IMGT Repertoire (IG and TR)

Fct: FUNCTIONALITY
- F: Functional
- P: Pseudogene
- ORF: Open Reading Frame
R: Rearranged
T: Transcribed
Pr: Translated into protein

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

Click on:

IMGT gene name to get the corresponding IMGT/GENE-DB entry,
IMGT allele name to see the corresponding Alignments of alleles,
accession number to get the corresponding IMGT/LIGM-DB entry.

IMGT subgroup		IMGT gene name	IMGT allele name	Fct		R	T	Pr	Positions in the locus	IMGT/LIGM-DB reference sequences						IMGT/LIGM-DB sequences from the literature
IMGT subgroup		IMGT gene name	IMGT allele name	Fct		R	T	Pr	Positions in the locus	Strain	Clone names	Accession numbers	Positions in the sequence	Secondary accession numbers		Strain	Clone names	Accession numbers	Positions in the sequence
IGHV3	(3)	IGHV3S1	IGHV3S1*01	F									VHH1	AF305944	[1]
		IGHV3S2	IGHV3S2*01	F									VHH2	AF305945	[1]
		IGHV3S3	IGHV3S3*01	F									VHH3	AF305946	[1]
		IGHV3S4	IGHV3S4*01	F									VHH4	AF305947	[1]
		IGHV3S5	IGHV3S5*01	F									VHH5	AF305948	[1]
		IGHV3S6	IGHV3S6*01	F									VH1	AF305949	[1]
		IGHV3S7	IGHV3S7*01	P	(1)								Vpseudo1	AF305950	[1]
		IGHV3S8	IGHV3S8*01	P	(2)								Vpseudo2	AF305951	[1]

IMGT notes:

(1) In frame STOP-CODON (positions 127-129) at codon 43 in FR2-IMGT.
(2) In frame STOP-CODON (positions 307-309) at codon 103 in FR3-IMGT.
(3) Previously annotaded as IGHV1 subgroup.The Llama (Lama glama) IGHV3 genes belong, as those of the Arabian camel (Camelus dromedarius) IGHV3 genes, to two sets based on amino acid sequences and, probably on the presence or lack of light chain in the antibodies. The functional IGHV3S6 gene and the IGHV3S7 and IGHV3S8 pseudogenes belong to the first set. The functional IGHV3S1 to IGHV3S5 genes belong to the second set. Four FR2-IMGT positions (42, 49, 50 and 52 in the IMGT unique numbering) show amino acid differences characteristic of each set:

FR2-IMGT amino acid positions 42 49 50 52

IGHV3S6, IGHV3S7(P), IGHV3S8(P) V G L W

IGHV3S1 to IGHV3S5 F,Y E R G,L,W

FR2-IMGT amino acid positions	42	49	50	52
IGHV3S6, IGHV3S7(P), IGHV3S8(P)	V	G	L	W
IGHV3S1 to IGHV3S5	F,Y	E	R	G,L,W

IMGT references:

[1] Woolven B.P. et al., Unpublished.

See also (IMGT Scientific chart):

Created:: 05/02/2002
Last updated:: 22/09/2023
Authors:: Joumana Jabado-Michaloud, Dominique Scaviner

IMGT Repertoire (IG and TR)

Gene table: Llama (Lama glama) IGHV