M30033 ,IGHV3S4 AASRDTNKGEVYLKLTGMKPEETAVYYC AI
#c M24676 ,IGHV4S1 LLSQKAS.EIANVGTSILLQCEVS GYNINDHH.... MHWVRQAPGPGTIEWLA AYRSDTT... YISESFK.ERVTPST..SGSTAQLRISKLSRSDTATYYC AT
#c M24677 ,IGHV5S1 DIELVQPSS.EIKSPGESVKLSCKTS GYTFTDYW.... IHWIQQVPGKGLQWMGV IDPSDAYT.. SYSPSYQ.GRCQISTDNSQSTAFLQLNNLKVEDTAIYYC AR
#c M24678 ,IGHV6S1 QITLDQPGS.TLVKPSDTLKIACKVS VSVSSYY..... WTWVRQTPGKGLEYMGR ITSSGGT... EHTPAFQ.NRVTLTRDAAKNEIYLALSSMRSEDSGTYYC AS
#c M24679 ,IGHV7S1 EVTVSLSVP.ELVKPSEKLKLVCKVS GALITDGSKIHA VDYIRQFSGSTFEFLAH INYAAGT... ALNPDLK.SRLTLSRDTAKNEAYLEISGMTAGDTAMYYC AK
#c M24680 ,IGHV8S1 QITLDQPGS.AVVNPSGTLKLSCKVS VSVTSQH..... WAWTWQAPGKGLEYIGY LNSDGSS... YPAPSFQ.SRVTLTRDSSKNEISLQMTSMKSEDSGTYYC AN
#c M30034 ,IGHV8S2 WAWTWQAPGKGLEYIGY LNSGGSS... YPAPSFK.SRATFTRDTSKNEISLQMTSMKSEDSGTYFC AR
#c M30035 ,IGHV8S3 ASKNEISLQMTSMKSEDSGTYFC AR
#c M24681 ,IGHV9S1 EILLTQSNP.EIKKPGESVKITCKTS GFTFTDYY.... MHWVRQAPRGGLQWIGG IDPDDGET.. NYLSSLE.ERLTVTTDNSISTVYLEISRLMLEDTATYYC AR
#c M30036 ,IGHV9S2 EILLTQSNP.ENKKPGESVKITCKTS GFTFIDYY.... MHWVRQAPRGGLQWIGG IDPDDGET.. TYLSSLE.ERLTVTTDNSISTVYLDISRLMLEDTATYYC AR
#c M27254 ,IGHV10S1 QTPGKGLEWLGA IWYDGSKT.. VYAKSVE.GRLVITRNNAEQVTFMELKNLVYQDTAVYYC TR
#c M27255 ,IGHV11S1 LTCKTS GYDFGSYG.... MNWVQQIPGKGLAWVAN INTETGNT.. VYPSSFK.GRFTITKDNSISTAYLEISSLKPEDTATYYC AN
#c: rearranged cDNA.
Created: 18/07/2003
Software material and data coming from IMGT server may be used for academic research only,
provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics
information system® http://www.imgt.org
(founder and director: Marie-Paule Lefranc, Montpellier, France)."
References to cite:
Lefranc, M.-P. et al.,
Nucleic Acids Research, 27, 209-212 (1999)
Cover of NAR;
Ruiz, M. et al.,
Nucleic Acids Research, 28, 219-221 (2000);
Lefranc, M.-P.,
Nucleic Acids Research, 29, 207-209 (2001);
Lefranc, M.-P.,
Nucleic Acids Res., 31, 307-310 (2003);
Lefranc, M.-P. et al.,
In Silico Biol., 5, 0006 (2004) [Epub],
5, 45-60 (2005);
Lefranc, M.-P. et al.,
Nucleic Acids Res., 33, D593-D597 (2005)
Full text;
Lefranc, M.-P. et al.,
Nucleic Acids Research 2009 37:
D1006-D1012; doi:10.1093/nar/gkn838
Full text.
Author: Delphine Guiraudou
Contact: Marie-Paule Lefranc
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IMGT founder and director: Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr
Bioinformatics manager: Véronique Giudicelli Veronique.Giudicelli@igh.cnrs.fr Computer manager: Patrice Duroux Patrice.Duroux@igh.cnrs.fr Webmaster: Chantal Ginestoux Chantal.Ginestoux@igh.cnrs.fr |
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Citing IMGT © Copyright 1995-2012 IMGT®, the international ImMunoGeneTics information system® |
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