The IGHC protein display numbering is according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.
Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CH-S and in pages edited before 14/10/2009).
The hinge exon(s) are shown at the end of the protein display.
_____________________________________________________________________________________________________________________________________________________________________________________________
IGHC
genes
_____________________________________________________________________________________________________________________________________________________________________________________________
A AB B BC C CD D DE E EF F FG G CH-S
--------------> ----------> ------> -------> -----------> -------> ---------->
1 10 15 16 20 23 30 36 39 41 45 77 84 85 89 96 97 104 110 118 121 130 140 150
7654321|........|....|123|...|...... ...|.....| |.....|1234567|......|12345677654321|..........|12|....... .....|....... ..|.........|.........|.........|
CH1
J00220 ,IGHA1 (A)SPTSPKVFPLSLCSTQP....DGNVVIACLVQ GFFPQ.EPLS VTWSESGQGV....TARNFPPSQDASG.....DLYTTSSQLTLPATQC..LAGKSVTC HVKHY...TNPSQ DVTVPCP
J00221 ,IGHA2 (A)SPTSPKVFPLSLDSTPQ....DGNVVVACLVQ GFFPQ.EPLS VTWSESGQNV....TARNFPPSQDASG.....DLYTTSSQLTLPATQC..PDGKSVTC HVKHY...TNPSQ DVTVPCP
K02875 ,IGHD (A)PTKAPDVFPIISGCRHPKD..NSPVVLACLIT GYHP..TSVT VTWYMGTQSQ....PQRTFPEIQRRD......SYYMTSSQLSTPLQQW...RQGEYKC VVQHT...ASKSK KEIFRWP
J00222 ,IGHE (A)STQSPSVFPLTRCCKNIPSN.ATSVTLGCLAT GYFP..EPVM VTCDTGSLNG....TTMTLPATTLTLS.....GHYATISLLTVSGAW....AKQMFTC RVAHTPSSTDWVD NKTFS
J00228 ,IGHG1 (A)STKGPSVFPLAPSSKSTS...GGTAALGCLVK DYFP..EPVT VSWNSGALTS....GVHTFPAVLQSS......GLYSLSSVVTVPSSSL...GTQTYIC NVNHKP..SNTKV DKKV
J00230 ,IGHG2 (A)STKGPSVFPLAPCSRSTS...ESTAALGCLVK DYFP..EPVT VSWNSGALTS....GVHTFPAVLQSS......GLYSLSSVVTVPSSNF...GTQTYTC NVDHKP..SNTKV DKTV
X03604 ,IGHG3 (A)STKGPSVFPLAPCSRSTS...GGTAALGCLVK DYFP..EPVT VSWNSGALTS....GVHTFPAVLQSS......GLYSLSSVVTVPSSSL...GTQTYTC NVNHKP..SNTKV DKRV
K01316 ,IGHG4 (A)STKGPSVFPLAPCSRSTS...ESTAALGCLVK DYFP..EPVT VSWNSGALTS....GVHTFPAVLQSS......GLYSLSSVVTVPSSSL...GTKTYTC NVDHKP..SNTKV DKRV
X06766 ,IGHGP (A)STKGPSVFPLVPSSRSVS...EGTAALGCLVK DYFP..EPVT VSWNSGALTR....SVHTFPAVLQSS......GLYSLSSVVTVPSSSL...GTQTYTC NVDHKP..SNTKV DKTV
X14940 ,IGHM (G)SASAPTLFPLVSCENSPSD..TSSVAVGCLAQ DFLP..DSIT LSWKYKNNSDIS..STRGFPSVLRGG.......KYAATSQVLLPSKDVMQGTDEHVVC KVQHP....NGNK EKNVPLP
CH2
J00220 ,IGHA1 CCHPRLSLHRPALEDLLL..GSEANLTCTLT GLRDA.SGVT FTWTPSSGKS....AVQGPPERDLCG.......CYSVSSVLPGCAEPW..NHGKTFTC TAAYPE..SKTPL TATLSKS
J00221 ,IGHA2 CCHPRLSLHRPALEDLLL..GSEANLTCTLT GLRDA.SGAT FTWTPSSGKS....AVQGPPERDLCG.......CYSVSSVLPGCAQPW..NHGETFTC TAAHPE..LKTPL TANITKS
K02878 ,IGHD (E)CPSHTQPLGVYLLTPAVQDLWL..RDKATFTCFVV GSDL..KDAH LTWEVAGKVPTG..GVEEGLLERHSN......GSQSQHSRLTLPRSLW..NAGTSVTC TLNHPS..LPPQR LMALREP
J00222 ,IGHE (V)CSRDFTPPTVKILQSSCDGGGHF.PPTIQLLCLVS GYTP..GTIN ITWLEDGQVMD...VDLSTASTTQEG......ELASTQSELTLSQKHW..LSDRTYTC QVTYQ....GHTF EDSTKKCA
J00228 ,IGHG1 (A)PELLGGPSVFLFPPKPKDTLMI.SRTPEVTCVVV DVSHEDPEVK FNWYVDGVEVH...NAKTKPREEQYN......STYRVVSVLTVLHQDW..LNGKEYKC KVSNKA..LPAPI EKTISKAK
J00230 ,IGHG2 (A)P.PVAGPSVFLFPPKPKDTLMI.SRTPEVTCVVV DVSHEDPEVQ FNWYVDGVEVH...NAKTKPREEQFN......STFRVVSVLTVVHQDW..LNGKEYKC KVSNKG..LPAPI EKTISKTK
X03604 ,IGHG3 (A)PELLGGPSVFLFPPKPKDTLMI.SRTPEVTCVVV DVSHEDPEVQ FKWYVDGVEVH...NAKTKPREEQYN......STFRVVSVLTVLHQDW..LNGKEYKC KVSNKA..LPAPI EKTISKTK
K01316 ,IGHG4 (A)PEFLGGPSVFLFPPKPKDTLMI.SRTPEVTCVVV DVSQEDPEVQ FNWYVDGVEVH...NAKTKPREEQFN......STYRVVSVLTVLHQDW..LNGKEYKC KVSNKG..LPSSI EKTISKAK
X06766 ,IGHGP (T)TEPLGGPSVFLFPPKPKDTLMI.SRTPEVTCVVV DVSHEDPEVK FNWYVDGVEVH...NAKTKPWEEQYN......STYHVVSVLTVVHQNW..LNGREYKC KVSNKG..LPAPI EKTISKTK
X14940 ,IGHM (V)IAELPPKVSVFVPPRDGFFGN.PRKSKLICQAT GFSP..RQIQ VSWLREGKQVGS..GVTTDQVQAEAKES..GPTTYKVTSTLTIKESDW..LGQSMFTC RVDHR....GLTF QQNASSMCVP
CH3
J00220 ,IGHA1 (G)NTFRPEVHLLPPPSEELAL..NELVTLTCLAR GFSP..KDVL VRWLQGSQELPRE.KYLTWASRQEPSQG...TTTFAVTSILRVAAEDW..KKGDTFSC MVGHEA.LPLAFT QKTIDRLA...GKPTHVNVSVVMAEVDGTCY
J00221 ,IGHA2 (G)NTFRPEVHLLPPPSEELAL..NELVTLTCLAR GFSP..KDVL VRWLQGSQELPRE.KYLTWASRQEPSQG...TTTFAVTSILRVAAEDW..KKGDTFSC MVGHEA.LPLAFT QKTIDRLA...GKPTHVNVSVVMAEVDGTCY
K02879 ,IGHD (A)AQAPVKLSLNLLASSDPP..EAASWLLCEVS GFSP..PNIL LMWLEDQREVNTS.GFAPARPPPQPRS.....TTFWAWSVLRVPAPPS..PQPATYTC VVSHEDSRTLLNA SRSLEVS (Y)VTDHGPMK
J00222 ,IGHE (D)SNPRGVSAYLSRPSPFDLFI..RKSPTITCLVV DLAPSKGTVN LTWSRASGKPV...NHSTRKEEKQRN......GTLTVTSTLPVGTRDW..IEGETYQC RVTHPH..LPRAL MRSTTKTS
J00228 ,IGHG1 (G)QPREPQVYTLPPSRDELT...KNQVSLTCLVK GFYP..SDIA VEWESNGQPEN...NYKTTPPVLDSD......GSFFLYSKLTVDKSRW..QQGNVFSC SVMHEA.LHNHYT QKSLSLSP...GK
J00230 ,IGHG2 (G)QPREPQVYTLPPSREEMT...KNQVSLTCLVK GFYP..SDIA VEWESNGQPEN...NYKTTPPMLDSD......GSFFLYSKLTVDKSRW..QQGNVFSC SVMHEA.LHNHYT QKSLSLSP...GK
X03604 ,IGHG3 (G)QPREPQVYTLPPSREEMT...KNQVSLTCLVK GFYP..SDIA VEWESSGQPEN...NYNTTPPMLDSD......GSFFLYSKLTVDKSRW..QQGNIFSC SVMHEA.LHNRFT QKSLSLSP...GK
K01316 ,IGHG4 (G)QPREPQVYTLPPSQEEMT...KNQVSLTCLVK GFYP..SDIA VEWESNGQPEN...NYKTTPPVLDSD......GSFFLYSRLTVDKSRW..QEGNVFSC SVMHEA.LHNHYT QKSLSLSL...GK
X06766 ,IGHGP (G)QPREPQVYTLPPSQK.MT...KNQVTLTCLVK GFYP..SDIT VEWESNGQPEN...NYKTTPPMLDSN......GSFFLYSKLTVDKSRW..QQGNVFSC SVMHEG.LHNHYT QKSLSLSP...GK
X14940 ,IGHM (D)QDTAIRVFAIPPSFASIFL..TKSTKLTCLVT DLTTY.DSVT ISWTRQNGEAV...KTHTNISESHPN......ATFSAVGEASICEDDW..NSGERFTC TVTHTD..LPSPL KQTISRPK
CH4
J00222 ,IGHE (G)PRAAPEVYAFATPEWPGS...RDKRTLACLIQ NFMP..EDIS VQWLHNEVQLPDA.RHSTTQPRKTKG......SGFFVFSRLEVTRAEW..EQKDEFIC RAVHEAASPSQTV QRAVSVNP...GK
X14940 ,IGHM (G)VALHRPDVYLLPPAREQLNL..RESATITCLVT GFSP..ADVF VQWMQRGQPLSPE.KYVTSAPMPEPQA....PGRYFAHSILTVSEEEW..NTGETYTC VVAHEA.LPNRVT ERTVDKST...GKPTLYNVSLVMSDTAGTCY
M
M60193 ,IGHA1 (G)SCSVADWQMPPPYVVLDLPQETLEEETPGANLWPTTITFLTLFLLSLFYSTALTVTSVRGPSGNREGPQY
M60194 ,IGHA2 (G)SCCVADWQMPPPYVVLDLPQETLEEETPGANLWPTTITFLTLFLLSLFYSTALTVTSVRGPSGKREGPQY
M1 M2
K02881 ,IGHD (Y)LAMTPLIPQSKDENSDDYTTFDDVGSLWTTLSTFVALFILTLLYSGIVTFIK VK (K02882)
X63693 ,IGHE (E)LDVCVEEAEGEAPWTWTGLCIFAALFLLSVSYSAALTLLM VQRFLSATRQGRPQTSLDYTNVLQPHA
X52847 ,IGHG1 (E)LQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFK VKWIFSSVVDLKQTIIPDYRNMIGQGA
AB006775,IGHG2 (E)LQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATITFFK VKWIFSSVVDLKQTIVPDYRNMIRQGA (AB006776)
D78345 ,IGHG3 (E)LQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFK VKWIFSSVVDLKQTIIPDYRNMIGQGA
AL928742,IGHG4*04 (E)LQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFK VKWIFSSVVDLKQTIVPDYRNMIRQGA
X52849 ,IGHGP (E)LQLEESCAEAQDGELDGLWTTITIFITLFLLSVCYSATVTFFK VKWIFSSVVDLKQTIVPDYRNMIGQGA (X52848)
X14940 ,IGHM (E)GEVSADEEGFENLWATASTFIVLFLLSLFYSTTVTLFK VK
CONNECTING-REGION | TRANSMEMBRANE-REGION | CYTOPLASMIC-REGION
Hinge
J00220 ,IGHA1 (V)PSTPPTPSPSTPPTPSPS
J00221 ,IGHA2 (V)PPPPP
K02876 ,IGHD [H1] (E)SPKAQASSVPTAQPQAEGSLAKATTAPATTRNT [H2] (G)RGGEEKKKEKEKEEQEERETKTP (K02877)
J00228 ,IGHG1 (E)PKSCDKTHTCPPCP
J00230 ,IGHG2 (E)RKCCVECPPCP
X03604 ,IGHG3 [H1](E)LKTPLGDTTHTCPRCP [H2] (E)PKSCDTPPPCPRCP [H3] (E)PKSCDTPPPCPRCP [H4] (E)PKSCDTPPPCPRCP
K01316 ,IGHG4 (E)SKYGPPCPSCP
X06766 ,IGHGP (E)PKTPCCDTTHTCPPCA
Created: 23/03/2001
Last updated: Friday, 08-Jul-2011 13:53:56 CEST
Authors: Christèle Martinez-Jean and Nathalie Bosc
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
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Marie-Paule.Lefranc@igh.cnrs.fr
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