|Haplotypes [1-3]||H2 complex loci and genes (1)||Strains (3)|
|bc (9)||b||b||b||b||-||b||-||b||f||129/J, 129/Ola, A.BY(8),
C3H.SW (4), C57L/J(8), LP/J
|q2||q2||q2||q2||q2||-||q2||q2||a||a|| B10.G, BUB/BnJ,
|k/d2 ?||a||A/J (5), A/He,
"Many haplotypes of the mouse major histocompatibility complex (Mhc), H2, are known by the names given to them by George Snell, starting in 1948... d for dilute of DBA/2 (Gorer at al. 1948), b for Black of C57BL (6 and10) and p for pink-eyed of P (Snell and Higgins 1951), k for Kinky of K8 (Snell 1951), q (of DBA/1) and r of RIII (Snell et al. 1953a), and s of A.SW (Snell 1958)... f for Fused (of) A.CA (Snell 1958)." 
|(1)||Genes for the K, A, E and D loci are shown in the header lower row. Genes are not shown for the other loci. The absence of expression of H2-EA is indicated by a dash.|
|(2)||Phenotypes of Qa1 and Tla, shown in green, are from .|
|(3)||Prototype strains are underlined. Strains quoted in IMGT Repertoire are in bold. Click here for a complete list of the mouse strains in IMGT Repertoire.|
|(4)||Haplotype "b" in  instead of "bc".|
|(5)||Haplotype "a (k/d)" in  instead of "a".|
[mgi-list] E-mails following a demand to IMGT,
on the availability of a B6.H2 strain.
"Two strains which carry the H2k haplotype on a C57BL/6 background are available at the Jackson
"In addition, B10.BR has an H2^k haplotype imbedded on background nearly identical to B6."
"As John implied, C57BL/6 and C57BL/10 do share a common ancestry. Despite their common origin, however,
the two strains are known to differ at the EA9, Igh2 and Lv loci, as well as at the H9
minor histocompatibility locus. Molecular studies also have identified numerous PCR and
RFLP polymorphisms between the two strains, and I would not be surprised if the strains
differed at additional loci (see McClive P. J. et al. (1994) C57BL/6 and C57BL/10 inbred
mouse strains differ at multiple loci on chromosome 4. Immunogenet. 39, 286-288. and
Slingsby et al. (1996) New microsatellite polymorphisms identified between C57BL-6, C57BL- 10,
and C57BL-KsJ inbred mouse strains. Immunogenet. 43, 72-75.).
Although both C57BL/6 and C57BL/10 are H2, since they do differ at least one minor
histocompatibility locus, I would not be surprised if tissue grafts from one strain to
the other were rejected in a long-term study. Unfortunately, I do not have a reference
where graft rejection between the two strains has been reported (although I admit that
I have not performed an exhaustive search!)."
(Jim Yeadon, e-mail 18/03/2003)
"Many strains labeled "H2-b" differ from C57BL/6 in the
H2-T region, and actually have the haplotype "bc". Thus, 129 (H2^bc) and
B6(H2^b) are NOT compatible strains."
(John Rodgers, Baylor College of Medicine Houston, e-mail to mgi list 05/07/2005)
"A.BY is H2^bc. A.BY was developed by Snell using a mouse from France (NOT from
B6) and he later found that B6 and A.BY are histoincompatible; this was
mapped to the TL region. C57L/J (leaden) is also H2^bc according to .
The H2^b and H2^bc haplotypes are essentially identical in the "classical" H2 region
and in the Q region - minor difference in the reported sequences of these strains
might be sequencing error. This include H2K, H2D, Q1-Q10. Note also that there is
NO "L" gene in either haplotype. There is a single D gene. The big
differences occur in the T region, which includes TL and Qa1, and "H2-B1"
aka H2-blastocyst which has a significant early termination codon in B6 but
is active in 129. H2^b and H2^bc strains reject tissues and suffer GVHD on
the basis of T-region differences, as first discovered decades ago by
"H2^b" used in the literature may cover different haplotypes (H2^b and H2^bc
in this table) with respect to the MHC regions.
"Commonly-used strains break down into those that are C57BL/6-like, and
those that are 129-like. The haplotype of 129 is actually called "H2^bc",
which does not indicate heterozygosity but just "bc". H2^b and H2^bc are
"identical" (with room for sequencing errors and mutations creeping in
during the last century) in the "classic" H2 region running from the K locus
through the Qa2 region, probably extending out to Q10 (I'm not too sure
about the extent of their similarity). Thereafter the two haplotypes differ
greatly, so that their "T" regions are very different. This region includes
Qa1 and TL, both of which can affect transplantion, GVHD etc.
(John Rodgers, Baylor College of Medicine Houston, e-mail to mgi-list, 13/08/2005)
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