Only the *01 allele of each functional, ORF and in-frame pseudogene V-REGION is shown.
Letters in red correspond to amino acids which are polymorphic in the other alleles.
For C-REGIONs, letters in bold correspond to additional positions in the IMGT unique numbering.
For C-REGIONs, letters between parentheses correspond to amino acids resulting from the splicing.
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IGHV FR1-IMGT CDR1-IMGT FR2-IMGT CDR2-IMGT FR3-IMGT CDR3-IMGT
gene (1-26) (27-38) (39-55) (56-65) (66-104) (105-115)
_________________ __________________________ ____________ _________________ __________ _______________________________________ ____________
1 10 20 30 40 50 60 70 80 90 100 110
.........|.........|...... ...|........ .|.........|..... ....|..... ....|.........|.........|.........|.... .....|......
Z49188 ,IGHV1S1 QVRLQESGP.SLVKPSQTLSLTCTVS GFSLTSNA.... VGWVRQAPGKVPEWLGG ISSGGST... YYNPALK.SRLSITRDTSKSQVSLSLSSVTTEDTAVYYC AR.........
Z49180 ,IGHV1S2 QVRLQESGP.SLVKPSQTLSLTCTVS GFSLTSYG.... VGWVRQAPGKALEWLGG IYNDGDT... GYNPALK.SRLSITRDTSKSQVSLSLSSVTTEDTAVYYC AR.........
Z49182 ,IGHV1S3 QVQLQESGP.SLVKPSQTLSLTCTVS GFSLTSNA.... VGWVRQAPGKALEWVGD IYSGGSI... HYNPALK.SRLSITRDTSKSQVSLSLSSVTTEDTAVYYC AR.........
Z49186 ,IGHV1S4 QVQLQESGP.SLVKPSQTLSLTCTVS GFSLTSYG.... VGWVRQAPGKALEWVGN IYSGGST... YYNPALK.SRLSITRDTSKSQVSLSLSSVTTEDTAVYYC AR.........
Z49187 ,IGHV1S5 QVRLQESGP.SLVKPSQTLSLTCTVS GFSLTSNA.... VGWVRQAPGKAPEWVGG IDNDGDT... GYNPALK.SRLSITRDTSKSQVSLSLSSVTTEDTAVYYC AR.........
Z49181 ,IGHV1S6 QVQLQESGP.SLVKPSQTLSLTCTVS GFSLTSYR.... AGWVRQAPGKAPEWVGG TSSGGST... GYNPALK.SQLSITRDNSKSQASLSLSSVTTEDTAVYYC AR.........
#c AJ505121,IGHV1S7 QVQLQESGP.SLVKPSQTLSLTCTVS GFSLTSYG.... VDWVRQAPGKALEWVGV IYSGGST... YYHPALK.SRLSITRDTSKSQVSLSLSSVTTEDTAVYYC AA.........
Z49183 ,IGHV1S8 QVRLQESGP.SLVKPSQTLSLTCTVS GFSLTSKA.... VGCVRQPPGKAPEWVGG IDNDGDT... GYNPALK.SRLSITRDTSKSQVSLSLSSVTTEDTAVYYC AR.........
Z49184 ,IGHV1S9 KVRLQESGP.SLVKPSQTLSLTCTVS GFSLTSKA.... VGCVRQPPGKAPEWVGG IDNDGDT... GYNPALK.SRLSITRDTSKSQVSLSLSSVTTEDTAVYYC AR.........
Z49185 ,IGHV1S10 QVRLQESGP.SLVKPSQTLSLTCTVS GFSLTSKA.... VGCVRQPPGKAPEWVGG IDNDGDT... GYNPALK.SRLSITRDTSKSQVSLSLSSVTTEDTAVYYC AR.........
IMGT note:
| (1) | IGHV1S8 | No INIT-CODON (CAA instead of ATG) and a DELETION of 11 nucleotides at position 9 in L-PART1, and no CONSERVED_TRP. | |
| IGHV1S9 | DELETION of 11 nucleotides at position 9 in L-PART1, and no CONSERVED_TRP. | ||
| IGHV1S10 | DELETION of 11 nucleotides at position 9 in L-PART1, and no CONSERVED_TRP. |
#c: rearranged cDNA.
Created: 18/11/2002
Author: Delphine Guiraudou
Contact: Marie-Paule Lefranc
Software material and data coming from IMGT server may be used for academic research only, provided that it is referred to IMGT®, and cited as "IMGT®, the international ImMunoGeneTics information system® http://www.imgt.org (founder and director: Marie-Paule Lefranc, Montpellier, France)." References to cite: Lefranc, M.-P. et al., Nucleic Acids Research, 27, 209-212 (1999) Cover of NAR; Ruiz, M. et al., Nucleic Acids Research, 28, 219-221 (2000); Lefranc, M.-P., Nucleic Acids Research, 29, 207-209 (2001); Lefranc, M.-P., Nucleic Acids Res., 31, 307-310 (2003); Lefranc, M.-P. et al., In Silico Biol., 5, 0006 (2004) [Epub], 5, 45-60 (2005); Lefranc, M.-P. et al., Nucleic Acids Res., 33, D593-D597 (2005) Full text; Lefranc, M.-P. et al., Nucleic Acids Research 2009 37: D1006-D1012; doi:10.1093/nar/gkn838 Full text.
For any other use please contact Marie-Paule Lefranc Marie-Paule.Lefranc@igh.cnrs.fr.
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