IMGT Repertoire (IG and TR)

Fct: FUNCTIONALITY
- F: Functional
- P: Pseudogene
- ORF: Open Reading Frame
T: Transcribed
Pr: Translated into protein

"+" or "-" indicates if the gene sequences have been found (+) or not been found (-) transcribed (T) and/or translated into protein (Pr). Arbitrarily that information is shown on the first line of each gene when the data have been confirmed by several studies.

Functionality is shown between parentheses, (F) and (P), when the accession number refers to rearranged genomic DNA or cDNA and the corresponding germline gene has not yet been isolated.
Functionality is shown between brackets, [F] and [P], when the accession number refers to genomic DNA, but not known as being germline or rearranged.

Click on:

IMGT gene name to get the corresponding IMGT/GENE-DB entry,
IMGT allele name to see the corresponding Alignments of alleles,
accession number to get the corresponding IMGT/LIGM-DB entry.

In the "Clone names" column of "IMGT/LIGM-DB reference sequences" are shown the names of the lambda phages (for genomic sequences) or of the clones (for cDNA), and between parentheses cell lines, from which are derived the reference sequences.

IMGT gene name	IMGT allele name		Fct		Chromosomal localization	T	Pr	Positions in the locus	IMGT/LIGM-DB reference sequences										IMGT/LIGM-DB sequences from the literature
IMGT gene name	IMGT allele name		Fct		Chromosomal localization	T	Pr	Positions in the locus	Clone names	Exons	Accession numbers	Positions in the sequence			Secondary accession numbers				Clone names	Accession numbers	Positions in the sequence
	TRGC1		TRGC1*01	(1)	F	7p14					lambda-D19 (D-PLL)	EX1			M14996	[3]			41..370				X02758	[1]	(2)		23..>178
																						T-gamma-5	M17325	[4]	(3)	c	<1..309
																							AF159056	[6]			108237..108566
																							BC072387	[7]		c	378..707
																							BC105589	[7]		c(st)	279..608
																							M16768	[8]		c	564..893
																						CM000669.2	IMGT000011				122378..122707
												EX2			M14997	[3]			25..72			T-gamma-5	M17325	[4]	(3)	c	310..357
																							AF159056	[6]			111697..111744
																							BC072387	[7]		c	708..755
																							BC105589	[7]		c(st)	609..656
																							M16768	[8]		c	894..941
																						CM000669.2	IMGT000011				125838..125885
												EX3			M14998	[3]			174..313			T-gamma-5	M17325	[4]	(3)	c	358..498
																							AF159056	[6]			113685..113824
																							BC072387	[7]		c	756..896
																							BC105589	[7]		c(st)	657..797
																							M16768	[8]		c	942..1082
																						CM000669.2	IMGT000011				127826..127965
			TRGC1*02	(1)	F	7p14					lambda-R-gamma (Raji)	EX1			M14999	[3]	(2)		1..>300				X02757	[1]	(2)		23..>178
												EX2
												EX3
			TRGC1*03	(1)	(F)	7p14					TCRGV9, V2	EX1			BC072396	[7]		c	804..1133				BC030554	[7]		c	745..1074
																						HGP02	M27334	[11]		c	1..330
																							X72500	[13]	(6)	c
												EX2			BC072396	[7]		c	1134..1181				BC030554	[7]		c	1075..1122
																						HGP02	M27334	[11]		c	331..378
																							X72500	[13]	(6)	c
												EX3			BC072396	[7]		c	1182..1322				BC030554	[7]		c	1123..1263
																						HGP02	M27334	[11]		c	379..519
																							X72500	[13]	(6)	c
			TRGC1*04	(1)	(F)	7p14						EX1			AF151103	[9]		c	61..390
												EX2			AF151103	[9]		c	391..438
												EX3			AF151103	[9]		c	439..579
			TRGC1*05	(1)	(F)	7p14					TCRGV9, V2	EX1			BC062761	[7]		c	56..385
												EX2			BC062761	[7]		c	386..433
												EX3			BC062761	[7]		c	434..574
	TRGC2	(4)	TRGC2*01(2x)	(5)	F	7p14					lambda-D7 (D-PLL)	EX1			M15002	[3]			1..330			pTgamma-1(HPB-MLT)	M13231	[2]		c	410..739
											pTgamma-1 (HPB-MLT)	EX2T			M13231	[2]		c	740..787
												EX2			M13231	[2]		c	788..835
												EX3			M13231	[2]		c	836..976
			TRGC2*02(2x)	(5)	F	7p14					lambdaD11 (D-PLL)	EX1			M15001	[3]			1..330				BC017861	[7]		c	466..795
											lambdaS9 (SUPT1)	EX2R			M15004	[3]			6..53				BC017861	[7]		c	796..843
												EX2			M15005	[3]			6..53				BC017861	[7]		c	844..891
												EX3			M15007	[3]			2..141				BC017861	[7]		c	892..1032
			TRGC2*03(2x)		(F)	7p14					F-gamma-7 (Fro 2.2)	EX1			M17324	[4]		c	1..329
												EX2R			M17324	[4]		c	330..377
												EX2			M17324	[4]		c	378..425
												EX3			M17324	[4]		c	426..566
			TRGC2*04(2x)		F	7p14						EX1			AF159056	[6]			108237..108566
												EX2R			AF159056	[6]
												EX2			AF159056	[6]			111697..111744
												EX3			AF159056	[6]			113685..113824
			TRGC2*05(3x)		(F)	7p14					p-gamma-1 (PEER)	EX1			M17323	[4]		c	1..329				M30894	[12]		c
											lambdaR12 (RPMI 8402)	EX2T			M25318	[5]			7..54			p-gamma-1(PEER)	M17323	[4]		c	330..377
											lambdaR12 (RPMI 8402)	EX2T			M25318	[5]			7..54				M30894	[12]		c
											p-gamma-1 (PEER)	EX2R			M17323	[4]		c	378..425				M30894	[12]		c
												EX2			M17323	[4]		c	426..473				M30894	[12]		c
												EX3			M17323	[4]		c	474..614				M30894	[12]		c
			TRGC2*06(2x)		(F)	7p14					K (MOLT13 leukemia)	EX1			Y00790	[10]		c	439..768			CM000669.2	IMGT000011				138484..138813
												EX2R			Y00790	[10]		c	769..816			CM000669.2	IMGT000011				142826..142873
												EX2			Y00790	[10]		c	817..864			CM000669.2	IMGT000011				145581..145628
												EX3			Y00790	[10]		c	865..1005			CM000669.2	IMGT000011				147890..148029
			TRGC2*07(2x)		(F)	7p14					HGP08	EX1			M27331	[11]		c	1..330
EX2R												M27331	[11]	c	331..378
EX2												M27331	[11]	c	379..426
EX3												M27331	[11]	c	427..567
TRGC2*08(2x)			(F)		7p14					HGP06	EX1	M27332	[11]	c	1..330
											EX2R	M27332	[11]	c	331..378
											EX2	M27332	[11]	c	379..426
											EX3	M27332	[11]	c	427..564

c: cDNA sequence.
(st): sterile transcipt.

IMGT notes:

(1) TRGC1*01 and TRGC1*02 alleles were previously designated as gamma1^b (D19 gamma1) and gamma1^a (Raji gamma1), respectively [15].
(2) Partial C-GENE: partial EX1 in 3'.
(3) Partial C-REGION: partial EX1 in 5'.
(4) The TRGC2 gene contains four or five exons due to the duplication (EX2T-EX2 or EX2R-EX2) or triplication (EX2T-EX2R-EX2) of exon 2 [5]. (2x) or (3x) indicates the duplication or triplication of the TRGC2 exon 2; respectively [14].
(5) TRGC2*01(2x) and TRGC2*02(2x) alleles were previously designated as gamma2^b (D7 gamma2) and gamma2^a (D11 gamma2), respectively [15].
(6) Productive, truncated chain at its C-terminal end following introduction of a STOP-CODON at position 7 of EX3 to obtain a soluble form.

IMGT references:

[1] Lefranc M.-P. and Rabbitts T.H., Nature, 316, 464-466 (1985). PMID:2991773
[2] Dialynas D.P. et al., Proc. Natl. Acad. Sci. U.S.A., 83, 2619-2623 (1986). PMID:3458221
[3] Lefranc M.-P. et al., Proc. Natl. Acad. Sci. U.S.A., 83, 9596-9600 (1986). PMID:2879283
[4] Pelicci P.G. et al., Science, 237, 1051-1055 (1987). PMID:3112943
[5] Buresi C. et al., Immunogenetics, 29, 161-172 (1989). PMID:2564370
[6] Zhan M. et al., Unpublished.
[7] Strausberg R.L. et al., Proc. Natl. Acad. Sci. U.S.A., 99, 16899-16903 (2002). PMID:12477932
[8] Krangel M.S. et al., Science, 237, 64-67 (1987). PMID:2955517
[9] Essand M. et al., Proc. Natl. Acad. Sci. U.S.A., 96, 9287-9292 (1999). PMID:10430935
[10] Hochstenbach F. et al., J. Exp. Med., 168, 761-776 (1988). PMID:3261778
[11] Yoshikai Y. et al., Eur. J. Immunol., 17, 119-126 (1987). PMID:2949984
[12] Littman D.R. et al., Nature, 326, 85-88 (1987). PMID:3102973
[13] Davodeau F. et al., J. Biol. Chem., 268, 15455-15460 (1993). PMID:8340374
[14] Ghanem N. et al., Hum genet., 86, 450-456 (1991). PMID:1673112
[15] Lefranc M.-P. et al., Proc. Natl. Acad. Sci. U.S.A., 83, 9596-9600 (1986). PMID:2879283

More information:

See also (IMGT Scientific chart):

Created:: 04/06/1997
Last updated:: 22/09/2023
Authors:: Nathalie Pallarès, Manuel Ruiz, Christèle Martinez-Jean, Joumana Jabado-Michaloud

IMGT Repertoire (IG and TR)

Gene table: human (Homo sapiens) TRGC