Citing IMGT dynamic tools: Sanou G., Zeitoun G. et al. IMGT® at scale: FAIR, Dynamic and Automated Tools for Immune Locus Analysis, Nucleic Acids Research. 2025;,gkaf1024. doi: 10.1093/nar/gkaf1024 (Free Article) PMID: 41091930.
Program version: v. 

Add information about removed genes/alleles.
May 15th, 2025.

Add the possibility to obtain a gene table per strain (for mouse now and for other species later) and allotypes/isotypes for human.
September 25th, 2024.

Bibliographical references in alphabetic order, small design changes and addition of "NL" for non-localized gene.
June 14th, 2024.

Addition of 'Score for IMGT allele confirmation' as well as NCBI TPA accession numbers.
September 20th, 2023.

Implementation of the dynamic gene table.

Gene table legend:

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene, when the data have been confirmed by several studies.

Functionality is shown in parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.

IMGT allele confirmation: A scoring system is employed to indicate the number of IMGT/LIGM-DB reference sequences and other sequences from the literature in which an IG or TR gene allele has been identified and annotated.

Removed genes/alleles
If a gene/allele existence or name has to be changed, the old name or gene/allele would be deleted and its name won't be reused. They are kept in the gene table for historical reasons.
A single star ()
indicates that an IG or TR gene allele is annotated in the reference sequence only.
Two stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in one sequence from the literature.
Three stars ()
indicate that an IG or TR gene allele is annotated in its reference sequence and in at least two sequences from the literature.
In the Excel file, the stars are represented by the plus symbol (+).

Click on:
  • IMGT gene name to get the corresponding IMGT/GENE-DB entry (link).
  • IMGT allele name to see the corresponding Alignments of alleles (link).
  • Accession number to get the corresponding IMGT/LIGM-DB entry (link).
  • MAP: mapped sequences. Click to access GENE-DB «LOCALIZATION IN GENOME ASSEMBLIES» (link).
  • [number] to access the corresponding IMGT reference (popover).
  • (number) to see the corresponding IMGT note (popover).
Options:
  • You can show/hide columns (), download data () or put the table in fullscreen () using buttons.
See also (IMGT Scientific chart):
Select a species and a IMGT group to get the gene table:
Only IMGT available species/group are shown in the drop-down list.
The gene table can take several seconds to appear, please be patient.

The 7 human (Homo sapiens) IGKV subgroups belong to three clans (Figure IGKV clans). Clans comprise, respectively:

IGKV gene names are designated by a number for the subgroup, followed by a dash and a number for the localization from 3' to 5' in the locus. The IGKV genes of the distal duplicated V-CLUSTER are designated by the same number as the corresponding genes in the proximal V-CLUSTER, with the letter D added.

Gene table of human (Homo sapiens) IGKV IMGT group:
IMGT sub­groupIMGT gene nameIMGT allele nameScore for
IMGT allele
confirmation		FctChromosomosal
localization		R T PrIMGT/LIGM-DB reference sequencesIMGT/LIGM-DB sequences from the literature
Clone namesAccession
numbers		Positions
in the sequence
(L-V-GENE-UNIT)
or V-REGION (*)		Secondary
accession
numbers		Clone namesAccession
numbers		Positions
in the sequence
(L-V-GENE-UNIT)
or V-REGION (*)
IGKV1IGKV1-5 IGKV1-5*01 F 2p11.2
RTPr
++
 L12 Z00001 [2,25,26] 488-774 * HK102 J00245 [2] 313-599 *
IGKV1IGKV1-5 IGKV1-5*02 F 2p11.2 V1 M23851 [26] 483-769 *
IGKV1IGKV1-5 IGKV1-5*03 F 2p11.2
RTPr
+++
 IMGT000281 [39] MAP 1844151-1844656 IMGT000273 [33] 1857687-1858192
IMGT000305 [9,20] 1794962-1795467
IMGT000308 [9,20] 1784176-1784681
L12a X72813 [23] 45-331 *
IGKV1IGKV1-5 IGKV1-5*04 F 2p11.2 MW316670 [38] 73-578 ABC9_3_5_000043998700_O9 OL352712 [45] complement(20146-20651)
IGKV1IGKV1-5 IGKV1-5*05 F 2p11.2 MW316676 [38] 73-578
IGKV1IGKV1-6 IGKV1-6*01 F 2p11.2
RTPr
++
 L11(Vf) M64858 [49] MAP 323-609 * IMGT000273 [33] 1838730-1839230
IMGT000281 [39] 1825188-1825694
IMGT000305 [9,20] 1775999-1776505
IMGT000308 [9,20] 1765214-1765720
OL352720 [45] complement(411-917)
DPK3 X93621 [14] 1-287 *
IGKV1IGKV1-6 IGKV1-6*02 F 2p11.2
RTPr
++
 KM455558 [60] MAP 1-501
IGKV1IGKV1D-7-1 IGKV1D-7-1*01 F 2p11.2 IGKV1-NL1 IMGT000273 [33] complement(23560-24064) IGKV1-NL1 Y14865 [27] 351-637 *
IGKV1IGKV1-8 IGKV1-8*01 F (38) 2p11.2
RTPr
++
 L9(Ve) Z00014 [43,52] MAP 957-1456 K02097 [43] IMGT000273 [33] 1812585-1813084
IMGT000281 [39] 1799058-1799557
IMGT000305 [9,20] 1749859-1750358
IMGT000308 [9,20] 1739076-1739575
KM455559 [60] 103-602
MW316672 [38] 328-827
OL352717 [45] complement(17748-18247)
IGKV1IGKV1-8 IGKV1-8*02 F 2p11.2 MW316669 [38] 322-827 ABC11_2_1_000047367100_G10 OL352715 [45] complement(23510-24015)
IGKV1IGKV1-8 IGKV1-8*03 F 2p11.2 MW316671 [38] 322-827
IGKV1IGKV1-8 IGKV1-8*04 F 2p11.2 ABC13_11_000049760000_M18 OL352720 [45] complement(26577-27076)
IGKV1IGKV1D-8 IGKV1D-8*01 F 2p11.2
RTPr
++
 L24(Ve";V13;Q3) Z00008 [26,61] 495-781 * IMGT000273 [33] complement(48422-48708) *
IMGT000305 [9,20] complement(23958-24462)
L24a X72819 [23] 295-579 *
DPK10 X93628 [14] 1-287 *
IGKV1IGKV1D-8 IGKV1D-8*02 F 2p11.2 KM455563 [60] MAP 1-499 IMGT000281 [39] complement(23959-24409)
IMGT000308 [9,20] complement(23986-24484)
IGKV1IGKV1D-8 IGKV1D-8*03 F 2p11.2 KM455567 [60] 1-505
IGKV1IGKV1D-8 IGKV1D-8*04 (F) (1) 2p11.2
RTPr
++
 IGKV1D-8*01_S8780 MK308861 [59] (39) #c 1-287 *
IGKV1IGKV1-9 IGKV1-9*01 F (40) 2p11.2
RTPr
++
 L8(Vd) Z00013 [43,52] MAP 690-1195 K02096 [43] IMGT000273 [33] 1795006-1795511
IMGT000281 [39] 1781479-1781984
IMGT000305 [9,20] 1732280-1732785
IMGT000308 [9,20] 1721499-1722004
DPK8 X93626 [14] 1-287 *
IGKV1IGKV1-9 IGKV1-9*02 F 2p11.2 ABC14_3_1_000001132522_A14 OL352717 [45] complement(35319-35824)
IGKV1IGKV1-9 IGKV1-9*03 F 2p11.2 ABC9_3_5_000043887700_E3 OL352723 [45] complement(9682-10187)
IGKV1IGKV1-12 IGKV1-12*01 F 2p11.2
RTPr
+++
 L5 V01577 [23,43,52] MAP 1170-1674 IMGT000273 [33] 1764754-1765258
IMGT000281 [39] 1751233-1751737
IMGT000305 [9,20] 1702035-1702539
IMGT000308 [9,20] 1691253-1691757
Vb K02094 [43] 1359-1645 *
DPK5 X93623 [14] 1-287 *
IGKV1IGKV1-12 IGKV1-12*02 F 2p11.2
RTPr
++
 L5/19a(V4b;Vb') V01576 [25,43] (41,42) 1361-1647 *
IGKV1IGKV1D-12 IGKV1D-12*01 F 2p11.2
RTPr
++
 L19(Vb") X17263 [23,42] (41) 321-607 * IMGT000273 [33] complement(109457-109961)
IMGT000305 [9,20] complement(85019-85523)
DPK6 X93624 [14] 1-287 *
IGKV1IGKV1D-12 IGKV1D-12*02 F 2p11.2 IMGT000281 [39] MAP complement(85012-85517) IMGT000308 [9,20] complement(85030-85535)
L5/19a(V4b;Vb') V01576 [25,43] (41,42) 1361-1647 *
IGKV1IGKV1-13 IGKV1-13*01 P (43) 2p11.2 L4(Va) Z00010 [43,52] MAP 427-933 K02093 [43] IMGT000273 [33] 1758985-1759491
IMGT000281 [39] 1745465-1745971
IMGT000305 [9,20] 1696267-1696773
IMGT000308 [9,20] 1685485-1685991
DPK31 X93647 [14] 1-287 *
IGKV1IGKV1-13 IGKV1-13*02 F (44) 2p11.2
RTPr
+++
 L4/18a(V4a;Va') Z00006 [25,43] 939-1225 * K02098 [43]
IGKV1IGKV1D-13 IGKV1D-13*01 F (2) 2p11.2
RTPr
++
 L18(Va") X17262 [23,42] 322-608 * IMGT000273 [33] complement(115223-115729)
IMGT000305 [9,20] complement(90785-91291)
IGKV1IGKV1D-13 IGKV1D-13*02 F 2p11.2 KM455562 [60] MAP 1-501 IMGT000281 [39] complement(90773-91273)
IMGT000308 [9,20] complement(90791-91291)
IGKV1IGKV1-16 IGKV1-16*01 F 2p11.2
RTPr
+++
 L1(HK137;Q14) J00248 [3] 322-608 *
IGKV1IGKV1-16 IGKV1-16*02 F 2p11.2
RTPr
++
 IMGT000281 [39] MAP 1691601-1692106 FM164406 [11] ° 1-287 *
IMGT000273 [33] 1705123-1705628
IMGT000305 [9,20] 1642404-1642909
IMGT000308 [9,20] 1631624-1632129
IGKV1IGKV1D-16 IGKV1D-16*01 F 2p11.2
RTPr
++
 L15(HK166;Q13) K01323 [3] MAP 131-636 IMGT000273 [33] complement(169062-169567)
IMGT000281 [39] complement(144608-145113)
IMGT000305 [9,20] complement(144629-145134)
IMGT000308 [9,20] complement(144626-145131)
HK134 X92329 [3] 322-608 *
DPK7 X93625 [14] 1-287 *
IGKV1IGKV1D-16 IGKV1D-16*02 F 2p11.2
RTPr
+
 L15a(HK101) V00558 [2,23] 322-608 * HK146 K01322 [3] 322-608 *
HK189 K01324 [3] 322-608 *
IGKV1IGKV1-17 IGKV1-17*01 F 2p11.2
RTPr
+++
 A30 X72808 [23] MAP 397-902 A30 D88254 [56] 889-1175 *
IMGT000273 [33] 1687640-1688145
IMGT000281 [39] 1674119-1674624
IMGT000305 [9,20] 1624922-1625427
IMGT000308 [9,20] 1614141-1614646
SG3 X92334 [19] 19-287 *
IGKV1IGKV1-17 IGKV1-17*02 F 2p11.2
RTPr
++
 A30 D88255 [56] 842-1128 *
IGKV1IGKV1-17 IGKV1-17*03 F 2p11.2
RTPr
++
 KM455566 [60] 1-500 FM164407 [11] (45) ° 1-287 *
IGKV1IGKV1D-17 IGKV1D-17*01 F 2p11.2
RTPr
++
 L14(Q4) X63392 [22,32] MAP 986-1491 IMGT000273 [33] complement(186509-187014)
IMGT000281 [39] complement(162055-162560)
IMGT000305 [9,20] complement(162077-162582)
IMGT000308 [9,20] complement(162073-162578)
DPK2 Z27498 [14] 1-287 *
IGKV1IGKV1-22 IGKV1-22*01 P (3) 2p11.2 A25 X71885 [47] MAP 2665-3162 IMGT000273 [33] 1634239-1634736
IMGT000305 [9,20] 1571539-1572036
IMGT000308 [9,20] 1560746-1561243
ABC11_000047249200_N16 OL352729 [45] complement(16573-17070)
IGKV1IGKV1-22 IGKV1-22*02 P (4) 2p11.2 IMGT000281 [39] MAP 1620731-1621228
IGKV1IGKV1D-22 IGKV1D-22*01 P (5) 2p11.2 A9 X71887 [47] MAP 2664-3161 IMGT000273 [33] complement(258577-259074)
IMGT000281 [39] complement(234185-234682)
IMGT000305 [9,20] complement(234186-234683)
IMGT000308 [9,20] complement(234191-234688)
IGKV1IGKV1-27 IGKV1-27*01 F (46) 2p11.2
RTPr
++
 A20(Y2) X63398 [32] MAP 323-827 IMGT000281 [39] 1578045-1578549
IMGT000305 [9,20] 1528859-1529363
IMGT000308 [9,20] 1518064-1518568
DPK4 X93622 [14] 1-287 *
IGKV1IGKV1-27 IGKV1-27*02 F 2p11.2 ABC9_3_5_000045486800_B7 OL352710 [45] complement(6960-7464) IMGT000273 [33] 1591558-1592062
IGKV1IGKV1-27 IGKV1-27*03 F 2p11.2 ABC13_11_000001008122_I9 OL352716 [45] complement(13259-13763)
IGKV1IGKV1D-27 IGKV1D-27*01 P (6) 2p11.2 A4(A4a;V52) Z00004 [25,26] MAP 525-1030 M23848 #g [26] IMGT000281 [39] complement(276053-276558)
IMGT000305 [9,20] complement(276052-276557)
IMGT000308 [9,20] complement(276058-276563)
DPK30 X93646 [14] 1-288 *
IGKV1IGKV1D-27 IGKV1D-27*02 P (7) 2p11.2 IMGT000273 [33] complement(300448-300953)
IGKV1IGKV1-32 IGKV1-32*01 P (8) 2p11.2 A15 X71883 [47] MAP 560-1054 IMGT000273 [33] 1551445-1551939
IMGT000281 [39] 1537922-1538416
IMGT000305 [9,20] 1488736-1489230
IMGT000308 [9,20] 1477943-1478437
HK100 J00250 [2,4] 315-607 *
A15a V00560 [2] 248-540 *
DPK35 (47) X93651 [14] 1-293 *
IGKV1IGKV1D-32 IGKV1D-32*01 P (9) 2p11.2 O9 X71896 MAP 578-1072 IMGT000281 [39] complement(316503-316997)
IMGT000305 [9,20] complement(316484-316978)
IMGT000308 [9,20] complement(316521-317015)
IGKV1IGKV1D-32 IGKV1D-32*02 P (10) 2p11.2 IMGT000273 [33] complement(340889-341383)
IGKV1IGKV1-33 IGKV1-33*01 F 2p11.2
RTPr
+++
 O18 M64856 [49] MAP 131-635 IMGT000273 [33] 1536515-1537019
IMGT000281 [39] 1523136-1523640
IMGT000305 [9,20] 1473754-1474258
IMGT000308 [9,20] 1462893-1463397
018a M64857 [49] 1334-1618 *
DPK1 (47) X93620 [14] <1->287 *
IGKV1IGKV1D-33 IGKV1D-33*01 F 2p11.2
RTPr
++
 O8 M64855 [49] MAP (41) 131-635 IMGT000273 [33] complement(355856-356360)
IMGT000281 [39] complement(331110-331614)
IMGT000305 [9,20] complement(331094-331598)
IMGT000308 [9,20] complement(331130-331634)
DPK1 (47) X93620 [14] <1->287 *
IGKV1IGKV1-35 IGKV1-35*01 P (11) 2p11.2 O16(Q1) X71890 [47] MAP 456-959 IMGT000273 [33] 1517821-1518324
IMGT000281 [39] 1504441-1504944
IMGT000305 [9,20] 1455060-1455563
IMGT000308 [9,20] 1444200-1444703
IGKV1IGKV1-35 IGKV1-35*02 P (48) 2p11.2 O6/16a(V55) Z00005 [25,26] (42) 163-449 *
IGKV1IGKV1D-35 IGKV1D-35*01 P (11) 2p11.2 O6 X71894 MAP 121-624 IMGT000281 [39] complement(349867-350370)
IMGT000305 [9,20] complement(349850-350353)
IMGT000308 [9,20] complement(349888-350391)
IGKV1IGKV1D-35 IGKV1D-35*02 P (48) 2p11.2 O6/16a(V55) Z00005 [25,26] (42) 163-449 *
IGKV1IGKV1D-35 IGKV1D-35*03 P (12) 2p11.2 IMGT000273 [33] complement(374564-375067)
IGKV1IGKV1-37 IGKV1-37*01 ORF (13) 2p11.2
RTPr
++
 O14(Q5) X59316 [40] MAP 356-860 IMGT000273 [33] 1507253-1507757
IMGT000281 [39] 1493873-1494377
IMGT000305 [9,20] 1444492-1444996
IMGT000308 [9,20] 1433632-1434136
O4/14a(DILp1) X70466 [37] (42) 1->285 *
DPK11 (47) X93629 [14] 1-287 *
IGKV1IGKV1D-37 IGKV1D-37*01 ORF (14) 2p11.2
RTPr
+
 O4 X71893 [47] MAP (41) 437-941 IMGT000273 [33] complement(385138-385642)
IMGT000281 [39] complement(360440-360944)
IMGT000305 [9,20] complement(360419-360923)
IMGT000308 [9,20] complement(360461-360965)
O4/14a(DILp1) X70466 [37] (42) 1->285 *
DPK11 (47) X93629 [14] 1-287 *
IGKV1IGKV1-39 IGKV1-39*01 F 2p11.2
RTPr
+++
 O12 X59315 [15,40] MAP 134-638 IMGT000273 [33] 1485018-1485522
IMGT000281 [39] 1471511-1472015
IMGT000305 [9,20] 1422129-1422633
IMGT000308 [9,20] 1411267-1411771
DPK9 (47) X93627 [14] 1-287 *
IGKV1IGKV1-39 IGKV1-39*02 P (49) 2p11.2 O12a(V3b) X59318 [40] 841-1127 *
IGKV1IGKV1D-39 IGKV1D-39*01 F 2p11.2
RTPr
++
 O2 X59312 [15,40] MAP (41) 134-638 IMGT000273 [33] complement(407386-407890)
IMGT000281 [39] complement(382676-383180)
IMGT000305 [9,20] complement(382655-383159)
IMGT000308 [9,20] complement(382837-383341)
DPK9 (47) X93627 [14] 1-287 *
IGKV1IGKV1-40-1 IGKV1-40-1*01 F 2p11.2 IMGT000281 [39] MAP 1026104-1026602 IMGT000273 [33] 1042565-1043063
IMGT000305 [9,20] 975944-976442
IMGT000308 [9,20] 977204-977702
IGKV1IGKV1D-40-1 IGKV1D-40-1*01 F 2p11.2 IMGT000281 [39] MAP complement(873927-874425) IMGT000273 [33] complement(890657-891155)
IMGT000305 [9,20] complement(823718-824216)
IMGT000308 [9,20] complement(825032-825530)
IGKV1IGKV1D-42 IGKV1D-42*01 ORF (50) 2p11.2 L22 X72816 [23] 391-677 * IMGT000273 [33] complement(79111-79601)
IMGT000305 [9,20] complement(54674-55170)
IGKV1IGKV1D-42 IGKV1D-42*02 ORF (15) 2p11.2 KM455560 [60] MAP 1-491 IMGT000281 [39] complement(54666-55156)
IMGT000308 [9,20] complement(54690-55180)
IGKV1IGKV1D-43 IGKV1D-43*01 F 2p11.2
RTPr
+
 L23(Q2) X72817 [23] MAP 150-655 IMGT000273 [33] complement(59247-59752)
IMGT000281 [39] complement(34812-35317)
IMGT000305 [9,20] complement(34810-35315)
IMGT000308 [9,20] complement(34839-35344)
L23a X72818 [23] 290-574 *
IGKV2IGKV2-4 IGKV2-4*01 P (51) 2p11.2 L13(Q6) X72814 [23] MAP 569-1326 IMGT000273 [33] 1873085-1873842
IMGT000281 [39] 1859549-1860306
IMGT000305 [9,20] 1810360-1811117
IMGT000308 [9,20] 1799574-1800331
IGKV2IGKV2-4 IGKV2-4*02 P (16) 2p11.2 ABC9_3_5_000043998700_O9 OL352712 [45] complement(4495-5252)
IGKV2IGKV2-10 IGKV2-10*01 P (52) 2p11.2 L7 Z00012 [43] MAP 121-842 IMGT000273 [33] 1784776-1785497
IMGT000281 [39] 1771251-1771972
IMGT000305 [9,20] 1722053-1722774
IMGT000308 [9,20] 1711271-1711992
Vc K02095 [43] 212-512 *
IGKV2IGKV2-10 IGKV2-10*02 P (17) 2p11.2 ABC9_3_5_000043887700_E3 OL352723 [45] complement(19669-20388)
IGKV2IGKV2D-10 IGKV2D-10*01 P (52) 2p11.2 L21(Vc") X17265 [23,42] MAP 122-915 IMGT000273 [33] complement(89148-89941)
IMGT000281 [39] complement(64692-65485)
IMGT000305 [9,20] complement(64715-65508)
IMGT000308 [9,20] complement(64712-65505)
IGKV2IGKV2-14 IGKV2-14*01 P (53) 2p11.2 L3(Q12) X72810 [23] MAP 191-984 IMGT000273 [33] 1726668-1727461
IMGT000281 [39] 1713148-1713941
IMGT000305 [9,20] 1663950-1664743
IMGT000308 [9,20] 1653168-1653961
OL352711 [45] complement(23619-24412)
IGKV2IGKV2D-14 IGKV2D-14*01 P (53) 2p11.2 L17(Vz") X72811 [23] MAP 221-1014 IMGT000273 [33] complement(147246-148039)
IMGT000281 [39] complement(122797-123590)
IMGT000305 [9,20] complement(122808-123601)
IMGT000308 [9,20] complement(122815-123608)
IGKV2IGKV2-18 IGKV2-18*01 P (54) 2p11.2 A29 X63400 [32] MAP 341-1147 IMGT000273 [33] 1675969-1676775
IMGT000281 [39] 1662461-1663267
IMGT000305 [9,20] 1613264-1614070
IMGT000308 [9,20] 1602470-1603276
DPK27 X93643 [14] 1-302 *
IGKV2IGKV2D-18 IGKV2D-18*01 P (54) 2p11.2 A13 X63395 [32] MAP 308-1114 IMGT000273 [33] complement(216439-217245)
IMGT000281 [39] complement(191986-192792)
IMGT000305 [9,20] complement(192006-192812)
IMGT000308 [9,20] complement(192010-192816)
IGKV2IGKV2-19 IGKV2-19*01 P (55) 2p11.2 A28 X12692 [53] MAP 823-1080 * IMGT000273 [33] 1670213-1670470 *
IMGT000305 [9,20] 1607508-1607765 *
IMGT000308 [9,20] 1596714-1596971 *
IGKV2IGKV2D-19 IGKV2D-19*01 P (18) 2p11.2 A12 X71882 [47] MAP 441-701 * IMGT000273 [33] complement(222771-223031) *
IMGT000281 [39] complement(198316-198576) *
IMGT000305 [9,20] complement(198335-198595) *
IMGT000308 [9,20] complement(198340-198600) *
IGKV2IGKV2-23 IGKV2-23*01 P (19) 2p11.2 A24 X71885 [47] MAP 1338-1549 * IMGT000273 [33] 1632912-1633123 *
IMGT000281 [39] 1618900-1619936
IMGT000305 [9,20] 1570212-1570423 *
IMGT000308 [9,20] 1559419-1559630 *
ABC11_000047249200_N16 OL352729 [45] complement(18186->18397) *
IGKV2IGKV2D-23 IGKV2D-23*01 P (19) 2p11.2 A8 X71887 [47] MAP 1337-1549 * IMGT000273 [33] complement(260189-260401) *
IMGT000281 [39] complement(235477-236512)
IMGT000305 [9,20] complement(235798-236010) *
IMGT000308 [9,20] complement(235803-236015) *
IGKV2IGKV2-24 IGKV2-24*01 F 2p11.2
RTPr
++
 A23 X12684 [53] MAP 154-986 IMGT000273 [33] 1628321-1629153
IMGT000281 [39] 1614813-1615645
IMGT000305 [9,20] 1565621-1566453
IMGT000308 [9,20] 1554828-1555660
DPK16 X93633 [14] 1-302 *
IGKV2IGKV2-24 IGKV2-24*02 F 2p11.2 ABC11_000047249200_N16 OL352729 [45] complement(22148-22980)
IGKV2IGKV2D-24 IGKV2D-24*01 ORF (20) 2p11.2
RTPr
+
 A7 X63401 [32] MAP 185-1017 IMGT000273 [33] complement(264158-264990)
IMGT000281 [39] complement(239764-240596)
IMGT000305 [9,20] complement(239765-240597)
IMGT000308 [9,20] complement(239770-240602)
DPK17 X93634 [14] 1-302 *
IGKV2IGKV2-26 IGKV2-26*01 P (21) 2p11.2
RTPr
+
 A21 X71884 [47] MAP 505-1285 IMGT000273 [33] 1608621-1609402
IMGT000281 [39] 1595110-1595891
IMGT000305 [9,20] 1545924-1546705
IMGT000308 [9,20] 1535129-1535910
IGKV2IGKV2D-26 IGKV2D-26*01 F (56) 2p11.2
RTPr
+
 cos142 AP001216 [50] 30326-31106 A5 X12689 [53] 562-862 *
IGKV2IGKV2D-26 IGKV2D-26*02 F 2p11.2
RTPr
+
 DPK14 Z27499 [13,14] 1-302 *
IGKV2IGKV2D-26 IGKV2D-26*03 F 2p11.2 KM455565 [60] MAP 1-781 IMGT000281 [39] complement(258695-259475)
IMGT000305 [9,20] complement(258692-259472)
IMGT000308 [9,20] complement(258697-259477)
IGKV2IGKV2D-26 IGKV2D-26*04 F 2p11.2 IMGT000273 [33] complement(283097-283877)
IGKV2IGKV2-28 IGKV2-28*01 F 2p11.2
RTPr
+++
 A19(Q7) X63397 [32] MAP 305-1068 IMGT000273 [33] 1583028-1583791
IMGT000281 [39] 1569511-1570274
IMGT000305 [9,20] 1520321-1521084
IMGT000308 [9,20] 1509530-1510293
ABC9_3_5_000045486800_B7 OL352710 [45] complement(15255-16018)
ABC13_11_000001008122_I9 OL352716 [45] complement(21532-22295)
DPK15 (47) X93632 [14] 1-302 *
IGKV2IGKV2D-28 IGKV2D-28*01 F 2p11.2
RTPr
++
 A3 X12691 [53] MAP (41) 304-1067 IMGT000273 [33] complement(309034-309797)
IMGT000305 [9,20] complement(284650-285413)
IMGT000308 [9,20] complement(284658-285421)
DPK15 (47) X93632 [14] 1-302 *
RR25gl Z46616 [17,18] 1->300 *
IGKV2IGKV2D-28 IGKV2D-28*02 F 2p11.2 IMGT000281 [39] MAP complement(284645-285408)
IGKV2IGKV2-29 IGKV2-29*01 P (57) 2p11.2
RTPr
++
 A18(A18a) X63396 [32] MAP 322-1078 IMGT000273 [33] 1570548-1571304
IMGT000281 [39] 1557031-1557787
IMGT000305 [9,20] 1507840-1508596
IMGT000308 [9,20] 1497050-1497806
OL352716 [45] complement(34016-34771)
DPK28 X93644 [14] 1-302 *
IGKV2IGKV2-29 IGKV2-29*02 F 2p11.2
RTPr
++
 A18b U41645 [1] 587-888 * OL352710 [45] complement(27743-28499)
IGKV2IGKV2-29 IGKV2-29*03 F 2p11.2
RTPr
++
 A18c (58) AJ783437 [28] 1-302 * A18d N/D Unknown
IGKV2IGKV2D-29 IGKV2D-29*01 F 2p11.2
RTPr
+++
 A2(A2a) M31952 [46,48] MAP 324-1081 IMGT000281 [39] complement(297124-297881)
IMGT000305 [9,20] complement(297129-297886)
IMGT000308 [9,20] complement(297137-297894)
DPK12 X93630 [14] 1-302 *
IGKV2IGKV2D-29 IGKV2D-29*02 F (59) 2p11.2
RTPr
++
 A2c U41644 [1] 585-886 * IMGT000273 [33] complement(321514-322271)
IGKV2IGKV2-30 IGKV2-30*01 F 2p11.2
RTPr
+++
 A17 X63403 [32] MAP 898-1713 IMGT000273 [33] 1559892-1560707
IMGT000281 [39] 1546374-1547189
IMGT000305 [9,20] 1497185-1498000
IMGT000308 [9,20] 1486394-1487209
DPK18 X93635 [14] 1-302 *
IGKV2IGKV2-30 IGKV2-30*02 [F] (22) 2p11.2
RTPr
++
 FM164408 [11] ° 1-302 *
IGKV2IGKV2D-30 IGKV2D-30*01 F 2p11.2
RTPr
++
 A1 X63402 [32] MAP 507-1322 IMGT000273 [33] complement(332103-332918)
IMGT000281 [39] complement(307714-308529)
IMGT000305 [9,20] complement(307719-308534)
IMGT000308 [9,20] complement(307727-308542)
DPK19 X93636 [14] 1-302 *
IGKV2IGKV2-36 IGKV2-36*01 P (23) 2p11.2 O15(Q8) X71889 [47] 144-377 *
IGKV2IGKV2-36 IGKV2-36*02 P (24) 2p11.2 IMGT000100 [21,31] MAP <949912->950145 * IMGT000273 [33] 1509534-1509767 *
IMGT000281 [39] 1496154-1496387 *
IMGT000305 [9,20] 1446773-1447006 *
IMGT000308 [9,20] 1435913-1436146 *
IGKV2IGKV2D-36 IGKV2D-36*01 P (25) 2p11.2 O5 X71893 [47] MAP <2718->2951 * IMGT000273 [33] complement(383127-383360) *
IMGT000281 [39] complement(358430-358663) *
IMGT000305 [9,20] complement(358409-358642) *
IMGT000308 [9,20] complement(358451-358684) *
IGKV2IGKV2-38 IGKV2-38*01 P (26) 2p11.2 O13 X71888 [47] 580-819 *
IGKV2IGKV2-38 IGKV2-38*02 P (27) 2p11.2 IMGT000100 [21,31] MAP <935227-935468 * IMGT000273 [33] 1494976-1495217 *
IMGT000281 [39] 1481469-1481710 *
IMGT000305 [9,20] 1432090-1432331 *
IMGT000308 [9,20] 1421224-1421465 *
IGKV2IGKV2D-38 IGKV2D-38*01 P (26) 2p11.2 O3 X71892 [47] MAP 872-1111 * IMGT000273 [33] complement(397692-397931) *
IMGT000281 [39] complement(372983-373222) *
IMGT000305 [9,20] complement(372962-373201) *
IMGT000308 [9,20] complement(373141-373380) *
IGKV2IGKV2-40 IGKV2-40*01 F 2p11.2
RTPr
++
 O11 X59314 [40] MAP 889-1652 IMGT000273 [33] 1474268-1475031
IMGT000281 [39] 1460762-1461525
IMGT000305 [9,20] 1411379-1412142
IMGT000308 [9,20] 1400517-1401280
DPK13 (47) X93631 [14] 1-305 *
IGKV2IGKV2-40 IGKV2-40*02 F 2p11.2
RTPr
++
 O11a(V3a) X59317 [40] <1-251 *
IGKV2IGKV2D-40 IGKV2D-40*01 F 2p11.2
RTPr
++
 O1 X59311 [40] MAP (41) 146-909 IMGT000281 [39] complement(393167-393930)
IMGT000305 [9,20] complement(393144-393907)
IMGT000308 [9,20] complement(393325-394088)
DPK13 (47) X93631 [14] 1-305 *
IGKV2IGKV2D-40 IGKV2D-40*02 F 2p11.2 IMGT000273 [33] complement(417875-418638)
IGKV3IGKV3-7 IGKV3-7*01 ORF (60) 2p11.2
RTPr
+
 L10(kv3h) X02725 [23,41] 363-652 *
IGKV3IGKV3-7 IGKV3-7*02 ORF (60) 2p11.2 L10a X72812 [23] 363-652 *
IGKV3IGKV3-7 IGKV3-7*03 ORF (60) 2p11.2 Vh K02769 [41] 363-652 *
IGKV3IGKV3-7 IGKV3-7*04 ORF (28) 2p11.2 ABC14_3_1_000001132522_A14 OL352717 [45] MAP complement(3806-4352) FM164409 [12] ° 1-290 *
IMGT000273 [33] 1826479-1827025
IMGT000281 [39] 1812951-1813497
IMGT000305 [9,20] 1763753-1764299
IMGT000308 [9,20] 1752968-1753514
IGKV3IGKV3-7 IGKV3-7*05 ORF (28) 2p11.2 ABC11_2_1_000047367100_G10 OL352715 [45] complement(9599-10145)
IGKV3IGKV3-7 IGKV3-7*06 ORF (28) 2p11.2 ABC13_11_000049760000_M18 OL352720 [45] complement(12622-13176)
IGKV3IGKV3D-7 IGKV3D-7*01 F 2p11.2 L25(V138;Q9) X72820 [23] MAP 441-1002 IMGT000273 [33] complement(9684-10245)
IMGT000281 [39] complement(9971-10532)
IMGT000305 [9,20] complement(9973-10534)
IMGT000308 [9,20] complement(10001-10562)
DPK23 Z27500 [13,14] 1-290 *
IGKV3IGKV3-11 IGKV3-11*01 F 2p11.2
RTPr
++
 L6 X01668 [23,41] MAP 134-677 IMGT000273 [33] 1777772-1778315
IMGT000281 [39] 1764247-1764790
IMGT000305 [9,20] 1715049-1715592
IMGT000308 [9,20] 1704267-1704810
13K20/13K23 L37726 [24] 1->268 *
OL352723 [45] complement(26839-27382)
38K/L6a X92342 [29] 1-285 *
IGKV3IGKV3-11 IGKV3-11*02 F 2p11.2
RTPr
++
 Vg(kv3g) K02768 [41] 363-649 *
IGKV3IGKV3D-11 IGKV3D-11*01 F 2p11.2
RTPr
++
 L20(Vg";kv3g") X17264 [23,42] 312-598 * IMGT000273 [33] complement(96394-96937)
IMGT000305 [9,20] complement(71956-72499)
13K11/13K12 L37725 [24] 1->268 *
IGKV3IGKV3D-11 IGKV3D-11*02 F 2p11.2 KM455561 [60] MAP 1-544 IMGT000281 [39] complement(71933-72476)
IMGT000308 [9,20] complement(71953-72496)
IGKV3IGKV3D-11 IGKV3D-11*03 F 2p11.2 3A7 L19271 [62] 1-519
IGKV3IGKV3-15 IGKV3-15*01 F 2p11.2
RTPr
+++
 L2(Humkv328h5;Q11) M23090 [34] MAP 676-1219 IMGT000273 [33] 1719762-1720305
IMGT000281 [39] 1706242-1706785
IMGT000305 [9,20] 1657044-1657587
IMGT000308 [9,20] 1646262-1646805
DPK21 X93638 [14] 1-287 *
IGKV3IGKV3-15 IGKV3-15*02 F 2p11.2 ABC13_11_000000946222_P15 OL352711 [45] complement(30775-31318)
IGKV3IGKV3D-15 IGKV3D-15*01 F 2p11.2
RTPr
++
 L16(Q10) X72815 [23] (41) 300-586 * IMGT000273 [33] complement(154390-154933)
IMGT000305 [9,20] complement(129952-130495)
Humkv328/L16b M23088 [34] 905-1189 *
Humkv328h2/L16a M23089 [34] 905-1189 *
Humkv31es Y00640 [7] 95-381 *
IGKV3IGKV3D-15 IGKV3D-15*02 P (61) 2p11.2
RTPr
++
 L16c(Humkv329) M23091 [34] 905-1191 *
IGKV3IGKV3D-15 IGKV3D-15*03 F 2p11.2 KM455564 [60] MAP 1-544 IMGT000281 [39] complement(129947-130490)
IMGT000308 [9,20] complement(129965-130508)
IGKV3IGKV3-20 IGKV3-20*01 F 2p11.2
RTPr
+++
 A27 X12686 [35,53] MAP 108-672 IMGT000273 [33] 1662343-1662907
IMGT000281 [39] 1648835-1649399
IMGT000305 [9,20] 1599638-1600202
IMGT000308 [9,20] 1588844-1589408
A27a(Humkv325) M15038 [44] 432-719 *
Humkv321 M15039 [6] <1-165 *
Tou-kv325 X56593 [58] 13->299 *
DPK22 X93639 [14] 1-290 *
IGKV3IGKV3-20 IGKV3-20*02 F (29) 2p11.2 13K18 L37729 [24] 1->271 *
IGKV3IGKV3D-20 IGKV3D-20*01 F 2p11.2
RTPr
++
 A11 X12687 [35,53] MAP 108-672 IMGT000273 [33] complement(230336-230900)
IMGT000281 [39] complement(205881-206445)
IMGT000305 [9,20] complement(205900-206464)
IMGT000308 [9,20] complement(205905-206469)
Humkv305/A11a M14507 [6] 435-722 *
DPK20 X93637 [14] 1-290 *
IGKV3IGKV3D-20 IGKV3D-20*02 ORF (30) 2p11.2
RTPr
++
 3A9 L19272 [62] (62) 223-512 *
IGKV3IGKV3-25 IGKV3-25*01 P (63) 2p11.2 A22 X06583 [54] MAP 636-2439 IMGT000273 [33] 1612693-1612959 *
IMGT000281 [39] 1597671-1599476
IMGT000305 [9,20] 1548485-1550288
IMGT000308 [9,20] 1537690-1539495
OL352729 [45] complement(38335-38601) *
DPK29 X93645 [14] 1-267 *
IGKV3IGKV3D-25 IGKV3D-25*01 P (63) 2p11.2 A6 X71886 [47] MAP 628-2412 IMGT000273 [33] complement(279571-279829) *
IMGT000281 [39] complement(255141-256927)
IMGT000305 [9,20] complement(255166-255424) *
IMGT000308 [9,20] complement(255143-255429)
IGKV3IGKV3-31 IGKV3-31*01 P (31) 2p11.2 A16 X71883 [47] MAP 1839-2405 IMGT000273 [33] 1552725-1553291
IMGT000281 [39] 1539202-1539768
IMGT000305 [9,20] 1490016-1490582
IMGT000308 [9,20] 1479223-1479789
A16/O10b(Humkv310) M17764 [8] (42) 94-381 *
A16a(Humkv301) M17765 [8] 97-381 *
IGKV3IGKV3D-31 IGKV3D-31*01 P (32) 2p11.2 O10 X71896 1857-2424
IGKV3IGKV3D-31 IGKV3D-31*02 P (33) 2p11.2 IMGT000100 [21,31] MAP complement(315100-315667) IMGT000273 [33] complement(339536-340103)
IMGT000281 [39] complement(315150-315717)
IMGT000305 [9,20] complement(315131-315698)
IMGT000308 [9,20] complement(315168-315735)
A16/O10b(Humkv310) M17764 [8] (42) 94-381 *
IGKV3IGKV3-34 IGKV3-34*01 P (34) 2p11.2 O17 X71891 [47] MAP 588-1148 IMGT000273 [33] 1529203-1529763
IMGT000281 [39] 1515823-1516383
IMGT000305 [9,20] 1466442-1467002
IMGT000308 [9,20] 1455581-1456141
IGKV3IGKV3D-34 IGKV3D-34*01 P (35) 2p11.2 O7 X71895 MAP 588-1148 IMGT000273 [33] complement(363112-363672)
IMGT000281 [39] complement(338366-338926)
IMGT000305 [9,20] complement(338350-338910)
IMGT000308 [9,20] complement(338386-338946)
IGKV4IGKV4-1 IGKV4-1*01 F 2p11.2
RTPr
+++
 B3 Z00023 [30] MAP 98-709 AF017732 [5] (64) complement(34004-34308) *
IMGT000281 [39] complement(1905765-1906376)
IMGT000305 [9,20] complement(1856567-1857178)
IMGT000308 [9,20] complement(1845783-1846394)
HSIGKVZM L33853 [16] 284->586 *
ABC14_4_1_000000985114_K20 OL352726 [45] 9771-10382
VkIV-GL S56916 [57] 1-305 *
DPK24 X93640 [14] 1-305 *
FSA10gl Z46615 [18] 1-303 *
IGKV4IGKV4-1 IGKV4-1*02 F 2p11.2 MW316673 [38] 309-920
IGKV4IGKV4-1 IGKV4-1*03 F 2p11.2 ABC10_2_1_000044246300_H4 OL352714 [45] 21111-21722
IGKV5IGKV5-2 IGKV5-2*01 F 2p11.2
RTPr
++
 B2(EV15) X02485 [51] MAP 304-822 AF017732 [5] (65) complement(22376-22662) *
IMGT000305 [9,20] complement(1844936-1845455)
ABC10_2_1_000044246300_H4 OL352714 [45] 32833-33352
IGKV5IGKV5-2 IGKV5-2*02 F 2p11.2 ABC14_4_1_000000985114_K20 OL352726 [45] MAP 21494-22013 IMGT000281 [39] complement(1894134-1894653)
IMGT000308 [9,20] complement(1834152-1834671)
IGKV6IGKV6-21 IGKV6-21*01 F (66) 2p11.2
RTPr
+
 A26 X63399 [32] MAP 507-1088 IMGT000273 [33] 1645149-1645730
IMGT000281 [39] 1631641-1632222
IMGT000305 [9,20] 1582444-1583025
IMGT000308 [9,20] 1571650-1572231
DPK26 (47) X93642 [14] 1-287 *
IGKV6IGKV6-21 IGKV6-21*02 F 2p11.2 KM455568 [60] 1-582 ABC11_000047249200_N16 OL352729 [45] complement(5584-6165)
IGKV6IGKV6D-21 IGKV6D-21*01 F (67) 2p11.2 A10 X12683 [55] (41) 645-931 * HSIGKAU M27750 [55] 640-926 *
DPK26 (47) X93642 [14] 1-287 *
IGKV6IGKV6D-21 IGKV6D-21*02 F 2p11.2
RTPr
++
 KM455569 [60] MAP 32-613 IMGT000273 [33] complement(247610-248191)
IMGT000281 [39] complement(223203-223784)
IMGT000305 [9,20] complement(223209-223790)
IMGT000308 [9,20] complement(223214-223795)
IGKV6IGKV6D-41 IGKV6D-41*01 ORF (68) 2p11.2 HSIGKAV M27751 [55] MAP (69) 220-800 IMGT000273 [33] complement(199562-200142)
IMGT000281 [39] complement(175108-175688)
IMGT000305 [9,20] complement(175130-175710)
IMGT000308 [9,20] complement(175126-175706)
DPK25 X93641 [14] 1-287 *
IGKV7IGKV7-3 IGKV7-3*01 P (54) 2p11.2 B1 X12682 [36] MAP 683-1311 AF017732 [5] 4786-5084 *
IMGT000305 [9,20] 1827072-1827700
IGKV7IGKV7-3 IGKV7-3*02 P (36) 2p11.2 ABC14_4_1_000000985114_K20 OL352726 [45] MAP complement(39245-39873) IMGT000281 [39] 1876274-1876902
IMGT000308 [9,20] 1816290-1816918
IGKV7IGKV7-3 IGKV7-3*03 P (37) 2p11.2 IMGT000273 [33] 1889796-1890424
IMGT notes: ↑
  1. Inferred functionality:(F)
  2. Initially considered as an ORF, due to a non canonical V-HEPTAMER: CATAGTG instead of CACAGTG [11], has been found rearranged and transcribed in a 'productive' sequence (DQ101035)
  3. Pseudogene because of an insertion, stop codons and frameshifts (K.F. Schable and al., Biol. Chem. Hoppe-Seyler 375:189-199 (1994)), VK1
  4. no CONSERVED-TRP: STOP-CODON instead of Trp, several STOP-CODON in V-REGION, frameshift in V-REGION: insertion of 4 nt in FR3-IMGT
  5. Pseudogene because of stop codons and one insertion (K.F. Schable and al., Biol. Chem. Hoppe-Seyler 375:189-199 (1994)), VK1
  6. Pseudogene, Insertion of 1 bp (g) between codon 70 and 71, leading to a frameshift
  7. frameshift in V-REGION: insertion of 1 nt in FR3-IMGT
  8. Pseudogene because of insertions and deletions leading to frameshifts (K.F. Schable and al., Biol. Chem. Hoppe-Seyler 375:189-199 (1994)), VK1
  9. Pseudogene because of insertions and one deletion (K.F. Schable and al., Biol. Chem. Hoppe-Seyler 375:189-199 (1994)), VK1
  10. STOP-CODON in L-PART1, frameshifts in V-REGION: several insertions and deletions
  11. Pseudogene because of an insertion and a deletion (K.F. Schable and al., Biol. Chem. Hoppe-Seyler 375:189-199 (1994))
  12. frameshifts in V-REGION: deletion of 1 nt and insertion of 1 nt in FR1-IMGT
  13. ORF because 2nd_CYS replaced by a Glycine in FR3-IMGT
  14. because 2nd_CYS replaced by a Glycine
  15. non canonical V-HEPTAMER: cacaggg instead of cacagtg
  16. no INIT-CODON: Val instead of Met
  17. no INIT-CODON: Val instead of Met, frameshifts in V-REGION: several insertions and deletions
  18. 5' part deleted, starts with codon 14 of FR1-IMGT
  19. First fragment of the V-REGION
  20. ORF because 1st-CYS replaced by a Phenylalanine in FR1-IMGT
  21. Pseudogene because of an insertion leading to a frameshift in FR2 (K.F. Schable and al., Biol. Chem. Hoppe-Seyler 375:189-199 (1994))
  22. In the absence of complete sequence the functionality (ORF) has been assigned based on the other alleles
  23. Truncated
  24. truncated pseudogene, no L-PART2, no V-RS
  25. Pseudogene because V-REGION truncated, and stop codon in V-region (K.F. Schable and al., Biol. Chem. Hoppe-Seyler 375:189-199 (1994)), VK2
  26. 5' part of V-REGION truncated
  27. truncated pseudogene, no L-PART2, several STOP-CODON in V-REGION
  28. noncanonical ACCEPTOR-SPLICE: nggnn instead of nagnn
  29. In the ID line RNA should be replaced by DNA, correction asked to EMBL on the 10/01/2001.
  30. Chimeric sequence between IGKV3D-20 in 5', codons 1 to 106, and IGHV3D-11 in 3', codons 107 to 111, and absence of transcripts
  31. Pseudogene because of a deletion leading to a frameshift (K.F. Schable and al., Biol. Chem. Hoppe-Seyler 375:189-199 (1994)), VK3
  32. Pseudogene because of an insertion and a frameshift (K.F. Schable and al., Biol. Chem. Hoppe-Seyler 375:189-199 (1994)), VK3
  33. STOP-CODON in L-PART1, frameshift in V-REGION: deletion of 2 nt in FR1-IMGT
  34. Pseudogene because of stop codons, and insertion in FR3 leading to a frameshift (K.F. Schable and al., Biol. Chem. Hoppe-Seyler 375:189-199 (1994))
  35. Pseudogene because stop codons, and insertion of 1 bp in FR3 (K.F. Schable and al., Biol. Chem. Hoppe-Seyler 375:189-199 (1994))
  36. no INIT-CODON: Ile instead of Met, frameshift in L-PART1: insertion of 1 nt causing defectuous DONOR-SPLICE, frameshift in V-REGION: deletion of 1 nt in FR3-IMGT
  37. no INIT-CODON
  38. Based on a 21 bp DELETION starting at nucleotide 4 of DECAMER (Ichiyoshi Y. et al., J. Immunol., 154, 226-238 (1995)) (http://www.imgt.org/IMGTrepertoire/Regulation/promoters/human/IGK/IGKV/Hu_IGKVpromoters.html), the IGKV1-8 functionality was initially defined as "ORF". However the identification of several transcripts indicated that the IGKV1-8 gene is functional (Stamatopoulos K., Belessi C. and Lefranc M. P. 10/10/2007). As the deletion is not observed in KM455559, the 21 bp deletion in Z00014 may correspond to an artefact or to a promoter polymorphism of IGHV8*01.
  39. Inferred allele: IMGT-NC_Report_2020-3-1120_Homsap_IGKV_IGLV.
  40. TTTGCTT instead of TTTGCAT in the core sequence of the DECAMER element (Ichiyoshi Y. et al., J. Immunol., 154, 226-238 (1995)), but transcript found (Giachino C. et al., J. Exp. Med., 181, 1245-1250 (1995)).
  41. Means that the rearrangement, transcript or protein could not be assigned to the gene in the proximal or distal cluster.
  42. It is not known if this sequence corresponds to that gene or to its duplicate. For that reason, the sequence appears twice in the IMGT/GENE-DB reference sequences.
  43. CONSERVED-TRP replaced by a STOP-CODON in FR2-IMGT, and non canonical V-HEPTAMER: CATAGTG instead of CACAGTG (Ichiyoshi Y. et al., J. Immunol., 154, 226-238 (1995)).
  44. IGKV1-13*02, initially considered as an ORF, has been found rearranged and expressed in a functional anti-TPO sequence (clone TR1.9) (L12099) (Chazenbalk G.D. et al., J. Clin. Invest., 92, 62-74 (1993)) (N. Chapal, S. Roux, T. Chardes and M.-P. Lefranc, comment, 9/11/2000). The Fab of that clone has been crystallized and its 3D structure determined (PDB: 1vge). Note that the four first amino acids ELVM of the V-REGION in L12099 and PDB: 1vge are introduced by the primer. The IgA1 theoretical model (PDB: 1iga) uses the 1vge sequence and structure for the kappa chain (M.-P. Lefranc comments, 28/09/2001)
  45. The sequence FM164407 previously designated as IGKV1D-17*02 has been shown to correspond to allele IGKV1-17*03 (19/01/2015).
  46. Non canonical V-HEPTAMER: CACTGTG instead of CACAGTG (Chen P.P. et al., J. Immunol., 139, 1727-1733 (1987)), but rearrangement products and productive cDNA found ((Giachino C. et al., J. Exp. Med., 181, 1245-1250 (1995)) and see IMGT/GENE-DB).
  47. As the DPK sequences only contain the V-REGION, some of them could be assigned neither to a gene or its duplicate, nor to any allele of the gene.
  48. DELETION of nucleotide 4, and INSERTION of 1 bp at position 15/16. Defective DONOR-SPLICE (Ichiyoshi Y. et al., J. Immunol., 154, 226-238 (1995)).
  49. STOP-CODON in L-PART1 (Ichiyoshi Y. et al., J. Immunol., 154, 226-238 (1995)).
  50. TTTGCTT instead of TTTGCAT in the core sequence of the DECAMER, and altered V-HEPTAMER: CACAGGG instead of CACAGTG (Ichiyoshi Y. et al., J. Immunol., 154, 226-238 (1995)).
  51. No INIT-CODON: ATG replaced by GTG (Ichiyoshi Y. et al., J. Immunol., 154, 226-238 (1995)).
  52. DELETION of 1 bp at position 74 leading to a frameshift, no INIT-CODON: ATG replaced by GTG, and non canonical ACCEPTOR-SPLICE (Ichiyoshi Y. et al., J. Immunol., 154, 226-238 (1995)).
  53. No INIT-CODON: ATG replaced by GTG , CT instead of GT in ACCEPTOR_SPLICE, and DELETION of 1 bp at position 4 leading to a frameshift, and non canonical V-HEPTAMER (Ichiyoshi Y. et al., J. Immunol., 154, 226-238 (1995)).
  54. No INIT-CODON: ATG replaced by ATA (Ichiyoshi Y. et al., J. Immunol., 154, 226-238 (1995)).
  55. No Vk-gene related sequence was found upstream of codon 12, 5' part of V-REGION truncated (Ichiyoshi Y. et al., J. Immunol., 154, 226-238 (1995)).
  56. INSERTION of 1 bp in codon 45 (134^135>ins^a) and DELETION of 1 bp in codon 51 (g153>del) (Ichiyoshi Y. et al., J. Immunol., 154, 226-238 (1995)). The insertion in codon 45 leads to a frameshift but the normal reading frame is reestablished by the deletion in codon 51. The resulting sequence shows six amino acid changes from codon 46 to 51 in the FR2-IMGT. The frameshift originally described in FR1-IMGT (Kimberly V.D. et al., J. Clin. Invest., 87, 1603-1613 (1991)) has not been confirmed.
  57. STOP-CODON at position 88 in FR3-IMGT (Ichiyoshi Y. et al., J. Immunol., 154, 226-238 (1995)).
  58. The most 3' nucleotide of L-PART2 of A18c is A instead of G. This allele is described as IGKV2-29*03 (L-PART2 g12>a) according to the IMGT numbering for coding regions.
  59. IGKV2D-29*02, initially considered as an ORF due to a non canonical V-HEPTAMER: CACAGAG instead of CACAGTG, has been found rearranged and transcribed in a 'productive' sequence (DQ101097).
  60. GG instead of AG in the ACCEPTOR_SPLICE (Ichiyoshi Y. et al., J. Immunol., 154, 226-238 (1995)).
  61. STOP-CODON in CDR3 in codon 94 (Ichiyoshi Y. et al., J. Immunol., 154, 226-238 (1995)).
  62. The sequence L19272 obtained by Polymerase Chain Reaction (PCR) has the features of a chimeric sequence between two different genes belonging to the Homo sapiens IGKV3 subgroup (IGKV3D-20 in 5', codons 1 to 106, and IGHV3D-11*02 in 3', codons 107 to 111). This sequence has been assigned to IGKV3D-20*02 allele with the functionality ORF (chimeric sequence and absence of identified transcripts). This assignment needs to be confirmed by analysis of other genomic and mapped germline clones. (M-P. Lefranc, IMGT-NC, 15/02/15)
  63. Heavily mutated, insertion of 1.2 kb in V-INTRON. INSERTION of: 3 bp in codon -14/13, 7 bp in codon 81, and DELETION of: 2 bp in codon 27A, 24 bp from codon 56 to 65, 1 bp in codon 83 [11].
  64. IGKV4-1 is in an inverted orientation of transcription.
  65. IGKV5-2 is in an inverted orientation of transcription.
  66. IGKV6-21*01, initially considered as an ORF, due to a non canonical V-HEPTAMER: CACTGTG instead of CACAGTG (Ichiyoshi Y. et al., J. Immunol., 154, 226-238 (1995)), has been found rearranged.
  67. IGKV6D-21*01, initially considered as an ORF, due to a non canonical V-HEPTAMER: CACTGTG instead of CACAGTG (Ichiyoshi Y. et al., J. Immunol., 154, 226-238 (1995)), has been found rearranged.
  68. Non canonical V-HEPTAMER: CACTGTG instead of CACAGTG (Ichiyoshi Y. et al., J. Immunol., 154, 226-238 (1995)).
  69. In EMBL, a new accession number M27751 was created, the original accession number X12688 becoming secondary accession number of M27751.
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