Humanized antibodies
3D representation: CAMPATH-1H (PDB: 1bey)
IMGT/3Dstructure-DB card: 1bey
Humanized antibody CAMPATH-1H with grafted "Rat-CDR"
Legend:
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"Rat-CDR" are colored with standardized IMGT colors for CDR-IMGT.
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FR-IMGT amino acids limiting the CDR-IMGT regions (positions 26 and 39 for the CDR1-IMGT, 55 and 66 for the CDR2-IMGT, 104 and 118 for the CDR3-IMGT) are shown.
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F28 and T31 are amino acids restored by mutagenesis in amino acids corresponding to the rat sequence designated as "backmutations".
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This image has been generated with the program RASMOL version 2.6 [1] from the PDG file 1bey [2].
Humanized antibody CAMPATH-1H with CDR-IMGT delimitations
Legend:
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CDR-IMGT regions are colored as according to the IMGT color menu
IGK V-J-REGION: CDR1-IMGT (blue), CDR2-IMGT (green), CDR3-IMGT (greenblue)
IGH V-D-J-REGION: CDR1-IMGT (red), CDR2-IMGT (orange), CDR3-IMGT (purple)
The N (cyan) and C (magenta) ends of each region are also colored.
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FR-IMGT amino acids limiting the CDR-IMGT regions (positions 26 and 39 for the CDR1-IMGT, 55 and 66 for the CDR2-IMGT, 104 and 118 for the CDR3-IMGT) are shown.
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Letters A to G indicate the designation in 3D structure of beta strands.
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This image has been generated with the program RASMOL version 2.6 [1] from the PDG file 1bey [2].
Reference:
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[1] | Sayle, R. and Milner-White, E.J., TIBS, 20, 374-376 (1995). |
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[2] | Cheetham, G. M. T. et al., J. Mol. Biol. 284, 85-99 (1998). |
Created: 07/06/2001
Author: Lisa truong
