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"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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IMGT gene name IMGT allele name Fct Haplotypes T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Strain Clone names Exons Accession numbers Positions in the sequence Secondary accession numbers Strain Clone names Accession numbers Positions in the sequence
IGHA IGHA*01 F + IgA-A.I CH1 AY039245 [2] RGR.1 AY294619 [5] (3)
H+CH2 (1) AY039245 [2] RGR.1 AY294619 [5] (3)
CH3 (including CHS) AY039245 [2]
IGHA*02 F IgA-A.II CH1 AY039246 [2]
H+CH2 (1) AY039246 [2]
CH3 (including CHS) AY039246 [2]
IGHA*03 F IgA-B.II CH1 AY039247 [2]
H+CH2 (1) AY039247 [2]
CH3 (including CHS) AY039247 [2]
IGHA*04 F + IgA-B.I CH1 AY039248 [2] RWy2.1 AY294622 [5] (3)
H+CH2 (1) AY039248 [2] RWy2.1 AY294622 [5] (3)
CH3 (including CHS) AY039248 [2]
IGHA*05 F IgA-C.I CH1 AY039249 [2]
H+CH2 (1) AY039249 [2]
CH3 (including CHS) AY039249 [2]
IGHA*06 F IgA-D.I CH1 AY039250 [2]
H+CH2 (1) AY039250 [2]
CH3 (including CHS) AY039250 [2]
IGHA*07 F IgA-D.II CH1 AY039251 [2]
H+CH2 (1) AY039251 [2] UTS372 AB013760 [3] (2)
CH3 (including CHS) AY039251 [2]
IGHA*08 F IgA-C.II CH1 AY039252 [2]
IgA-D.I H+CH2 (1) AY039252 [2]
CH3 (including CHS) AY039252 [2]
IGHA*09 F UTS378 C alpha CH1 AB013768 [3] (3)
H+CH2 (1) AB013768 [3] (3)
UTS520 C alpha CH1 AB013769 [3] (3)
IGHA*10 F UTS520 C alpha H+CH2 (1) AB013769 [3] (3)
IGHA*11 F UTS493 C alpha CH1 AB013767 [3] (3)
H+CH2 (1) AB013767 [3] (3)
IGHA*12 F UTS380 C alpha H+CH2 (1) AB013757 [3] (2)
IGHA*13 F UTS382 C alpha H+CH2 (1) AB013761 [3] (2)
IGHA*14 (F) + RUa8 CH1 AY294614 [5] c(s)
H+CH2 (1) AY294614 [5] c(s)
CH3 (including CHS) AY294614 [5] c(s)
IGHA*15 (F) + RGz7 RGz7.1 CH1 AY294616 [5] (3)
H+CH2 (1) AY294616 [5] (3)
IGHA*16 (F) + RGz7 RGz7.2 CH1 AY294617 [5] (3)
H+CH2 (1) AY294617 [5] (3)
IGHA*17 (F) + RGR RGR.2 CH1 AY294618 [5] (3)
H+CH2 (1) AY294618 [5] (3)
IGHA*18 (F) + RLi1 RLi1.1 CH1 AY294620 [5] (3)
H+CH2 (1) AY294620 [5] (3)
IGHA*19 (F) + RLi1 RLi1.2 CH1 AY294621 [5] (3)
H+CH2 (1) AY294621 [5] (3)
IGHA*20 (F) + RWy2 RWy2.2 CH1 AY294623 [5] (3)
H+CH2 (1) AY294623 [5] (3)
IGHA*21 (F) + RGz7 CH1 AY294615 c(s)
H+CH2 (1) AY294615 c(s)
CH3 (including CHS) AY294615 c(s)
IGHA*22 F AG07107 CM014342.1 CH1 IMGT000064 MAP 1956843..1957142
H+CH2 IMGT000064 MAP 1957357..1957689
CH3 (including CHS) IMGT000064 MAP 1957901..1958232
M IMGT000064 MAP 1960848..1961059
IGHA*23 F rheMacS_CGG.01 CM017744.1 CH1 IMGT000099 2477366..2477668
H+CH2 IMGT000099 2477883..2478224
CH3 (including CHS) IMGT000099 2478435..2478826
M IMGT000099 2481392..2481603
IGHA*24 F RUp15 CH1 SBKD01000511 403542..403841
H+CH2 SBKD01000511 404056..404388
CH3 (including CHS) SBKD01000511 404599..404990
M SBKD01000511 407548..407759
IGHD IGHD*01 (F) + CH1 DQ297181 [7] (5)
H1 DQ297181 [7] (5)
H2 DQ297181 [7] (5)
CH2 DQ297181 [7] (5)
CH3 DQ297181 [7] (5)
IGHD*02 (F) + CH1 DQ297180 [7] (5)
H1 DQ297180 [7] (5)
H2 DQ297180 [7] (5)
CH2 DQ297180 [7] (5)
CH3 DQ297180 [7] (5)
IGHD*03 F AG07107 CM014342.1 CH1 IMGT000064 MAP 1722155..1722463
H1 IMGT000064 MAP 1722947..1723048
H2 IMGT000064 MAP 1726496..1726557
CH2 IMGT000064 MAP 1727290..1727613
CH3 IMGT000064 MAP 1727917..1728240
CHS IMGT000064 MAP 1730163..1730188 17573 CM000293.1 NW_001121238 [6] (6) complement(184669..184694)
M1 IMGT000064 MAP 1730991..1731148 17573 CM000293.1 NW_001121238 [6] (6) complement(183710..183867)
M2 IMGT000064 MAP 1731432..1731437 17573 CM000293.1 NW_001121238 [6] (6) complement(183418..183426)
IGHD*04 F rheMacS_CGG.01 CM017744.1 CH1 IMGT000099 2240002..2240310
H1 IMGT000099 2240794..2240895
H2 IMGT000099 2244342..2244404
CH2 IMGT000099 2245136..2245459
CH3 IMGT000099 2245763..2246086
CHS IMGT000099 2248013..2248038
M1 IMGT000099 2248840..2248997
M2 IMGT000099 2249281..2249286
IGHD*05 P (9) RUp15 CH1 SBKD01000511 170902..171210
H1 SBKD01000511 171694..171795
H2 SBKD01000511 175241..175303
CH2 SBKD01000511 176034..176357
CH3 SBKD01000511 176660..176983
CHS SBKD01000511 178907..178932
M1 SBKD01000511 179734..179890
M2 SBKD01000511 180173..180178
IGHE IGHE*01 F AG07107 CM014342.1 CH1 IMGT000064 MAP 1943782..1944090 RUp15 SBKD01000511 391193..391501
CH2 IMGT000064 MAP 1944288..1944608 RUp15 SBKD01000511 391699..392019
CH3 IMGT000064 MAP 1944694..1945020 RUp15 SBKD01000511 392105..392431
CH4 (including CHS) IMGT000064 MAP 1945107..1945429 RUp15 SBKD01000511 392518..392846
M1 IMGT000064 MAP 1947523..1947644 RUp15 SBKD01000511 394931..395052
M2 IMGT000064 MAP 1947729..1947812 RUp15 SBKD01000511 395137..395217
IGHE*02 F rheMacS_CGG.01 CM017744.1 CH1 IMGT000099 2463950..2464258
CH2 IMGT000099 2464456..2464776
CH3 IMGT000099 2464862..2465185
CH4 (including CHS) IMGT000099 2465272..2465600
M1 IMGT000099 2467675..2467796
M2 IMGT000099 2467881..2467961
IGHG1 IGHG1*01 F 17573 CM000293.1 CH1 NW_001121238 [6] complement(117212..117505)
H NW_001121238 [6] complement(116767..116820)
CH2 NW_001121238 [6] complement(116319..116648)
CH3 (including CHS) NW_001121238 [6] complement(115908..116221)
M1 NW_001121238 [6] complement(114454..114584)
M2 NW_001121238 [6] complement(112173..112256)
IGHG1*02 F Indian isolate RWy2 CH1 AY292507 [5] Chinese isolate RJz7 AY292502 [5] (5)
Chinese isolate RGz7 AY292503 [5] (5)
Chinese isolate RUa8 AY292504 [5] (5)
Indian isolate RGr AY292505 [5] (5)
Indian isolate RLi1 AY292506 [5] (5)
H AY292507 [5] Chinese isolate RJz7 AY292502 [5] (5)
Chinese isolate RGz7 AY292503 [5] (5)
Chinese isolate RUa8 AY292504 [5] (5)
Indian isolate RGr AY292505 [5] (5)
Indian isolate RLi1 AY292506 [5] (5)
CH2 AY292507 [5] Chinese isolate RJz7 AY292502 [5] (5)
Chinese isolate RGz7 AY292503 [5] (5)
Chinese isolate RUa8 AY292504 [5] (5)
Indian isolate RGr AY292505 [5] (5)
Indian isolate RLi1 AY292506 [5] (5)
CH3 (including CHS) AY292507 [5] Chinese isolate RJz7 AY292502 [5] (5)
Chinese isolate RGz7 AY292503 [5] (5)
Chinese isolate RUa8 AY292504 [5] (5)
Indian isolate RGr AY292505 [5] (5)
Indian isolate RLi1 AY292506 [5] (5)
IGHG1*03 F AG07107 CM014342.1 CH1 IMGT000064 MAP 1796884..1797177 rheMacS_CGG.01 CM017744.1 IMGT000099 2314059..2314352
H IMGT000064 MAP 1797569..1797622 rheMacS_CGG.01 CM017744.1 IMGT000099 2314744..2314797
CH2 IMGT000064 MAP 1797741..1798070 rheMacS_CGG.01 CM017744.1 IMGT000099 2314916..2315245
CH3 (including CHS) IMGT000064 MAP 1798168..1798481 rheMacS_CGG.01 CM017744.1 IMGT000099 2315344..2315663
M1 IMGT000064 MAP 1799786..1799916 rheMacS_CGG.01 CM017744.1 IMGT000099 2316963..2317093
M2 IMGT000064 MAP 1802382..1802465 rheMacS_CGG.01 CM017744.1 IMGT000099 2319580..2319660
CH1 IMGT000064 MAP 1796884..1797177 RUp15 SBKD01000511 244762..245055
H IMGT000064 MAP 1797569..1797622 RUp15 SBKD01000511 245447..245500
CH2 IMGT000064 MAP 1797741..1798070 RUp15 SBKD01000511 245619..245948
CH3 (including CHS) IMGT000064 MAP 1798168..1798481 RUp15 SBKD01000511 246046..246365
M1 IMGT000064 MAP 1799786..1799916 RUp15 SBKD01000511 247661..247791
M2 IMGT000064 MAP 1802382..1802465 RUp15 SBKD01000511 250870..250950
IGHG2 IGHG2*01 F Indian isolate RWy2 CH1 AY292519 [5] (5)
H AY292519 [5] (5)
CH2 AY292519 [5] (5)
CH3 (including CHS) AY292519 [5] (5)
IGHG2*02 F Chinese isolate RJz7 CH1 AY292514 [5] (5) Chinese isolate RGz7 AY292515 [5] (5)
Chinese isolate RUa8 AY292516 [5] (5)
H AY292514 [5] (5) Chinese isolate RGz7 AY292515 [5] (5)
Chinese isolate RUa8 AY292516 [5] (5)
CH2 AY292514 [5] (5) Chinese isolate RGz7 AY292515 [5] (5)
Chinese isolate RUa8 AY292516 [5] (5)
CH3 (including CHS) AY292514 [5] (5) Chinese isolate RGz7 AY292515 [5] (5)
Chinese isolate RUa8 AY292516 [5] (5)
IGHG2*03 F Indian isolate RGr CH1 AY292517 [5] (5)
H AY292517 [5] (5)
CH2 AY292517 [5] (5)
CH3 (including CHS) AY292517 [5] (5)
IGHG2*04 F Indian isolate RLi1 CH1 AY292518 [5] (5)
H AY292518 [5] (5)
CH2 AY292518 [5] (5)
CH3 (including CHS) AY292518 [5] (5)
IGHG2*05 (F) + 1D2/1D5 CH1 AF045539 [1] c(s)
H AF045539 [1] c(s)
CH2 AF045539 [1] c(s)
CH3 (including CHS) AF045539 [1] c(s)
IGHG2*06 F PMac CH1 AF300440 [4] (3)
H AF300440 [4] (3)
CH2 AF300440 [4] (3)
IGHG2*07 F 17573 CM000293.1 CH3 (including CHS) NW_001121238 [6] complement(43796..44109)
M1 NW_001121238 [6] complement(42358..42488)
M2 NW_001121238 [6] complement(40410..40493)
IGHG2*08 F AG07107 CM014342.1 CH1 IMGT000064 MAP 1862106..1862399
H IMGT000064 MAP 1862788..1862823
CH2 IMGT000064 MAP 1862942..1863268
CH3 (including CHS) IMGT000064 MAP 1863366..1863679
M1 IMGT000064 MAP 1864986..1865116
M2 IMGT000064 MAP 1867127..1867210
IGHG2*09 F rheMacS_CGG.01 CM017744.1 CH1 IMGT000099 2379253..2379546
H IMGT000099 2379935..2379970
CH2 IMGT000099 2380089..2380415
CH3 (including CHS) IMGT000099 2380513..2380832
M1 IMGT000099 2382133..2382263
M2 IMGT000099 2384238..2384318
IGHG2*10 P (10) RUp15 CH1 SBKD01000511 310578..310871
H SBKD01000511 311260..311295
CH2 SBKD01000511 311414..311739
CH3 (including CHS) SBKD01000511 311837..312156
M1 SBKD01000511 313457..313587
M2 SBKD01000511 315597..315677
IGHG3 IGHG3*01 F Indian isolate RLi1 CH1 AY292512 [5] (5) Indian isolate RWy2 AY292513 [5] (5)
H AY292512 [5] (5) Indian isolate RWy2 AY292513 [5] (5)
CH2 AY292512 [5] (5) Indian isolate RWy2 AY292513 [5] (5)
CH3 (including CHS) AY292512 [5] (5) Indian isolate RWy2 AY292513 [5] (5)
IGHG3*02 F Indian isolate RGr CH1 AY292511 [5] (5)
H AY292511 [5] (5)
CH2 AY292511 [5] (5)
CH3 (including CHS) AY292511 [5] (5)
IGHG3*03 F Chinese isolate RJz7 CH1 AY292508 [5] (5) Indian isolate RGr AY292509 [5] (5)
H AY292508 [5] (5) Indian isolate RGr AY292509 [5] (5)
CH2 AY292508 [5] (5) Indian isolate RGr AY292509 [5] (5)
CH3 (including CHS) AY292508 [5] (5) Indian isolate RGr AY292509 [5] (5)
IGHG3*04 F Indian isolate RUa8 CH1 AY292510 [5] (5)
H AY292510 [5] (5)
CH2 AY292510 [5] (5)
CH3 (including CHS) AY292510 [5] (5)
IGHG3*05 (P) (9) + CH1 AF045538 [1] (4) c(m)
H AF045538 [1] (4) c(m)
CH2 AF045538 [1] (4) c(m)
CH3 AF045538 [1] (4) c(m)
M1 AF045538 [1] (4) c(m)
IGHG3*06 F PMac CH1 AF300438 [4] (3)
H AF300438 [4] (3)
CH2 AF300438 [4] (3)
CH3 (including CHS) AF300438 [4] (3)
IGHG3*07 F AG07107 CM014342.1 CH1 IMGT000064 MAP 1888750..1889043 17573 CM000293.1 NW_001121238 [6] (7) complement(20216..20509)
H IMGT000064 MAP 1889433..1889483
CH2 IMGT000064 MAP 1889602..1889931
CH3 (including CHS) IMGT000064 MAP 1890029..1890342
M1 IMGT000064 MAP 1891649..1891779
M2 IMGT000064 MAP 1894491..1894574 17573 CM000293.1 NW_001121238 [6] (7) complement(14327..14410)
IGHG3*08 F rheMacS_CGG.01 CM017744.1 CH1 IMGT000099 2405896..2406189
H IMGT000099 2406579..2406629
CH2 IMGT000099 2406748..2407077
CH3 (including CHS) IMGT000099 2407175..2407494
M1 IMGT000099 2408795..2408925
M2 IMGT000099 2411574..2411654
IGHG3*09 P (11) RUp15 CH1 SBKD01000511 337194..337487
H SBKD01000511 337877..337927
CH2 SBKD01000511 338046..338375
CH3 (including CHS) SBKD01000511 338473..338791
M1 SBKD01000511 340091..340221
M2 SBKD01000511 342920..343000
IGHG4 IGHG4*01 F Chinese isolate RGr CH1 AY292520 [5] (5) Indian isolate RWy2 AY292521 [5] (5)
H AY292520 [5] (5) Indian isolate RWy2 AY292521 [5] (5)
CH2 AY292520 [5] (5) Indian isolate RWy2 AY292521 [5] (5)
CH3 (including CHS) AY292520 [5] (5) Indian isolate RWy2 AY292521 [5] (5)
IGHG4*02 F Indian isolate RLi1 CH1 AY292522 [5] (5)
H AY292522 [5] (5)
CH2 AY292522 [5] (5)
CH3 (including CHS) AY292522 [5] (5)
IGHG4*03 F Chinese isolate RJz7 CH1 AY292523 [5] (5) Chinese isolate RGz7 AY292524 [5] (5)
H AY292523 [5] (5) Chinese isolate RGz7 AY292524 [5] (5)
CH2 AY292523 [5] (5) Chinese isolate RGz7 AY292524 [5] (5)
CH3 (including CHS) AY292523 [5] (5) Chinese isolate RGz7 AY292524 [5] (5)
IGHG4*04 F Chinese isolate RGz7 CH1 AY292525 [5] (5)
H AY292525 [5] (5)
CH2 AY292525 [5] (5)
CH3 (including CHS) AY292525 [5] (5)
IGHG4*05 F AG07107 CM014342.1 CH1 IMGT000064 MAP 1913065..1913358
H IMGT000064 MAP 1913752..1913781
CH2 IMGT000064 MAP 1913900..1914229
CH3 (including CHS) IMGT000064 MAP 1914327..1914640
M1 IMGT000064 MAP 1915949..1916079
M2 IMGT000064 MAP 1919557..1919640
IGHG4*06 F rheMacS_CGG.01 CM017744.1 CH1 IMGT000099 2430201..2430494
H IMGT000099 2430883..2430912
CH2 IMGT000099 2431031..2431360
CH3 (including CHS) IMGT000099 2431458..2431777
M1 IMGT000099 2433078..2433208
M2 IMGT000099 2439980..2440060
IGHG4*07 P (12) RUp15 CH1 SBKD01000511 361520..361813
H SBKD01000511 362203..362232
CH2 SBKD01000511 362351..362680
CH3 (including CHS) SBKD01000511 362778..363096
M1 SBKD01000511 364397..364527
M2 SBKD01000511 366631..366711
IGHM IGHM*01 (F) + CH1 AF046784 [1] (4) c(m)
CH2 AF046784 [1] (4) c(m)
CH3 AF046784 [1] (4) c(m)
CH4 (including CHS) AF046784 [1] (4) c(m)
M1 AF046784 [1] (4) c(m)
M2 AF046784 [1] (4) c(m)
IGHM*02 P (8) 17573 CM000293.1 CH1 NW_001121238 [6] complement(203083..203376)
CH2 NW_001121238 [6] complement(202656..202991)
CH3 NW_001121238 [6] complement(202116..202433)
CH4 (including CHS) NW_001121238 [6] complement(201604..201935)
IGHM*03 F AG07107 CM014342.1 CH1 IMGT000064 MAP 1712265..1712579
CH2 IMGT000064 MAP 1712670..1713005
CH3 IMGT000064 MAP 1713228..1713545
CH4 (including CHS) IMGT000064 MAP 1713726..1714057
M1 IMGT000064 MAP 1716180..1716295
M2 IMGT000064 MAP 1716485..1716490
IGHM*04 F rheMacS_CGG.01 CM017744.1 CH1 IMGT000099 2230115..2230429
CH2 IMGT000099 2230521..2230856
CH3 IMGT000099 2231079..2231396
CH4 (including CHS) IMGT000099 2231577..2231968
M1 IMGT000099 2234031..2234146
M2 IMGT000099 2234336..2234341
IGHM*05 P (13) RUp15 CH1 SBKD01000511 161355..161669
CH2 SBKD01000511 161761..162096
CH3 SBKD01000511 162318..162634
CH4 (including CHS) SBKD01000511 162813..163206
M1 SBKD01000511 165270..165385
M2 SBKD01000511 165575..165580

MAP: Mapped reference sequences.
c: cDNA sequence.
(s): trancript of a secreted chain.
(m): trancript of a membrane chain.

IMGT notes:
  1. (1) In the IGHA gene, the hinge (H) and CH2 are joined in a single exon.
  2. (2) Partial C-GENE: no CH1 and CH2 is partial in 3'
  3. (3) Partial C-GENE: CH1 is partial in 5' and CH2 is partial in 3'
  4. (4) Partial C-GENE: M1 is partial in 3'
  5. (5) Partial C-GENE: CH3 is partial in 3'
  6. (6) Partial C-GENE: no CH1, H1, H2, CH2 and CH3
  7. (7) Partial C-GENE: no H, CH2, CH3 and M1
  8. (8) pseudogene: frameshifts in CH1
  9. (9) pseudogene: frameshift in M1
  10. (10) pseudogene: frameshift in CH2
  11. (11) pseudogene: frameshift in CH2
  12. (12) pseudogene: frameshift in CH3
  13. (13) pseudogene: frameshift in CH3, frameshift in CH4
IMGT references:
  1. [1] Calvas P. et al., Scand. J. Immunol., 49, 595-610 (1999). PMID:10354371
  2. [2] Scinicariello F. and Attanasio R., Immunology, 103, 441-448 (2001). PMID:11529934
  3. [3] Sumiyama K. et al., Mol. Biol. Evol., 19, 1093-1099 (2002). PMID:12082128
  4. [4] Fortenfant F.et al., Unpublished (2002).
  5. [5] Scinicariello,F. et al., Immunology 111 (1), 66-74 (2004). PMID:14678200
  6. [6] Gibbs R.A. et al., Science. 316(5822):222-234 (2007).
  7. [7] Rogers K.A. et al., Immunology 118(1):88-100 (2006). PMID:16630026
Created:
15/02/2021
Last updated:
22/09/2023
Authors:
Viviane Nguefack Ngoune, Alexandre Albani, Saida Saljoqi, Nathalie Bosc, Gérard Lefranc, Sofia Kossida, Marie-Paule Lefranc