The hinge exon(s) are shown at the end of the protein display.The IGHC protein display numbering is according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.
Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CH-S and in pages edited before 14/10/2009).
The hinge exon(s) are shown at the end of the protein display.
_____________________________________________________________________________________________________________________________________________________________________________________________
IGHC
genes
_____________________________________________________________________________________________________________________________________________________________________________________________
A AB B BC C CD D DE E EF F FG G CH-S
--------------> ----------> ------> -------> -----------> -------> ---------->
1 10 15 16 20 23 30 36 39 41 45 77 84 85 89 96 97 104 110 118 121 130 140 150
7654321|........|....|123|...|...... ...|.....| |.....|1234567|......|12345677654321|..........|12|....... .....|....... ..|.........|.........|.........|
CH1
AF012110,IGHA c (V)PKTSPTVFPMSLCDSRT....GDSVALGCLAQ GFFP..EPVT LSWNYNGSEG....TVRSYPAMLSGN.......TYLQTSVLDLPANQC....PEAYKC GAKHY....DTSV DANVPCPV
AF035194,IGHE c (E)PLTAPSVFPLMSCCDSNS...GGKAFLGCLAT GYFP..ESVT INWNSEVLDE....IITNFPATYDPTS.....GRYTTTSQLTVSDL.....SDQEFTC SVDHLP..TSTKI KKTLSL
AF035195,IGHG c (A)RPTAPSVFPLVSSCGQET...QAQMALGCLVT SYFP..EPVT VTWNSGTTTS....GIQTYPSVLQPS......GLYTLTSQLTIPADSW...SSQSYTC NVAHPA..TSTKI DKKI
AF012109,IGHM c (A)LPSAPNLFSLSPCLNSGVE..DAPVAVGCLAK DFLP..DSIN FSWTYQNQSAVSHTDLKIFPSQMSGP.......TYTATSQVILPALDV..LQDSYLVC KASHL....NSNK QVQVSLP
CH2
AF012110,IGHA c SGVHVSLSGPSLESLLL..GIGANLTCTLS GIKNS.NGAT FTWVHDTAQASTLRPIQGAPEQDSNG.......KYRVSSVLEICTEEW..LRGDTFSC TVSHS...EIETT TKTIYKPK
AF035194,IGHE c (P)ECGPVTIIPPTVKLFHSSCDPRGDA.HSTIQLLCLVS GFSP..AKVH VTWLVDGQEAEN..LFPYTTRPKREGG.....QTFSLQSEVNITQGQW..MSSNTYTC HVKHN....GSIF EDSAQKCS
AF035195,IGHG c (V)DAGGPSVFVFPPNPQDVLKL.SRSPKVTCMVV DVSDA.SGVQ ITWFKGEEEV....SSPKLTQKKLNN......GTFQVVSNLPVVHQEW..LKGTSYTC KVNTSE..LPVVE RKTISHTK
AF012109,IGHM c (D)TTSSSPNVTVYIPPRDAFSNSGLRKSKLICQVT DFRP..REIK LTWLREGRPVSS..GFSTGQVLPDGS......GTYFLQSSLTINESDW..LSQSTFTC RVDHL....NAQF QKNVSSSCAI
CH3
AF012110,IGHA c (V)PQIPPQIYLLAPSADEQAL..NEMVSITCLVR GFSP..EDVF IRWLKGSEELPKK.DYITSNPYPEPKS....TSTYMVSSILQVQSTDW..KNENKYSC VVGHEA.LPLNFT QQTIDRLC...GKPTNVNVSVIMSDIYGTCY
AF035194,IGHE c (D)TDPRGISAYILPPTPQDLFV..KKVPTIGCLIV DLASA.ENVK VTWSRESGGPV...NPSSLVVKEQYN......GTFTVTSHLPVNTDDW..IEGDTYTC RLESPD..MPVPL IRTISKAP
AF035195,IGHG c (G)ERKKPDIYVFGPHPDELKQ..KDDVSITCLVT NFFP..EDVV IEWQKNNNPESED.KYYTTPTTREKS.......TYFFYSKLIVKKRDW..DNQNSYTC VVLHEA.FPNQIS QRTISASP...GK
AF012109,IGHM c (S)TDSPIEAFAIPPSFASIFV..TKSAKLTCVVT NLPTY.DSLS ISWTRKDGQLL...KTKVKVFSSHPN......GTFTAEGEATVCAEEW..NSGEAFKC IVTHSD..HPVPL KKEIFKPQ
CH4
AF035194,IGHE c (G)KRLAPEVYMLPPSPEET....GTTRTVTCLIR GFYP..SEIS VQWLFNNEEDHTG.HHTTTRPQKDHGT....DPSFFLYSRMLVNKSIW..EKGNLVTC RVVHEALPGSRTL EKSLHYSA...GN
AF012109,IGHM c (E)VDLHAPSVYLLHPNPEELSL..RESVTVTCMMK DFSP..PDVF VQWMHKGQPIPSE.KYVTSSPHQDPQK....GGRYFSYSILTVSEAQW..NSGDPFTC VVAHEA.LPLSST ERTVDKST...GKPTLVNVSLVLADTTNTCY
Hinge
AF012110,IGHA c (V)PPRPCDCP
AF035195,IGHG c (E)ATTTTCPCCKCNT
c: cDNA sequence
Created: 01/07/2002
Last updated: Thursday, 18-Jan-2007 09:13:39 CET
Author: Christèle Martinez-Jean
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.
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