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Potential Germline Repertoire

Immunoglobulin heavy IGH genes

Subgroup Number of genes
IGHV1
IGHV2
IGHV3
IGHV4
IGHV5
IGHV6
IGHV7
 9
3
18-20**(+1*)
6-9**(+1*)
1
1
0-1**
Total 38-44(+2*)

Immunoglobulin kappa IGK genes

Subgroup Number of genes
IGKV1
IGKV2
IGKV3
IGKV4
IGKV5 		15(+2*)
7(+2*)
6(+1*)
1
1
Total 30(+5*)

Immunoglobulin lambda IGL genes

Subgroup Number of genes
IGLV1
IGLV2
IGLV3
IGLV4
IGLV5
IGLV6
IGLV7
IGLV8
IGLV9
IGLV10
 5
5
8 (+2*)
3
3-4**
1
1(+1*)
1
1
1
Total 29-30(+3*)

T cell receptor alpha TRA genes

Number of functional genes
per subgroup		 Subgroup Number of genes
1 gene TRAV2, 3*, 4, 5-7, 10,
14°, 16-22, 23°, 24,
25, 27, 29°*, 30,34, 35,
36°, 39-41		 25 (+2*)
2 genes TRAV1, 9, 13, 26, 38° 10
3 genes TRAV123
6 genes TRAV86
  Total 44 (+2*)

T cell receptor beta TRB genes

Number of functional genes
per subgroup		 Subgroup Number of genes
0-1 gene TRBV16
TRBV30		 1*
1*
1 gene TRBV2, 2, 9, 13-15,
18-20, 24, 25, 27-29		 14
2-3 genes TRBV4,
TRBV10
TRBV11
TRBV12		 2 (+1**)
2 (+1*)
3
3
5-8 genes TRBV5
TRBV6
TRBV7		5
6 (+1*,+1**)
5 (+2*)
  Total 40 (+6*, +2**)

T cell receptor gamma TRG genes

Subgroup Number of genes
TRGV1 3(+2**)
TRGV2 1
Total 4 (+2**)

T cell receptor delta TRD genes

Subgroup Number of genes
TRDV1 1
TRDV2 1
TRDV3 1
TRAV14/DV14
TRAV23/DV6
TRAV29/DV5
TRAV36/DV7
TRAV38/DV8		 1
1
1*
1
1
Total 7 (+1*)

* Genes with alleles of different functionalities.
** Allelic polymorphism by insertion/deletion.
° Subgroup with TRAV/DV gene(s).