The hinge exon(s) are shown at the end of the protein display.The IGHC protein display numbering is according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.
Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CH-S and in pages edited before 14/10/2009).
The hinge exon(s) are shown at the end of the protein display.
_____________________________________________________________________________________________________________________________________________________________________________________________
IGHC
genes
_____________________________________________________________________________________________________________________________________________________________________________________________
A AB B BC C CD D DE E EF F FG G CH-S
--------------> ----------> ------> -------> -----------> -------> ---------->
1 10 15 16 20 23 30 36 39 41 45 77 84 85 89 96 97 104 110 118 121 130 140 150
7654321|........|....|123|...|...... ...|.....| |.....|1234567|......|12345677654321|..........|12|....... .....|....... ..|.........|.........|.........|
CH1
U12594 ,IGHA c (V)SETSPKIFPLTLGSSEP....AGYVVIACLVR DFFPS.EPLT VTWSPSREGV....IVRNFPPAQAGG.......LYTMSSQLTLPVEQC..PADQILKC QVQHL...SKSSQ SVNVPCKVL
U96100 ,IGHE c (A)SIQGPLVYPLTSCCKTG....ATSKTLGCLVR GYFP..EPVT VTWDTGSLNS....STLTFPAVQDSSS.....SLYTVTSQVTILGEW....TNQKLTC SVAHA....ANTT IRTIT
U03778 ,IGHG1 c (A)PKTAPSVYPLAPCGRDVS...GPNVALGCLAS SYFP..EPVT VTWNSGALTS....GVHTFPSVLQPS......GLYSLSSMVTVPASSL...SSKSYTC NVNHPA..TTTKV DKRV
U03779 ,IGHG2A c (A)PKTAPSVYPLAPCSRDTS...GPNVALGCLAS SYFP..EPVT VTWNSGALSS....GVHTFPSVLQPS......GLYSLSSMVTVPASSL...SSKSYTC NVNHPA..TTTKV DKRV
U03780 ,IGHG2B c (A)PKTAPLVYPLAPCGRDTS...GPNVALGCLAS SYFP..EPVT VTWNSGALTS....GVHTFPSVLQPS......GLYSLSSMVTVPASSL...SSKSYTC NVNHPA..TTTKV DKRV
U03781 ,IGHG3 c (A)PKTAPSVYPLAPCGRDTS...GPNVALGCLAS SYFP..EPVT MTWNSGALTS....GVHTFPSVLQPS......GLYSLSSMVTVPASSL...SSKSYTC NVNHPA..TTTKV DKRV
U03782 ,IGHG4 c TFPSVLQPS......GLYSLSSMVTVPASSL...SSKSYTC NVNHPA..TTTKV DKRV
M81771 ,IGHG5 c (1)(A)PKTAPSVYPLAPCGRDTS...GPNVALGCLAS SYFP..EPVT VTWNSGALTS....GVHTFPSVLQPA......GLYSLSSMVTVPASSL...SSKSYTC NVNHPA..TTTKV DKRV
U50149 ,IGHM (E)SQSAPNLYPLVSCVSPPSD..ESLVALGCLAR DFLP..SSVT FSWNYKNSSKVSSQNIQDFPSVLRGG.......KYLASSRVLLPSVSIPQDPEAFLVC EVQHP....SGTK SVSISGP
CH2
U12594 ,IGHA c CCKPSLSLQPPALADLLL..GSNASLTCTLS GLKKS.EGVS FTWQPSGGKD....AVQASPTRDSCG.......CYSVSSILPGCADPW..NKGETFSC TAAHSE..LKSAL TATITKPK
U96100 ,IGHE c (G)CTKNFTDPSLRFFYSSCDPHGDA.QATIHLRCYIS GYTP..GKMK VTWLVDGQEDRN..LFSYTAPDQLEG......KLASTYSEVNITQGQW..ASQITYTC QVSYY....GFIY EKHALRCTA
U03778 ,IGHG1 c (V)AGPSVFIFPPKPKDTLMI.SQTPEVTCVVV DVSKEHAEVQ FSWYVDGVEVH...TAETRPKEEQFN......STYRVVSVLPIQHQDW..LKGKEFKC KVNNVD..LPAPI TRTISKAI
U03779 ,IGHG2A c (S)PGPSVFIFPPKPKDTLMI.SRTPQVTCVVV DVSQENPEVQ FSWYVDGVEVH...TAQTRPKEEQFN......STYRVVSVLPIQHQDW..LNGKEFKC KVNNKD..LPAPI TRIISKAK
U03780 ,IGHG2B c (S)PGPSVFIFPPKPKDTLMI.SRTPQVTCVVV DVSQENPEVQ FSWYVDGVEVH...TAQTRPKEEQFN......STYRVVSVLPIQHQDW..LNGKEFKC KVNNKD..LPAPI TRIISKAK
U03781 ,IGHG3 c (V)AGPSVFIFPPKPKDTLMI.SQTPEVTCVVV DVSKEHAEVQ FSWYVDGVEVH...TAETRPKEEQFN......STYRVVSVLPIQHQDW..LKGKEFKC KVNNVD..LPAPI TRTISKAI
U03782 ,IGHG4 c (G)PGPSAFIFPPKPKDTLMI.SRTPKVTCVVV DVSQENPEVQ FSWYVDGVEVH...TAQTRPKEEQFN......STYRVVSVLPIQHQDW..LNGKEFKC KVNNKD..LPAPI TRIISKAK
M81771 ,IGHG5 c (G)PGPSAFIFPPKPKDTFMI.SRTPKVTCVVV DVSQENPEVQ FSWYVDGVEVH...TAQTRPKEEQFN......STYRVVSVLPIQHQDW..LNGKEFKC KVNNKD..LPAPI TRIISKAK
U50149 ,IGHM (V)VEEQPPVLNIFVPTRESFSSTPQRTSKLICQAS DFSP..KQIS MAWFRDGKRVVS..GVSTGPVETLQSS....PVTYRLHSMLTVTESEW..LSQSVFTC QVEHK....GLNY EKNASSLCTS
CH3
U12594 ,IGHA c (V)NTFRPQVHLLPPPSEELAL..NELVTLTCLVR GFSP..KDVL VRWLQGGQELPRD.KYLVWESLPEPGQA...IPTYAVTSVLRVDAEDW..KQGDTFSC MVGHEA.LPLAFT QKTIDRLA...GKPTHVNVSVVMAEAEGICY
U96100 ,IGHE c (E)SEPRGVSAYLSPPTPLDLYV..HKSPKLTCLVV DLASS.ENVN LLWSRENKGGVILPPPGPPVIKPQFN......GTFSATSTLPVNVSDW..IEGETYYC NVTHPD..LPKPI LRSISKGP
U03778 ,IGHG1 c (2)(G)QSREPQVYTLPPPAEELS...RSKVTLTCLVI GFYP..PDIH VEWKSNGQPEPEN.TYRTTPPQQDVD......GTFFLYSKLAVDKARW..DHGDKFEC AVMHEA.LHNHYT QKSISKTQ...GK
U03779 ,IGHG2A c (2)(G)QTREPQVYTLPPHAEELS...RSKVSITCLVI GFYP..PDID VEWQRNGQPEPEG.NYRTTPPQQDVD......GTYFLYSKFSVDKASW..QGGGIFQC AVMHEA.LHNHYT QKSISKTP...GK
U03780 ,IGHG2B c (2)(G)QTREPQVYTLPPHAEELS...RSKVSITCLVI GFYP..PDID VEWQRNGQPEPEG.NYRTTPPQQDVD......GTYFLYSKFSVDKASW..QGGGIFQC AVMHEA.LHNHYT QKSISKTP...GK
U03781 ,IGHG3 c (2)(G)QSREPQVYTLPPPAEELS...RSKVTVTCLVI GFYP..PDIH VEWKSNGQPEPEG.NYRTTPPQQDVD......GTFFLYSKLAVDKARW..DHGETFEC AVMHEA.LHNHYT QKSISKTQ...GK
U03782 ,IGHG4 c (2)(G)QTREPQVYTLPPPTEELS...RSKVTLTCLVT GFYP..PDID VEWQRNGQPEPEG.NYRTTPPQQDVD......GTYFLYSKLAVDKASW..QRGDTFQC AVMHEA.LHNHYT QKSIFKTP...GK
M81771 ,IGHG5 c (2)(G)QTREPQVYTLPPPTEELS...RSKLSVTCLIT GFYP..PDID VEWQRNGQPEPEG.NYRTTPPQQDVD......GTYFLYSKLAVDKASW..QRGDPFQC AVMHEA.LHNHYT QKSIFKTP...GN
U50149 ,IGHM (N)PNSPITVFAIAPSFAGIFL..TKSAKLSCLVT GLVTR.ESLN ISWTRQDGEVL...KTSIVFSEIYAN......GTFGARGEASVCVEDW..ESGDRFTC TVTHTD..LPSPL KQSVSKPR
CH4
U96100 ,IGHE c (G)KRVTPEVYVLWSPDELK....KGRLTLTCLIQ NFFP..ADIS VLWLRNDAPVQAD.RHSTTRPHKASDS....LPSFFVYSRLVVSQSDW...EQNKFAC EVIHEALPGSRTL QKEVSKNP...GK
U50149 ,IGHM (G)IARHMPSVYVLPPAPEELSL..QEWASVTCLVK GFSP..ADVF VQWLQKGEPVSAD.KYVTSAPVPEPEPK..APASYFVQSVLTVSAKDW..SDGETYTC VVGHEA.LPHTVT ERTVDKST...GKPTLYNVSLVLSDTASTCY
M1 M2
U50148 ,IGHM (E)GEVSAEEEGFENLNTMASTFIVLFLLSLFYSTTVTLFK VK
CONNECTING-REGION | TRANSMEMBRANE-REGION | CYTOPLASMIC-REGION
Hinge
U03778 ,IGHG1 c (G)IHQPQTCPICPGCE
U03779 ,IGHG2A c (G)TKTKPPCPICPACE
U03780 ,IGHG2B c (G)TKTKPPCPICPACE
U03781 ,IGHG3 c (G)TKTKPPCPICPGCE
U03782 ,IGHG4 c (G)TKTKPPCPICPACE
M81771 ,IGHG5 c (G)RPCPICPACE
c: cDNA sequence
IMGT notes:
Created: 01/07/2002
Last updated: Monday, 11-Jul-2011 12:56:59 CEST
Author: Christèle Martinez-Jean
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
|
IMGT founder and director: Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr
Bioinformatics manager: Véronique Giudicelli Veronique.Giudicelli@igh.cnrs.fr Computer manager: Patrice Duroux Patrice.Duroux@igh.cnrs.fr Webmaster: Chantal Ginestoux Chantal.Ginestoux@igh.cnrs.fr |
|
|
|
|
Citing IMGT © Copyright 1995-2012 IMGT®, the international ImMunoGeneTics information system® |
|||
