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Toll-like receptors and their ligands

Toll-like receptor (TLR) Ligands
Viruses Bacteria Fungi Parasites Endogenous ligands Small/synthetic molecules
TLR1/TLR2 Mycobacterium triacyl lipopeptides, lipoarabinomannan (LAM) Yeast zymosan Trypanosoma cruzi glycosylphosphatidyl inositol (GPI) linked proteins
TLR2/TLR2 n.i.
TLR2/TLR6 diacyl lipopeptides, lipoteichoic acid (LTA) peptidoglycan Yeast zymosan Trypanosoma cruzi glycosylphosphatidyl inositol (GPI) linked proteins
TLR3 dsRNA
TLR4 Lipopolysaccharides (LPS) Hsp60, Hsp70? Hyaluronic acid? Herapan sulfate? Fibrinogen? Taxol (Mouse TLR4)
TLR5 Flagellin
TLR7 ssRNA Imidazoquinolines (Mouse TLR7), loxoribine
TLR8 ssRNA Imidazoquinolines (Human TLR8)
TLR9 Viral CpG Bacterial CpG
TLR10 n.i.
TLR11 Uropathogenic bacteria (Mouse TLR11) Trypanosoma gondii profilin (Mouse TLR11), apicomplexan profilins?
TLR12 n.i.
TLR13 n.i.

n.i.: not identified
The information in this table is from the literature and from the CliniSciences s.a. newsletter (06/10/08).