Other IgSF entries

IMGT RPI entry from gene to protein for Homo sapiens CTLA4

Citing IMGT RPI entry for CTLA4

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004) pdf with permission from Research Signpost

IMGT gene name and definition

Chromosomal localization

Gene exon/intron organization

CTLA4 Gene exon/intron organization

Legend:

Number of alleles: 3

IMGT reference alleles

Allele names Gene functionality IMGT reference sequences
Exons Accession numbers Molecule type
CTLA4*01 F EX1 M74363 [1] gDNA
EX2-4 M37243-M37245 cDNA
CTLA4*02 F EX1-4 AC010138 cDNA (1)
CTLA4*03 F EX1-4 AF411058 [2] cDNA (2)

IMGT reference sequences (in FASTA format) for the allele(s): CTLA4*01 to CTLA4*03

Other sequences from the literature

Allele names Gene functionality IMGT reference sequences
Clones Exons Accession numbers Molecule type
CTLA4*02 F EX1-4 AF414120 cDNA
MGC:104099 EX1-4 BC074842
MGC:103840 EX1-4 BC074843
EX1-4 NM_005214
CTLA4*03 F EX1-4 AY209009 cDNA
MGC:97034 EX1-4 BC069566

Corresponding protein database accession numbers

Allele names Accession numbers Number of amino acids Protein isoform
Nucleotide databases Protein databases
CTLA4*01 M37243 223 aa 1
CTLA4*02 AC010138 P16410 223 aa 1
NM_005214 NP_005205 223 aa 1
CTLA4*03 AF411058 223 aa 1
IMGT notes:
  1. (1) EX2[D] 332g>a; 122A>T numbering according to IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN.
  2. (2) In EX1 49a>g, 17T>A this mutation has been linked to autoimmune diseases such as Graves' disease and type 1 diabetes and EX2[D] 332g>a; 122A>T numbering according to IMGT unique numbering for V-DOMAIN and V-LIKE-DOMAIN.
IMGT references:
  1. [1] Dariavach, P., Mattei,M.G., Golstein,P. and Lefranc,M.P. Eur. J. Immunol. 18, 1901-1905 (1988). PMID:3220103
  2. [2] Ling,V., Wu,P.W. et al. Genomics 78, 155-168 (2001). PMID:11735222

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

CTLA4*01: M74363(g)

Nucleotide sequence

1        atggcttgcc ttggatttca gcggcacaag gctcagctga acctggctac caggacctgg

61       ccctgcactc tcctgttttt tcttctcttc atccctgtct tctgcaaagc aatgcacgtg

121      gcccagcctg ctgtggtact ggccagcagc cgaggcatcg ccagctttgt gtgtgagtat

181      gcatctccag gcaaagccac tgaggtccgg gtgacagtgc ttcggcaggc tgacagccag

241      gtgactgaag tctgtgcggc aacctacatg atggggaatg agttgacctt cctagatgat

301      tccatctgca cgggcacctc cagtggaaat caagtgaacc tcactatcca aggactgagg

361      gccatggaca cgggactcta catctgcaag gtggagctca tgtacccacc gccatactac

421      ctgggcatag gcaacggagc ccagatttat gtaattgatc cagaaccgtg cccagattct

481      gacttcctcc tctggatcct tgcagcagtt agttcggggt tgttttttta tagctttctc

541      ctcacagctg tttctttgag caaaatgcta aagaaaagaa gccctcttac aacaggggtc

601      tatgtgaaaa tgcccccaac agagccagaa tgtgaaaagc aatttcagcc ttattttatt

661      cccatcaatt ga
Nucleotide sequence in FASTA format (without gaps) CTLA4*01

Amino acid sequence

1        MACLGFQRHK AQLNLATRTW PCTLLFFLLF IPVFCKAMHV AQPAVVLASS RGIASFVCEY

61       ASPGKATEVR VTVLRQADSQ VTEVCAATYM MGNELTFLDD SICTGTSSGN QVNLTIQGLR

121      AMDTGLYICK VELMYPPPYY LGIGNGAQIY VIDPEPCPDS DFLLWILAAV SSGLFFYSFL

181      LTAVSLSKML KKRSPLTTGV YVKMPPTEPE CEKQFQPYFI PIN*
Amino acid sequence in FASTA format (without gap) CTLA4*01

Legend: