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QUESTION 2:

What is the organization of the human TRD locus?


ANSWER to question 2:

The human TRD locus on chromosome 14 at 14q11.2 comprises a cluster of 10 genes: 1 TRDV, 3 TRDD and 4 TRDJ, the unique TRDC gene, and 3' of TRDC, 1 TRDV in inverted orientation. The cluster spans 60kb and is localized between the TRAV and TRAJ genes. 1 TRDV gene is localized at 360 kb of TRDC, among the TRAV genes. 5 genes described as TRAV/DV have been found rearranged to either TRDD or to TRAJ, and can therefore be used for the synthesis of delta and alpha chains.


Created: 11/06/2001
Last updated: Friday, 22-Sep-2023 18:15:35 CEST
Editor: Elodie Foulquier