IMGT Repertoire (IG and TR)

Fct: FUNCTIONALITY
- F: Functional
- P: Pseudogene
- ORF: Open Reading Frame
T: Transcribed
Pr: Translated into protein

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

Click on:

IMGT gene name to get the corresponding IMGT/GENE-DB entry,
IMGT allele name to see the corresponding Alignments of alleles,
accession number to get the corresponding IMGT/LIGM-DB entry.

IMGT gene name	IMGT allele name	Fct	T		Pr	Positions in the locus	IMGT/LIGM-DB reference sequences							IMGT/LIGM-DB sequences from the literature
IMGT gene name	IMGT allele name	Fct	T		Pr	Positions in the locus	Breed	Clone names	Exons	Accession numbers	Positions in the sequence	Secondary accession numbers		Breed			Clone names	Accession numbers	Positions in the sequence
	IGHA	IGHA*01	(F)									CH1		AF024645	[6]	c(s)
												H+CH2	(2)	AF024645	[6]	c(s)
												CH3 (including CHS)		AF024645	[6]	c(s)
	IGHD	IGHD*01	(F)									CH1		AF411238	[7]	c(s)
												H1		AF411238	[7]	c(s)
												H2		AF411238	[7]	c(s)
												CH2		AF411238	[7]	c(s)
												CH3		AF411238	[7]	c(s)
												M1		AF411238	[7]	c(s)
												M2		AF411238	[7]	c(s)
	IGHG1	IGHG1*01	(F)								3B2	CH1		X69797	[5]	c(s)
												H		X69797	[5]	c(s)
												CH2		X69797	[5]	c(s)
												CH3(including CHS)		X69797	[5]	c(s)
	IGHG2	IGHG2*01	(F)									CH1		X70983	[3]	c(s)
												H		X70983	[3]	c(s)
												CH2		X70983	[3]	c(s)
												CH3(including CHS)		X70983	[3]	c(s)
	IGHE	IGHE*01	(F)	(1)							1-4	CH1		M84356	[1]	c(s)
												CH2		M84356	[1]	c(s)
												CH3		M84356	[1]	c(s)
												CH4(including CHS)		M84356	[1]	c(s)
	IGHM	IGHM*01	(F)								SHμ7	CH1		X59994	[2]	c(s)
												CH2		X59994	[2]	c(s)
												CH3		X59994	[2]	c(s)
												CH4(including CHS)		X59994	[2]	c(s)
		IGHM*02	(F)								IgM29	CH1		L04260	[4]	c(m)
												CH2		L04260	[4]	c(m)
												CH3		L04260	[4]	c(m)
												CH4		L04260	[4]	c(m)
												M1		L04260	[4]	c(m)
												M2		L04260	[4]	c(m)

c: cDNA sequence.
(m): transcript of a membrane chain.
(s): transcript of a secreted chain.

IMGT notes:

(1) Gene supposed to be functional: DELETION of nucleotide G in the L-REGION in EMBL flat file is probably due to a sequencing or typing error.
(2) In the IGHA gene, the hinge and CH2 are joined in a single exon.

IMGT references:

[1] Engwerda C.R. et al., Vet. Immunol. Immunopathol., 34, 115-126 (1992). PMID:1279886
[2] Patri S. and Nau F., Mol. Immunol., 29, 829-836 (1992). PMID:1635560
[3] Clarkson C.A. et al., Mol. Immunol., 30, 1195-1204 (1993). PMID:8413324
[4] Hein W.R. and Dudler L., Mol. Immunol., 30, 783-784 (1993). PMID:8502245
[5] Dufour V. et al., J. Immunol., 156, 2163-2170 (1996). PMID:8690905
[6] White G.P. et al., Immunogenetics, 48, 359-362 (1998). PMID:9745016
[7] Zhao Y. et al., J. Immunol., 169, 4408-4416 (2002). PMID:12370374

See also (IMGT Scientific chart):

Created:: 06/01/1999
Last updated:: 22/09/2023
Authors:: Christèle Martinez-Jean and Joumana Jabado-Michaloud

IMGT Repertoire (IG and TR)

Gene table: sheep (Ovis aries) IGHC