IMGT Repertoire (IG and TR)

3D representation: Human (Homo sapiens) TRGC1 C-DOMAIN

Here you are: IMGT Web resources > IMGT Repertoire (IG and TR) > 3. 2D and 3D structures

TR γδ G115 (PDB: 1hxm_B)

IMGT/3Dstructure-DB card: 1hxm

The TRGC1 C-DOMAIN is shown in two different orientations.

Side view (backbone model)

	C-DOMAIN C-GAMMA1 TRGC1

A C-DOMAIN corresponds to the complete C-REGION, to most of the C-REGION, or to part of the C-REGION, depending on the immunoglobulin or T cell receptor chain type.
This figure shows the C-DOMAIN of a gamma chain (PDB: 1hxm_B) of a gamma-delta T cell receptor in two different orientations. Only the C-GAMMA, part of the TRG C-REGION, is displayed. The carbohydrates are not shown.
In the PDB file, the sequence includes 10 amino acids of the CONNECTING-REGION of the gamma chain, however, the 3D structure only includes C-GAMMA amino acids up to position 124 (according to the IMGT unique numbering for C-DOMAIN and C-LIKE-DOMAIN).
The strands C, F and G are on the external face of C-GAMMA. Strands A, B , D and E are on the interface with the C-DELTA in the gamma-delta T cell receptor.

Legend:

C-DOMAIN loops are colored according to the IMGT color menu:
- TRG BC loop (blue), FG loop (gark green)
C-DOMAIN strands are colored according to the IMGT color menu for strand representation: A, B and C strands (orange), transversal CD strand (grey), D strand (yellow), E, F, G strands (blue).

This image has been generated with the program RASMOL version 2.6 [1] from the PDB file 1hxm [2], containing the atomic coordinates of the crystal structure of a human Vgamma9/Vdelta2 T cell receptor.

See also:

References:
[1] Sayle, R. and Milner-White, E.J. TIBS, 20, 374 (1995).
[2] Allison, T.J. et al., Nature, 411, 820-824 (2001).