IMGT Repertoire (IG and TR)

frameshifts in V-REGION, no L-PART1, non canonical V-HEPTAMER: tatttat instead of cacagtg and non canonical V-NONAMER: acgtaaatc instead of tcagaaacc
no L-PART1, frameshifts in V-REGION and no V-RS
no CONSERVED-TRP: STOP-CODON instead of Trp, frameshift in V-REGION: deletion of 1 nt in FR2-IMGT, no V-HEPTAMER
insertions in V-REGION (10 AA are added), STOP-CODON at position 106 (last 3' codon of germline CDR3-IMGT) may disappear during rearrangements
insertions in V-REGION: 10 AA are added, STOP-CODON at position 106 (last 3' codon of germline CDR3-IMGT) may disappear during rearrangements
frameshift in V-REGION, no L-PART1, no V-RS
no L-PART1, frameshifts in V-REGION, non canonical ACCEPTOR-SPLICE: natnn instead of nagnn and no V-RS in 3'UTR
no L-PART1, several STOP-CODON in V-REGION, no V-RS
no L-PART1, frameshifts in V-REGION: several insertions and deletions, no V-RS
INIT-CODON is replaced by Tyr and 1st-CYS is replaced by in frame STOP-CODON
STOP-CODON in L-PART1
frameshifts in V-REGION
frameshifts in V-REGION: several insertions and deletions
deletion in L-PART1 (1 nt is missing) and in frame STOP-CODON in FR1-IMGT
frameshift in L-PART1
frameshift in L-PART1, frameshift in L-PART2
in frame STOP-CODON in L-PART1
CONSERVED-TRP is replaced by Cys and non canonical DONOR-SPLICE: ngc instead of ngt
noncanonical DONOR-SPLICE: ngc instead of ngt, no CONSERVED-TRP: Cys instead of Trp
INIT-CODON is replaced by Ile and frameshifts in V-REGION
no INIT-CODON: Ile instead of Met, frameshift in V-REGION: deletion of 1 nt in FR1-IMGT
INIT-CODON is replaced by Arg
no INIT-CODON: Phe instead of Met, STOP-CODON in V-REGION: position 5, frameshift in V-REGION: deletion of 1 nt in FR1-IMGT
frameshift in L-PART1, frameshift in V-REGION: deletion of 5 nt in FR2-IMGT
STOP-CODON in V-REGION: position 55, frameshift in V-REGION: insertion of 2 nt in FR3-IMGT
STOP-CODON in L-PART1, several STOP-CODON in V-REGION
no INIT-CODON: Arg instead of Met
no INIT-CODON: Ile instead of Met, STOP-CODON in V-REGION: position 8, frameshift in V-REGION: deletion of 1 nt in FR3-IMGT
STOP-CODON in V-REGION: position 12, frameshifts in V-REGION: several insertions
frameshift in V-REGION: insertion of 14 nt in FR3-IMGT
STOP-CODON in V-REGION: position 107
no CONSERVED-TRP: STOP-CODON instead of Trp
STOP-CODON in V-REGION: position 54
no INIT-CODON: Ile instead of Met
no INIT-CODON: Ile instead of Met, several STOP-CODON in V-REGION, frameshifts in V-REGION: deletion of 2 nt and 1 nt in FR1-IMGT
no INIT-CODON: Ile instead of Met, STOP-CODON in V-REGION: position 5, frameshift in V-REGION: deletion of 1 nt in FR1-IMGT
no 1st-CYS: Ser instead of Cys
frameshift in L-PART1, STOP-CODON in V-REGION: position 5, frameshifts in V-REGION: several deletions
frameshift in L-PART1, several STOP-CODON in V-REGION, frameshifts in V-REGION: several insertions and deletions
STOP-CODON in V-REGION: position 52, frameshift in V-REGION: deletion of 2 nt in FR3-IMGT
STOP-CODON in L-PART1, STOP-CODON in V-REGION: position 5, frameshifts in V-REGION: several deletions
frameshift in L-PART2
several STOP-CODON in V-REGION
no L-PART1, several STOP-CODON in V-REGION
STOP-CODON in V-REGION: position 59
STOP-CODON in V-REGION: position 51
frameshift in L-PART1, several STOP-CODON in V-REGION
no V-NONAMER
STOP-CODON in V-REGION: position 67, frameshift in V-REGION: deletion of 1 nt in FR3-IMGT
STOP-CODON in V-REGION: position 51, frameshift in V-REGION: deletion of 7 nt in FR3-IMGT
STOP-CODON in V-REGION: position 11
no 1st-CYS: Phe instead of Cys
noncanonical DONOR-SPLICE: ntt instead of ngt, noncanonical V-NONAMER: tataaatac instead of tcagaaacc
no INIT-CODON: Ile instead of Met, STOP-CODON in V-REGION: position 54
frameshift in L-PART1, frameshift in V-REGION: deletion of 2 nt in FR3-IMGT
STOP-CODON in L-PART1, frameshift in V-REGION: deletion of 5 nt in FR1-IMGT
frameshift in V-REGION: deletion of 1 nt in FR1-IMGT
no 2nd-CYS: Ser instead of Cys
no INIT-CODON: Ile instead of Met, STOP-CODON in V-REGION: position 67
no 2nd-CYS: Phe instead of Cys
no INIT-CODON: Ile instead of Met, frameshifts in V-REGION: several insertions and deletions
no INIT-CODON: Ile instead of Met, frameshift in V-REGION: deletion of 1 nt in FR2-IMGT
noncanonical DONOR-SPLICE: ntt instead of ngt, no 2nd-CYS: Arg instead of Cys
no INIT-CODON:Ile instead of Met
noncanonical V-NONAMER: tagaaatac instead of cagaaaacc, noncanonical DONOR-SPLICE: ntt instead of ngt
frameshifts in V-REGION: several insertions and deletions, frameshift in L-PART1: deletion of 4 nt causing defectuous DONOR-SPLICE
STOP-CODON in V-REGION: position 37
no INIT-CODON: Ile instead of Met, several STOP-CODON in V-REGION
no V-RS
frameshift in V-REGION: deletion of 1 nt in FR3-IMGT
frameshift in V-REGION: deletion of 2 nt in FR3-IMGT
no DONOR-SPLICE, STOP-CODON in V-REGION: position 51
non canonical V-HEPTAMER but this V-GENE has been found rearranged
CONSERVED-TRP is replaced by in frame STOP-CODON
in frame STOP-CODON in CDR1-IMGT and 2nd-CYS is replaced by Ser
CONSERVED-TRP is replaced by Cys
CONSERVED-TRP is replaced by Cys, non canonical DONOR-SPLICE: ngc instead of ngt and non canonical V-HEPTAMER: tattgct instead of cacagct
INIT-CODON is replaced by Ile, in frame STOP-CODON in FR2-IMGT and CONSERVED-TRP is replaced by Leu
INIT-CODON is replaced by Ile, in frame STOP-CODON in FR1-IMGT and non canonical DONOR-SPLICE: nat instead of ngt
in frame STOP-CODON in FR2-IMGT, 1st-CYS is replaced by Phe and 2nd-CYS is replaced by Phe
frameshifts in V-REGION, deletion in L-PART1 (1 nt is missing) and non canonical ACCEPTOR-SPLICE: natnn instead of nagnn
in frame STOP-CODON in L-PART1, in frame STOP-CODON in CDR1-IMGT and 1st-CYS is replaced by Ser
Pseudogene due to a DELETION of 1 nucleotide in the FR2-IMGT
no CONSERVED-TRP: Cys instead of Trp
in frame STOP-CODON in FR2-IMGT, non canonical DONOR-SPLICE: nca instead of ngt and 2nd-CYS is replaced by Arg
Pseudogene due to a STOP-CODON in FR2-IMGT and Conserved-Cys is replaced by Arg
Pseudogene due to a STOP-CODON in frame (positions 236-238) in the FR2-IMGT
no 2nd-CYS: Arg instead of Cys, noncanonical V-HEPTAMER: ctcagtt instead of cacagtg
noncanonical DONOR-SPLICE: ngg instead of ngt
frameshifts in V-REGION, in frame STOP-CODON in L-PART1 and non canonical DONOR-SPLICE: ntt instead of ngt
Pseudogene because of frameshifts in V-REGION.
frameshifts in V-REGION: several deletions
frameshift in V-REGION: insertion of 1 nt in FR3-IMGT
Pseudogene due to a STOP-CODON in frame (positions 957-959) at codon 89 in FR3-IMGT
frameshift in V-REGION: insertion of 1 nt in FR2-IMGT
frameshift in V-REGION: deletion of 1 nt in CDR1-IMGT
frameshift in V-REGION: insertion of 1 nt in FR1-IMGT
Pseudogene because of in frame STOP-CODON in V-REGION.
noncanonical V-NONAMER: tccgaaaat instead of tcagaaacc
STOP-CODON in V-REGION: position 102
no L-PART2, STOP-CODON in V-REGION: position 3, frameshifts in V-REGION: several deletions
STOP-CODON in V-REGION: position 44
noncanonical V-NONAMER: tcaaaaata instead of tcagaaacc
STOP-CODON in V-REGION: position 52
no 2nd-CYS: Gly instead of Cys
no INIT-CODON: Arg instead of Met, frameshifts in V-REGION: several insertions and deletions
noncanonical V-NONAMER: ccgaaaacc instead of tcagaaacc
frameshift in V-REGION: deletion of 1 nt in FR2-IMGT
in frame STOP-CODON in FR1-IMGT and non canonical DONOR-SPLICE: ngg instead of ngt
in frame STOP-CODON in V-REGION at positions AA 41 and 54
noncanonical DONOR-SPLICE: ngg instead of ngt, unexpected V-SPACER length: 10 nt instead of 23 nt
noncanonical ACCEPTOR-SPLICE: nggnn instead of nagnn
no L-PART1, no L-PART2, frameshifts in V-REGION: several insertions and deletions
Pseudogene because no INIT-CODON in the L-PART1 (ATG is replaced by ACG)
CONSERVED-TRP is replaced by in frame STOP-CODON and in frame STOP-CODON in FR2-IMGT
frameshifts in V-REGION.
frameshifts in V-REGION, putative limit in 3' of V-REGION, non canonical DONOR-SPLICE: ngg instead of ngt and no V-RS in 3'UTR
INIT-CODON is replaced by Ile
in frame STOP-CODON in FR2-IMGT
several STOP-CODON in V-REGION, frameshift in V-REGION: deletion of 1 nt in FR3-IMGT
STOP-CODON in V-REGION: position 3, frameshifts in V-REGION: several insertions and deletions, no V-RS
Reference sequence: V102
non canonical V-NONAMER, however this V-GENE has been found rearranged
in frame STOP-CODON in FR1-IMGT
In frame STOP-CODON (positions 300-302) at codon 44 in FR2-IMGT
pseudogene due to a STOP-CODON in frame (positions 300-302) in the FR2-IMGT.
Pseudogene due to a STOP-CODON in frame instead of conserved-Trp in FR2-IMGT
Pseudogene due to a STOP-CODON in frame in FR2_IMGT
Pseudogene due to no INIT-CODON in L-PART1
Pseudogene due to a STOP-CODON in frame in FR1-IMGT
Pseudogene due to a STOP-CODON in frame in FR2-IMGT
Strain A/J
In frame STOP-CODON (positions 530-532) at codon 90 in FR3-IMGT
Pseudogene due to a STOP-CODON in frame (positions 375-377) in FR2-IMGT
Pseudogene due to a DELETION of 1 nucleotide (g between positions 395/396) in FR2-IMGT leading a frameshift
Pseudogene due to a STOP-CODON in frame at codon 54 in FR2-IMGT
Pseudogene due to a STOP-CODON in frame at codon 67 in FR3-IMGT
Pseudogene because of the Conserved-Trp is replaced by a STOP-CODON
Pseudogene due to a STOP-CODON in frame at codon 27 in CDR1-IMGT
partial FR3-IMGT (AA 93 to 104 are absent) and no CDR3-IMGT
partial FR3-IMGT (AA 93 to 104 are absent), no CDR3-IMGT
truncated pseudogene
Reference sequence: VH101
in frame STOP-CODON in CDR1-IMGT
truncated gene, insertion of 7247kbs between IGHV2-7*02 (part 5') and IGHV2-7*02 (part 3')
frameshift in L-PART2, frameshift in V-REGION: deletion of 2 nt in FR1-IMGT
no L-PART1, no L-PART2, frameshift in V-REGION: deletion of 1 nt in FR2-IMGT
STOP-CODON at position 106 (last 3' codon of germline V-REGION) may disappear during rearrangements
in frame STOP-CODON in V-REGION at position AA 51
in frame STOP-CODON in FR3-IMGT
in frame STOP-CODON in V-REGION
STOP-CODON in V-REGION: position 67
several STOP-CODON in V-REGION, deletions in V-REGION: AA 105 to 115 are missing, no V-RS
several STOP-CODON in V-REGION, no V-RS
STOP-CODON in V-REGION: position 38, deletions in V-REGION: AA 100 to 115 are missing, no V-RS
frameshift in V-REGION and no V-RS
no CONSERVED-TRP: STOP-CODON instead of Trp, several STOP-CODON in V-REGION, no V-RS
frameshifts in V-REGION and no V-RS in 3'UTR
frameshifts in V-REGION: several insertions and deletions, no V-RS
STOP-CODON in L-PART2, frameshift in V-REGION: deletion of 2 nt in CDR1-IMGT, no V-RS
STOP-CODON in V-REGION: position 75
Reference sequence: VH283
several STOP-CODON in V-REGION, deletions in V-REGION: AA 101 to 115 are missing, no V-RS
in frame STOP-CODON in CDR1-IMGT, in frame STOP-CODON in FR3-IMGT and no V-RS in 3'UTR
frameshift in L-PART1, frameshift in V-REGION: deletion of 1 nt in CDR1-IMGT
STOP-CODON in V-REGION: position 38
in frame STOP-CODON in L-PART1 and frameshifts in V-REGION
in frame STOP-CODON in L-PART1, frameshifts in V-REGION and no V-RS
frameshift in V-REGION: deletion of 1 nt in FR1-IMGT, no V-RS
frameshift in L-PART1, frameshift in V-REGION: deletion of 8 nt in CDR1-IMGT
frameshift in V-REGION: deletion of 8 nt in CDR1-IMGT
in frame STOP-CODON in FR3-IMGT and frameshift in L-PART1
frameshift in L-PART1, frameshift in V-REGION, no V-RS
frameshift in L-PART1, several STOP-CODON in V-REGION, no V-RS
in frame STOP-CODON in L-PART1, frameshifts in V-REGION and no V-RS in 3'UTR
no L-PART1 and frameshifts in V-REGION
no INIT-CODON: Ile instead of Met, STOP-CODON in L-PART1, STOP-CODON in L-PART2, STOP-CODON in V-REGION: position 44, frameshifts in V-REGION: several insertions and deletions, no V-RS
no INIT-CODON: Ile instead of Met, STOP-CODON in L-PART1, STOP-CODON in L-PART2, frameshifts in V-REGION: several insertions and deletions, no V-RS
noncanonical V-NONAMER: ccaccaacc instead of tcaaaaacc
non canonical V-HEPTAMER: cacagta instead of cacagtg and non canonical V-NONAMER: ccaccaacc instead of tcagaaaac
noncanonical DONOR-SPLICE: ngc instead of ngt
non canonical DONOR-SPLICE: ngc instead of ngt
noncanonical V-NONAMER: ccaccaacc instead of tcagaaacc
deletion in V-SPACER (17 nt instead of 23 nt)
frameshifts in V-REGION, in frame STOP-CODON in L-PART1 and non canonical DONOR-SPLICE: naa instead of ngt
STOP-CODON in L-PART1, no DONOR-SPLICE, several STOP-CODON in V-REGION, frameshift in V-REGION: deletion of 1 nt in FR3-IMGT
2nd-CYS is replaced by Gly
noncanonical V-NONAMER: gcaatattt instead of acaaaaatt
frameshift in V-REGION: deletion of 4 nt in FR1-IMGT, no V-RS
frameshift in V-REGION: deletion of 4 nt in FR1-IMGT, deletions in V-REGION: AA 105 to 107 are missing, no V-HEPTAMER
non canonical V-NONAMER: gcaatagtt instead of tcagaaacc
STOP-CODON in V-REGION: position 14, frameshift in V-REGION: deletion of 4 nt in FR3-IMGT
STOP-CODON at position 106 (last (or penultimate) 3’ codon of germline CDR3-IMGT) may disappear during rearrangements, noncanonical V-HEPTAMER: cgcattg instead of cacagtg, noncanonical V-NONAMER: acagtaatt instead of tcagaaacc
functionality defined as pseudo because of frameshifts; partiality in 5'due to preceding gap
no L-PART1
noncanonical V-NONAMER:acagtatt instead of tcagaaacc
frameshift in L-PART1, several STOP-CODON in V-REGION, no CONSERVED-TRP: STOP-CODON instead of Trp
STOP-CODON in L-PART1, STOP-CODON in V-REGION: position 13, frameshift in V-REGION: deletion of 4 nt in FR3-IMGT
frameshift in V-REGION: deletion of 4 nt in FR3-IMGT
noncanonical V-HEPTAMER: catattg instead of cacagtg
noncanonical V-NONAMER: acattattt instead of acaaaaatt
noncanonical V-HEPTAMER: cacgttg instead of cacaatg, noncanonical V-NONAMER: aaactattt instead of tagaaatac
noncanonical V-HEPTAMER: cacgttg instead of cacagtg, noncanonical V-NONAMER: aaactattt instead of tagaaatac
STOP-CODON at position 106 (last (or penultimate) 3’ codon of germline CDR3-IMGT) may disappear during rearrangements, noncanonical V-NONAMER: acagtattt instead of tagaaatac
noncanonical V-NONAMER: atagtaatt instead of acataaacc
noncanonical V-HEPTAMER:cacgttg instead of cacaatg, noncanonical V-NONAMER:aaagtattt instead of acaaaaatt
noncanonical V-HEPTAMER: cacgttg instead of cacagtg, noncanonical V-NONAMER: aaagtattt instead of acaaaaatt
no INIT-CODON: Thr instead of Met
2nd-CYS is replaced by Ser
in frame STOP-CODON in FR1-IMGT and in frame STOP-CODON in CDR3-IMGT
frameshifts in V-REGION: several insertions and deletions, deletions in V-REGION: AA 103 to 106 are missing
STOP-CODON in V-REGION: position 110
no L-PART1, several STOP-CODON in V-REGION, no CONSERVED-TRP: STOP-CODON instead of Trp, frameshifts in V-REGION: several insertions and deletions
in frame STOP-CODON in FR1-IMGT, in frame STOP-CODON in CDR3-IMGT and CONSERVED-TRP is replaced by Cys
frameshift in L-PART1, no L-PART2, deletions in V-REGION: AA 1 to 14 are missing, no CONSERVED-TRP: STOP-CODON instead of Trp, several STOP-CODON in V-REGION
no CONSERVED-TRP: STOP-CODON instead of Trp, several STOP-CODON in V-REGION
Pseudogene due to DELETIONs in the FR2-IMGT and in the CDR2-IMGT leading to frameshifts
Pseudogene due to a STOP-CODON in the FR2-IMGT
noncanonical ACCEPTOR-SPLICE: tattc instead of nagnn, however this gene has been found rearranged
no L-PART1, frameshift in V-REGION: deletion of 8 nt in FR1-IMGT
no L-PART1, STOP-CODON in V-REGION: position 11, frameshift in V-REGION: deletion of 8 nt in FR1-IMGT
frameshift in V-REGION, no L-PART1
no L-PART1, frameshift in FR3-IMGT
in frame STOP-CODON in the FR1-IMGT and 2nd-CYS is replaced by Tyr
in frame STOP-CODON in FR1-IMGT and in frame STOP-CODON in CDR2-IMGT
frameshift in L-PART1, STOP-CODON in V-REGION: position 3
STOP-CODON in V-REGION: position 17
noncanonical DONOR-SPLICE: nat instead of ngt
in frame STOP-CODON in FR1-IMGT and 2nd-CYS is replaced by Tyr
frameshift in V-REGION
CONSERVED-TRP is replaced by Arg and 2nd-CYS is replaced by Tyr
Unproductive due to an INSERTION of 1 bp in FR1-IMGT and an INSERTION of 1 bp in FR3-IMGT leading to frameshifts
deletion in L-PART1 (1 nt is missing)
2nd-CYS is replaced by Trp
in frame STOP-CODON in FR1-IMGT and CONSERVED-TRP is replaced by STOP-CODON
no L-PART1, no V-RS
no L-PART1, no L-PART2, frameshifts in V-REGION and no V-RS in 3'UTR
no L-PART1, no L-PART2, truncated pseudogene, no V-RS
non canonical DONOR-SPLICE, however this V-GENE has been found rearranged
non canonical V-NONAMER: acaaaaccc instead of actaaaacc
frameshift in V-REGION: deletion of 2 nt in FR2-IMGT
Two potential gene and alleles, IGHV1-55*01 and IGHV1-9*01, correspond to V165.1, based on IMGT/V-QUEST analysis of rearranged IMGT/LIGM-DB sequences (V. Giudicelli, G. Folch, J. Jabado-Michaloud, M.-P. Lefranc (09/12/15)).
Partial V-REGION: partial FR3-IMGT (AA 93 to 104 are absent), no CDR3-IMGT. These sequences were isolated from liver genomic DNA. Most of these sequences are probably germline but some could be from B cells rearranged sequences. In order to assess the level of B lymphocyte contamination in liver, quantative PCR assay was performed. The level of rearranged templates in liver DNA is about one rearranged VH186.2-related gene for every 1000-4000 unrearranged VH186.2-related templates (Rothenfluh in Ph.D thesis) citation in [53]. Based on this observation, the authors consider that their sequences are germline.
Partial V-REGION: partial FR1-IMGT (AA 1 to 3 are absent) and partial FR3-IMGT (AA 100 to 104 are absent).
One gene and allele IGHV1-52*01 seem to correspond to CH10, based on IMGT/V-QUEST analysis of rearranged IMGT/LIGM-DB sequences (V. Giudicelli, G. Folch, J. Jabado-Michaloud, M.-P. Lefranc (09/12/15)).
Two potential genes and alleles, IGHV1-64*01 and IGHV1-72*01, seem to correspond to C1H4, based on IMGT/V-QUEST analysis of rearranged IMGT/LIGM-DB sequences (V. Giudicelli, G. Folch, J. Jabado-Michaloud, M.-P. Lefranc (09/12/15)).
Sterile transcript.
Partial V-REGION: partial FR1-IMGT (AA 1 to 3 are absent).
In frame STOP-CODON (positions 309-311) at codon 41 instead of the CONSERVED-TRP in FR2-IMGT.
The sequence described in the manuscript is different from the one submitted to the EMBL data library. Nucleotide a at position 261 in EMBL flat file (codon 11 in FR1-IMGT), nucleotide g in the manuscript.
DELETION of 1 nucleotide (between positions 787/788) in FR2-IMGT.
L26866 and J00535 are mentioned as identical in Weiller et al. [69], the nucleotide t missing between positions 63/64 in L26866 EMBL flat file seems to be a typing error.
ORF because of no CONSERVED-TRP.
Four nucleotides of the V-REGION of the V104A sequence from Givol et al. [22] were corrected by Blankestein et al. [5]. Nucleotides gc at positions 1096-1097 in EMBL flat file are replaced by nucleotides ca (g148>c, c149>a, A55>Q in the IMGT unique V-REGION numbering), nucleotide g at position 1111 is replaced by nucleotide a (g163>a, G60>S in CDR2-IMGT) and nucleotide c at position 1132 is replaced by g (c184>g, Q69>E in FR3-IMGT).
In frame STOP-CODON (positions 1031-1033) at codon 102 in FR3-IMGT, and non canonical V-HEPTAMER: cacagcg instead of cacagtg.
Partial V-REGION: partial FR1-IMGT (AA 1 to 16 are absent).
Partial V-REGION: partial FR1-IMGT (AA 1 to 16 are absent) and partial FR3-IMGT (AA 100 to 104 are absent).
Partial V-REGION: partial FR1-IMGT (AA 1 to 16 are absent) and partial FR3-IMGT (AA 98 to 104 are absent). This sequence differs by 2 nucleotides from K02154 and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
Partial V-REGION: partial FR3-IMGT (AA 100 to 104 are absent).
No INIT-CODON in L-PART1.
Partial V-REGION: partial FR1-IMGT (AA 1 to 3 are absent) and partial FR3-IMGT (AA 81 to 104 are absent).
Partial V-REGION: partial FR1-IMGT (AA 1 to 11 are absent).
Sterile transcript, partial V-REGION: partial FR1-IMGT (AA 1 to 3 are absent) and partial FR3-IMGT (AA 81 to 104 are absent).
Partial V-REGION: partial FR1-IMGT (AA 1 to 10 are absent).
M34984 differs from M34983 by two additional nucleotides (nucleotides ga) at the end of the CDR3-IMGT.
In frame STOP-CODON (positions 851-853) at codon 54 in FR2-IMGT.
No INIT-CODON in L-PART1, and non canonical V-HEPTAMER: gacagtg instead of cacagtg.
In frame STOP-CODON (positions 62-64) at codon 1 in FR1-IMGT.
This sequence differs by 1 nucleotide from L33936 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
CONSERVED-TRP is replaced by a STOP-CODON.
This sequence differs by 1 nucleotide from X03399
Second part is localized from 482458..482621 after an insertion of 7247kbs
Partial V-REGION: partial FR3-IMGT (AA 92 to 104 are absent), no CDR3-IMGT.
Non canonical V-HEPTAMER: cacattg instead of cacagtg.
Partial V-REGION: partial FR3-IMGT (AA 102 to 104 are absent), no CDR3-IMGT.
The nucleotide c at position 271 in the EMBL flat file is a typing error because this nucleotide is a g in the manuscript (c271>g in the IMGT unique V-REGION numbering.)
The nucleotide c at position 271 in the EMBL flat file is a typing error because this nucleotide is a g in the manuscript (c271>g in the IMGT unique V-REGION numbering.) This sequence differs by 1 nucleotide from K02791 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
These sequences were isolated from liver genomic DNA by PCR using a sense FR1 primer and a FR3 antisense primer. They are probably germline but this needs to be confirmed with a germline sequence.
This sequence differs by 1 nucleotide from M34983 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
Partial V-REGION: partial FR1-IMGT (AA 1 to 12 are absent).
Partial V-REGION: partial FR1-IMGT (AA 1 to 23 are absent).
This sequence differs by 4 nucleotides from K02890 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
Partial V-REGION: partial FR1-IMGT (AA 1 to 24 are absent).
This sequence differs by 1 nucleotide from X03400 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
This sequence differs by 5 nucleotides from X67409 in the V-REGION and is temporarily considered as an allele of this sequence, these data need to be confirmed with a germline sequence.
Partial V-REGION: partial CDR2-IMGT and no FR3-IMGT.
Partial V-REGION: partial FR1-IMGT (AA 3 to 5 are absent ), partial FR3-IMGT (AA 67 to 104 are absent).
J00538 is a sequence constructed from data of 4 different sources. Positions 443-856 correspond to the germline sequence from V00758. Other parts of the sequence are derived from rearranged clones and need to be confirmed by genomic germline data.
V00758 is also part of J00538 (positions 443-856) which is a sequence constructed from data of 4 different sources. See note (90).
The nucleotides c at position 151 and g at position 292 in the J00524 EMBL flat file are typing errors (c151>g and g292>c). The sequences J00500 and J00524 are identical.
This sequence is mentioned as identical to the V3 sequence from Crews et al. [14], in Siu et al. [62], the nucleotide a at position 773 in the M16724 EMBL flat file (instead of g, in J00504 Crews et al. [14]) may represent a typing error.
The nucleotides t at position 140, t at position 144 and a at position 145 in the J00526 EMBL flat file seem to be typing errors (t140>c, t144>a, a145>g).
Partial V-REGION: partial FR3-IMGT (AA 103 to 104 are absent), no CDR3-IMGT.
Partial V-REGION: partial FR3-IMGT (AA 104 is absent), in frame STOP-CODON at codon 103 in FR3-IMGT.
Partial V-REGION: partial FR3-IMGT (AA 103 to 106 are absent), in frame STOP-CODON (positions 146-148) at codon 52 in FR2-IMGT.
Partial V-REGION: partial CDR3-IMGT (AA 105 to 106 are absent). This sequence differs by 1 nucleotide from Z15022 and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
Partial V-REGION: partial CDR3-IMGT (AA 105 to 106 are absent).
Partial V-REGION: partial FR1-IMGT (AA 1 to 3 are absent), partial CDR3-IMGT (AA 105 to 106 are absent).
Partial V-REGION: partial FR1-IMGT (AA 1 to 2 are absent), no CDR3-IMGT.
This sequence differs by 3 nucleotides from AF064443 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
This sequence differs by 2 nucleotides from AF064442 in the V-REGION and is temporarily considered as an allele of this sequence, but these data need to be confirmed with a germline sequence.
This sequence differs by 1 nucleotide from the putative germline sequence from Chao et al. (PMID: 1557050).
This sequence is identical to the putative germline sequence from Chao et al. (PMID: 1557050).
insertions in V-REGION: 10 AA are added, STOP-CODON at position 106 (last 3' codon of germline CDR3-IMGT) my disappear during rearrangements
unexpected V-SPACER length: 18 nt instead of 23 nt
noncanonical V-NONAMER: atagtaatt instead of acacaaacc, however this V-GENE has been found rearranged
DELETION of 1 nucleotide in the FR1-IMGT leading to a frameshift.
JUNCTION is out_of_ frame .

IMGT references: ↑

Akolkar P.N. et al., Different VL and VH germ-line genes are used to produce similar combining sites with specificity for alpha(1----6)dextrans, J. Immunol, vol. 138, no. 12, 1987, pp. 4472-4479. PUBMED: 2438345
Bard J.A. and Birshtein B.K, Rearrangement of a VH-associated LINE-1 element with the expressed IgH cluster in a murine myeloma cell line, J. Immunol, vol. 154, no. 1, 1995, pp. 201-208. PUBMED: 7995940
Behar S.M. and Scharff M.D, Somatic diversification of the S107 (T15) VH11 germ-line gene that encodes the heavy-chain variable region of antibodies to double-stranded DNA in (NZB x NZW)F1 mice, Proc. Natl. Acad. Sci. U.S.A, vol. 85, no. 11, 1988, pp. 3970-3974. DOI: 10.1073/pnas.85.11.3970
Blankenstein T. and Krawinkel U, Unpublished.
Blankenstein T. et al., Analysis of immunoglobulin heavy chain V-region genes belonging to the V NP-gene family, Nucleic Acids Res, vol. 12, no. 17, 1984, pp. 6887-6900. DOI: 10.1093/nar/12.17.6887
Blankenstein T. et al., Evolution of pseudogenes in the immunoglobulin VH-gene family of the mouse, Immunogenetics, vol. 26, no. 4-5, 1987, pp. 237-248. DOI: 10.1007/BF00346518
Bothwell A.L. et al., Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region, Cell, vol. 24, no. 3, 1981, pp. 625-637. DOI: 10.1016/0092-8674(81)90089-1
Carlsson L. et al., Developmentally controlled selection of antibody genes: characterization of individual VH7183 genes and evidence for stage-specific somatic diversification, Eur. J. Immunol, vol. 22, no. 1, 1992, pp. 71-78. PUBMED: 1730262
Chao, M, and E W Voss Jr. “Autoimmune VH gene family: PCR-generated murine germline VH10 genes.” Molecular immunology vol. 29,3 (1992): 439-42. DOI: 10.1016/0161-5890(92)90032-s
Chukwuocha R.U. et al., Sequences of four new members of the VH7183 gene family in BALB/c mice, Immunogenetics, vol. 40, no. 1, 1994, pp. 76-78. DOI: 10.1007/BF00163968
Clarke C. et al., An immunoglobulin promoter region is unaltered by DNA rearrangement and somatic mutation during B-cell development, Nucleic Acids Res, vol. 10, no. 23, 1982, pp. 7731-7749. DOI: 10.1093/nar/10.23.7731
Cohen J.B. and Givol D, Allelic immunoglobulin VH genes in two mouse strains: possible germline gene recombination, EMBO J, vol. 2, no. 11, 1983, pp. 2013-2018. PUBMED: 6416826
Cohen J.B. et al., Simple DNA sequences in homologous flanking regions near immunoglobulin VH genes: a role in gene interaction?, Nucleic Acids Res, vol. 10, no. 11, 1982, pp. 3353-3370. DOI: 10.1093/nar/10.11.3353
Crews S. et al., A single VH gene segment encodes the immune response to phosphorylcholine: somatic mutation is correlated with the class of the antibody, Cell, vol. 25, no. 1, 1981, pp. 59-66. DOI: 10.1016/0092-8674(81)90231-2
Dzierzak E.A. et al., Molecular characterization of antibodies bearing Id-460. I. The structure of two highly homologous VH genes used to produce idiotype positive immunoglobulins, J. Immunol, vol. 136, no. 5, 1986, pp. 1864-1870. PUBMED: 3081634
Early P. et al., An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JH, Cell, vol. 19, no. 4, 1980, pp. 981-992. DOI: 10.1016/0092-8674(80)90089-6
Ferguson S.E. et al., Analysis of a novel VHS107 haplotype in CLA-2 and WSA mice. Evidence for gene conversion among IgVH genes in outbred populations, J. Exp. Med, vol. 170, no. 6, 1989, pp. 1811-1823. DOI: 10.1084/jem.170.6.1811
Fish S. and Manser T, Influence of the macromolecular form of a B cell epitope on the expression of antibody variable and constant region structure, J. Exp. Med, vol. 166, no. 3, 1987, pp. 711-724. DOI: 10.1084/jem.166.3.711
Foster M.H. et al., Molecular analysis of spontaneous nephrotropic anti-laminin antibodies in an autoimmune MRL-lpr/lpr mouse, J. Immunol, vol. 151, no. 2, 1993, pp. 814-824. PUBMED: 8335911
Gefter M.L. et al., Analysis of the anti-azobenzenearsonate response at the molecular level, Ann. Inst. Pasteur Immunol, vol. 135, 1984, pp. 17-30.
Gerondakis S. et al., Activation of immunoglobulin mu gene expression involves stepwise demethylation, EMBO J, vol. 3, no. 12, 1984, pp. 3013-3021. PUBMED: 6098461
Givol D. et al., Diversity of germ-line immunoglobulin VH genes, Nature, vol. 292, no. 5822, 1981, pp. 426-430. DOI: 10.1038/292426a0
Haines B.B. et al., Germline diversity of the expressed BALB/c VhJ558 gene family, Unpublished.
Hardy R.R. et al., A single VH gene is utilized predominantly in anti-BrMRBC hybridomas derived from purified Ly-1 B cells. Definition of the VH11 family, J. Immunol, vol. 142, no. 10, 1989, pp. 3643-3651. PUBMED: 2497178
Hartman A.B. and Rudikoff S, VH genes encoding the immune response to beta-(1,6)-galactan: somatic mutation in IgM molecules, EMBO J, vol. 3, no. 12, 1984, pp. 3023-3030. PUBMED: 6098462
Honjo T. et al., Rearrangements of immunoglobulin genes during differentiation and evolution, Immunol. Rev, vol. 59, 1981, pp. 33-67. PUBMED: 6796498
Huang H. et al., An immunoglobulin VH pseudogene, J. Mol. Appl. Genet, vol. 1, no. 2, 1981, pp. 93-101. PUBMED: 6286821
Johnston C.M. et al., Complete sequence assembly and characterization of the C57BL/6 mouse Ig heavy chain V region, J. Immunol, vol. 176, no. 7, 2006, pp. 4221-4234. PUBMED: 16547259
Kataoka T. et al., The nucleotide sequences of rearranged and germline immunoglobulin VH genes of a mouse myeloma MC101 and evolution of VH genes in mouse, J. Biol. Chem, vol. 257, no. 1, 1982, pp. 277-285. PUBMED: 6273429
Kemp D.J. et al., Organization of genes and spacers within the mouse immunoglobulin VH locus, J. Mol. Appl. Genet, vol. 1, no. 3, 1981, pp. 245-261. PUBMED: 6286826
Kim S.K. et al., Antibody diversity: somatic hypermutation of rearranged VH genes, Cell, vol. 27, no. 3 Pt 2, 1981, pp. 573-581. DOI: 10.1016/0092-8674(81)90399-8
Klein D. et al., I.29 lymphoma cells express a nonmutated VH gene before and after H chain switch, J. Immunol, vol. 140, no. 5, 1988, pp. 1676-1684. PUBMED: 3126234
Kleinfield R.W. and Weigert M.G, Interspersion of the VHQ52 and VH7183 gene families in the NFS/N mouse, J. Immunol, vol. 142, no. 12, 1989, pp. 4483-4492. PUBMED: 2498431
Kofler R, A new murine Ig VH gene family, J. Immunol, vol. 140, no. 11, 1988, pp. 4031-4034. PUBMED: 3131427
Kroemer G. et al., Evidence for a new murine immunoglobulin heavy chain variable region gene family, Immunol. Invest, vol. 16, no. 2, 1987, pp. 107-116. PUBMED: 2887512
Langdon S.D. et al., Germline sequences of V(H)7183 gene family members in C57BL/6 mice demonstrate natural selection of particular sequences during recent evolution, Immunogenetics, vol. 51, no. 3, 2000, pp. 241-245. DOI: 10.1007/s002510050038
Lawler A.M. et al., Adult B-cell repertoire is biased toward two heavy-chain variable-region genes that rearrange frequently in fetal pre-B cells, Proc. Natl. Acad. Sci. U.S.A, vol. 84, no. 8, 1987, pp. 2454-2458. DOI: 10.1073/pnas.84.8.2454
Lek S. et al., The sequence of Mus musculus BAC clone RP23-123N21, Unpublished.
Loh D.Y. et al., Molecular basis of a mouse strain-specific anti-hapten response, Cell, vol. 33, no. 1, 1983, pp. 85-93. DOI: 10.1016/0092-8674(83)90337-9
Maeda T. et al., The DJH complex remains active in recombination to VH segments after the loss of mu-chain expression in mu-positive pre-B cells, J. Immunol, vol. 142, no. 10, 1989, pp. 3652-3656. PUBMED: 2497179
Mainville C.A. et al., Deletional mapping of fifteen mouse VH gene families reveals a common organization for three Igh haplotypes, J. Immunol, vol. 156, no. 3, 1996, pp. 1038-1046. PUBMED: 8557977
Maizels N. and Bothwell A.L.M, The T-cell-independent immune response to the hapten NP uses a large repertoire of heavy chain genes, Cell, vol. 43, no. 3 Pt 2, 1985, pp. 715-720. DOI: 10.1016/0092-8674(85)90244-2
Manso,T. et al., IMGT(R) databases, related tools and web resources through three main axes of research and development, Nucleic Acids Res, vol. 50, no. D1, 2022, pp. D1262-D1272. PUBMED: 34875068
Maranhao A.Q. and Brigido M.M, Cloning of a germ line VH gene fragment related to the 36-60 (VH3) family, Unpublished.
Mural, Richard J et al. “A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome.” Science (New York, N.Y.) vol. 296,5573 (2002): 1661-71. DOI: 10.1126/science.1069193
Near R.I. et al., Expression and rearrangement of homologous immunoglobulin VH genes in two mouse strains, Proc. Natl. Acad. Sci. U.S.A, vol. 81, no. 7, 1984, pp. 2167-2171. PUBMED: 6326109
Ollo R. et al., Mouse heavy chain variable regions: nucleotide sequence of a germ-line VH gene segment, Nucleic Acids Res, vol. 9, no. 16, 1981, pp. 4099-4109. DOI: 10.1093/nar/9.16.4099
Ollo R. et al., Structural relationships among mouse and human immunoglobulin VH genes in the subgroup III, Nucleic Acids Res, vol. 11, no. 22, 1983, pp. 7887-7897. DOI: 10.1093/nar/11.22.7887
Ono M. et al., A new germline VH gene encoding a mouse nephritogenic autoantibody, Immunogenetics, vol. 42, no. 5, 1995, pp. 426-427. DOI: 10.1007/BF00179407
Ono M. et al., Sequence analysis of the germ-line VH gene corresponding to a nephritogenic antibody in MRL/lpr lupus mice, Clin. Exp. Immunol, vol. 100, no. 2, 1995, pp. 284-290. PUBMED: 7743668
Pawlitzky I. et al., Identification of a candidate regulatory element within the 5' flanking region of the mouse Igh locus defined by pro-B cell-specific hypersensitivity associated with binding of PU.1, Pax5, and E2A, J. Immunol, vol. 176, no. 11, 2006, pp. 6839-6851. PUBMED: 16709844
Perlmutter R.M. et al., Diversity in the germline antibody repertoire. Molecular evolution of the T15 VN gene family, J. Exp. Med, vol. 162, no. 6, 1985, pp. 1998-2016. DOI: 10.1084/jem.162.6.1998
Press J.L. and Giorgetti C.A, Molecular and kinetic analysis of an epitope-specific shift in the B cell memory response to a multideterminant antigen, J. Immunol, vol. 151, no. 4, 1993, pp. 1998-2013. PUBMED: 7688392
Press J.L. et al., A new germline VH36-60 gene is used in the neonatal primary and adult memory response to (T,G)-A--L, Mol. Immunol, vol. 28, no. 11, 1991, pp. 1217-1224. DOI: 10.1016/0161-5890(91)90008-8
Rathbun G.A. et al., Molecular characterization of the A/J J558 family of heavy chain variable region gene segments, J. Mol. Biol, vol. 202, no. 3, 1988, pp. 383-395. DOI: 10.1016/0022-2836(88)90272-0
Reininger L. et al., A member of a new VH gene family encodes anti-bromelinized mouse red blood cell autoantibodies, Eur. J. Immunol.
Reininger L. et al., A member of a new VH gene family encodes antibromelinized mouse red blood cell autoantibodies, Eur. J. Immunol, vol. 18, no. 10, 1988, pp. 1521-1526. PUBMED: 2903828
Retter I. et al., A 1.5 Mb BAC contig spanning the 129/Sv mouse Igh-C and proximal Igh-V locus, Unpublished.
Retter I. et al., Sequence and characterization of the Ig heavy chain constant and partial variable region of the mouse strain 129S1, J. Immunol, vol. 179, no. 4, 2007, pp. 2419-2427. PUBMED: 17675503
Rixon M.W. et al., Preferential use of a H chain V region in antitumor-associated glycoprotein-72 monoclonal antibodies, J. Immunol, vol. 151, no. 11, 1993, pp. 6559-6568. PUBMED: 8245485
Rothenfluh H.S, Somatic hypermutation and germline evolution of immunoglobulin variable region genes, Unpublished.
Rothenfluh H.S. et al., Analysis of patterns of DNA sequence variation in flanking and coding regions of murine germ-line immunoglobulin heavy-chain variable genes: evolutionary implications, Proc. Natl. Acad. Sci. U.S.A, vol. 91, no. 25, 1994, pp. 12163-12167. PUBMED: 7991601
Rothenfluh H.S. et al., Evolution of V genes: DNA sequence structure of functional germline genes and pseudogenes, Immunogenetics, vol. 42, no. 3, 1995, pp. 159-171. DOI: 10.1007/BF00191221
Sakano H. et al., Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes, Nature, vol. 286, no. 5774, 1980, pp. 676-683. DOI: 10.1038/286676a0
Schiff C. et al., Functional and pseudogenes are similarly organized and may equally contribute to the extensive antibody diversity of the IgVHII family, EMBO J, vol. 4, no. 5, 1985, pp. 1225-1230. PUBMED: 3924600
Schiff C. et al., Genetic basis for expression of the idiotypic network. One unique Ig VH germline gene accounts for the major family of Ab1 and Ab3 (Ab1') antibodies of the GAT system, J. Exp. Med, vol. 163, no. 3, 1986, pp. 573-587. DOI: 10.1084/jem.163.3.573
Schmid-Siegert E. et al., Reference mouse strain assemblies for BALB/c Nude and NOD/SCID mouse models, Unpublished.
Schreiber E. et al., The sequence of Mus musculus BAC clone RP23-172K2, Unpublished.
Seidl K.J. et al., Frequent Occurrence of Identical Heavy and Light Chain Immunoglobulin Rearrangements, Unpublished.
Sequeira A. et al., Characterization of a murine immunoglobulin VH gene segment in subgroup III: a new member of the 7183 gene family, Mol. Immunol, vol. 29, no. 3, 1992, pp. 425-430. DOI: 10.1016/0161-5890(92)90030-2
Sheehan, K M et al. “The utilization of individual VH exons in the primary repertoire of adult BALB/c mice.” Journal of immunology (Baltimore, Md. : 1950) vol. 151,10 (1993): 5364-75. PUBMED: 8228231
Shimizu T. and Yamagishi H, Biased reading frames of pre-existing DH--JH coding joints and preferential nucleotide insertions at VH--DJH signal joints of excision products of immunoglobulin heavy chain gene rearrangements, EMBO J, vol. 11, no. 13, 1992, pp. 4869-4875. PUBMED: 1464314
Siekevitz M. et al., The genetic basis of antibody production: a single heavy chain variable region gene encodes all molecules bearing the dominant anti-arsonate idiotype in the strain A mouse, Eur. J. Immunol, vol. 13, no. 2, 1983, pp. 123-132. PUBMED: 6403356
Sims, M J et al. “Characterization of germ-line genes of the VGAM3.8 VH gene family from BALB/c mice.” Journal of immunology (Baltimore, Md. : 1950) vol. 149,5 (1992): 1642-8. PUBMED: 1506687
Siu G. et al., Structure of the T15 VH gene subfamily: identification of immunoglobulin gene promotor homologies, J. Immunol, vol. 138, no. 12, 1987, pp. 4466-4471. PUBMED: 3108392
Smith D.R, Genome Therapeutics Corporation Sequencing Center: Mouse Genome Sequence Data, Unpublished.
Tao W. and Bothwell A.L, Development of B cell lineages during a primary anti-hapten immune response, J. Immunol, vol. 145, no. 10, 1990, pp. 3216-3222. PUBMED: 2230115
Thane N. et al., The sequence of Mus musculus BAC clone RP23-230L2, Unpublished.
Thomas J.W, Anti-insulin and regulatory anti-idiotypic antibodies use the same germ-line VHIX gene, Eur. J. Immunol, vol. 22, no. 9, 1992, pp. 2445-2448. PUBMED: 1516630
Trepicchio W.Jr. et al., The heavy chain genes of a lupus anti-DNA autoantibody are encoded in the germ line of a nonautoimmune strain of mouse and conserved in strains of mice polymorphic for this gene locus, J. Immunol, vol. 139, no. 9, 1987, pp. 3139-3145. PUBMED: 3117887
Tutter A. et al., Structure, Map position, and evolution of two newly diverged mouse immunoglobulin VH gene families, Unpublished.
Ucker D.S. et al., An unusual clonotypic determinant on a cytotoxic T lymphocyte line is encoded by an immunoglobulin heavy chain variable region gene, J. Immunol, vol. 135, no. 6, 1985, pp. 4204-4214. PUBMED: 2415604
Weiller G.F. et al., Recombination signature of germline immunoglobulin variable genes, Immunol. Cell Biol, vol. 76, no. 2, 1998, pp. 179-185. PUBMED: 9619489
Whitcomb E.A. et al., Germline structure and differential utilization of Igha and Ighb VH10 genes, J. Immunol, vol. 162, no. 3, 1999, pp. 1541-1550. PUBMED: 9973411
Williams G.S. et al., Unequal VH gene rearrangement frequency within the large VH7183 gene family is not due to recombination signal sequence variation, and mapping of the genes shows a bias of rearrangement based on chromosomal location, J. Immunol, vol. 167, no. 1, 2001, pp. 257-263. PUBMED: 11418657
Winter D.B. et al., Allelic differences in the VHOx-1 gene explain the absence of a B cell clonal dominance in the primary response of C57BL/6 mice to phthalate, J. Immunol, vol. 155, no. 5, 1995, pp. 2445-2452. PUBMED: 7650375
Winter E. et al., Members of novel VH gene families are found in VDJ regions of polyclonally activated B-lymphocytes, EMBO J, vol. 4, no. 11, 1985, pp. 2861-2867. PUBMED: 2998759
Yancopoulos G.D. and Alt F.W, Developmentally controlled and tissue-specific expression of unrearranged VH gene segments, Cell, vol. 40, no. 2, 1985, pp. 271-281. DOI: 10.1016/0092-8674(85)90141-2
Yancopoulos G.D. et al., Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines, Nature, vol. 311, no. 5988, 1984, pp. 727-733. DOI: 10.1038/311727a0
Young D. and Kearney J.F, Sequence analysis and antigen binding characteristics of Ig SCID Ig+ mice, Int. Immunol, vol. 7, no. 5, 1995, pp. 807-819. DOI: 10.1093/intimm/7.5.807
Zheng X. et al., The sequence of Mus musculus BAC clone RP23-333D9, Unpublished.
Zylstra P. et al., PCR amplification of murine immunoglobulin germline V genes: strategies for minimisation or recombination artefacts, Unpublished.

IMGT Repertoire (IG and TR)

Dynamic gene tables per IMGT group and per species (IMGT/GeneTables)

Gene table legend:

IMGT notes: ↑

IMGT references: ↑

IMGT Repertoire (IG and TR)

Dynamic gene tables per IMGT group and per species (IMGT/GeneTables)

Version 1.4

Version 1.3

Version 1.2

Version 1.1

Version 1.0

Gene table legend:

IMGT notes: ↑

IMGT references: ↑