The orientation of the human (Homo sapiens) IGK locus on the chromosome 2 (2p11.2) is reverse (REV).
Legend:
Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.
A double slash // indicates a gap in genome assembly. Distances in bp (base pair) or in kb (kilobase) associated with a double slash are taken
into account in the length of the lines and included in the numbers displayed at the right end of the lines.
A dotted line ... indicates the distance in kb (kilobase) between the locus and its bornes (5' borne and the most 5' gene in the locus and/or 3'
borne and the most 3' gene in the locus) on the top and bottom lines, respectively. These distances are not represented at scale and are not
included in the numbers displayed at the right ends of these two lines.
The IGKV genes of the proximal V-CLUSTER
are designated by a number for the subgroup, followed by a hyphen and a number for the localization from 3' to 5' in the locus.
The IGKV genes of the distal duplicated V-CLUSTER are designated by the same numbers as the corresponding
genes in the proximal V-CLUSTER, with the letter D added.
Arrows show the IGKV genes whose orientation is opposite to that of the
J-C-CLUSTER.
• No 5' borne conserved between species has been identified upstream of IGKV3D-7 (F), the most 5' gene in the locus.
• RPIA (ribose 5-phosphate isomerase A) (3' borne) has been identified 106 kb downstream of IGKC (F), the most 3' gene in the locus.
The Human (Homo sapiens) IGKV genes belong to seven subgroups (Gene table: Human IGKV) which are part of three clans (Figure IGKV clans). Clans comprise, respectively:
This representation is taking into account the polymorphic duplication in the locus
(see references from Zachau's group below).
Small triangles indicate parts which are absent in the proximal or distal V-CLUSTER when considering
the duplication in the human IGK locus.
Gene localization is according to data from IMGT/LocusView.
This locus representation with only the functional genes is used with IMGT/GeneFrequency.
* When needed, indicate the presence of allele(s) with another functionality: see above human (Homo sapiens) IGK locus
The orientation of the human (Homo sapiens) IGKV/OR22 locus on the chromosome 22 (22q11) is reverse (REV).
Legend:
Colors are according to IMGT color menu for genes.
The boxes representing the genes are not to scale. Exons are not shown.
A double slash // indicates a gap in genome assembly. Distances in bp (base pair) or in kb (kilobase) associated with a double slash are taken
into account in the length of the lines and included in the numbers displayed at the right end of the lines.
A dotted line ... indicates the distance in kb (kilobase) between the locus and its bornes (5' borne and the most 5' gene in the locus and/or 3'
borne and the most 3' gene in the locus) on the top and bottom lines, respectively. These distances are not represented at scale and are not
included in the numbers displayed at the right ends of these two lines.