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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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The Bull shark (Carcharhinus leucas) IGHV genes and alleles have a temporary designation based on the IMGT gene name nomenclature rules for the unmapped genes, the incomplete loci, or the cDNAs in the absence of germline genes.

IMGT subgroup IMGT gene name IMGT allele name Fct R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Accession numbers Positions in the sequence Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence
IGHV1 IGHV1S1 IGHV1S1*01 (F) + + U50611 [1] #c
IGHV1S2 IGHV1S2*01 (F) + + U50612 [1] #c
IGHV1S3 IGHV1S3*01 (F) + + U50613 [1] #c
IGHV1S4 IGHV1S4*01 (F) + + U50614 [1] #c

#c: rearranged cDNA.

IMGT references:
  1. [1] Bernstein R.M. et al., Proc. Natl. Acad. Sci. U.S.A., 93, 3289-3293 (1996). PMID:8622930
  2. [2] Roman, T. et al., Immunogenetics, 43, 325-326 (1996). PMID:9110939
Created:
17/05/2001
Last updated:
22/09/2023
Authors:
Lorena Betancourt, Dominique Scaviner