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QUESTION 2:

What is the organization of the human TRG locus?

ANSWER to question 2:

The human TRG locus on chromosome 7 at 7p14 spans 160 kb. It consist of 19-22 genes: 12-15 TRGV belonging to 6 subgroups, upstream of a duplicated J-C-cluster, which comprises, for the first part, 3 TRGJ (TRGJP1, TRGJP and TRGJ1) and the TRGC1 gene, and for the second part, 2 TRGJ (TRGJP2 and TRGJ2) and the TRGC2 gene.
Two haplotypes with 12 or 14 TRGV genes correspond to allelic polymorphisms by insertion/deletion of the V4 and V5 genes. A rare haplotype with 15 TRGV genes has been detected by Southern analysis.

Created: 11/06/2001
Last updated: Friday, 22-Sep-2023 18:15:36 CEST
Author: Marie-Paule Lefranc
Editor: Elodie Foulquier