IMGT Lexique

ITAM

Immunoreceptor Tyrosine-based Activation Motif.

(D/E)xxYxx(L/I)x_6-8Yxx(L/I)
ITAMs consist of semiconserved spaced tyrosines, where x denotes nonconserved residues [1].

D/E
x
x
Y
x
x
L/I
x
x
x
x
x
x
x
x
Y
x
x
L/I

ITAM multiplicity and thymocyte selection [2].

References:
[1]	Reth, M. Nature 338, 383-384 (1989).
[2]	Love, P. E. and Shores, E. W. Immunity 12, 591-597 (2000).