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QUESTION 2:

What is the organization of the human TRA locus?


ANSWER to question 2:

The human TRA locus on chromosome 14 at 14q11.2 spans 1000 kb. It consists of 116 genes: 54 TRAV, 61 TRAJ and a unique TRAC gene. The TRD locus is nestled in the TRA locus between the TRAV and TRAJ genes. Among the 54 variable genes are included 5 genes designated as TRAV/DV which belong to 5 different subgroups and which have been found rearranged either to TRAJ or to TRDD genes and can therefore be used in the synthesis of alpha or delta chains.


Created: 11/06/2001
Last updated: Friday, 22-Sep-2023 18:15:34 CEST
Editor: Elodie Foulquier