Citing IMGT databases: Manso T. et al. IMGT® databases, related tools and web resources through three main axes of research and development. Nucleic Acids Res. 2022 Jan 7;50(D1):D1262-D1272. doi: 10.1093/nar/gkab1136 PMID: 34875068 Free PMC article.
Program version: v. 

Add the possibility to obtain a gene table per strain (for mouse now and for other species later) and allotypes/isotypes for human.
September 25th, 2024.

Bibliographical references in alphabetic order, small design changes and addition of "NL" for non-localized gene.
June 14th, 2024.

Addition of 'Score for IMGT allele confirmation' as well as NCBI TPA accession numbers.
September 20th, 2023.

Implementation of the dynamic gene table.

Gene table legend:

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene, when the data have been confirmed by several studies.

Functionality is shown in parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.

IMGT allele confirmation: A scoring system is employed to indicate the number of IMGT/LIGM-DB reference sequences and other sequences from the literature in which an IG or TR gene allele has been identified and annotated.

A single star ()
indicates that an IG or TR gene allele is annotated in the reference sequence only.
Two stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in one sequence from the literature.
Three stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in at least two sequences from the literature.
In the Excel file, the stars are represented by the plus symbol (+).
Click on:
  • IMGT gene name to get the corresponding IMGT/GENE-DB entry (link).
  • IMGT allele name to see the corresponding Alignments of alleles (link).
  • Accession number to get the corresponding IMGT/LIGM-DB entry (link).
  • MAP: mapped sequences. Click to access GENE-DB «LOCALIZATION IN GENOME ASSEMBLIES» (link).
  • [number] to access the corresponding IMGT reference (popover).
  • (number) to see the corresponding IMGT note (popover).
Options:
  • You can show/hide columns (), download data () or put the table in fullscreen () using buttons.
See also (IMGT Scientific chart):
Select a species and a IMGT group to get the gene table:
Only IMGT available species/group are shown in the drop-down list.
The gene table can take several seconds to appear, please be patient.
Gene table of dog (Canis lupus familiaris) IGHC IMGT group:
IMGT gene nameIMGT allele nameScore for
IMGT allele
confirmation		FctChromosomosal
localization		ExonsR T PrIMGT/LIGM-DB reference sequencesIMGT/LIGM-DB sequences from the literature
Clone namesBreedAccession
numbers		Positions
in the sequence		Secondary
accession
numbers		Clone namesBreedAccession
numbers		Positions
in the sequence
IGHA IGHA*01 F 8 CH1 CM000008.3 boxer IMGT000001 MAP [3] 1419857-1420162 boxer AAEX03006125 [1,2] complement(108353-108658)
IGHA IGHA*01 F 8 H-CH2 CM000008.3 boxer IMGT000001 MAP [3] 1420410-1420751 boxer AAEX03006125 [1,2] complement(107764-108105)
IGHA IGHA*01 F 8 CH3-CHS CM000008.3 boxer IMGT000001 MAP [3] 1420953-1421338 boxer AAEX03006125 [1,2] complement(107177-107562)
IGHA IGHA*01 F 8 M CM000008.3 boxer IMGT000001 MAP [3] 1423586-1423797 boxer AAEX03006125 [1,2] complement(104718-104929)
IGHA IGHA*02 F 8 CH1 L36871 [4] 188-493
IGHA IGHA*02 F 8 H-CH2 L36871 [4] 739-1077
IGHA IGHA*02 F 8 CH3-CHS L36871 [4] 1279-1664
IGHD IGHD*01 ORF (1) 8 CH1 CM000008.3 boxer IMGT000001 MAP [3] 1302503-1302787
IGHD IGHD*01 ORF (1) 8 H1 CM000008.3 boxer IMGT000001 MAP [3] 1303096-1303185
IGHD IGHD*01 ORF (2) 8 H2 CM000008.3 boxer IMGT000001 MAP [3] 1304450-1304518
IGHD IGHD*01 ORF (1) 8 CH2 CM000008.3 boxer IMGT000001 MAP [3] 1304784-1305110
IGHD IGHD*01 ORF (3) 8 CH3 CM000008.3 boxer IMGT000001 MAP [3] 1305307-1305618
IGHD IGHD*01 ORF (1) 8 M1 CM000008.3 boxer IMGT000001 MAP [3] 1309381-1309529
IGHD IGHD*01 ORF (1) 8 M2 CM000008.3 boxer IMGT000001 MAP [3] 1309817-1309822
IGHE IGHE*01 F 8 CH1 CM000008.3 boxer IMGT000001 MAP [3] 1406272-1406568 boxer AAEX03006125 [1,2] complement(121947-122243)
IGHE IGHE*01 F 8 CH2 CM000008.3 boxer IMGT000001 MAP [3] 1406765-1407088 boxer AAEX03006125 [1,2] complement(121427-121750)
IGHE IGHE*01 F 8 CH3 CM000008.3 boxer IMGT000001 MAP [3] 1407181-1407501 boxer AAEX03006125 [1,2] complement(121014-121334)
IGHE IGHE*01 F 8 CH4-CHS CM000008.3 boxer IMGT000001 MAP [3] 1407576-1407913 boxer AAEX03006125 [1,2] complement(120602-120939)
IGHE IGHE*01 F 8 M1 CM000008.3 boxer IMGT000001 MAP [3] 1409868-1409995 boxer AAEX03006125 [1,2] complement(118520-118647)
IGHE IGHE*01 F 8 M2 CM000008.3 boxer IMGT000001 MAP [3] 1410090-1410170 boxer AAEX03006125 [1,2] complement(118345-118425)
IGHE IGHE*02 F 8 CH1 L36872 [4] 91-387
IGHE IGHE*02 F 8 CH2 L36872 [4] 584-907
IGHE IGHE*02 F 8 CH3 L36872 [4] 1000-1320
IGHE IGHE*02 F 8 CH4-CHS L36872 [4] 1395-1732
IGHG1 IGHG1*01 (F) 8 CH1
RTPr
++
 IgG-A (4) AF354264 [5] #c 481-771
IGHG1 IGHG1*01 (F) 8 H
RTPr
++
 IgG-A (4) AF354264 [5] #c 772-813
IGHG1 IGHG1*01 (F) 8 CH2
RTPr
++
 IgG-A (4) AF354264 [5] #c 814-1143
IGHG1 IGHG1*01 (F) 8 CH3-CHS
RTPr
++
 IgG-A (4) AF354264 [5] #c 1144-1473
IGHG2 IGHG2*01 F 8 CH1 CM000008.3 boxer IMGT000001 MAP [3] 1360885-1361175 boxer AAEX03006126 [1,2] complement(26664-26954)
IGHG2 IGHG2*01 F 8 H CM000008.3 boxer IMGT000001 MAP [3] 1361465-1361521 boxer AAEX03006126 [1,2] complement(26318-26374)
IGHG2 IGHG2*01 F 8 CH2 CM000008.3 boxer IMGT000001 MAP [3] 1361648-1361977 boxer AAEX03006126 [1,2] complement(25862-26191)
IGHG2 IGHG2*01 F 8 CH3-CHS CM000008.3 boxer IMGT000001 MAP [3] 1362084-1362409 boxer AAEX03006126 [1,2] complement(25430-25755)
IGHG2 IGHG2*01 F 8 M1 CM000008.3 boxer IMGT000001 MAP [3] 1363846-1363976 boxer AAEX03006126 [1,2] complement(23863-23993)
IGHG2 IGHG2*01 F 8 M2 CM000008.3 boxer IMGT000001 MAP [3] 1365672-1365752 boxer AAEX03006126 [1,2] complement(22087-22167)
IGHG2 IGHG2*02 (F) 8 CH1
RTPr
++
 IgG-B (4) AF354265 [5] #c 446-736
IGHG2 IGHG2*02 (F) 8 H
RTPr
++
 IgG-B (4) AF354265 [5] #c 737-793
IGHG2 IGHG2*02 (F) 8 CH2
RTPr
++
 IgG-B (4) AF354265 [5] #c 794-1123
IGHG2 IGHG2*02 (F) 8 CH3-CHS
RTPr
++
 IgG-B (4) AF354265 [5] #c 1124-1450
IGHG3 IGHG3*01 (F) 8 CH1
RTPr
++
 IgG-C (4) AF354266 [5] #c 455-745
IGHG3 IGHG3*01 (F) 8 H
RTPr
++
 IgG-C (4) AF354266 [5] #c 746-796
IGHG3 IGHG3*01 (F) 8 CH2
RTPr
++
 IgG-C (4) AF354266 [5] #c 797-1126
IGHG3 IGHG3*01 (F) 8 CH3-CHS
RTPr
++
 IgG-C (4) AF354266 [5] #c 1127-1453
IGHG4 IGHG4*01 (F) 8 CH1
RTPr
++
 IgG-D (4) AF354267 [5] #c 465-755
IGHG4 IGHG4*01 (F) 8 H
RTPr
++
 IgG-D (4) AF354267 [5] #c 756-797
IGHG4 IGHG4*01 (F) 8 CH2
RTPr
++
 IgG-D (4) AF354267 [5] #c 798-1127
IGHG4 IGHG4*01 (F) 8 CH3-CHS
RTPr
++
 IgG-D (4) AF354267 [5] #c 1128-1457
IGHM IGHM*01 F 8 CH1 CM000008.3 boxer IMGT000001 MAP [3] 1290316-1290633 boxer AAEX03006126 [1,2] complement(97206-97523)
IGHM IGHM*01 F 8 CH2 CM000008.3 boxer IMGT000001 MAP [3] 1290713-1291051 boxer AAEX03006126 [1,2] complement(96788-97126)
IGHM IGHM*01 F 8 CH3 CM000008.3 boxer IMGT000001 MAP [3] 1291309-1291626 boxer AAEX03006126 [1,2] complement(96213-96530)
IGHM IGHM*01 F 8 CH4-CHS CM000008.3 boxer IMGT000001 MAP [3] 1291730-1292121 boxer AAEX03006126 [1,2] complement(95718-96109)
IGHM IGHM*01 F 8 M1 CM000008.3 boxer IMGT000001 MAP [3] 1294683-1294798 boxer AAEX03006126 [1,2] complement(93041-93156)
IGHM IGHM*01 F 8 M2 CM000008.3 boxer IMGT000001 MAP [3] 1294903-1294908 boxer AAEX03006126 [1,2] complement(92931-92936)
IMGT notes: ↑
  1. noncanonical DONOR-SPLICE ngc instead of ngt in H2
  2. Noncanonical DONOR-SPLICE ngc instead of ngt
  3. No CHS found
  4. Canine IgG subclass biological characterization (modified from Table 8 PUBMED 24268690).

    Canine IgGIgG1IgG2IgG3IgG4
    Induction of cytolytic activity (ADCC)--/+++++++--
    Complement binding (human C1q)--/+++++--/+
    Fc gamma receptor I (FcγRI)+++++--/+
    Fc gamma receptor IIb (FcγRIIb)++++
    Fc gamma receptor III (FcγRIII)--+--/+--
    Fc neonatal receptor I (FcRn)++++--/+++
    Reactivity with protein A--/++++----
    Reactivity with protein G++++++++


    '+++' indicates very tight binding or high reactivity, '++' indicates good binding, '+' indicates that some binding was observed, '--/+' indicates little to no activation/binding, and '--' represents no binding. The table has been updated with the canine subclass names IgG1, IgG2, IgG3, IgG4, instead of A, B, C and D. For comparison with Structural and biological properties of human immunoglobulins, click here.
IMGT references: ↑
  1. Johnson J. et al., Version 3.1 of The Genome Sequence of Canis lupus familiaris (dog), Unpublished.
  2. Lindblad-Toh K. et al., Genome sequence, comparative analysis and haplotype structure of the domestic dog, Nature, vol. 438, no. 7069, 2005, pp. 803-819. DOI: 10.1038/nature04338
  3. Martin, Jolyon et al. “Comprehensive annotation and evolutionary insights into the canine (Canis lupus familiaris) antigen receptor loci.” Immunogenetics vol. 70,4 (2018): 223-236. DOI: 10.1007/s00251-017-1028-0
  4. Patel M. et al., Sequence of the dog immunoglobulin alpha and epsilon constant region genes, Immunogenetics, vol. 41, no. 5, 1995, pp. 282-286. DOI: 10.1007/BF00172152
  5. Tang L. et al., Cloning and characterization of cDNAs encoding four different canine immunoglobulin gamma chains, Vet. Immunol. Immunopathol, vol. 80, no. 3-4, 2001, pp. 259-270. DOI: 10.1016/S0165-2427(01)00318-X