Here you are: IMGT Web resources > IMGT Repertoire > 2. Proteins and alleles
Citing IMGT reference directory:
Lefranc, M.-P. and Lefranc, G. The Immunoglobulin FactsBook Academic Press, London, UK (458 pages), (2001)
Lefranc, M.-P. and Lefranc, G. The T cell receptor FactsBook Academic Press, London, UK (398 pages), (2001)
Introduction
IMGT/V-QUEST reference directory sets
- Overview
- IMGT/V-QUEST reference directory sets per taxon
- IMGT/V-QUEST reference directory sets for several taxons
IMGT/GENE-DB reference directory sets
References


Introduction

The IMGT reference directory in
FASTA format is constituted by sets of immunoglobulin (IG) or T cell receptor (TR) sequences which are isolated from the IMGT reference sequences.

IMGT/V-QUEST reference directory sets

Overview

In the V-REGION sets, IMGT gaps have been introduced according to the IMGT unique numbering [1] [2] [3] [4].

 F+ORF+in-frame P
IMGT GroupsNucleotides
IGHV Human, Mouse, Rat, Rabbit, Rhesus monkey, Sheep, Pig, Teleostei, Atlantic cod, Channel catfish, Rainbow trout, Zebrafish, Chondrichthyes, Platypus, Alpaca, Crab-eating macaque, Bovine, Dog, Chicken
IGHD Human, Mouse, Rat, Rabbit, Rhesus monkey, Pig, Rainbow trout, Zebrafish, Chondrichthyes, Platypus, Alpaca, Crab-eating macaque, Bovine, Dog, Sheep, Chicken
IGHJ Human, Mouse, Rat, Rabbit, Sheep, Rhesus monkey, Pig, Rainbow trout, Zebrafish, Chondrichthyes, Platypus, Alpaca, Crab-eating macaque, Bovine, Dog, Chicken
IGKV Human, Mouse, Rat, Rabbit, Pig, Rhesus monkey, Dog, Goat, Sheep
IGKJ Human, Mouse, Rat, Rabbit, Pig, Rhesus monkey, Dog, Goat, Sheep
IGLV Human, Mouse, Rat, Rabbit, Pig, Rhesus monkey, Dog
IGLJ Human, Mouse, Rat, Rabbit, Pig, Rhesus monkey, Dog
IGIV Teleostei, Zebrafish
IGIJ Zebrafish
 F+ORF+in-frame P
IMGT GroupsNucleotides
TRAV Human, Mouse, Ma's night monkey, Sheep, Zebrafish , Dog, Rhesus monkey
TRAJ Human, Mouse, Ma's night monkey, Sheep, Zebrafish, Dog, Rhesus monkey
TRBV Human, Mouse, Ma's night monkey, Rhesus Monkey , Rainbow trout, Dog
TRBD Human, Mouse, Rhesus Monkey , Rainbow trout, Dog
TRBJ Human, Mouse, Ma's night monkey , Rhesus Monkey , Rainbow trout, Dog
TRGV Human, Mouse, Ma's night monkey, Bovine, Camel
TRGJ Human, Mouse, Ma's night monkey, Bovine, Camel
TRDV Human, Mouse, Ma's night monkey, Bovine, Camel, Sheep, Zebrafish, Dog, Rhesus monkey
TRDD Human, Mouse, Ma's night monkey, Bovine, Sheep, Zebrafish, Dog, Rhesus monkey
TRDJ Human, Mouse, Ma's night monkey, Bovine, Sheep, Zebrafish, Dog, Rhesus monkey

IMGT/V-QUEST reference directory sets per taxon

    F+ORF+in-frame P
    IG groups TR groups
MAMMALIA EUTHERIA (placentals) Homo sapiens
(human)
IGHV, IGHD, IGHJ
IGKV, IGKJ
IGLV, IGLJ
TRAV, TRAJ
TRBV, TRBD, TRBJ
TRDV, TRDD, TRDJ
TRGV, TRGJ
Mus musculus, Mus spretus
(mouse) (1)
IGHV, IGHD, IGHJ
IGKV (2), IGKJ
IGLV, IGLJ
TRAV, TRAJ
TRBV, TRBD, TRBJ
TRDV, TRDD, TRDJ
TRGV, TRGJ
Aotus nancymaae
(Ma's night monkey)
  TRAV , TRAJ
TRBV , TRBJ
TRGV , TRGJ
TRDV , TRDJ
Bos taurus
(bovine)
IGHV, IGHD, IGHJ, TRDV, TRDD, TRDJ
TRGV, TRGJ
Camelius dromedarius
(Arabian camel)
TRDV
TRGV, TRGJ
Canis lupus familiaris
(dog)
IGHV, IGHD, IGHJ
IGKV, IGKJ
TRAV, TRAJ
TRBV, TRBD, TRBJ
TRDV, TRDD, TRDJ
TRGV, TRGJ
Capra hircus
(goat)
IGKV, IGKJ,  
Macaca fascicularis
(crab-eating macaque)
IGHV, IGHD, IGHJ  
Macaca mulatta
(Rhesus monkey)
IGHV, IGHD, IGHJ
IGKV, IGKJ
IGLV, IGLJ
TRAV, TRAJ, TRBV, TRBD, TRBJ, TRDV, TRDD, TRDJ
Oryctolagus cuniculus
(rabbit)
IGHV, IGHD, IGHJ
IGKV, IGKJ
IGLV, IGLJ
 
Ovis aries
(sheep)
IGHV, IGHD, IGHJ, IGKV, IGKJ TRAV, TRAJ
TRDV, TRDD, TRDJ
Rattus norvegicus
(Norway rat) (3)
IGHV, IGHD, IGHJ
IGKV, IGKJ
IGLV, IGLJ
 
Sus scrofa
(pig)
IGHV, IGHD, IGHJ
IGKV, IGKJ
IGLV, IGLJ
 
Vicugna pacos
(alpaca)
IGHV, IGHD, IGHJ  
MAMMALIA PROTHERIA (monotremes) Ornithorhynchus anatinus
(platypus)
IGHV, IGHD, IGHJ  
AVES (birds) Gallus gallus
(chicken)
IGHV, IGHD, IGHJ  
TELEOSTEI (4) Danio rerio
(zebrafish)
IGHV, IGHD, IGHJ
IGIV, IGIJ
TRAV TRAJ
TRDV, TRDD, TRDJ
Gadus morhua
(Atlantic cod)
IGHV  
Ictalurus punctatus
(Channel catfish)
IGHV  
Oncorhynchus mykiss
(Rainbow trout)
IGHV, IGHD, IGHJ, TRBV, TRBD, TRBJ
CHONDRICHTHYES (5)      

IMGT/V-QUEST reference directory sets for several taxons

Teleostei: IGHV , IGIV

The Teleostei IGHV and IGIV sets contain pooled sequences from several species (detailed in the table below).
These sets are not included in IMGT/HighV-QUEST.
The Teleostei pooled IGHD and IGHJ sets are not currently available.
TeleosteiIMGT Group
Number of sequences
Latin name English name short name IGHV IGIV
Anarhichas minor Spotted wolffish Anamin102
Carassius auratus Goldfish Caraur4-
Chaenocephalus aceratus Blackfin icefishChaace2-
Cyprinus carpio Common carp Cypcar-29
Danio rerio Zebrafish Danrer4111
Dicentrarchus labrax European sea bass Diclab-18
Elops saurus Ladyfish Elosau2-
Gadus morhua Atlantic cod Gadmor7634
Ictalurus punctatus Channel catfish Ictpun4010
Notothenia corricepsYellowbelly rockcodNotcor4-
Oncorhynchus mykiss Rainbow trout Oncmyk5817
Paralichthys olivaceus Bastard halibut Paroli3-
Salvelinus alpinus Charr Salalp13-
Salmo salar Atlantic salmon Salsal4416
Scophthalmus maximus Turbot Scomax1-
Seriola quinqueradiata Five-ray yellowtail Serqui-40
Siniperca chuatsi Chinese perch Sinchu-5
Takifugu rubripes TorafuguTakrub9-
Trematomus bernachii Emerald rockcod Treber38-

Chondrichthyes: IGHV , IGHD , IGHJ

The Chondrichthyes IGHV , IGHD and IGHJ sets contain pooled sequences from several species sets
(detailed in the table below).
These sets are not included in IMGT/HighV-QUEST.
ChondrichtyesIMGT Group
Number of sequences
Latin name English name short name IGHV IGHD IGHJ
Carcharhinus leucas Bull shark Carleu444
Carcharhinus plumbeus Sandbar shark Carplu888
Ginglyomostoma cirratum Nurse shark Gincir535952
Heterodontus francisci Horned shark Hetfra172418
Hydrolagus colliei Spotted ratfish Hydcol121715
Leucoraja erinacea Little skate Leueri575
Orectolobus maculatus Spotted wobbegong sharkOremac888
Raja eglanteria Clearnose skate Rajegl151

Notes

(1) Mouse IG set contains sequences from Mus musculus plus 9 from Mus spretus (IGKV: Musspr_IGKV10-94*01, Musspr_IGKV10-96*01; IGLV: Musspr_IGLV2*01, Musspr_IGLV3*01, Musspr_IGLV4*01, Musspr_IGLV4*02, Musspr_IGLV8*01; IGLJ Musspr_IGLJ4*01, Musspr_IGLJ5*01,).
(2) The IGKV4-52*01 (AJ239198) and the IGKV4-54*01 (AJ231223) V-REGION nucleotide sequences are 100% identical. These two genes differ by one nucleotide in their L-PART2 (at position 12 according to the IMGT numbering).
(3) The IGHV and IGLV genes have a provisional nomenclature which may be updated. The definitive nomenclature will be available once the rat IGH and IGL locus are completely sequenced.
(4) Teleostei are available as separate sets for 4 species as shown in the table per taxon and as pooled with sequences of other species (in the set 'Teleostei' for several taxons).
(5) Chondrichthyes are currently only available as pooled sequences of several species (in the set 'Chondrichthyes' for several taxons).

IMGT/GENE-DB reference directory sets

The available IMGT/GENE-DB reference directory sets are the following :


They are divided in:

Note that the IMGT/GENE-DB sets also include the orphons.


IMGT/GENE-DB also provides examples of artificially spliced sequences (for more exhaustive functionalities, please query IMGT/GENE-DB):

IG "V-REGION", "D-REGION", "J-REGION", "C-GENE exon" sets

  F+ORF+all P F+ORF+in-frame P F+ORF+in-frame P with IMGT gaps
IMGT Groups Nucleotides Nucleotides Amino acids Nucleotides Amino acids
IGHV Human, Mouse, Rat, Rabbit, Rainbow trout, Rhesus monkey, Pig, Zebrafish, Platypus, Alpaca, Crab-eating macaque, Dog, Chicken Human, Mouse, Rat, Rabbit, Rainbow trout, Rhesus monkey, Pig, Zebrafish, Platypus, Alpaca, Crab-eating macaque, Dog, Chicken Human, Mouse, Rat, Rabbit, Rainbow trout, Rhesus monkey, Pig, Zebrafish, Platypus, Alpaca, Crab-eating macaque, Dog, Chicken Human, Mouse, Rat, Rabbit, Rainbow trout, Rhesus monkey, Pig, Zebrafish, Platypus, Alpaca, Crab-eating macaque, Dog, Chicken Human, Mouse, Rat, Rabbit, Rainbow trout, Rhesus monkey, Pig, Zebrafish Platypus, Alpaca, Crab-eating macaque, Dog, Chicken
IGHD Human, Mouse, Rat, Rabbit, Rainbow trout, Rhesus monkey, Pig, Zebrafish, Platypus, Alpaca, Crab-eating macaque, Dog, Sheep, Chicken Human, Mouse, Rat, Rabbit, Rainbow trout, Rhesus monkey, Pig, Zebrafish, Platypus, Alpaca, Crab-eating macaque, Dog, Sheep, Chicken Human, Mouse, Rat, Rabbit, Rainbow trout, Rhesus monkey, Pig, Zebrafish, Platypus, Alpaca, Crab-eating macaque, Dog Sheep, Chicken    
IGHJ Human, Mouse, Rat, Rabbit, Rainbow trout, Rhesus monkey, Pig, Zebrafish, Platypus, Alpaca, Crab-eating macaque, Dog, Chicken Human, Mouse, Rat, Rabbit, Rainbow trout, Rhesus monkey, Pig, Zebrafish, Platypus, Alpaca, Crab-eating macaque, Dog, Chicken Human, Mouse, Rat, Rabbit, Rainbow trout, Rhesus monkey, Pig, Zebrafish, Platypus, Alpaca, Crab-eating macaque, Dog, Chicken    
IGHC Human, Mouse, Rat, Rainbow trout, Pig, Platypus, Alpaca, Crab-eating macaque, Dog Human, Mouse, Rat, Rainbow trout, Pig, Platypus, Alpaca, Crab-eating macaque, Dog Human, Mouse, Rat, Rainbow trout, Pig, Platypus, Alpaca, Crab-eating macaque, Dog Human, Mouse, Rat, Rainbow trout, Pig, Platypus, Alpaca, Crab-eating macaque, Dog Human, Mouse, Rat, Rainbow trout, Pig, Platypus, Alpaca, Crab-eating macaque, Dog
IGKV Human, Mouse, Pig, Rat, Rabbit, Rhesus monkey, Dog, Goat, Sheep Human, Mouse, Pig, Rat, Rabbit, Rhesus monkey, Dog, Goat, Sheep Human, Mouse, Pig, Rat, Rabbit, Rhesus monkey, Dog, Goat, Sheep Human, Mouse, Pig, Rat, Rabbit, Rhesus monkey, Dog, Goat, Sheep Human, Mouse, Pig, Rat, Rabbit, Rhesus monkey, Dog, Goat, Sheep
IGKJ Human, Mouse, Pig, Rat, Rabbit, Rhesus monkey, Dog, Goat, Sheep Human, Mouse, Pig, Rat, Rabbit, Rhesus monkey, Dog, Goat, Sheep Human, Mouse, Pig, Rat, Rabbit, Rhesus monkey, Dog, Goat, Sheep    
IGKC Human, Mouse, Pig, Rat, Rabbit, Dog, Goat, Sheep Human, Mouse, Pig, Rat, Rabbit, Dog, Goat, Sheep Human, Mouse, Pig, Rat, Rabbit, Dog, Goat, Sheep Human, Mouse, Pig, Rat, Rabbit, Dog, Goat, Sheep Human, Mouse, Pig, Rat, Rabbit, Dog, Goat, Sheep
IGLV Human, Mouse, Rat, Rabbit, Rhesus monkey, Pig Human, Mouse, Rat, Rabbit, Rhesus monkey, Pig Human, Mouse, Rat, Rabbit, Rhesus monkey, Pig Human, Mouse, Rat, Rabbit, Rhesus monkey, Pig Human, Mouse, Rat, Rabbit, Rhesus monkey, Pig
IGLJ Human, Mouse, Rat, Rabbit, Rhesus monkey, Pig Human, Mouse, Rat, Rabbit, Rhesus monkey, Pig Human, Mouse, Rat, Rabbit, Rhesus monkey, Pig    
IGLC Human, Mouse, Rat, Rabbit, Pig, Rhesus monkey Human, Mouse, Rat, Rabbit, Pig, Rhesus monkey Human, Mouse, Rat, Rabbit, Pig, Rhesus monkey Human, Mouse, Rat, Rabbit, Pig, Rhesus monkey Human, Mouse, Rat, Rabbit, Pig, Rhesus monkey
IGIV Zebrafish Zebrafish Zebrafish Zebrafish Zebrafish
IGIJ Zebrafish Zebrafish Zebrafish    
IGIC Zebrafish Zebrafish Zebrafish Zebrafish Zebrafish

TR "V-REGION", "D-REGION", "J-REGION", "C-GENE exon" sets

  F+ORF+all P F+ORF+in-frame P F+ORF+in-frame P with IMGT gaps
IMGT Groups Nucleotides Nucleotides Amino acids Nucleotides Amino acids
TRAV Human, Mouse, Sheep, Zebrafish, Dog, Rhesus monkey Human, Mouse, Sheep, Zebrafish, Dog, Rhesus monkey Human, Mouse, Sheep, Zebrafish, Dog, Rhesus monkey Human, Mouse, Sheep, Zebrafish, Dog, Rhesus monkey Human, Mouse, Sheep, Zebrafish, Dog, Rhesus monkey
TRAJ Human, Mouse, Bovine, Sheep, Zebrafish, Dog, Rhesus monkey Human, Mouse, Bovine, Sheep, Zebrafish, Dog, Rhesus monkey Human, Mouse, Bovine, Sheep, Zebrafish, Dog, Rhesus monkey    
TRAC Human, Mouse, Bovine, Sheep, Zebrafish, Dog Human, Mouse, Bovine, Sheep, Zebrafish, Dog Human, Mouse, Bovine, Sheep, Zebrafish, Dog Human, Mouse, Bovine, Sheep, Zebrafish, Dog Human, Mouse, Bovine, Sheep, Zebrafish, Dog
TRBV Human, Mouse, Rhesus Monkey, Dog, Rainbow trout Human, Mouse, Rhesus Monkey, Dog, Rainbow trout Human, Mouse, Rhesus Monkey, Dog, Rainbow trout Human, Mouse, Rhesus Monkey, Dog, Rainbow trout Human, Mouse, Rhesus Monkey, Dog, Rainbow trout
TRBD Human, Mouse, Rhesus Monkey, Dog, Rainbow trout Human, Mouse, Rhesus Monkey, Dog, Rainbow trout Human, Mouse, Rhesus Monkey, Dog, Rainbow trout    
TRBJ Human, Mouse, Rhesus Monkey, Dog, Rainbow trout Human, Mouse, Rhesus Monkey, Dog, Rainbow trout Human, Mouse, Rhesus Monkey, Dog, Rainbow trout    
TRBC Human, Mouse, Dog Human, Mouse, Dog Human, Mouse, Dog Human, Mouse, Dog Human, Mouse, Dog
TRGV Human, Mouse, Dog, Bovine, Camel Human, Mouse, Dog, Bovine, Camel Human, Mouse, Dog, Bovine, Camel Human, Mouse, Dog, Bovine, Camel Human, Mouse, Dog, Bovine, Camel
TRGJ Human, Mouse, Dog, Bovine, Camel Human, Mouse, Dog, Bovine, Camel Human, Mouse, Dog, Bovine, Camel    
TRGC Human, Mouse, Dog Human, Mouse, Dog Human, Mouse, Dog Human, Mouse, Dog Human, Mouse, Dog
TRDV Human, Mouse, Bovine, Camel, Sheep, Zebrafish, Dog, Rhesus monkey Human, Mouse, Bovine, Camel, Sheep Zebrafish, Dog, Rhesus monkey Human, Mouse, Bovine, Camel, Sheep, Zebrafish, Dog, Rhesus monkey Human, Mouse, Bovine, Camel, Sheep, Zebrafish, Dog, Rhesus monkey Human, Mouse, Bovine, Camel, Sheep, Zebrafish, Dog, Rhesus monkey
TRDD Human, Mouse, Bovine, Sheep, Zebrafish, Dog, Rhesus monkey Human, Mouse, Bovine, Sheep, Zebrafish, Dog, Rhesus monkey Human, Mouse, Bovine, Sheep, Zebrafish, Dog, Rhesus monkey    
TRDJ Human, Mouse, Bovine, Sheep, Zebrafish, Dog, Rhesus monkey Human, Mouse, Bovine, Sheep, Zebrafish, Dog, Rhesus monkey Human, Mouse, Bovine, Sheep, Zebrafish, Dog, Rhesus monkey    
TRDC Human, Mouse, Sheep, Zebrafish, Dog Human, Mouse, Sheep, Zebrafish, Dog Human, Mouse, Sheep, Zebrafish, Dog Human, Mouse, Sheep, Zebrafish, Dog Human, Mouse, Sheep, Zebrafish, Dog

"L-PART1+L-PART2" artificially spliced sets

 F+ORF+all PF+ORF+in-frame P
IMGT Groups NucleotidesAmino acids
IGHV Human, Mouse, Rat, Rabbit, Rainbow trout, Rhesus monkey, Pig, Zebrafish, Platypus, Alpaca, Crab-eating macaque, Dog, Chicken Human, Mouse, Rat, Rabbit, Rainbow trout, Rhesus monkey, Pig, Zebrafish, Platypus, Alpaca, Crab-eating macaque, Dog, Chicken
IGKV Human, Mouse, Rat, Rabbit, Pig, Rhesus monkey, Dog, Goat, Sheep Human, Mouse, Rat, Rabbit, Pig, Rhesus monkey, Dog, Goat, Sheep
IGLV Human, Mouse, Rat, Rabbit, Pig, Rhesus monkey Human, Mouse, Rat, Rabbit, Pig, Rhesus monkey
IGIV Zebrafish Zebrafish
 F+ORF+all PF+ORF+in-frame P
IMGT Groups NucleotidesAmino acids
TRAV Human, Mouse, Sheep, Zebrafish, Dog, Rhesus monkey Human, Mouse, Sheep, Zebrafish, Dog, Rhesus monkey
TRBV Human, Mouse, Rhesus Monkey, Dog, Rainbow trout, Dog Human, Mouse, Rhesus Monkey, Dog, Rainbow trout, Dog
TRGV Human, Mouse, Bovine, Dog, Camel, Human, Mouse, Bovine, Dog, Camel
TRDV Human, Mouse, Bovine, Camel, Sheep, Zebrafish, Dog, Rhesus monkey Human, Mouse, Bovine, Camel, Sheep, Zebrafish, Dog, Rhesus monkey

"L-PART1+V-EXON" artificially spliced sets

 F+ORF+all PF+ORF+in-frame P
IMGT GroupsNucleotidesAmino acids
IGHV Human, Mouse, Rat, Rabbit, Rainbow trout, Rhesus monkey, Pig, Zebrafish, Platypus, Alpaca, Crab-eating macaque, Dog, Chicken Human, Mouse, Rat, Rabbit, Rainbow trout, Rhesus monkey, Pig, Zebrafish, Platypus, Alpaca, Crab-eating macaque, Dog, Chicken
IGKV Human, Mouse, Rat, Rabbit, Pig, Rhesus monkey, Dog, Goat, Sheep Human, Mouse, Rat, Rabbit, Pig, Rhesus monkey, Dog, Goat, Sheep
IGLV Human, Mouse, Rat, Rabbit, Pig, Rhesus monkey Human, Mouse Rat, Rabbit, Pig, Rhesus monkey
IGIV Zebrafish Zebrafish
 F+ORF+all PF+ORF+in-frame P
IMGT Groups NucleotidesAmino acids
TRAV Human, Mouse, Sheep, Zebrafish, Dog, Rhesus monkey Human, Mouse, Sheep, Zebrafish, Dog, Rhesus monkey
TRBV Human, Mouse, Rhesus Monkey, Dog, Rainbow trout, Dog Human, Mouse, Rhesus Monkey, Dog, Rainbow trout, Dog
TRGV Human, Mouse, Bovine, Dog, Camel Human, Mouse, Bovine, Dog, Camel
TRDV Human, Mouse, Bovine, Camel, Sheep, Zebrafish, Dog, Rhesus monkey Human, Mouse, Bovine, Camel, Sheep, Zebrafish, Dog, Rhesus monkey

Constant gene artificially spliced exons sets

 F+ORF+in-frame PF+ORF+in-frame P
IMGT Groups NucleotidesAmino acids
IGHC Human, Mouse, Rat, Alpaca Human, Mouse, Rat, Alpaca
IGKC Human Human,
IGLC Human Human
 F+ORF+in-frame PF+ORF+in-frame P
IMGT Groups NucleotidesAmino acids
TRAC Human, Mouse Human, Mouse
TRBC Human, Mouse Human, Mouse
TRGC Human, Mouse Human, Mouse
TRDC Human, Mouse Human, Mouse


References:

[1] Lefranc M.-P. "Unique database numbering system for immunogenetic analysis" Immunology Today, 18: 509 (1997).
[2] Lefranc M.-P. "The IMGT unique numbering for immunoglobulins, T cell Receptors and Ig-like domains" The immunologist, 7,132-136 (1999).
[3] Lefranc M.-P. et al. "IMGT unique numbering for immunoglobulin and Tcell receptor variable domains and Ig superfamily V-like domains" Dev. Comp. Immunol., 27, 55-77 (2003).
[4] Lefranc M.-P. et al. "IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains" Dev. Comp. Immunol., 2005, 29, 185-203 PMID: 15572068