IMGT Repertoire (IG and TR)


Gene table: human (Homo sapiens) TRGC

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

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In the "Clone names" column of "IMGT/LIGM-DB reference sequences" are shown the names of the lambda phages (for genomic sequences) or of the clones (for cDNA), and between parentheses cell lines, from which are derived the reference sequences.

IMGT gene name IMGT allele name Fct Chromosomal localization T Pr Positions in the locus IMGT/LIGM-DB reference sequences IMGT/LIGM-DB sequences from the literature
Clone names Exons Accession numbers Positions in the sequence Secondary accession numbers Clone names Accession numbers Positions in the sequence
TRGC1 TRGC1*01 (1) F 7p14 lambda-D19 (D-PLL) EX1 M14996 [3] 41..370 X02758 [1] (2) 23..>178
T-gamma-5 M17325 [4] (3) c <1..309
AF159056 [6] 108237..108566
BC072387 [7] c 378..707
BC105589 [7] c(st) 279..608
M16768 [8] c 564..893
CM000669.2 IMGT000011 122378..122707
EX2 M14997 [3] 25..72 T-gamma-5 M17325 [4] (3) c 310..357
AF159056 [6] 111697..111744
BC072387 [7] c 708..755
BC105589 [7] c(st) 609..656
M16768 [8] c 894..941
CM000669.2 IMGT000011 125838..125885
EX3 M14998 [3] 174..313 T-gamma-5 M17325 [4] (3) c 358..498
AF159056 [6] 113685..113824
BC072387 [7] c 756..896
BC105589 [7] c(st) 657..797
M16768 [8] c 942..1082
CM000669.2 IMGT000011 127826..127965
TRGC1*02 (1) F 7p14 lambda-R-gamma (Raji) EX1 M14999 [3] (2) 1..>300 X02757 [1] (2) 23..>178
EX2
EX3
TRGC1*03 (1) (F) 7p14 TCRGV9, V2 EX1 BC072396 [7] c 804..1133 BC030554 [7] c 745..1074
HGP02 M27334 [11] c 1..330
X72500 [13] (6) c
EX2 BC072396 [7] c 1134..1181 BC030554 [7] c 1075..1122
HGP02 M27334 [11] c 331..378
X72500 [13] (6) c
EX3 BC072396 [7] c 1182..1322 BC030554 [7] c 1123..1263
HGP02 M27334 [11] c 379..519
X72500 [13] (6) c
TRGC1*04 (1) (F) 7p14 EX1 AF151103 [9] c 61..390
EX2 AF151103 [9] c 391..438
EX3 AF151103 [9] c 439..579
TRGC1*05 (1) (F) 7p14 TCRGV9, V2 EX1 BC062761 [7] c 56..385
EX2 BC062761 [7] c 386..433
EX3 BC062761 [7] c 434..574
TRGC2 (4) TRGC2*01(2x) (5) F 7p14 lambda-D7 (D-PLL) EX1 M15002 [3] 1..330 pTgamma-1(HPB-MLT) M13231 [2] c 410..739
pTgamma-1 (HPB-MLT) EX2T M13231 [2] c 740..787
EX2 M13231 [2] c 788..835
EX3 M13231 [2] c 836..976
TRGC2*02(2x) (5) F 7p14 lambdaD11 (D-PLL) EX1 M15001 [3] 1..330 BC017861 [7] c 466..795
lambdaS9 (SUPT1) EX2R M15004 [3] 6..53 BC017861 [7] c 796..843
EX2 M15005 [3] 6..53 BC017861 [7] c 844..891
EX3 M15007 [3] 2..141 BC017861 [7] c 892..1032
TRGC2*03(2x) (F) 7p14 F-gamma-7 (Fro 2.2) EX1 M17324 [4] c 1..329
EX2R M17324 [4] c 330..377
EX2 M17324 [4] c 378..425
EX3 M17324 [4] c 426..566
TRGC2*04(2x) F 7p14 EX1 AF159056 [6] 108237..108566
EX2R AF159056 [6]
EX2 AF159056 [6] 111697..111744
EX3 AF159056 [6] 113685..113824
TRGC2*05(3x) (F) 7p14 p-gamma-1 (PEER) EX1 M17323 [4] c 1..329 M30894 [12] c
lambdaR12 (RPMI 8402) EX2T M25318 [5] 7..54 p-gamma-1(PEER) M17323 [4] c 330..377
M30894 [12] c
p-gamma-1 (PEER) EX2R M17323 [4] c 378..425 M30894 [12] c
EX2 M17323 [4] c 426..473 M30894 [12] c
EX3 M17323 [4] c 474..614 M30894 [12] c
TRGC2*06(2x) (F) 7p14 K (MOLT13 leukemia) EX1 Y00790 [10] c 439..768 CM000669.2 IMGT000011 138484..138813
EX2R Y00790 [10] c 769..816 CM000669.2 IMGT000011 142826..142873
EX2 Y00790 [10] c 817..864 CM000669.2 IMGT000011 145581..145628
EX3 Y00790 [10] c 865..1005 CM000669.2 IMGT000011 147890..148029
TRGC2*07(2x) (F) 7p14 HGP08 EX1 M27331 [11] c 1..330
EX2R M27331 [11] c 331..378
EX2 M27331 [11] c 379..426
EX3 M27331 [11] c 427..567
TRGC2*08(2x) (F) 7p14 HGP06 EX1 M27332 [11] c 1..330
EX2R M27332 [11] c 331..378
EX2 M27332 [11] c 379..426
EX3 M27332 [11] c 427..564

c: cDNA sequence.
(st): sterile transcipt.

IMGT notes:
  1. (1) TRGC1*01 and TRGC1*02 alleles were previously designated as gamma1b (D19 gamma1) and gamma1a (Raji gamma1), respectively [15].
  2. (2) Partial C-GENE: partial EX1 in 3'.
  3. (3) Partial C-REGION: partial EX1 in 5'.
  4. (4) The TRGC2 gene contains four or five exons due to the duplication (EX2T-EX2 or EX2R-EX2) or triplication (EX2T-EX2R-EX2) of exon 2 [5]. (2x) or (3x) indicates the duplication or triplication of the TRGC2 exon 2; respectively [14].
  5. (5) TRGC2*01(2x) and TRGC2*02(2x) alleles were previously designated as gamma2b (D7 gamma2) and gamma2a (D11 gamma2), respectively [15].
  6. (6) Productive, truncated chain at its C-terminal end following introduction of a STOP-CODON at position 7 of EX3 to obtain a soluble form.
IMGT references:
  1. [1] Lefranc M.-P. and Rabbitts T.H., Nature, 316, 464-466 (1985). PMID:2991773
  2. [2] Dialynas D.P. et al., Proc. Natl. Acad. Sci. U.S.A., 83, 2619-2623 (1986). PMID:3458221
  3. [3] Lefranc M.-P. et al., Proc. Natl. Acad. Sci. U.S.A., 83, 9596-9600 (1986). PMID:2879283
  4. [4] Pelicci P.G. et al., Science, 237, 1051-1055 (1987). PMID:3112943
  5. [5] Buresi C. et al., Immunogenetics, 29, 161-172 (1989). PMID:2564370
  6. [6] Zhan M. et al., Unpublished.
  7. [7] Strausberg R.L. et al., Proc. Natl. Acad. Sci. U.S.A., 99, 16899-16903 (2002). PMID:12477932
  8. [8] Krangel M.S. et al., Science, 237, 64-67 (1987). PMID:2955517
  9. [9] Essand M. et al., Proc. Natl. Acad. Sci. U.S.A., 96, 9287-9292 (1999). PMID:10430935
  10. [10] Hochstenbach F. et al., J. Exp. Med., 168, 761-776 (1988). PMID:3261778
  11. [11] Yoshikai Y. et al., Eur. J. Immunol., 17, 119-126 (1987). PMID:2949984
  12. [12] Littman D.R. et al., Nature, 326, 85-88 (1987). PMID:3102973
  13. [13] Davodeau F. et al., J. Biol. Chem., 268, 15455-15460 (1993). PMID:8340374
  14. [14] Ghanem N. et al., Hum genet., 86, 450-456 (1991). PMID:1673112
  15. [15] Lefranc M.-P. et al., Proc. Natl. Acad. Sci. U.S.A., 83, 9596-9600 (1986). PMID:2879283
Created:
04/06/1997
Last updated:
22/09/2023
Authors:
Nathalie Pallarès, Manuel Ruiz, Christèle Martinez-Jean, Joumana Jabado-Michaloud