IMGT Repertoire (IG and TR)

Frameshift in L-PART1, STOP-CODON in L-PART1, no 1st-Cys: Arg instead of Cys
No 1st-Cys: STOP-CONDON instead of Cys
No 1st-CYS: STOP-CODON instead of Cys
Frameshift in V-REGION: deletion of 11 nt in FR3-IMGT
STOP-CODON in FR2-IMGT: position 51, STOP-CODON in FR3-IMGT: position 75, frameshift in FR3-IMGT: deletion of 11 nt
several STOP-CODON in V-REGION, frameshift in V-REGION: deletion of 11 nt in FR3-IMGT
Noncanonical DONOR-SPLICE: nat instead of ngt
Noncanonical DONOR-SPLICE: nat instead of ngt, noncanonical V-NONAMER: gcactaatc instead of acataaagg
No CONSERVED-TRP: Ser instead of Trp
STOP-CODON in V-REGION: position 40
No CONSERVED-TRP: Arg instead of Trp
No 1st-Cys: Tyr instead of Cys
No 2nd-Cys: Arg instead of Cys
Frameshift in V-REGION: deletion of 1 nt in FR3-IMGT
Frameshift in V-REGION: insertion of 1 nt in FR3-IMGT
Frameshifts in V-REGION: deletion of 1 nt and deletion of 1 nt in FR3-IMGT, and insertion of 1 nt in FR3-IMGT
frameshifts in V-REGION: deletion of 1nt and deletion of 1nt in FR3-IMGT, and insertion of 1nt in FR3-IMGT
STOP-CODON in V-REGION: position 43
No L-PART1, frameshifts in V-REGION
Frameshift in V-REGION: 2 nt deleted in FR3-IMGT
No L-PART1, frameshifts in V-REGION: several insertions and deletions, several STOP-CODON in V-REGION
Frameshifts in V-REGION: deletion of 3 nt in FR1-IMGT, 8 nt in CDR1-IMGT and 2 nt in FR3-IMGT
Frameshift in V-REGION: deletion of 3 nt in FR1-IMGT, 8 nt in CDR1-IMGT and 2 nt in FR3-IMGT
frameshifts in V-REGION: several insertions and deletions
STOP-CODON in V-REGION: position 92
STOP-CODON in L-PART1
STOP-CODON in FR3-IMGT
STOP-CODON in V-REGION: position 55
STOP-CODON in CDR2-IMGT
no INIT-CODON: Ile instead of Met
STOP-CODON in CDR1-IMGT
STOP-CODON in V-REGION: position 38
No 2nd-Cys: Tyr instead of Cys
no 2nd-CYS: Tyr instead of Cys, noncanonical V-NONAMER: gtgcaaacc instead of acataaagg
Frameshift in L-PART1
frameshift in L-PART1 causing defectuous DONOR-SPLICE
Several frameshifts in V-REGION
STOP-CODON in V-REGION : position 80, no 2nd-Cys: Tyr instead of Cys
STOP-CODON in V-REGION: position 80
No INIT-CODON: His instead of Met, frameshifts in L-PART1, L-PART2 and V-REGION, several STOP-CODON in V-REGION
Frameshifts in L-PART1, L-PART2 and V-REGION, no INIT-CODON: His instead of Met
No INIT-CODON: Lys instead of Met, frameshifts in L-PART2 and V-REGION, several STOP-CODON in V-REGION
Frameshifts in L-PART2 and V-REGION: several insertions and deletions, no INIT-CODON: Lys instead of Met, several STOP-CODON in V-REGION
no INIT-CODON: Lys instead of Met, frameshift in L-PART2, frameshifts in V-REGION: several insertions and deletions
No L-PART1 and no L-PART2, frameshifts in V-REGION: several insertions and deletions, truncated and degenerated gene
The original L36092 sequence (684973 bp) has been split in EMBL into three sequences of 267156 bp (U66059), 215422 bp (U66060) and 232650 bp (U66061), L36092 has become secondary accession number of U66059, U66060 and U66061. In IMGT, the original sequence L36092 which is fully annotated has also been kept as primary accession number, in addition to U66059, U66060 and U66061 (Rowen L. et al. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. PMID: 8650574).
Arbitrary limits of the DNA sequence assigned to the different TRBV genes. V-GENE positions are those in the Accession number L36092.
V-GENE is partial: no L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 100 to 108 are absent (partial FR3-IMGT and no CDR3-IMGT).
V-GENE is partial: no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 93 to 108 are absent (partial FR3-IMGT and no CDR3-IMGT).
V-REGION is partial: AA 1 to 24 and 106 to 108 are absent (partial FR1-IMGT, partial CDR3-IMGT). AA position 55, 83 are missing, probably typing errors.
V-REGION is partial: AA 1 to 24 and 106 to 108 are absent (partial FR1-IMGT, no CDR1-IMGT, no FR2-IMGT, no CDR2-IMGT, no FR3-IMGT, partial CDR3-IMGT). G position 47 is missing, ACT position 70 to 72 are missing, A position 110 inserted, GGA position 139 to 141 are missing and A position 73 replaced by G, probably typing errors.
V-GENE is partial: partial L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 100 to 108 are absent (partial FR3-IMGT and no CDR3-IMGT).
V-GENE is partial: partial L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 21 to 108 are absent (partial FR1-IMGT, no CDR1-IMGT, no FR2-IMGT, no CDR2-IMGT, no FR3-IMGT, no CDR3-IMGT).
Frameshift in V-EXON. Although it is not excluded that the sequence 172780-172829 in L66059, L36092 may represent a very degenerate leader peptide, it was not labeled as L-PART1 for the following reasons (i) the translated sequence is not particularly hydrophobic (ii) the sequence shows no similarity with the other TRBV L-PART1, included the one from TRBV8-2, also a pseudogene but with a clearly identified L-PART1 (iii) the DONOR-SPLICE displays a codon-start 2 instead of being a codon-start 3 (note by M.-P. Lefranc, added on 07/04/2004, following a question by V. Herle).
L14431 differs from TRBV7-4*01 by the nucleotide DELETION (c255>del) and (t266>del) which create a frameshift.
V-GENE is partial: partial L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 25 to 108 are absent (partial FR1-IMGT, no CDR1-IMGT, no FR2-IMGT, no CDR2-IMGT, no FR3-IMGT, no CDR3-IMGT).
V-GENE is partial: Partial L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 24 to 108 are absent (partial FR1-IMGT, no CDR1-IMGT, no FR2-IMGT, no CDR2-IMGT, no FR3-IMGT, no CDR3-IMGT).
V-REGION is partial: AA 1 to 3 and 76 to 108 are absent (partial FR1-IMGT, partial FR3-IMGT, no CDR3-IMGT).
The original L36092 sequence (684973 bp) has been split in EMBL into three sequences of 267156 bp (U66059), 215422 bp (U66060) and 232650 bp (U66061), L36092 has become secondary accession number of U66059, U66060 and U66061. In IMGT, the original sequence L36092 which is fully annotated has also been kept as primary accession number, in addition to U66059, U66060 and U66061 (Rowen L. et al. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. PMID: 8650574)..
V-REGION is partial: AA 105 to 108 are absent (no CDR3-IMGT).
This gene was previously entered in the databases as V21.2, M33234 [13], but has been shown to contain several nucleotide errors.
The insertion of 1 nt in the L-PART1 of AB305822, compared to the L-PART1 of AB305924, may be due to a sequencing error.
V-GENE is partial: no V-NONAMER.
V-GENE is partial: no L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 90 to 108 are absent (partial FR3-IMGT and no CDR3-IMGT).
V-GENE is partial: no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 9 to 108 are absent (partial FR1-IMGT, no CDR1-IMGT, no FR2-IMGT, no CDR2-IMGT, no FR3-IMGT, no CDR3-IMGT).
V-GENE is partial: no L-PART1, no V-HEPTAMER, no V-NONAMER and V-REGION is partial: AA 99 to 108 are absent (partial FR3-IMGT and no CDR3-IMGT).
1st_CYS replaced by STOP-CODON in V-EXON.
The not confirmed TRBV6-2*02 (P) and TRBV6-2*03 (P) alleles were deleted (13/07/2018). M31347 (g#) (formerly TRBV6-2*02 (P)) was assigned to TRBV6-2*01 with a deletion of 1 nt 'g' (nt 147) due to a probable sequencing error in V-REGION (Assignment of rearranged cDNAs and gDNAs to germline genes: Human TRBV).
STOP-CODON in FR2-IMGT
In the human TRB locus, the TRBV30 gene is localized in 3' from the TRBC2 gene and is in inverted orientation of transcription. Due to its polarity opposite to the TRB D-J-C-CLUSTERs, TRBV30 rearranges by an inversional joining (Rowen L. et al. The complete 685-kilobase DNA sequence of the human beta T cell receptor locus. PMID: 8650574).
In the human TRB locus, the TRBV30 gene is localized in 3' from the TRBC2 gene and is in inverted orientation of transcription. Due to its polarity opposite to the TRB D-J-C-CLUSTERs, TRBV30 rearranges by an inversional joining [11].

IMGT references: ↑

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IMGT Repertoire (IG and TR)

Dynamic gene tables per IMGT group and per species (IMGT/GeneTables)

Gene table legend:

IMGT notes: ↑

IMGT references: ↑

IMGT Repertoire (IG and TR)

Dynamic gene tables per IMGT group and per species (IMGT/GeneTables)

Version 1.4

Version 1.3

Version 1.2

Version 1.1

Version 1.0

Gene table legend:

IMGT notes: ↑

IMGT references: ↑