Protein display: Human IGK V-REGIONs

Print of this table: Scaviner, D. et al., Exp. Clin. Immunogenet., 16, 234-240 (1999). PMID:10575277

Only the *01 allele of each functional or ORF V-REGION is shown, except for IGKV1-13 and IGKV2-29 for which the *02 allele is displayed, the *01 allele being a pseudogene.

Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.

One pseudogene has been included: IGKV7-3, single member of the IGKV7 subgroup, which has no INIT-CODON (ATG replaced by ATA). 
_______________________________________________________________________________________________________________________________________________

      IGKV                            FR1-IMGT           CDR1-IMGT       FR2-IMGT      CDR2-IMGT                  FR3-IMGT                 CDR3-IMGT
      gene                             (1-26)             (27-38)        (39-55)        (56-65)                   (66-104)                 (105-115)
___________________________  __________________________ ____________ _________________ __________ _______________________________________ ___________
                             1       10        20         30         40        50         60         70        80        90        100       110

                             .........|.........|...... ...|........ .|.........|..... ....|..... ....|.........|.........|.........|.... .....|.....

  Z00001  ,IGKV1-5           DIQMTQSPSTLSASVGDRVTITCRAS QSISSW...... LAWYQQKPGKAPKLLIY DAS....... SLESGVP.SRFSGSG..SGTEFTLTISSLQPDDFATYYC QQYNSYS....
  M64858  ,IGKV1-6           AIQMTQSPSSLSASVGDRVTITCRAS QGIRND...... LGWYQQKPGKAPKLLIY AAS....... SLQSGVP.SRFSGSG..SGTDFTLTISSLQPEDFATYYC LQDYNYP....
  Z00014  ,IGKV1-8           AIRMTQSPSSFSASTGDRVTITCRAS QGISSY...... LAWYQQKPGKAPKLLIY AAS....... TLQSGVP.SRFSGSG..SGTDFTLTISCLQSEDFATYYC QQYYSYP....
  Z00008  ,IGKV1D-8          VIWMTQSPSLLSASTGDRVTISCRMS QGISSY...... LAWYQQKPGKAPELLIY AAS....... TLQSGVP.SRFSGSG..SGTDFTLTISCLQSEDFATYYC QQYYSFP....
  Z00013  ,IGKV1-9           DIQLTQSPSFLSASVGDRVTITCRAS QGISSY...... LAWYQQKPGKAPKLLIY AAS....... TLQSGVP.SRFSGSG..SGTEFTLTISSLQPEDFATYYC QQLNSYP....
  V01577  ,IGKV1-12          DIQMTQSPSSVSASVGDRVTITCRAS QGISSW...... LAWYQQKPGKAPKLLIY AAS....... SLQSGVP.SRFSGSG..SGTDFTLTISSLQPEDFATYYC QQANSFP....
  X17263  ,IGKV1D-12         DIQMTQSPSSVSASVGDRVTITCRAS QGISSW...... LAWYQQKPGKAPKLLIY AAS....... SLQSGVP.SRFSGSG..SGTDFTLTISSLQPEDFATYYC QQANSFP....
  Z00006  ,IGKV1-13*02       AIQLTQSPSSLSASVGDRVTITCRAS QGISSA...... LAWYQQKPGKAPKLLIY DAS....... SLESGVP.SRFSGSG..SGTDFTLTISSLQPEDFATYYC QQFNSYP....
  X17262  ,IGKV1D-13         AIQLTQSPSSLSASVGDRVTITCRAS QGISSA...... LAWYQQKPGKAPKLLIY DAS....... SLESGVP.SRFSGSG..SGTDFTLTISSLQPEDFATYYC QQFNNYP....
  J00248  ,IGKV1-16          DIQMTQSPSSLSASVGDRVTITCRAS QGISNY...... LAWFQQKPGKAPKSLIY AAS....... SLQSGVP.SRFSGSG..SGTDFTLTISSLQPEDFATYYC QQYNSYP....
  K01323  ,IGKV1D-16         DIQMTQSPSSLSASVGDRVTITCRAS QGISSW...... LAWYQQKPEKAPKSLIY AAS....... SLQSGVP.SRFSGSG..SGTDFTLTISSLQPEDFATYYC QQYNSYP....
  X72808  ,IGKV1-17          DIQMTQSPSSLSASVGDRVTITCRAS QGIRND...... LGWYQQKPGKAPKRLIY AAS....... SLQSGVP.SRFSGSG..SGTEFTLTISSLQPEDFATYYC LQHNSYP....
  X63392  ,IGKV1D-17         NIQMTQSPSAMSASVGDRVTITCRAR QGISNY...... LAWFQQKPGKVPKHLIY AAS....... SLQSGVP.SRFSGSG..SGTEFTLTISSLQPEDFATYYC LQHNSYP....
  X63398  ,IGKV1-27          DIQMTQSPSSLSASVGDRVTITCRAS QGISNY...... LAWYQQKPGKVPKLLIY AAS....... TLQSGVP.SRFSGSG..SGTDFTLTISSLQPEDVATYYC QKYNSAP....
  M64856  ,IGKV1-33          DIQMTQSPSSLSASVGDRVTITCQAS QDISNY...... LNWYQQKPGKAPKLLIY DAS....... NLETGVP.SRFSGSG..SGTDFTFTISSLQPEDIATYYC QQYDNLP....
  M64855  ,IGKV1D-33         DIQMTQSPSSLSASVGDRVTITCQAS QDISNY...... LNWYQQKPGKAPKLLIY DAS....... NLETGVP.SRFSGSG..SGTDFTFTISSLQPEDIATYYC QQYDNLP....
  X59316  ,IGKV1-37          DIQLTQSPSSLSASVGDRVTITCRVS QGISSY...... LNWYRQKPGKVPKLLIY SAS....... NLQSGVP.SRFSGSG..SGTDFTLTISSLQPEDVATYYG QRTYNAP....
  X71893  ,IGKV1D-37         DIQLTQSPSSLSASVGDRVTITCRVS QGISSY...... LNWYRQKPGKVPKLLIY SAS....... NLQSGVP.SRFSGSG..SGTDFTLTISSLQPEDVATYYG QRTYNAP....
  X59315  ,IGKV1-39          DIQMTQSPSSLSASVGDRVTITCRAS QSISSY...... LNWYQQKPGKAPKLLIY AAS....... SLQSGVP.SRFSGSG..SGTDFTLTISSLQPEDFATYYC QQSYSTP....
  X59312  ,IGKV1D-39         DIQMTQSPSSLSASVGDRVTITCRAS QSISSY...... LNWYQQKPGKAPKLLIY AAS....... SLQSGVP.SRFSGSG..SGTDFTLTISSLQPEDFATYYC QQSYSTP....
  X72816  ,IGKV1D-42         DIQMIQSPSFLSASVGDRVSIICWAS EGISSN...... LAWYLQKPGKSPKLFLY DAK....... DLHPGVS.SRFSGRG..SGTDFTLTIISLKPEDFAAYYC KQDFSYP....
  X72817  ,IGKV1D-43         AIRMTQSPFSLSASVGDRVTITCWAS QGISSY...... LAWYQQKPAKAPKLFIY YAS....... SLQSGVP.SRFSGSG..SGTDYTLTISSLQPEDFATYYC QQYYSTP....
  X12684  ,IGKV2-24          DIVMTQTPLSSPVTLGQPASISCRSS QSLVHSDGNTY. LSWLQQRPGQPPRLLIY KIS....... NRFSGVP.DRFSGSG..AGTDFTLKISRVEAEDVGVYYC MQATQFP....
  X63401  ,IGKV2D-24         DIVMTQTPLSSPVTLGQPASISFRSS QSLVHSDGNTY. LSWLQQRPGQPPRLLIY KVS....... NRFSGVP.DRFSGSG..AGTDFTLKISRVEAEDVGVYYC TQATQFP....
  X63397  ,IGKV2-28          DIVMTQSPLSLPVTPGEPASISCRSS QSLLHSNGYNY. LDWYLQKPGQSPQLLIY LGS....... NRASGVP.DRFSGSG..SGTDFTLKISRVEAEDVGVYYC MQALQTP....
  X12691  ,IGKV2D-28         DIVMTQSPLSLPVTPGEPASISCRSS QSLLHSNGYNY. LDWYLQKPGQSPQLLIY LGS....... NRASGVP.DRFSGSG..SGTDFTLKISRVEAEDVGVYYC MQALQTP....
  U61645  ,IGKV2-29*02       DIVMTQTPLSLSVTPGQPASISCKSS QSLLHSDGKTY. LYWYLQKPGQSPQLLIY EVS....... SRFSGVP.DRFSGSG..SGTDFTLKISRVEAEDVGVYY* MQGIHLP....
  M31952  ,IGKV2D-29         DIVMTQTPLSLSVTPGQPASISCKSS QSLLHSDGKTY. LYWYLQKPGQPPQLLIY EVS....... NRFSGVP.DRFSGSG..SGTDFTLKISRVEAEDVGVYYC MQSIQLP....
  X63403  ,IGKV2-30          DVVMTQSPLSLPVTLGQPASISCRSS QSLVYSDGNTY. LNWFQQRPGQSPRRLIY KVS....... NRDSGVP.DRFSGSG..SGTDFTLKISRVEAEDVGVYYC MQGTHWP....
  X63402  ,IGKV2D-30         DVVMTQSPLSLPVTLGQPASISCRSS QSLVYSDGNTY. LNWFQQRPGQSPRRLIY KVS....... NWDSGVP.DRFSGSG..SGTDFTLKISRVEAEDVGVYYC MQGTHWP....
  X59314  ,IGKV2-40          DIVMTQTPLSLPVTPGEPASISCRSS QSLLDSDDGNTY LDWYLQKPGQSPQLLIY TLS....... YRASGVP.DRFSGSG..SGTDFTLKISRVEAEDVGVYYC MQRIEFP....
  X59311  ,IGKV2D-40         DIVMTQTPLSLPVTPGEPASISCRSS QSLLDSDDGNTY LDWYLQKPGQSPQLLIY TLS....... YRASGVP.DRFSGSG..SGTDFTLKISRVEAEDVGVYYC MQRIEFP....
  X02725  ,IGKV3-7           EIVMTQSPPTLSLSPGERVTLSCRAS QSVSSSY..... LTWYQQKPGQAPRLLIY GAS....... TRATSIP.ARFSGSG..SGTDFTLTISSLQPEDFAVYYC QQDHNLP....
  X72820  ,IGKV3D-7          EIVMTQSPATLSLSPGERATLSCRAS QSVSSSY..... LSWYQQKPGQAPRLLIY GAS....... TRATGIP.ARFSGSG..SGTDFTLTISSLQPEDFAVYYC QQDYNLP....
  X01668  ,IGKV3-11          EIVLTQSPATLSLSPGERATLSCRAS QSVSSY...... LAWYQQKPGQAPRLLIY DAS....... NRATGIP.ARFSGSG..SGTDFTLTISSLEPEDFAVYYC QQRSNWP....
  X17264  ,IGKV3D-11         EIVLTQSPATLSLSPGERATLSCRAS QGVSSY...... LAWYQQKPGQAPRLLIY DAS....... NRATGIP.ARFSGSG..PGTDFTLTISSLEPEDFAVYYC QQRSNWH....
  M23090  ,IGKV3-15          EIVMTQSPATLSVSPGERATLSCRAS QSVSSN...... LAWYQQKPGQAPRLLIY GAS....... TRATGIP.ARFSGSG..SGTEFTLTISSLQSEDFAVYYC QQYNNWP....
  X72815  ,IGKV3D-15         EIVMTQSPATLSVSPGERATLSCRAS QSVSSN...... LAWYQQKPGQAPRLLIY GAS....... TRATGIP.ARFSGSG..SGTEFTLTISSLQSEDFAVYYC QQYNNWP....
  X12686  ,IGKV3-20          EIVLTQSPGTLSLSPGERATLSCRAS QSVSSSY..... LAWYQQKPGQAPRLLIY GAS....... SRATGIP.DRFSGSG..SGTDFTLTISRLEPEDFAVYYC QQYGSSP....
  X12687  ,IGKV3D-20         EIVLTQSPATLSLSPGERATLSCGAS QSVSSSY..... LAWYQQKPGLAPRLLIY DAS....... SRATGIP.DRFSGSG..SGTDFTLTISRLEPEDFAVYYC QQYGSSP....
  Z00023  ,IGKV4-1           DIVMTQSPDSLAVSLGERATINCKSS QSVLYSSNNKNY LAWYQQKPGQPPKLLIY WAS....... TRESGVP.DRFSGSG..SGTDFTLTISSLQAEDVAVYYC QQYYSTP....
  X02485  ,IGKV5-2           ETTLTQSPAFMSATPGDKVNISCKAS QDIDDD...... MNWYQQKPGEAAIFIIQ EAT....... TLVPGIP.PRFSGSG..YGTDFTLTINNIESEDAAYYFC LQHDNFP....
  X63399  ,IGKV6-21          EIVLTQSPDFQSVTPKEKVTITCRAS QSIGSS...... LHWYQQKPDQSPKLLIK YAS....... QSFSGVP.SRFSGSG..SGTDFTLTINSLEAEDAATYYC HQSSSLP....
  X12683  ,IGKV6D-21         EIVLTQSPDFQSVTPKEKVTITCRAS QSIGSS...... LHWYQQKPDQSPKLLIK YAS....... QSFSGVP.SRFSGSG..SGTDFTLTINSLEAEDAATYYC HQSSSLP....
(1)M27751 ,IGKV6D-41         DVVMTQSPAFLSVTPGEKVTITCQAS EGIGNY...... LYWYQQKPDQAPKLLIK YAS....... QSISGVP.SRFSGSG..SGTDFTFTISSLEAEDAATYYC QQGNKHP....
  X12682  ,IGKV7-3           DIVLTQSPASLAVSPGQRATITCRAS ESVSFLGINL.. IHWYQQKPGQPPKLLIY QAS....... NKDTGVP.ARFSGSG..SGTDFTLTINPVEANDTANYYC LQSKNFP....
IMGT note:
(1)In EMBL, a new accession number M27751 was created, the original accession number X12688 becoming secondary accession number of M27751.

Created: 20/10/97
Last updated: Wednesday, 29-Jun-2011 17:06:06 CEST
Author: Valérie Barbié
Contact: Marie-Paule Lefranc

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