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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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The 3 House mouse (Mus musculus) IGLV subgroups belong to three clans (Figure IGLV clans). Clans comprise, respectively:

Click here for Number of genes as deduced by RFLP analysis.

IMGT subgroup IMGT gene name IMGT allele name Fct Chromosomal localization R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Accession numbers Positions in the sequence
(L-V-GENE-UNIT)		 Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence
(L-V-GENE-UNIT)
IGLV1 IGLV1 IGLV1*01 F 16 (13.0 cM) + + BALB/c V1 MAP J00590 [2] BALB/c A1-13/eVl1 MAP X58409 [3]
V00811 [5]
C57BL/6J CM001009.3 MAP IMGT000117 185235..185717
129S1_SvImJ IMGT000124 [9] MAP 184958..185470
BALB/cJ IMGT000126 [9] MAP 184970..185452
DBA_2J IMGT000134 [9] MAP 184901-185383 (4)
IGLV1*02 F 16 (13.0 cM) BALB/c M315/eVl1 MAP X58417 [3]
IGLV2 IGLV2*01 F 16 (13.0 cM) V2 MAP J00599 [1] V00815 [1]
IGLV2*02 F 16 (13.0 cM) + BALB/c J558/eVl2 MAP X58412 [3] BALB/c X58418 [3]
M315e/Vl2 MAP X58423 [3]
X58424 [3]
C57BL/6J CM001009.3 MAP IMGT000117 9851..10333
129S1_SvImJ IMGT000124 [9] MAP 9559..10041
BALB/cJ IMGT000126 [9] MAP 9558..10040
DBA_2J IMGT000134 [9] MAP 9519-10001 (4)
IGLV2 IGLV3 (1) IGLV3*01 F 16 (13.0 cM) + BALB/c Lg1 MAP M34597 [4] BALB/c Y31 (lambdax) M34598 [8] #c
Vlx (Vlambda x) MAP D38129 [4]
C57BL/6J CM001009.3 MAP IMGT000117 29016..29527
129S1_SvImJ IMGT000124 [9] MAP 28721..29232
BALB/cJ IMGT000126 [9] MAP 28720..29231
DBA_2J IMGT000134 [9] MAP 28681-29192 (4)
IGLV3 (2) IGLV4 IGLV4*01 [F] 16 (13.0 cM) + + MBK MBK2 AF357985 [6] (3) ° SD26 M94349 [7] #c
IGLV5 IGLV5*01 [F] 16 (13.0 cM) + + PWK PWK1 AF357981 [6] (3) ° CZ81 M94351 [7] #c
IGLV6 IGLV6*01 [F] 16 (13.0 cM) PWK PWK3 AF357979 [6] (3) °
IGLV6*02 [F] 16 (13.0 cM) MAI MAI2 AF357983 [6] (3) °
IGLV6*03 [F] 16 (13.0 cM) MBK MBK4 AF357987 [6] (3) °
IGLV7 IGLV7*01 [F] 16 (13.0 cM) PWK PWK2 AF357980 [6] (3) °
IGLV7*02 [F] 16 (13.0 cM) MBK MBK1 AF357984 [6] (3) °
IGLV8 IGLV8*01 [F] 16 (13.0 cM) MAI MAI1 AF357982 [6] (3) °
IGLV8*02 [F] 16 (13.0 cM) MBK MBK3 AF357986 [6] (3) °

#c: rearranged cDNA.
°: genomic DNA, but not known as being germline or rearranged.
MAP: Mapped reference sequences.

IMGT notes:
  1. (1) The last codon of the CDR3-IMGT is a STOP-CODON which may disappear during rearrangements.
  2. (2) Gene identification needs to be confirmed with genomic mapping. Genes belonging to the IGLV3 subgroup may vary from 0 to at least 5, depending from Mus musculus strains as deduced from RFLP analysis [7]. The IGLV3 subgroup is absent in BALB/c and in other laboratory mice.
  3. (3) Partial V-REGION: partial FR1-IMGT (AA 1 to 4 are absent) and partial FR3-IMGT (AA 99 to 104 are absent).
  4. (4) Position of L-V-GENE-UNIT
  5. (5) Position of V-REGION
  6. (6) STOP-CODON at position 116 (last 3' codon of germline V-REGION) may disappear during rearrangements
IMGT references:
  1. [1] Tonegawa S. et al., Proc. Natl. Acad. Sci. USA, 75, 1485-1489 (1978). PMID:418414
  2. [2] Arp B. et al., Nature, 298, 184-187 (1982). PMID:6806667
  3. [3] Weiss S. and Wu GE, EMBO J., 6, 927-937 (1987). PMID:3109891
  4. [4] Sanchez P. et al., J. Immunol., 144, 2816-2820 (1990). PMID:2108215
  5. [5] Bernard O. et al., Cell, 15, 1133-1144 (1978). PMID:103630
  6. [6] Amrani Y.M. et al., Immunogenetics, 54, 106-119 (2002). PMID:12037603
  7. [7] Reidl L.S. et al., J. Immunol., 149, 471-480 (1992). PMID:1378065
  8. [8] Sanchez P. et al., Proc. Natl. Acad. Sci. USA, 84, 9185-9188 (1987). PMID:3122215
  9. [9] Keane T., Not published..
Created:
03/11/1999
Last updated:
22/09/2023
Authors:
Dominique Scaviner, Delphine Guiraudou, Guilhem Zeitoun and Yascim Kamel