IMGT Repertoire (RPI)

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Other IgSF entries

Homo sapiens: CD28, CTLA4
Mus musculus: CD28, CTLA4, ICOS

IMGT RPI entry from gene to protein for Homo sapiens ICOS

Citing IMGT RPI entry for ICOS

Duprat, E. et al. IMGT standardization for alleles and mutations of the V-LIKE-DOMAINs and C-LIKE-DOMAINs of the immunoglobulin superfamily, Recent Research Developments in Human Genetics, 2, 111-136 (2004)

with permission from Research Signpost

IMGT gene name and definition

IMGT gene name: Homo sapiens ICOS
IMGT gene definition: inducible T-cell co-stimulator

Chromosomal localization

Chromosome: 2
Chromosomal localization: 2q33

Gene exon/intron organization

Legend:

Length of the exons and introns are in base pairs.
Colors are according to IMGT Color menu for regions and domains

Number of alleles: 1

IMGT reference alleles

Allele names	Gene functionality	IMGT reference sequences
Allele names	Gene functionality	Exons	Accession numbers	Molecule type
ICOS*01	F	EX1-5	AF411058 [1]	gDNA

IMGT reference sequences (in FASTA format) for the allele(s): ICOS*01

Nucleotide sequence in FASTA format with gaps according to the IMGT unique numbering
Amino acid sequence in FASTA format with gaps according to the IMGT unique numbering
Nucleotide sequence in FASTA format without gaps
Amino acid sequence in FASTA format without gaps

Other sequences from the literature

Allele names	Gene functionality	IMGT reference sequences
Allele names	Gene functionality	Clones	Exons	Accession numbers	Molecule type
ICOS*01	F	BAC_22608	EX1-5	AF411059	gDNA
		RP11-278L16	EX1-5	AC103880
			EX1-5	AF488346
		RP11-278L16	EX1-5	AF488347
			EX1-5	AJ535718
			EX1-5	AB023135	cDNA
		MGC:40066	EX1-5	AJ277832
		MGC:39850	EX1-5	BC028210
			EX1-3	BC028006	cDNA(1) splicing B
			EX1-5	NM_012092	cDNA

Corresponding protein database accession numbers

Allele names	Accession numbers		Number of amino acids	Protein isoform
Allele names	Nucleotide databases	Protein databases	Number of amino acids	Protein isoform
ICOS*01	AF411058	Q9Y6W8	199 aa	1
ICOS*01	NM_012092	NP_036224	199 aa	1

IMGT notes:

(1) No EX4-5. 168 aa.

IMGT references:

[1] Ling,V., Wu,P.W. et al. Genomics 78, 155-168 (2001). PMID:11735222
[2] Strausberg,R.L. Proc. Natl. Acad. Sci. U.S.A. 99, 16899-16903 (2002). PMID:12477932

Genomic sequence

Coding region sequence

The coding region (CODING-REGION) sequence starts from INIT-CODON (or its encoded amino acid) to STOP-CODON (not included).
The nucleotide sequence is extracted from cDNA (c) sequences and/or is built by artificial exon joining from genomic DNA (g) sequences. The amino acid sequence is the translation of the nucleotide sequence.

ICOS*01: AF411058(g)

Nucleotide sequence

1        atgaagtcag gcctctggta tttctttctc ttctgcttgc gcattaaagt tttaacagga

61       gaaatcaatg gttctgccaa ttatgagatg tttatatttc acaacggagg tgtacaaatt

121      ttatgcaaat atcctgacat tgtccagcaa tttaaaatgc agttgctgaa aggggggcaa

181      atactctgcg atctcactaa gacaaaagga agtggaaaca cagtgtccat taagagtctg

241      aaattctgcc attctcagtt atccaacaac agtgtctctt tttttctata caacttggac

301      cattctcatg ccaactatta cttctgcaac ctatcaattt ttgatcctcc tccttttaaa

361      gtaactctta caggaggata tttgcatatt tatgaatcac aactttgttg ccagctgaag

421      ttctggttac ccataggatg tgcagccttt gttgtagtct gcattttggg atgcatactt

481      atttgttggc ttacaaaaaa gaagtattca tccagtgtgc acgaccctaa cggtgaatac

541      atgttcatga gagcagtgaa cacagccaaa aaatctagac tcacagatgt gaccctataa

Nucleotide sequence in FASTA format (without gaps) ICOS*01

Amino acid sequence

1        MKSGLWYFFL FCLRIKVLTG EINGSANYEM FIFHNGGVQI LCKYPDIVQQ FKMQLLKGGQ

61       ILCDLTKTKG SGNTVSIKSL KFCHSQLSNN SVSFFLYNLD HSHANYYFCN LSIFDPPPFK

121      VTLTGGYLHI YESQLCCQLK FWLPIGCAAF VVVCILGCIL ICWLTKKKYS SSVHDPNGEY

181      MFMRAVNTAK KSRLTDVTL*

Amino acid sequence in FASTA format (without gap) ICOS*01

Legend:

Colors are according to IMGT Color menu for regions and domains
Nucleotide and amino acid letters (in bold) in purple, green or blue are according to IMGT Color menu for splicing types.

IMGT links

IMGT Repertoire

Chromosomal localization:
Alignment of alleles:
Protein displays:
IMGT Collier de perles: V-LIKE-DOMAIN on one layer, V-LIKE-DOMAIN on two layers

External links

Genome databases

Entrez Gene: 29851
GENATLAS: ICOS
GeneCards: GC02P204626
GDB: 10450295
OMIM: 604558

Sequence databases

EMBL: AF411058, AF411059, AC103880, AF488346, AF488347, AJ535718, AB023135, AJ277832, BC028210, BC028006
GenBank: AF411058, AF411059, AC103880, AF488346, AF488347, AJ535718, AB023135, AJ277832, BC028210, BC028006
DDBJ: AF411058, AF411059, AC103880, AF488346, AF488347, AJ535718, AB023135, AJ277832, BC028210, BC028006
Swiss-Prot: Q9Y6W8
TrEMBL:
NCBI: NM_012092, NP_036224

Structure database

PDB: