Citing IMGT dynamic tools: Sanou G., Zeitoun G. et al. IMGT® at scale: FAIR, Dynamic and Automated Tools for Immune Locus Analysis, Nucleic Acids Research. 2025;,gkaf1024. doi: 10.1093/nar/gkaf1024 (Free Article) PMID: 41091930.
Program version: v. 

Add information about removed genes/alleles.
May 15th, 2025.

Add the possibility to obtain a gene table per strain (for mouse now and for other species later) and allotypes/isotypes for human.
September 25th, 2024.

Bibliographical references in alphabetic order, small design changes and addition of "NL" for non-localized gene.
June 14th, 2024.

Addition of 'Score for IMGT allele confirmation' as well as NCBI TPA accession numbers.
September 20th, 2023.

Implementation of the dynamic gene table.

Gene table legend:

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene, when the data have been confirmed by several studies.

Functionality is shown in parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.

IMGT allele confirmation: A scoring system is employed to indicate the number of IMGT/LIGM-DB reference sequences and other sequences from the literature in which an IG or TR gene allele has been identified and annotated.

Removed genes/alleles
If a gene/allele existence or name has to be changed, the old name or gene/allele would be deleted and its name won't be reused. They are kept in the gene table for historical reasons.
A single star ()
indicates that an IG or TR gene allele is annotated in the reference sequence only.
Two stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in one sequence from the literature.
Three stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in at least two sequences from the literature.
In the Excel file, the stars are represented by the plus symbol (+).

Click on:
  • IMGT gene name to get the corresponding IMGT/GENE-DB entry (link).
  • IMGT allele name to see the corresponding Alignments of alleles (link).
  • Accession number to get the corresponding IMGT/LIGM-DB entry (link).
  • MAP: mapped sequences. Click to access GENE-DB «LOCALIZATION IN GENOME ASSEMBLIES» (link).
  • [number] to access the corresponding IMGT reference (popover).
  • (number) to see the corresponding IMGT note (popover).
Options:
  • You can show/hide columns (), download data () or put the table in fullscreen () using buttons.
See also (IMGT Scientific chart):
Select a species and a IMGT group to get the gene table:
Only IMGT available species/group are shown in the drop-down list.
The gene table can take several seconds to appear, please be patient.
Gene table of human (Homo sapiens) IGKC IMGT group:
IMGT gene nameIMGT allele nameScore for
IMGT allele
confirmation		FctChromosomosal
localization		ExonsR T PrIMGT/LIGM-DB reference sequencesIMGT/LIGM-DB sequences from the literature
Clone namesAccession
numbers		Positions
in the sequence		Secondary
accession
numbers		Clone namesAccession
numbers		Positions
in the sequence
IGKC IGKC*01 F 2p11.2 C-REGION
RTPr
++
 Inv3 J00241 [5,6] ° MAP 334-653 IMGT000273 [9] 1947420-1947739
IMGT000281 [10] 1934256-1934575
IMGT000305 [2-4] 1885070-1885389
IMGT000308 [2-4] 1874283-1874602
U72063 [8] ° 337-656
X67858 [13] 4489-4808
X96754 [7] ° 289-608
IGKC IGKC*02 F 2p11.2 C-REGION geV-4 M11736 [11] ° 1033-1352
IGKC IGKC*03 F 2p11.2 C-REGION geV-3 M11737 [11] ° 1031-1350
IGKC IGKC*04 F 2p11.2 C-REGION
RTPr
++
 AF017732 [1] 62461-62780
IGKC IGKC*05 (F) 2p11.2 C-REGION
RTPr
++
 AF113887 [12] (1) #c 388-708
IMGT notes: ↑
  1. The IGKC*05 allele was found expressed in the Bence Jones protein BIF and the amyloid protein BIF (Solomon A. et al., Proc. Natl. Acad. Sci. USA, 95, 9547-9551 (1998))
IMGT references: ↑
  1. Brandt P. et al., Human DNA sequence from cosmids cos111 and cos607/6 on chromosome II contains ESTs, Unpublished.
  2. Chu et al., Approaching an Error-Free Diploid Human Genome Assembly of East Asian Origin, (misc) bioRxivorg, 2025, DOI: 10.1101/2025.08.01.667781
  3. Chu et al., Direct Submission, Computational Biology, Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation. Submitted (16-AUG-2025). NGDC, Beijing, 100101, China.
  4. He et al., T2T YAO: A Telomere to telomere Assembled Diploid Reference Genome for Han Chinese, Genomics Proteomics & Bioinformatics 21(6): 1085–1100 (2023), DOI: 10.1016/j.gpb.2023.08.001
  5. Hieter P.A. et al., Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments, Cell, vol. 22, no. 1 Pt 1, 1980, pp. 197-207. DOI: 10.1016/0092-8674(80)90168-3
  6. Hieter P.A. et al., Evolution of human immunoglobulin kappa J region genes, J. Biol. Chem, vol. 257, no. 3, 1982, pp. 1516-1522. PUBMED: 6276389
  7. Hilger C. et al., Unpublished.
  8. Hu W.X. et al., Comparison of NPC Transforming Gene Tx to Ig Kappa Constant Region Gene and Their Expression in Different Cell Lines (Chinese with English Abstract), Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao, vol. 27, 1995, pp. 215-221.
  9. Liao W.W. et al., A draft human pangenome reference, Nature, vol. 617, no. 7960, 2023, pp. 312-324. PUBMED: 37165242
  10. Nurk S. et al., The complete sequence of a human genome, Science, vol. 376, no. 6588, 2022, pp. 44-53. PUBMED: 35357919
  11. Stavnezer-Nordgren J. et al., Molecular defects in a human immunoglobulin kappa chain deficiency, Science, vol. 230, no. 4724, 1985, pp. 458-461. PUBMED: 3931219
  12. Wally J. et al., Identification of a novel substitution in the constant region of a gene coding for an amyloidogenic kappa1 light chain, Biochim. Biophys. Acta, vol. 1454, no. 1, 1999, pp. 49-56. DOI: 10.1016/S0925-4439(99)00019-8
  13. Whitehurst C. et al., Nucleotide sequence of the intron of the germline human kappa immunoglobulin gene connecting the J and C regions reveals a matrix association region (MAR) next to the enhancer, Nucleic Acids Res, vol. 20, no. 18, 1992, pp. 4929-4930. DOI: 10.1093/nar/20.18.4929