The hinge exon(s) are shown at the end of the protein display.The IGHC protein display numbering is according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.
Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.
N (Asn, asparagine) of potential N-glycosylation sites (NXS/T, where X is different from P), (N-linked glycosylation) is shown is green (site is underlined in CH-S and in pages edited before 14/10/2009).
The hinge exon(s) are shown at the end of the protein display.
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IGHC
genes
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A AB B BC C CD D DE E EF F FG G CH-S
--------------> ----------> ------> -------> -----------> -------> ---------->
1 10 15 16 20 23 30 36 39 41 45 77 84 85 89 96 97 104 110 118 121 130 140 150
7654321|........|....|123|...|...... ...|.....| |.....|1234567|......|12345677654321|..........|12|....... .....|....... ..|.........|.........|.........|
CH1
AF027382,IGHA c (N)PKVSPRLFPLSSFYSET....SDSIVLGCLAY RFFP..EPVD MTWDYSGSGG....TVRNYPAMLIGD.......AYTQASVLDLPADQC..SNTQAYEC QVQHY....DTSA NLTVPCKA
AF157617,IGHE c .TSTAPSVFPLVSGCDPNF...ESLSFLGCLVS GYFP..EPVT VSWNPEVLDG....IITTFPAAYDSTS.....GLYTTTSQLAISDG.....SSQEFTC SVDHLP..TSTKI EKHVST
AF157619,IGHG c (A)SPTAPSVFALAPNCGQGT...SSQVAMACLVS NYFP..EPVT VTWNSGAISS....GIQTYPSILQSS......GLYTSSSQLTVPADDW...LTKSYIC NVAHKP..TSTKT DKKI
AF157618,IGHM c (A)TQAAPNLFSLSSCWSSQMK..DAPVAVGCLAK DFLP..DSID FSWSYQNRSAVSNTDLKIFPSLMRGS.......TYTATSQVILHANDAFQGEDSYLVC KTRHP....RGDK EVQVPLR
CH2
AF027382,IGHA c CSKTAYVSLSPPSLESLLL..GTGANLTCTLS GLKSS.TGVE FTWARTPAPASTLSPIQGTAEQDSSG.......KYSVSSVLEICTEEW..IRGDVFSC TVSHP...EIETT TKTIYKPK
AF157617,IGHE c (G)PTKNGPVIPPTVKLFHSSCDPRGDA.HSTIQLLCLVS GFSP..ARVK VTWLVDGQEAEN..LFPYTTRPKREGS.....QTFSLQSELNITQGQW..TSLKTYTC QVTHN....GSIY RDNAQKCS
AF157619,IGHG c (A)CDVVGPSVFLFPPNPKDTLTL.SRVPKITCVVV DVSDA.SEVQ ISWYKGENAI....DSPKPTERKLNN......GTFQVVSTLSVAHQEW..LNGVAYTC KVDNKE..LPYPE RKTIFHTK
AF157618,IGHM c (D)HIINSPNVTVYIPPSDAFSSSSPRTSKLICQAT NFRP..NKIK LTWLQEGRPVLS..GISTGQVLPDGS......GTYLLQSSLTINENDW..LSQNTFTC RVEHE....GAQF QKNVSSTCFS
CH3
AF027382,IGHA c (V)TQIPPQVYVLPPSADELAL..NELVTIVCLVR GHSP..QEAL VQWMNGSEKLPRE.DYITSDPHPEPRG....TNTFIISSILQVSASEW..KAENKYSC VVGHEA.LPLNFT QQTIDRFS...GKPTNVNVSVIMSDVSGTCY
AF157617,IGHE c (D)TDPRGISAYLSPPSAFDLYV..SKAPVLTCLVV DLASA.ENVK VSWTRESGGTV...SPSSPVVKEQYN......GTVTITSTLPVQTDDW..VEGETYTC HLEHPD..LPFPL IRTISKAP
AF157619,IGHG c (G)NRKKPDVYVFAPHPDELKQ..KDTVSITCLVK SFFP..KEVV VEWQCNNNPESED.NYSTTEAMREND.......TFFVYSKLNVKKTKW..QENNHYTC TVLHEA.LPNQTS QRTISASSP..GK
AF157618,IGHM c (E)GPELPSEAFAIAPTFASIFV..TKSAKLTCLVT NLPTA.QNPN ITWTRANGQPL...ETTIKLSLSHLN......GTFSAEGEATVCAEDW..NAGEIFKC TVIHPN..HPVPL KKEIFKQQ
CH4
AF147617,IGHE c (G)KRIAPEVYMFPPSEEEK....GNTVSLTCLIR AFYP..ADIT VQWLRDNKDDHTG.HHTTTRPHKDHGP....DPSFFLYSRMVVNRSHW..QEGHTFTC RVVHEALPGTRTL DKSLHYST...GN
AF147618,IGHM c (G)AVMHAPAVYLLPPAPEELTL..REAATLTCLMR DFSP..ADVF VQWRHKGQPIPSE.KYVTSSPQQEPQK....AGLYFSHSTLTVSEENW..NAGDSYTC VVVHEA.LPLSVT EKTVDKST...GKPTLVNVSLVLSDASNTCY
Hinge
AF027382,IGHA c (A)VQDPSQC
AF157619,IGHG c (E)KISECTCCKCQ
c: cDNA sequence
Created: 01/07/2002
Last updated: Monday, 11-Jul-2011 12:57:02 CEST
Author: Christèle Martinez-Jean
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
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IMGT founder and director: Marie-Paule Lefranc
Marie-Paule.Lefranc@igh.cnrs.fr
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