Here you are: IMGT Web resources > IMGT Repertoire (IG and TR) > 1. Locus and genes
Citing this page:Pallarès et al., Exp. Clin. Immunogenet., 15, 8-18 (1998) pdf

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) rearranged (R), transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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For a given gene name, each horizontal line corresponds to a different allele. For more information, see Alignments of alleles and Tables of alleles (IMGT Repertoire).

IGLV gene names are designated by a number for the subgroup [1,23,24], followed by a dash and a number for the localization from 3' to 5' in the locus.
In the IGLV gene name column, the IGLV genes are listed, for each subgroup, according to their position from 3' to 5' in the locus.
Pseudogenes which could not be assigned to subgroups with functional genes are designated by a roman number between parentheses, corresponding to the clans [26], followed by a dash and a number for the localization from 3' to 5' in the locus.

The 11 human (Homo sapiens) IGLV subgroups belong to five clans (Figure IGLV clans). Two additional clans only contain pseudogenes. Clans comprise, respectively:

IMGT subgroup IMGT gene name IMGT allele name Fct Chromosomal localization R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Clone names Accession numbers Positions in the sequence
(L-V-GENE-UNIT)
Secondary accession numbers Clone names Accession numbers Positions in the sequence
(L-V-GENE-UNIT)
IGLV1 IGLV1-36 IGLV1-36*01 (32) F 22q11.2 + + 1a(1a.11.2) MAP Z73653 [1] V1-11 MAP D87009 [26]
D87010 [26]
DPL1 Z22187 [12]
lv1c2 U03900 [2]
lv1c2c U03901 [2]
IGLV1-40 IGLV1-40*01 (32) F 22q11.2 + + Humlv1042 MAP M94116 [7] 1e(1e.10.2) MAP Z73656 [1]
V1-13 MAP D87010 [26]
DPL8 Z22194 [12]
IGLV1-40*02 (32) F 22q11.2 + + Vlambda1.2(IGLV1S2) X53936 [13] DPL7 Z22193 [12]
IGLV1-40*03 (32) F 22q11.2 + + DPL6 Z22192 [12]
IGLV1-41 IGLV1-41*01 (32) ORF (2) 22q11.2 Humlv1041 MAP M94118 [7] Vlambda1.1(IGLV1S1) MAP X14615 [5]
1d(1d.8.3) MAP Z73655 [1]
DPL4 Z22212 [12]
IGLV1-41*02 (32) P (3) 22q11.2 V1-14P MAP D87010 [26]
IGLV1-44 IGLV1-44*01 (32) F 22q11.2 + + 1c(1c.10.2) MAP Z73654 [1] V1-16 MAP D86999 [26]
DPL2 Z22188 [12]
Humlv1L1 X59707 [7]
lv1L1a U03902 [2]
ABC13_11_000048870800_F24 MAP AC279207 [35] 38731..39237
IGLV1-44*02 (32) F 22q11.2 MAP MW316667 [37][53] 89..594
IGLV1-44*03 (32) F 22q11.2 MAP MW316668 [37][53] 87..593
IGLV1-47 IGLV1-47*01 (32) F 22q11.2 + + 1g(1g.400B5) MAP Z73663 [1] DPL3 Z22189 [12]
Humlv122 M94114 [7]
IGLV1-47*02 (32) F 22q11.2 + + V1-17 MAP D87016 [26]
IGLV1-47*03 (32) F 22q11.2 ABC13_11_000048870800_F24 MAP AC279207 [35] 15634..16140
IGLV1-50 IGLV1-50*01 (32) ORF (4) 22q11.2 Humlv101 MAP M94112 [7] 1f(1f.366F5) MAP Z73662 [1]
V1-18 MAP D87018 [26]
DPL9 Z22195 [12]
IGLV1-51 IGLV1-51*01 (32) F 22q11.2 + + 1b(1b.366F5) MAP Z73661 [1] V1-19 MAP D87018 [26]
DPL5 Z22191 [12]
lv117d U03870 [10]
IGLV1-51*02 (32) F 22q11.2 + + Humlv117 MAP M30446 [20] Humlv119 MAP [7](5)
IGLV1-62 IGLV1-62*01 (33) P (6) 22q11.2 V1-23P MAP D87022 [26]
IGLV2 IGLV2-5 IGLV2-5*01 (31) P (7) 22q11.2 2a1(2a1.51E6) MAP Z73641 [1] V1-1P MAP D87024 [26]
DPL15 Z22201 [12]
lv2120 L27696 [22]
IGLV2-5*02 (31) P (7) 22q11.2 psiVlambdaII.1 MAP X57825 [11]
IGLV2-8 IGLV2-8*01 (31) F 22q11.2 + + 2c(2c.118D9) MAP X97462 [1] V1-2 MAP D87021 [26]
EKL2046 Y12417 [32]
ABC13_11_000047484300_J24 MAP AC279221 [35] 32037..32544
IGLV2-8*02 (31) F 22q11.2 + + lv2046 L27695 [22]
IGLV2-8*03 (31) F 22q11.2 RXL2046 Y12418 [32]
IGLV2-11 IGLV2-11*01 (31) F 22q11.2 + + 174779_ABC12_000046886900_P4 MAP AC279423 [35] 40444..40953 2e(2e.2.2) MAP Z73657 [1]
V1-3 MAP D86998 [26]
EKL12 Y12414 [32]
ABC13_11_000047484300_J24 MAP AC279221 [35] 1746..2255
IGLV2-11*02 (31) F 22q11.2 + + DPL12 Z22198 [12]
IGLV2-11*03 (31) F 22q11.2 RXL12 Y12415 [32]
IGLV2-14 IGLV2-14*01 (31) F 22q11.2 + + 2a2(2a2.272A12) MAP Z73664 [1] V1-4 MAP D87015 [26]
DPL11 Z22197 [12]
lv215.23 L27693 [22]
IGLV2-14*02 (31) F 22q11.2 + + lv2018 L27822 [22]
IGLV2-14*03 (31) F 22q11.2 174779_ABC12_000046886900_P4 MAP AC279423 [35] 6759..7268 EKL11 MAP Y12412 [32] <1..>274 (36)
IGLV2-14*01_S5228 MAP MK308863 [36] (52) 1..297
IGLV2-14*04 (31) F 22q11.2 RXL11 Y12413 [32]
IGLV2-14*05 (31) F 22q11.2 MW316674 [37][53] 169..678
IGLV2-18 IGLV2-18*01 (31) F 22q11.2 + + 2d(2d.29D11) MAP Z73642 [1] V1-5 MAP D87007 [26]
D87015 [26]
DPL13 Z22199 [12]
lv2132 L27689 [22]
IGLV2-18*02 (31) F 22q11.2 + + lv216.21 L27697 [22] RLX13 Y12416 [32]
ABC12_000046968100_B3 MAP AC279210 [35] 36046..36554
IGLV2-18*03 (31) F 22q11.2 + + lv2007 L27694 [22]
IGLV2-18*04 (31) F 22q11.2 + + lv2113 L27692 [22]
IGLV2-23 IGLV2-23*01 (31) F 22q11.2 + + Vlambda2.1(IGLV2S1) MAP X14616 [17,18]
IGLV2-23*02 (31) F 22q11.2 + + 2b2(2b2.400B5) MAP Z73665 [1] EKL10 Y12411 [32]
ABC10_2_1_000044078800_J23 AC279208 [35] 2742..3251
ABC11_000047191900_P24 AC279219 [35] 2742..3251
ABC11_2_1_000049528800_P17 AC279213 [35] 27293..27802
IGLV2-23*03 (31) F 22q11.2 + + V1-7 MAP D86994 [26] DPL10 Z22196 [12]
lv2066 L27688 [22]
IGLV2-28 IGLV2-28*01 (31) P (8) 22q11.2 ABC11_000047999300_E7 MAP AC279318 [35] 9561..10058 2b1(2b1.22E4) MAP X97466 [1]
V1-8P MAP D86994 [26]
IGLV2-33 IGLV2-33*01 (31) ORF (9) 22q11.2 2f(2f.61E11) MAP Z73643 [1] V1-9 MAP D87014 [26]
DPL14 Z22200 [12]
lv2011 L27687 [22]
IGLV2-33*02 (31) ORF (9) 22q11.2 lv2110 L27823 [22]
IGLV2-33*03 (31) ORF (9) 22q11.2 lv2031 L27691 [22]
IGLV2-34 IGLV2-34*01 (31) P (10) 22q11.2 V1-10P MAP D87013 [26] lv216.376 L27690 [22]
IGLV2-34*02 (31) P (10) 22q11.2 DPL25 Z22209 [12]
IGLV3 IGLV3-1 IGLV3-1*01 (31) F 22q11.2 + + VLIII.1 MAP X57826 [11] 3r(3r.9C5) MAP Z73647 [1]
V2-1 MAP D87023 [26]
DPL23 Z22208 [12]
BHGL18-21 L26402 [27] (11)
BHGL6-13 L26403 [27] (11)
IGLV3-2 IGLV3-2*01 (31) P (12) 22q11.2 3q(3q.127E5) MAP X97468 [1]
IGLV3-2*02 (31) P (12) 22q11.2 psiVlambdaN.1 MAP X57828 [11] V2-2P MAP D87024 [26]
IGLV3-4 IGLV3-4*01 (31) P (8) 22q11.2 V2-3P MAP D87024 [26]
IGLV3-6 IGLV3-6*01 (31) P (8) 22q11.2 3a2(3a2.51E6) MAP X97465 [1] V2-4P MAP D87024 [26]
IGLV3-6*02 (31) P (8) 22q11.2 psiVlambdaIII.2 MAP X57827 [11]
IGLV3-7 IGLV3-7*01 (31) P (8) 22q11.2 3n(3n.118D9) MAP X97470 [1] V2-5P MAP D87024 [26]
IGLV3-9 IGLV3-9*01 (31) F 22q11.2 + + 3j(3j.118D9) MAP X97473 [1] V2-6 MAP D87021 [26]
ABC13_11_000047484300_J24 MAP AC279221 [35] 28343..29007
IGLV3-9*02 (31) F 22q11.2 + + IGLV3S6 X74288 [18]
IGLV3-9*03 (31) P (13) 22q11.2 psiVlambda1 X51754 [21]
IGLV3-10 IGLV3-10*01 (31) F 22q11.2 + + 3p(3p.81A4) MAP X97464 [1] V2-7 MAP D87021 [26]
IGLV3-10*02 (31) F 22q11.2 + + IGGLL295 L29166 [15]
IGLV3-10*03 (31) F 22q11.2 + + ABC13_11_000047484300_J24 MAP AC279221 [35] 21000..21538
IGLV3-12 IGLV3-12*01 (31) P (49) 22q11.2 174779_ABC12_000046886900_P4 MAP AC279423 [35] 19769..20557 3i(3i.2.2) MAP Z73658 [1] (50)
IGLV3-12*02 (31) F 22q11.2 V2-8 MAP D86998 [26]
IGLV3-13 IGLV3-13*01 (31) P (14) 22q11.2 3f(3f.119B4) MAP X97463 [1] V2-9P MAP D86998 [26]
D87015 [26]
IGLV3-13*02 (31) P (48) 22q11.2 174779_ABC12_000046886900_P4 MAP AC279423 [35] 10012..10547
IGLV3-15 IGLV3-15*01 (31) P (8) 22q11.2 V2-10P MAP D87015 [26] 174779_ABC12_000046886900_P4 MAP AC279423 [35] 3262..3931
IGLV3-16 IGLV3-16*01 (31) F 22q11.2 + + 3a(3a.119B4) MAP X97471 [1] V2-11 MAP D87015 [26]
IGLV3-17 IGLV3-17*01 (31) P (8) 22q11.2 3g(3g.29D11) MAP X97472 [1] V2-12P MAP D87015 [26]
Humlv413 M94117 [4]
IGLV3-19 IGLV3-19*01 (31) F 22q11.2 + + Vlambda3.1(IGLV3S1) MAP X56178 [3,18] V2-13 MAP D87007 [26]
DPL16 Z22202 [12]
Humlv418 M94113 [4]
IGLV4BR L35919 [28]
ABC12_000046968100_B3 MAP AC279210 [35] 22097..22628
IGLV3-19*02 (31) F 22q11.2 ABC10_2_1_000044078800_J23 MAP AC279208 [35] 25444..25975 ABC11_000047191900_P24 MAP AC279219 [35] 25444..25975
IGLV3-21 IGLV3-21*01 (31) F 22q11.2 + + IGLV3S2 MAP X71966 [18]
IGLV3-21*02 (31) F 22q11.2 + + V2-14 MAP D87007 [26]
IGLV3-21*03 (31) F 22q11.2 + + Humlv318 M94115 [4]
IGLV3-21*04 (31) F 22q11.2 ABC10_2_1_000044078800_J23 MAP AC279208 [35] 17209..18024 ABC11_000047191900_P24 MAP AC279219 [35] 17209..18024
ABC11_2_1_000049528800_P17 MAP AC279213 [35] 42250..>42372 (36)
ABC12_000046968100_B3 MAP AC279210 [35] 13858..14677
IGLV3-21*01_S5562 MAP MK308864 [36] (52) 1..290
IGLV3-22 IGLV3-22*01 (31) F 22q11.2 + + 3e(3e.272A12) MAP Z73666 [1] V2-15 MAP D87007 [26]
ABC12_000046968100_B3 MAP AC279210 [35] 5769..6297
IGLV3-22*02 (31) P (15) 22q11.2 IGLV3S3P MAP X71967 [18]
IGLV3-22*03 (31) F 22q11.2 ABC10_2_1_000044078800_J23 MAP AC279208 [35] 9121..9649 ABC11_000047191900_P24 MAP AC279219 [35] 9121..9649
ABC11_2_1_000049528800_P17 MAP AC279213 [35] 33672..34200
IGLV3-24 IGLV3-24*01 (31) P (16) 22q11.2 IGLV3S4P MAP X71968 [18]
IGLV3-24*02 (31) P (16) 22q11.2 V2-16P MAP D86994 [26]
IGLV3-24*03 (31) P (37) 22q11.2 ABC11_2_1_000049528800_P17 MAP AC279213 [35] 23782..24451 ABC11_000047999300_E7 MAP AC279318 [35] 39846..40129 (36)
IGLV3-25 IGLV3-25*01 (31) F 22q11.2 + + 3m(3m.102D1) MAP X97474 [1]
IGLV3-25*02 (31) F 22q11.2 + + V2-17 MAP D86994 [26]
IGLV3-25*03 (31) F 22q11.2 ABC11_2_1_000049528800_P17 MAP AC279213 [35] 16121..16672 IGGLL150 L29165 [15]
ABC11_000047999300_E7 MAP AC279318 [35] 32061..32350 (36)
IGLV3-25*02_S7225 MAP MK308865 [36] (52) 1..290
IGLV3-26 IGLV3-26*01 (31) P (17) 22q11.2 ABC11_000047999300_E7 MAP AC279318 [35] 18435..18723 (36) 3b(3b.57F5) MAP X97467 [1]
V2-18P MAP D86994 [26]
IGLV3-27 IGLV3-27*01 (31) F 22q11.2 + + V2-19 MAP D86994 [26] ABC11_000047999300_E7 MAP AC279318 [35] 13413..13934
IGLV3-29 IGLV3-29*01 (31) P (16) 22q11.2 ABC11_000047999300_E7 MAP AC279318 [35] 6041..6708 3c(3c.97H8) MAP Z73644 [1]
V2-20P MAP D87002 [26]
D87006 [26]
IGLV3-30 IGLV3-30*01 (31) P (8) 22q11.2 3o(3o.75H1) MAP Z73646 [1]
IGLV3-30*02 (31) P (8) 22q11.2 V2-21P MAP D87014 [26]
IGLV3-31 IGLV3-31*01 (31) P (18) 22q11.2 3k(3k.61E11) MAP X97469 [1] V2-22P MAP D87014 [26]
IGLV3-31*02 (31) P (18) 22q11.2 DPL17 Z22203 [12]
IGLV3-32 IGLV3-32*01 (31) ORF (19) 22q11.2 V2-23P MAP D87014 [26] 3i1(3i1.61E11) MAP Z73645 [1]
IGLV4 IGLV4-3 IGLV4-3*01 (31) F (20) 22q11.2 + + VlambdaN.2 MAP X57828 [11] 4c(4c127E5) MAP Z73652 [1]
V5-1 MAP D87024 [26]
DPL24 Z22211 [12]
IGLV4-60 IGLV4-60*01 (33) F 22q11.2 + + 4a(4a.366F5) MAP Z73667 [1]
IGLV4-60*02 (33) F 22q11.2 + + V5-4 MAP D87000 [26]
IGLV4-60*03 (33) F 22q11.2 ABC13_11_000047487500_B16 MAP AC279317 [35] 7131..7652 V5-4 MAP AF073885 [30] 1..297 (36)
IGLV4-60*04 (33) P (44) 22q11.2 ABC12_000046837000_A16 MAP AC279212 [35] 13903..14423
IGLV4-69 IGLV4-69*01 (33) F 22q11.2 + + 4b(4b.68B6) MAP Z73648 [1] V5-6 MAP D86993 [26]
IGLV8A1 L29806 [16]
IGLV4-69*02 (33) F 22q11.2 + + lv801 U03868 [10]
IGLV5 IGLV5-37 IGLV5-37*01 (32) F 22q11.2 + + 5e(5e.366F5) MAP Z73672 [1]
IGLV5-39 (21) IGLV5-39*01 (32) F 22q11.2 + + 5a(5a.366F5) MAP Z73668 [1]
IGLV5-39*02 (32) F 22q11.2 Vlambda5 MAP AF216776 [31]
IGLV5-45 IGLV5-45*01 (32) F 22q11.2 + + 5c(5c.366F5) MAP Z73670 [1]
IGLV5-45*02 (32) F 22q11.2 + + 5c(5c.400B5) MAP Z73671 [1] IGLV5-1 U93494 [25]
IGLV5-45*03 (32) F 22q11.2 + + V4-2 MAP D86999 [26] ABC13_11_000048870800_F24 MAP AC279207 [35] 33864..34394
IGLV5-45*04 (32) F 22q11.2 MAP KM455553 [34]
IGLV5-48 IGLV5-48*01 (32) ORF (22) 22q11.2 5d(5d.75A1) MAP Z73649 [1] V4-3 MAP D87016 [26]
ABC13_11_000048870800_F24 MAP AC279207 [35] 10775..11306
IGLV5-48*02 (32) P (34) 22q11.2 MAP KM455554 [34]
IGLV5-52 IGLV5-52*01 (32) F 22q11.2 + + 5b(5b.366F5) MAP Z73669 [1] V4-4 MAP D87018 [26]
IGLV6 IGLV6-57 IGLV6-57*01 (33) F 22q11.2 + + 6a(6a.366F5) MAP Z73673 [1] V1-22 MAP D86996 [26]
IGLV6S1 M87320 [19]
LV6SW-G X92337 [19]
IGLV6-57*02 (33) F 22q11.2 MAP KM455556 [34]
IGLV6-57*03 (33) F 22q11.2 ABC11_2_1_000049496000_N1 MAP AC279220 [35] 214..730
IGLV6-57*04 (33) F 22q11.2 MAP MW316677 [37][53] 63..358 IGLV6-57*01_S1429 MAP MK308866 [36] 1..296 (36)(52)
IGLV7 IGLV7-35 IGLV7-35*01 (32) P (23) 22q11.2 7c(7c.11.2) MAP Z73660 [1] V3-1P MAP D87009 [26]
IGLV7-43 IGLV7-43*01 (32) F 22q11.2 + + Vlambda7.1 MAP X14614 [5] 7a(7a.2.3) MAP Z73659 [1]
V3-2 MAP D86999 [26]
DPL18 Z22204 [12]
4A X01015 [6]
IGLV7-46 IGLV7-46*01 (32) F 22q11.2 + + 7b(7b.400B5) MAP Z73674 [1] DPL19 Z22205 [12]
ABC13_11_000048870800_F24 MAP AC279207 [35] 27495..27972
IGLV7-46*02 (32) F 22q11.2 + + V3-3 MAP D86999 [26]
IGLV7-46*03 (32) P (24) 22q11.2 DPL20 Z22210 [12]
IGLV7-46*04 (32) F 22q11.2 MW316675 [37][53] 210..687
IGLV8 IGLV8-61 IGLV8-61*01 (33) F 22q11.2 + + 8a(8a.88E1) MAP Z73650 [1] V3-4 MAP D87022 [26]
DPL21 Z22206 [12]
VL8 S39395 [8]
FL7 U03639 [9]
TL7 U03635 [9]
IGLV8-61*02 (33) F 22q11.2 + + BL7 U03637 [9]
IGLV8-61*03 (33) F (25) 22q11.2 IGLV8 AF266511 [33]
IGLV9 IGLV9-49 IGLV9-49*01 (32) F (20) 22q11.2 + + 9a(9a.366F5) MAP Z73675 [1] DPL22 Z22207 [12]
lv901m [10]
ABC13_11_000048870800_F24 MAP AC279207 [35] (40) 1063..1611
IGLV9-49*02 (32) F (20) 22q11.2 + + V5-2 MAP D87016 [26]
IGLV9-49*03 (32) F (20) 22q11.2 + + lv901e U03869 [10]
IGLV10 IGLV10-54 IGLV10-54*01 (33) F 22q11.2 + + 10a(10a.872F9) MAP Z73676 [1] ABC11_2_1_000049496000_N1 MAP AC279220 [35] 19204..19707
IGLV10-54*02 (33) F 22q11.2 + + V1-20 MAP D86996 [26]
IGLV10-54*03 (33) P (30) 22q11.2 gVlambdaX-4.4 S70116 [14]
IGLV10-54*04 (33) F 22q11.2 MW316678 [37][53] 148..651 IGLV10-54*01_S4180 MAP MK308862 [36] 1..296 (36)(52)
IGLV10-67 IGLV10-67*01 (33) P (8) 22q11.2 10b(10b.4E7) MAP Z73651 [1] V1-25P MAP D86993 [26]
IGLV10-67*02 (33) P (8) 22q11.2 gVlambdaX-5.5 X92335 [14]
IGLV11 IGLV11-55 IGLV11-55*01 (33) ORF (26) 22q11.2 V4-6 MAP D86996 [26] ABC11_2_1_000049496000_N1 MAP AC279220 [35] 6080..6601
IGLV11-55*02 (33) ORF (26) 22q11.2 MAP KM455555 [34]
IGLV(I) IGLV(I)-11-1 IGLV(I)-11-1*01 P (51) 22q11.2 174779_ABC12_000046886900_P4 MAP AC279423 [35] <22452..22620 (36)
IGLV(I)-20 IGLV(I)-20*01 (31) P 22q11.2 V1-6P MAP D87007 [26] ABC12_000046968100_B3 MAP AC279210 [35] 16594..16879 (36)
IGLV(I)-20*02 (31) P (39) 22q11.2 ABC10_2_1_000044078800_J23 MAP AC279208 [35] 19943..20228 (36) ABC11_000047191900_P24 MAP AC279219 [35] 19943..20228 (36)
IGLV(I)-38 IGLV(I)-38*01 (32) P 22q11.2 V1-12P MAP D87009 [26]
IGLV(I)-42 IGLV(I)-42*01 (32) P 22q11.2 - - VlambdaA MAP X14613 [5] V1-15P MAP D86999 [26]
IGLV(I)-56 IGLV(I)-56*01 (33) P 22q11.2 V1-21P MAP D86996 [26] ABC11_2_1_000049496000_N1 MAP AC279220 [35] 3138..3433 (36)
IGLV(I)-63 IGLV(I)-63*01 (33) P 22q11.2 V1-24P MAP D87022 [26]
IGLV(I)-68 IGLV(I)-68*01 (33) P 22q11.2 V1-26P MAP D86993 [26]
IGLV(I)-70 IGLV(I)-70*01 (33) P 22q11.2 V1-27P MAP D86993 [26]
IGLV(II) IGLV(II)-24-1 IGLV(II)-24-1*01 (33) P (41) 22q11.2 102D1 MAP D86994 [26] 27202..27485 (36) ABC11_2_1_000049528800_P17 MAP AC279213 [35] 19069..19352 (36)
ABC11_000047999300_E7 MAP AC279318 [35] 34786..35069 (36)
IGLV(III) IGLV(III)-59-1 IGLV(III)-59-1*01 P (38) 22q11.2 30E12 MAP D87000 [26] 18936..19225 (36) ABC12_000046837000_A16 MAP AC279212 [35] 20050..20339 (36)
IGLV(III)-59-1*02 P (38) 22q11.2 ABC13_11_000047487500_B16 MAP AC279317 [35] 13283..13572 (36)
IGLV(III)-60-1 IGLV(III)-60-1*01 P (45) 22q11.2 30E12 MAP D87000 [26] 7980..8247 (36) ABC12_000046837000_A16 MAP AC279212 [35] 9099..9366 (36)
IGLV(III)-60-1*02 P (45) 22q11.2 ABC13_11_000047487500_B16 MAP AC279317 [35] 2331..2599
IGLV(IV) IGLV(IV)-53 IGLV(IV)-53*01 (33) P 22q11.2 V4-5P MAP D86996 [26]
IGLV(IV)-53*02 (33) P (42) 22q11.2 ABC11_2_1_000049496000_N1 MAP AC279220 [35] 24230..24542 (36)
IGLV(IV)-55-1 IGLV(IV)-55-1*01 (33) P (43) 22q11.2 23F1 MAP D86996 [26] 12576..12887 (36) ABC11_2_1_000049496000_N1 MAP AC279220 [35] 3438..3749 (36)
IGLV(IV)-59 IGLV(IV)-59*01 (33) P 22q11.2 V4-7P MAP D87000 [26] ABC12_000046837000_A16 MAP AC279212 [35] 30880..31178 (36)
ABC13_11_000047487500_B16 MAP AC279317 [35] 24105..24403 (36)
IGLV(IV)-64 IGLV(IV)-64*01 (33) P 22q11.2 V4-8P MAP D87022 [26]
IGLV(IV)-65 IGLV(IV)-65*01 (33) P 22q11.2 V4-9P MAP D87022 [26]
IGLV(IV)-66-1 (27) IGLV(IV)-66-1*01 (33) P 22q11.2 MAP D87004 [26]
IGLV(V) IGLV(V)-58 IGLV(V)-58*01 (33) P 22q11.2 V5-3P MAP D87000 [26] ABC12_000046837000_A16 MAP AC279212 [35] 34596..34903 (36)
IGLV(V)-58*02 (33) P (46) 22q11.2 ABC13_11_000047487500_B16 MAP AC279317 [35] 27464..27771 (36)
IGLV(V)-66 IGLV(V)-66*01 (33) P 22q11.2 V5-5P MAP D87004 [26]
IGLV(VI) IGLV(VI)-22-1 (28) IGLV(VI)-22-1*01 (31) P 22q11.2 lambdavg2 MAP X71351 [18]
IGLV(VI)-22-1*02 (31) P (35) 22q11.2 ABC10_2_1_000044078800_J23 MAP AC279208 [35] 5545..5833 (36) ABC11_000047191900_P24 MAP AC279219 [35] 5545..5833 (36)
ABC11_2_1_000049528800_P17 MAP AC279213 [35] 30096..30384 (36)
IGLV(VI)-22-1*03 (31) P (35) 22q11.2 ABC12_000046968100_B3 MAP AC279210 [35] 2193..2485 (36)
IGLV(VI)-25-1 (28) IGLV(VI)-25-1*01 (31) P (47) 22q11.2 lambdavg3 MAP D86994 [26] ABC11_2_1_000049528800_P17 MAP AC279213 [35] 8480..8769 (36)
ABC11_000047999300_E7 MAP AC279318 [35] 24199..24488 (36)
IGLV(VII) IGLV(VII)-41-1 (29) IGLV(VII)-41-1*01 (32) P 22q11.2 lambdavg1 MAP X99568 [5]

MAP: Mapped reference sequences.
NL: Not Localized in the locus.

IMGT notes:
  1. (1) For frequencies of expression of the functional IGLV genes, see Ignatovich et al., J. Mol. Biol., 268, 69-77 (1997).
  2. (2) Non-canonical ACCEPTOR-SPLICE: nacnn instead of nagnn.
  3. (3) STOP-CODON at position 99 in FR3-IMGT.
  4. (4) Non-conserved OCTAMER sequence: ctgcacaa instead of atttgcat, non-conserved TATA_BOX, and unusual V-NONAMER sequence: agaagaacc instead of acaaaaacc.
  5. (5) Sequence of Humlv119 identical to that reported for Humlv117 but restriction maps are dissimilar.
  6. (6) STOP-CODONs at position 44 in FR2-IMGT and at position 111 in CDR3-IMGT.
  7. (7) STOP-CODON at position 103 in FR3-IMGT.
  8. (8) frameshift in V-REGION: deletion of 13 nts in FR2-IMGT, insertion of 1nt in FR3-IMGT.
  9. (9) Unusual V-HEPTAMER sequence: catagtg instead of cacagtg.
  10. (10) STOP-CODONs at position 18 in FR1-IMGT and at position 44 in FR2-IMGT.
  11. (11) BHGL18-21 and BHGL6-13 overlap by 49 nucleotides, BHGL18-21 corresponding to 5'UTR and 6 nucleotides from FR1-IMGT.
  12. (12) CONSERVED-TRP replaced by Ser in V-EXON, frameshift in FR3-IMGT.
  13. (13) DELETION of 1 pb in codon 32 leading to a frameshift in CDR1-IMGT.
  14. (14) STOP-CODON at position 109 in CDR3-IMGT.
  15. (15) DELETION of 1 pb in codon 47, and INSERTION of 5 nt between positions 50 to 51, leading to frameshifts in FR2-IMGT.
  16. (16) STOP-CODON in FR2-IMGT: position 40, frameshift in V-REGION: deletion of 5 nts in FR3-IMGT.
  17. (17) No INIT-CODON, STOP-CODON in FR2-IMGT: position 48, frameshift in V-REGION: deletion of 1 nt in FR3-IMGT.
  18. (18) STOP-CODONs at position 17 in FR1-IMGT and at position 55 in FR2-IMGT.
  19. (19) Non-canonical ACCEPTOR_SPLICE: nggnn instead of nagnn, and 2nd-CYS replaced by Tyr in V-EXON.
  20. (20) Since the STOP-CODON at the 3' end of the V-REGION can be deleted by rearrangement, the V-GENE is considered as functional.
  21. (21) IGLV5-39 becomes functional because it has been found rearranged (AF063696,AF063751).
  22. (22) Unusual V-HEPTAMER sequence: tacagtg instead of cacagtg.
  23. (23) 1st-CYS replaced by Tyr in V-EXON, frameshift in FR3-IMGT.
  24. (24) DELETION of 1 nt in codon 91 leading to a frameshift in FR3-IMGT.
  25. (25) V-REGION is partial: AA 1 to 3 are missing (partial FR1-IMGT), AA 100 to 104 are missing (partial FR3-IMGT) and no CDR3-IMGT.
  26. (26) Unusual V-SPACER length: 19 nt instead of 23 nt.
  27. (27) IGLV(IV)-66-1 has been identified in D87004 by IMGT curators (Folch, G., Giudicelli, V. and Lefranc, M.-P., IMGT On-line, 14/12/1999).
  28. (28) An additional vestigial pseudogene lambdavg3, which has 92% identity with lambdavg2 has been identified in D86994 by IMGT curators (N. Bosc, M.-P. Lefranc), between IGLV3-25 and IGLV3-26 (5.7kb downstream from IGLV3-26). The lambdavg2 and lambdavg3 sequences define a new clan IGLV(VI) and are designated as IGLV(VI)-22-1 (X71351)[18] and IGLV(VI)-25-1 (D86994)[26], respectively.
  29. (29) The highly diverged vestigial pseudogene lambdavgl (X99568)[5] has no CONSERVED_TRP and no 2nd_CYS (confirmed with D86999[26] although this accession number contains many sequencing or typing errors). Since this lambdavg1 sequence is unique in the human genome and can therefore be used as a STS (Sequence Tagged Site)[5] , the lambdavg1 was attributed to a new clan IGLV(VII) and designated as IGLV(VII)-41-1.
  30. (30) Frameshift in L-PART1.
  31. (31) V-CLUSTER: A.
  32. (32) V-CLUSTER: B.
  33. (33) V-CLUSTER: C.
  34. (34) In frame STOP-CODON in V-REGION and non canonical V-NONAMER: acgaaaacc instead of accaaaacc.
  35. (35) Frameshift in L-PART1, frameshift in V-REGION: several insertions and deletions, no V-RS.
  36. (36) Positions of V-REGION.
  37. (37) Frameshift in L-PART1, frameshift in V-REGION: deletion of 2 nt and 4 nt in FR3-IMGT.
  38. (38) STOP-CODON in FR1-IMGT: position 1 and 15, frameshift in V-REGION: several insertions and deletions in FR3-IMGT
  39. (39) No L-PART1, frameshift in V-REGION: several insertions and deletions.
  40. (40) STOP-CODON at position 106 (last 3' codon of germline CDR3-IMGT) may disappear during rearrangements.
  41. (41) No L-PART1, frameshift in L-PART2, frameshift in V-REGION: several insertions and deletions, No V-RS.
  42. (42) frameshift in V-REGION: several insertions and deletions, no V-NONAMER.
  43. (43) No L-PART1, frameshift in V-REGION: several insertions and deletions, No V-NONAMER.
  44. (44) frameshift in V-REGION: deletion of 1 nt in FR2-IMGT.
  45. (45) No L-PART1, deletion of 24 nt in V-REGION, frameshift in V-REGION: several insertions and deletions.
  46. (46) frameshift in V-REGION: several insertions and deletions.
  47. (47) frameshift in L-PART1, frameshift in L-PART2, frameshift in V-REGION: several insertions and deletions, no V-RS.
  48. (48) frameshift in L-PART1, STOP-CODON in CDR3-IMGT: position 109.
  49. (49) no INIT-CODON.
  50. (50) IGLV3-12*01 has been described as functional in Z73658 (V-GENE partial in 5' and 3'). However in AC279423, IGLV3-12*01 (with a complete V-GENE) the functionality is pseudogene because no INIT-CODON.
  51. (51) truncated pseudogene not assigned to subgroups with functional genes.
  52. (52) Inferred allele: IMGT-NC_Report_2020-3-1120_Homsap_IGKV_IGLV.
  53. (53) IMGT-NC_Report_2021-1-0608_Homsap_IGKV_IGLV.
IMGT references:
  1. [1] Williams, S.C., Frippiat, J.-P. et al., J. Mol. Biol., 264, 220-232 (1996). PMID:8951372
  2. [2] Deftos, M. et al., J. Clin. Invest., 93, 2545-2553 (1994). PMID:8200991
  3. [3] Frippiat J.P. et al., Nucl. Acids Res., 18, 7134 (1990). PMID:2124677
  4. [4] Daley, M.D. et al., Mol. Immunol., 29, 1515-1518 (1992). PMID:1454067
  5. [5] Alexandre, D. et al., Nucl. Acids Res., 17, 3975 (1989). PMID:2499871
  6. [6] Anderson, M.L. et al., Nucl. Acids Res., 12, 6647-6661 (1984). PMID:6091030
  7. [7] Daley, M.D. et al., Mol. Immunol., 29, 1031-1042 (1992). PMID:1495496
  8. [8] Winkler, T.H. et al., Eur. J. Immunol., 22, 1719-1728 (1992). PMID:1623920
  9. [9] Lee, G. et al., J. Neuroimmunol., 51, 45-52 (1994). PMID:7512577
  10. [10] Deftos, M. et al., Scand. J. Immunol., 39, 95-103 (1994). PMID:8290898
  11. [11] Combriato, G. and Klobeck, H.-G., Eur. J. Immunol., 21, 1513-1522 (1991). PMID:1904362
  12. [12] Williams, S.C. and Winter, G., Eur. J. Immunol., 23, 1456-1461 (1993). PMID:7916694
  13. [13] Bernard, F. et al., Nucl. Acids Res., 18, 7139 (1990). PMID:2124678
  14. [14] Stiernholm, N.B.J. et al., J. Immunol., 152, 4969-4975 (1994). PMID:8176215
  15. [15] Fang, Q. et al., J. Exp. Med., 179, 1445-1456 (1994). PMID:7545920
  16. [16] Ch'ang L.Y. et al., Mol. Immunol., 32, 49-55 (1995). PMID:7870058
  17. [17] Brockly, F. et al., Nucl. Acids Res., 17, 3976 (1989). PMID:2499872
  18. [18] Frippiat, J.-P. and Lefranc, M.-P., Mol. Immunol., 31, 657-670 (1994). PMID:8028600
  19. [19] Ch'ang, L.Y. et al., Mol. Immunol., 31, 531-536 (1994). PMID:8190128
  20. [20] Siminovitch K.A. et al., J. Clin. Invest., 84, 1675-1678 (1989). PMID:2509520
  21. [21] Vasicek, T.J. and Leder, P., J. Exp. Med., 172, 609-620 (1990). PMID:2115572
  22. [22] Irigoyen, M. et al., J. Clin. Invest., 94, 532-538 (1994). PMID:8040307
  23. [23] Chuchana, P. et al., Eur. J. Immunol., 20, 1317-1325 (1990). PMID:2114999
  24. [24] Frippiat, J.P. et al., Hum. Mol. Genet., 4, 983-991 (1995). PMID:7655473
  25. [25] Solomon, A. et al., Mol. Immunol., 34, 463-470 (1997). PMID:9307062
  26. [26] Kawasaki, K. et al., Genome Res., 7, 250-261 (1997). PMID:9074928
  27. [27] Harmer, I.J. et al., Arthritis Rheum., 38, 1068-1076 (1995). PMID:7639802
  28. [28] Eulitz, M. et al., J. Immunol., 154, 3256-3265 (1995). PMID:7897210
  29. [29] Stiernholm, N.B. and Berinstein, N.L., J. Immunol., 154, 1748-1761 (1995). PMID:7836759
  30. [30] Semrad, T.J. et al., Clin. Immunol., 99, 276-282 (2001). PMID:11318599
  31. [31] Moraes Junta, C. and Passos, G.A., Immunogenetics, 55, 10-15 (2003). PMID:12679855
  32. [32] Berek, C. et al., Immunogenetics, 46, 533-534 (1997). PMID:9321436
  33. [33] Tamia-Ferreira, M.C. et al., Biochim. Biophys. Acta, 1586, 108-112 (2002). PMID:11781155
  34. [34] Watson C.T. et al., Genes and Immunity, 16, 24-34 (2015). PMID:25338678
  35. [35] Rodriguez O.L. et al., Unpublished.
  36. [36] Vazquez Bernat N. et al., Front. Immunol., 10, 660-660(2019). PMID:31024532
  37. [37] Mikocziova I., Unpublished.

Chromosomal orphon set IGLV

IMGT subgroup IMGT gene name IMGT allele name Fct Chromosomal localization R T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Clone names Accession numbers Positions in the sequence Secondary accession numbers Clone names Accession numbers Positions in the sequence
IGLV8 IGLV8/OR8-1 IGLV8/OR8-1*01 P 8q11.2 [1] Orphée1 MAP Y08831 [1]
IGLV8/OR8-1*02 ORF 8q11.2 [1] TL6 MAP U03636 [2] FL6 U03640 [2]
IGLV/OR8-2 IGLV/OR8-2*01 (2) 8q11.2 [1] Orphée2 (3) MAP
IGLV(IV) IGLV(IV)/OR22-1 IGLV(IV)/OR22-1*01 P 22q11.2-22q12.1, at 9.4 Mb from the centromere [3,4] (6) bK390C10.1 (4) MAP AL008721 [3,4]
IGLV(IV)/OR22-2 IGLV(IV)/OR22-2*01 P 22q12.2-22q12.3, at 16.28 Mb from the centromere [3,4] (6) dJ149A16.4 (5) MAP AL021937 [3,4]
IGLV8/ORa IGLV8/ORa (2) (7)

MAP: Mapped reference sequences.

IMGT notes:
  1. (1) Orphée1 is on a 7.8 kb EcoRI fragment of YAC 15EH11 mapped to 8q11.2 [1].
  2. (2) Not sequenced.
  3. (3) Detected by Southern blot analysis of YAC 15EH11 DNA mapped to 8q11.2, using low stringency wash a mixture of ten IGLV subgroup specific probes and a 6.5 kb EcoRI fragment of YAC 15EH11 [1].
  4. (4) bK390C10.1 [4] isolated from AL008721.1 belongs to clan IGLV(IV). The 5' end is telomeric, whereas the 3' end is centromeric.
  5. (5) dJ149A16.4 [4] isolated from AL021937.1 belongs to clan IGLV(IV). An insertion leads to a frameshift and STOP-CODON.
  6. (6) The correlation between DNA sequence and chromosomal bands has not yet been made. Sequencing of the long arm of chromosome 22 [3] showed that it encompasses about 35 megabases. IGLV(IV)/O R22-1 is localized at 9.4 Mb from the centromere and IGLV(IV)/OR22-2 at 16.28 Mb from the centromere.
  7. (7) Detected by southern blot analysis using a IGLV8 subgroup probe [1] and Frippiat, J.P., personal communication.
IMGT references:
  1. [1] Frippiat, J.-P. et al., Eur. J. Immunol., 27, 1260-1265 (1997). PMID:9174619
  2. [2] Lee, G. et al., J. Neuroimmunol., 51, 45-52 (1994). PMID:7512577
  3. [3] Dunham, I. et al., Nature, 402, 489-495 (1999). PMID:10591208
  4. [4] The Sanger Centre: Human chromosome 22 Home.
Created:
24/07/1998
Last updated:
22/09/2023
Authors:
Emilie Carillon, Nathalie Pallarès, Nathalie Bosc, Géraldine Folch and Sofia Kossida