IMGT Repertoire (RPI)

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Other CD79 entries

Homo sapiens: CD79A
Mus musculus: CD79A, CD79B

IMGT RPI entry from gene to protein for Homo sapiens CD79B

Citing IMGT RPI entry for CD79B

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004)

with permission from Research Signpost

IMGT gene name and definition

IMGT gene name: Homo sapiens CD79B
IMGT gene definition: CD79B molecule, immunoglobulin-associated beta

Chromosomal localization

Chromosome: 17
Chromosomal localization: 17q23

Gene exon/intron organization

Legend:

Length of the exons and introns are in base pairs.
Colors are according to IMGT Color menu for regions and domains

Number of alleles: 4

IMGT reference alleles

Allele names	Gene functionality	IMGT reference sequences
Allele names	Gene functionality	Exons	Accession numbers	Molecule type
CD79B*01	F	EX1-6	U05259 [1]	gDNA
CD79B*02	F	EX1-6	BC002975	cDNA (1)
CD79B*03	F	EX1-6	M80461	cDNA (2)
CD79B*04	F	EX1-6	S52229 [2]	cDNA (3)

IMGT reference sequences (in FASTA format) for the allele(s): CD79B*01 to CD79B*04

Nucleotide sequence in FASTA format with gaps according to the IMGT unique numbering
Amino acid sequence in FASTA format with gaps according to the IMGT unique numbering
Nucleotide sequence in FASTA format without gaps
Amino acid sequence in FASTA format without gaps

Other sequences from the literature

Allele names	Gene functionality	IMGT reference sequences
Allele names	Gene functionality	Exons	Accession numbers	Molecule type
CD79B*01	F	EX1-6	AK222954	cDNA (4) splicing B
		EX1-6	AK223210	cDNA splicing B
		EX1-2,4-6	X83539	cDNA (5) splicing C
		EX1-2,4-6	S79249	cDNA (5) splicing C
		EX1	BC030210	cDNA
		EX1-6	NM_000626	cDNA splicing A
		EX1-6	NM_001039933	cDNA splicing B
		EX1-2,4-6	NM_021602	cDNA splicing C
CD79B*02		EX1-6	BC032651	cDNA

Corresponding protein database accession numbers

Allele names	Accession numbers		Number of amino acids	Protein isoform
Allele names	Nucleotide databases	Protein databases	Number of amino acids	Protein isoform
CD79B*01	U05259	P40259	229 aa	1
	NM_000626	NP_000617	229 aa	1
	NM_001039933	NP_001035022	230 aa	2
	NM_021602	NP_067613	125 aa	3
CD79B*02	BC002975		229 aa	1
CD79B*03	M80461		229 aa	1
CD79B*04	S52229		229 aa	1

IMGT notes:

(1) In EX3 [D] c312>t positions according to IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.
(2) In EX3 [D] g46>c, G16>R and c312>t, positions according to IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.
(3) In EX1 g48>t and in EX3 [D] g46>c, G16>R and c312>t, positions according to IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN.
(4) Splicing B (230 aa). This transcipt uses an alternative in-frame splice site in the EX2 5' ACCEPTOR-SPLICE site one codon upstream to the usual splice site.
(5) Splicing C (125 aa). This transcript is the smallest and lacks the EX3 [D] encoding the C-LIKE-DOMAIN.

IMGT references:

[1] Hashimoto S. Chiorazzi N. and Gregersen P.K. Immunogenetics 40, 145-149 (1994). PMID:7913081
[2] Hashimoto S. Gregersen P.K. and Chiorazzi N. J. Immunol. 150, 491-498 (1993). PMID:8419481

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

CD79B*01: L27587(g)

Nucleotide sequence

1        atggccaggc tggcgttgtc tcctgtgccc agccactgga tggtggcgtt gctgctgctg

61       ctctcagctg agccagtacc agcagccaga tcggaggacc ggtaccggaa tcccaaaggt

121      agtgcttgtt cgcggatctg gcagagccca cgtttcatag ccaggaaacg gggcttcacg

181      gtgaaaatgc actgctacat gaacagcgcc tccggcaatg tgagctggct ctggaagcag

241      gagatggacg agaatcccca gcagctgaag ctggaaaagg gccgcatgga agagtcccag

301      aacgaatctc tcgccaccct caccatccaa ggcatccggt ttgaggacaa tggcatctac

361      ttctgtcagc agaagtgcaa caacacctcg gaggtctacc agggctgcgg cacagagctg

421      cgagtcatgg gattcagcac cttggcacag ctgaagcaga ggaacacgct gaaggatggt

481      atcatcatga tccagacgct gctgatcatc ctcttcatca tcgtgcctat cttcctgctg

541      ctggacaagg atgacagcaa ggctggcatg gaggaagatc acacctacga gggcctggac

601      attgaccaga cagccaccta tgaggacata gtgacgctgc ggacagggga agtgaagtgg

661      tctgtaggtg agcacccagg ccaggagtga

Nucleotide sequence in FASTA format (without gaps) CD79B*01

Amino acid sequence

1        MARLALSPVP SHWMVALLLL LSAEPVPAAR SEDRYRNPKG SACSRIWQSP RFIARKRGFT

61       VKMHCYMNSA SGNVSWLWKQ EMDENPQQLK LEKGRMEESQ NESLATLTIQ GIRFEDNGIY

121      FCQQKCNNTS EVYQGCGTEL RVMGFSTLAQ LKQRNTLKDG IIMIQTLLII LFIIVPIFLL

181      LDKDDSKAGM EEDHTYEGLD IDQTATYEDI VTLRTGEVKW SVGEHPGQE*

Amino acid sequence in FASTA format (without gap) CD79B*01

Legend:

Colors are according to IMGT Color menu for regions and domains
Nucleotide and amino acid letters (in bold) in purple, green or blue are according to IMGT Color menu for splicing types.

IMGT links

IMGT Repertoire

Chromosomal localization:
Alignment of alleles:
Protein displays:
IMGT Collier de perles: C-LIKE-DOMAIN on one layer, C-LIKE-DOMAIN on two layers

External links

Nomenclature

HGNC: 1699

Genome Database

Entrez Gene: 974
GENATLAS: 854
GeneCards: GC17M059359
GDB: 133786
OMIM: 147245

Sequence database

EMBL: U05259, BC002975, M80461, S52229, AK222954, AK223210, X83539, S79249, BC030210, BC032651
GenBank: U05259, BC002975, M80461, S52229, AK222954, AK223210, X83539, S79249, BC030210, BC032651
DDBJ: U05259, BC002975, M80461, S52229, AK222954, AK223210, X83539, S79249, BC030210, BC032651
Swiss-Prot: P40259
TrEMBL: Q53FS2, Q6PIS4
NCBI: NM_000626, NP_000617, NM_001039933, NP_001035022, NM_021602, NP_067613

Structure database

PDB: