Citing IMGT dynamic tools: Sanou G., Zeitoun G. et al. IMGT® at scale: FAIR, Dynamic and Automated Tools for Immune Locus Analysis, Nucleic Acids Research. 2025;,gkaf1024. doi: 10.1093/nar/gkaf1024 (Free Article) PMID: 41091930.
Program version: v. 

Add information about removed genes/alleles.
May 15th, 2025.

Add the possibility to obtain a gene table per strain (for mouse now and for other species later) and allotypes/isotypes for human.
September 25th, 2024.

Bibliographical references in alphabetic order, small design changes and addition of "NL" for non-localized gene.
June 14th, 2024.

Addition of 'Score for IMGT allele confirmation' as well as NCBI TPA accession numbers.
September 20th, 2023.

Implementation of the dynamic gene table.

Gene table legend:

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene, when the data have been confirmed by several studies.

Functionality is shown in parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.

IMGT allele confirmation: A scoring system is employed to indicate the number of IMGT/LIGM-DB reference sequences and other sequences from the literature in which an IG or TR gene allele has been identified and annotated.

Removed genes/alleles
If a gene/allele existence or name has to be changed, the old name or gene/allele would be deleted and its name won't be reused. They are kept in the gene table for historical reasons.
A single star ()
indicates that an IG or TR gene allele is annotated in the reference sequence only.
Two stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in one sequence from the literature.
Three stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in at least two sequences from the literature.
In the Excel file, the stars are represented by the plus symbol (+).

Click on:
  • IMGT gene name to get the corresponding IMGT/GENE-DB entry (link).
  • IMGT allele name to see the corresponding Alignments of alleles (link).
  • Accession number to get the corresponding IMGT/LIGM-DB entry (link).
  • MAP: mapped sequences. Click to access GENE-DB «LOCALIZATION IN GENOME ASSEMBLIES» (link).
  • [number] to access the corresponding IMGT reference (popover).
  • (number) to see the corresponding IMGT note (popover).
Options:
  • You can show/hide columns (), download data () or put the table in fullscreen () using buttons.
See also (IMGT Scientific chart):
Select a species and a IMGT group to get the gene table:
Only IMGT available species/group are shown in the drop-down list.
The gene table can take several seconds to appear, please be patient.

Rearranged genomic or cDNA have been included in the Alignments of alleles and Tables of alleles when several sequences from independent sources have been found with the same mutations. These alleles need to be confirmed by complete germline genomic sequences.

Gene table of human (Homo sapiens) IGKJ IMGT group:
IMGT gene nameIMGT allele nameScore for
IMGT allele
confirmation		FctChromosomosal
localization		R T PrIMGT/LIGM-DB reference sequencesIMGT/LIGM-DB sequences from the literature
Clone namesAccession
numbers		Positions
in the sequence
(J-GENE-UNIT)
or J-REGION (*)		Secondary
accession
numbers		Clone namesAccession
numbers		Positions
in the sequence
(J-GENE-UNIT)
or J-REGION (*)
IGKJ1 IGKJ1*01 F 2p11.2
RTPr
++
 J1 J00242 [9,10] MAP 212-288 IMGT000281 [18] 1929978-1930054
IMGT000305 [2,8] 1880792-1880868
IMGT000308 [2,8] 1870005-1870081 *
X61584 [20] 251-288 *
X67858 [21] 251-288 *
IGKJ2 IGKJ2*01 F 2p11.2
RTPr
++
 J2 J00242 [9,10] MAP 573-650 IMGT000281 [18] 1930338-1930415
IMGT000305 [2,8] 1881152-1881229
IMGT000308 [2,8] 1870365-1870442
X61584 [20] 611-649 *
X63370 [12] #g 798-836 *
X67858 [21] 611-649 *
IGKJ2 IGKJ2*02 (F) 2p11.2
RTPr
++
 J2 Z70260 [19] #c 288-324 *
IGKJ2 IGKJ2*03 (F) 2p11.2
RTPr
++
 J2 U95246 [17] #c 281-318 *
IGKJ2 IGKJ2*04 F 2p11.2
RTPr
++
 IMGT000100 [11,15] MAP 1383767-1383844 AF189007 [5] (2) 151->167 *
L40735 [1] #c 265-300 *
J2 Z46620 [6,7] #c 302-339 *
IGKJ3 IGKJ3*01 F 2p11.2
RTPr
++
 J3 J00242 [9,10] MAP 880-955 IMGT000273 [16] 1943846-1943883 *
IMGT000281 [18] 1930644-1930719
IMGT000305 [2,8] 1881458-1881533
IMGT000308 [2,8] 1870671-1870746
X61584 [20] 915-952 *
X63370 [12] #g 1103-1140 *
X67858 [21] 916-953 *
IGKJ4 IGKJ4*01 F 2p11.2
RTPr
++
 J4 J00242 [9,10] MAP 1221-1297 D90159 [13,14] 15-52 *
IMGT000281 [18] 1930978-1931054
IMGT000305 [2,8] 1881792-1881868
IMGT000308 [2,8] 1871005-1871081
X61584 [20] 1249-1286 *
X67858 [21] 1251-1288 *
IGKJ4 IGKJ4*02 (F) 2p11.2
RTPr
++
 J4 AF103571 [4] #c 270-306 * AF189008 [5] (2) 154->169 *
IGKJ4 IGKJ4*03 ORF (1) 2p11.2 IMGT000273 [16] 1944142-1944218
IGKJ5 IGKJ5*01 F 2p11.2
RTPr
++
 J5 J00242 [9,10] MAP 1536-1612 IMGT000273 [16] 1944499-1944536 *
IMGT000281 [18] 1931296-1931372
IMGT000305 [2,8] 1882110-1882186
IMGT000308 [2,8] 1871323-1871399
X61584 [20] 1567-1604 *
X67858 [21] 1569-1606 *
IMGT notes: ↑
  1. noncanonical J-NONAMER:gatttatgc instead of ggtttttgt
  2. Partial J-REGION in 3' side.
IMGT references: ↑
  1. Bridges S.L.Jr. et al., Somatic mutation and CDR3 lengths of immunoglobulin kappa light chains expressed in patients with rheumatoid arthritis and in normal individuals, J. Clin. Invest, vol. 96, no. 2, 1995, pp. 831-841. PUBMED: 7635977
  2. Chu et al., Approaching an Error-Free Diploid Human Genome Assembly of East Asian Origin, (misc) bioRxivorg, 2025, DOI: 10.1101/2025.08.01.667781
  3. Chu et al., Direct Submission, Computational Biology, Beijing Institute of Genomics, Chinese Academy of Sciences / China National Center for Bioinformation. Submitted (16-AUG-2025). NGDC, Beijing, 100101, China.
  4. de Wildt R.M.T. et al., Analysis of heavy and light chain pairings indicates that receptor editing shapes the human antibody repertoire, J. Mol. Biol, vol. 285, no. 3, 1999, pp. 895-901. DOI: 10.1006/jmbi.1998.2396
  5. Feeney A.J, New alleles of human immunoglobulin kappa J segments IGKJ2 and IGKJ4, Immunogenetics, vol. 51, no. 6, 2000, pp. 487-488. DOI: 10.1007/s002510050647
  6. Giachino C. et al., k+l+ dual receptor B cells are present in the human peripheral repertoire, Unpublished.
  7. Giachino C. et al., kappa+lambda+ dual receptor B cells are present in the human peripheral repertoire, J. Exp. Med, vol. 181, no. 3, 1995, pp. 1245-1250. DOI: 10.1084/jem.181.3.1245
  8. He et al., T2T YAO: A Telomere to telomere Assembled Diploid Reference Genome for Han Chinese, Genomics Proteomics & Bioinformatics 21(6): 1085–1100 (2023), DOI: 10.1016/j.gpb.2023.08.001
  9. Hieter P.A. et al., Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments, Cell, vol. 22, no. 1 Pt 1, 1980, pp. 197-207. DOI: 10.1016/0092-8674(80)90168-3
  10. Hieter P.A. et al., Evolution of human immunoglobulin kappa J region genes, J. Biol. Chem, vol. 257, no. 3, 1982, pp. 1516-1522. PUBMED: 6276389
  11. Hillier,L.W. et al., Generation and annotation of the DNA sequences of human chromosomes 2 and 4, Nature, vol. 434, no. 7034, 2005, pp. 724-731. PUBMED: 15815621
  12. Huber C. et al., Ongoing V kappa-J kappa recombination after formation of a productive V kappa-J kappa coding joint, Eur. J. Immunol, vol. 22, no. 6, 1992, pp. 1561-1565. PUBMED: 1601042
  13. Kato S, Homo sapiens Ig kappa light chain gene, J-region, Unpublished.
  14. Kato S. et al., Genetic recombination in a chromosomal translocation t(2;8) (p11;q24) of a Burkitt's lymphoma cell line, KOBK101, Unpublished.
  15. Lander,E.S. et al., Initial sequencing and analysis of the human genome, Nature, vol. 409, no. 6822, 2001, pp. 860-921. PUBMED: 11237011
  16. Liao W.W. et al., A draft human pangenome reference, Nature, vol. 617, no. 7960, 2023, pp. 312-324. PUBMED: 37165242
  17. Manheimer-Lory A.J, Lupus-specific antibodies reveal an altered pattern of somatic mutation, Unpublished.
  18. Nurk S. et al., The complete sequence of a human genome, Science, vol. 376, no. 6588, 2022, pp. 44-53. PUBMED: 35357919
  19. Sahota S.S. et al., Myeloma VL gene sequences reveal somatic hypermutation with intraclonal homogeneity, and a role for VL in antigen selection, Unpublished.
  20. Stueber F. and Schroeder H.W, Unpublished.
  21. Whitehurst C. et al., Nucleotide sequence of the intron of the germline human kappa immunoglobulin gene connecting the J and C regions reveals a matrix association region (MAR) next to the enhancer, Nucleic Acids Res, vol. 20, no. 18, 1992, pp. 4929-4930. DOI: 10.1093/nar/20.18.4929