IMGT Repertoire (RPI)

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Other FCGR entries

Homo sapiens: FCGR1B, FCGR1C, FCGR2A, FCGR2B, FCGR3B
Mus musculus: FCGR1

IMGT RPI entry from gene to protein for Homo sapiens FCGR1A

Citing IMGT RPI entry for FCGR1A

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004)

with permission from Research Signpost

IMGT gene name and definition

IMGT gene name: Homo sapiens FCGR1A
IMGT gene definition: Fc fragment of IgG, high affinity Ia, Receptor for(CD64)

Chromosomal localization

Chromosome: 1
Chromosomal localization: 1q21.2-q21.3

Gene exon/intron organization

Legend:

Length of the exons and introns are in base pairs.
Colors are according to IMGT Color menu for regions and domains

Number of alleles: 3

IMGT reference alleles

Allele name	Gene functionality	IMGT reference sequences
Allele name	Gene functionality	Clone names	Accession numbers	Molecule type
FCGR1A*01	F		M91645 [1](1)	gDNA
FCGR1A*02	F	fcr135/p135	X14356/M21091 [2]	cDNA
FCGR1A*03	F		X14356 VAR1 [3]	cDNA

IMGT reference sequences (in FASTA format) for the allele(s): FCGR1A*01 to FCGR1A*03

Nucleotide sequence in FASTA format with gaps according to the IMGT unique numbering
Amino acid sequence in FASTA format with gaps according to the IMGT unique numbering
Nucleotide sequence in FASTA format without gaps
Amino acid sequence in FASTA format without gaps

Other sequences from the literature

Allele name	Gene functionality	IMGT reference sequences
Allele name	Gene functionality	Clone names	Accession numbers	Molecule type
FCGR1A*01	F		L03418[4]	cDNA
FCGR1A*01	Unknown	p98/X2 fcr98	X14355/M21090[2]	cDNA splicingB (2)

Corresponding protein database accession numbers

Allele name	Accession numbers		Number of amino acids	Protein isoform
Allele name	Nucleotide databases	Protein databases	Number of amino acids	Protein isoform
FCGR1A*01	M91645	Tr: Q92663	374 aa
FCGR1A*01	L03418	Tr: Q92663
FCGR1A*02	X14356/M21091	Sw: P12314	374 aa

IMGT notes:

(1) Exons previously submitted as M63830-M63835
(2) The last 12 codons and corresponding amino acids are different from the 42 last codons. No EX1 and EX2.

IMGT references:

[1] Ernst, L.K. et al, J. Biol. Chem., 267, 15692-15700 (1992). PMID:1379234
[2] Allen J.M. and Seed B., Nucl. Acids Res., 16, 11824 (1988). PMID:2974947
[3] Allen J.M. and Seed B., Science, 243, 378-381 (1989). PMID:2911749
[4] Porges, A.J. et al, J. Clin. Invest., 90, 2102-2109 (1992). PMID:1430234

Genomic sequence

Genomic sequence from M91645

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

FCGR1A*01: M91645(g)

Nucleotide sequence

1        atgtggttct tgacaactct gctcctttgg gttccagttg atgggcaagt ggacaccaca

61       aaggcagtga tcactttgca gcctccatgg gtcagcgtgt tccaagagga aaccgtaacc

121      ttgcactgtg aggtgctcca tctgcctggg agcagctcta cacagtggtt tctcaatggc

181      acagccactc agacctcgac ccccagctac agaatcacct ctgccagtgt caatgacagt

241      ggtgaataca ggtgccagag aggtctctca gggcgaagtg accccataca gctggaaatc

301      cacagaggct ggctactact gcaggtctcc agcagagtct tcacggaagg agaacctctg

361      gccttgaggt gtcatgcgtg gaaggataag ctggtgtaca atgtgcttta ctatcgaaat

421      ggcaaagcct ttaagttttt ccactggaat tctaacctca ccattctgaa aaccaacata

481      agtcacaatg gcacctacca ttgctcaggc atgggaaagc atcgctacac atcagcagga

541      atatctgtca ctgtgaaaga gctatttcca gctccagtgc tgaatgcatc tgtgacatcc

601      ccactcctgg aggggaatct ggtcaccctg agctgtgaaa caaagttgct cttgcagagg

661      cctggtttgc agctttactt ctccttctac atgggcagca agaccctgcg aggcaggaac

721      acatcctctg aataccaaat actaactgct agaagagaag actctgggtt atactggtgc

781      gaggctgcca cagaggatgg aaatgtcctt aagcgcagcc ctgagttgga gcttcaagtg

841      cttggcctcc agttaccaac tcctgtctgg tttcatgtcc ttttctatct ggcagtggga

901      ataatgtttt tagtgaacac tgttctctgg gtgacaatac gtaaagaact gaaaagaaag

961      aaaaagtggg atttagaaat ctctttggat tctggtcatg agaagaaggt aatttccagc

1021     cttcaagaag acagacattt agaagaagag ctgaaatgtc aggaacaaaa agaagaacag

1081     ctgcaggaag gggtgcaccg gaaggagccc cagggggcca cgtag

Nucleotide sequence in FASTA format (without gaps) FCGR1A*01

Amino acid sequence

1        MWFLTTLLLW VPVDGQVDTT KAVITLQPPW VSVFQEETVT LHCEVLHLPG SSSTQWFLNG

61       TATQTSTPSY RITSASVNDS GEYRCQRGLS GRSDPIQLEI HRGWLLLQVS SRVFTEGEPL

121      ALRCHAWKDK LVYNVLYYRN GKAFKFFHWN SNLTILKTNI SHNGTYHCSG MGKHRYTSAG

181      ISVTVKELFP APVLNASVTS PLLEGNLVTL SCETKLLLQR PGLQLYFSFY MGSKTLRGRN

241      TSSEYQILTA RREDSGLYWC EAATEDGNVL KRSPELELQV LGLQLPTPVW FHVLFYLAVG

301      IMFLVNTVLW VTIRKELKRK KKWDLEISLD SGHEKKVISS LQEDRHLEEE LKCQEQKEEQ

361      LQEGVHRKEP QGAT*

Amino acid sequence in FASTA format (without gap) FCGR1A*01

Legend:

Colors are according to IMGT Color menu for regions and domains
Nucleotide and amino acid letters (in bold) in purple, green or blue are according to IMGT Color menu for splicing types.

IMGT links

IMGT Repertoire

Chromosomal localization:
Alignment of alleles:
Protein displays: C-LIKE-DOMAIN
IMGT Collier de perles: C-LIKE-DOMAIN on one layer, C-LIKE-DOMAIN on two layers

External links

Nomenclature

HGNC: 3613

Genome databases

Entrez Gene: 2209
GENATLAS: 553
GeneCards: FCGR1A
GDB: 135911
OMIM: 146760

Sequence databases

EMBL: M91645
GenBank: M91645
DDBJ: M91645
Swiss-Prot: P12314
TrEMBL: Q92663
NCBI: NT_032962, NM_000566, NP_000557

Structure database

PDB: