Topoisomerase I inhibitors
Topoisomerase I inhibitors include:
- Camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata.
- Camptothecin derivatives which comprise :
- irinotecan (CPT-11)
- 10-hydroxy-7-ethylcamptothecin (SN-38), the active metabolite of irinotecan
- topotecan
- DX-8951f (exatecan mesylate), an hexacyclic camptothecin analog